AutismKB 2.0

Annotation Detail for DCLRE1C


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:DCLRE1C ( A-SCID,DCLREC1C,FLJ11360,FLJ36438,RS-SCID,SCIDA,SNM1C,hSNM1C )
Gene Full Name: DNA cross-link repair 1C
Band: 10p13
Quick LinksEntrez ID:64421; OMIM: 605988; Uniprot ID:DCR1C_HUMAN; ENSEMBL ID: ENSG00000152457; HGNC ID: 17642
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03450Non-homologous end-joining
hsa05340Primary immunodeficiency
No data
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
H00092T-B- Severe combined immunodeficiencies
Immune system diseases
Primary immunodeficiency
Desease IDDesease Name
1773Combined immunodeficiency
1870Drug abuse
2239Lymphoma
No data
No data
Desease Name
Omenn syndrome
Severe combined immunodeficiency, Athabascan type
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of DCLRE1C mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DCLRE1C mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of DCLRE1C mRNAincreases expression 20458559
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of DCLRE1C mRNAdecreases expression 20106945
C006780 bisphenol A bisphenol A results in decreased expression of DCLRE1C mRNAdecreases expression 20678512
D015084 2,4-Dichlorophenoxyacetic Acid 2,4-Dichlorophenoxyacetic Acid results in increased expression of DCLRE1C mRNAincreases expression 15878651
D005419 Flavonoids Flavonoids results in decreased expression of DCLRE1C mRNAdecreases expression 18035473
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of DCLRE1C mRNAaffects cotreatment|increases expression 17183730
C023844 potassium nitrate potassium nitrate results in increased expression of DCLRE1C mRNAincreases expression 15878651
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of DCLRE1C mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.728875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1019490988
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000230 Adenocarcinoma arsenic trioxide 4.4819825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4820127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.746695378
MESH:D000382 Agricultural Workers' Diseases 2,4-Dichlorophenoxyacetic Acid 5.3516132792
MESH:D000550 Amblyopia Valproic Acid 5.5017688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.7117497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001321 Autistic Disorder Valproic Acid 1.9918177632 20603192 16609825 18316065 18775368 15238991 19232924 17507914 17157402 18558336 17688650 18396377 19460635 18985861 18940202
MESH:D001714 Bipolar Disorder Valproic Acid 3.1517594078 20046352
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.8416206674
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.518888407
MESH:D001862 Bone Resorption bisphenol A 4.0311985600
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.1617474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 2.1617123778
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5111589617
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.1016705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.1015073043 16217749 11135700 15553829 14691202
MESH:D002278 Carcinoma in Situ bisphenol A 5.2317123778
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1419014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2812490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0920419170
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7620734317
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.7510525206
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.7516575769 17688650 8888407
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2318551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2815213294
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 4.0821346803 18551238
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.0819641884 1733752
MESH:D004421 Dystonia Valproic Acid 4.231851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.3717275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.183922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0120417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.747562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.303659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5612903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5616530937
MESH:D005234 Fatty Liver arsenic trioxide 8.4915073043
MESH:D005234 Fatty Liver Valproic Acid 8.4914986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.1516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.338888407 18558336
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4616904648
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7420471113
MESH:D006849 Hydrocephalus Valproic Acid 5.1017688650
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8416612254
MESH:D007248 Infertility, Male 2,4-Dichlorophenoxyacetic Acid 4.7112948887
MESH:D007249 Inflammation Flavonoids 2.7217296493
MESH:D007333 Insulin Resistance bisphenol A 3.3916393666
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.1216705839
MESH:D007938 Leukemia arsenic trioxide 2.9115070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9717077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9319077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0016467208 19850784 17050201 16968895 20471514
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.0017596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3217712046 11161223 17649720 17217047 16823087 12018890 11468182 16331271 17107899 16112521 12712474 15336539 9834237 19642359 19075265 19225113 16891316 12679006 17869043 15748426 15622746 16966277 15213294 16330433 19035177
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5516882451
MESH:D008113 Liver Neoplasms arsenic trioxide 4.7514682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.7521137059 20195826
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.8320377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4815213294
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5317228818
MESH:D008175 Lung Neoplasms arsenic trioxide 2.4619825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4620464547 18816296 18569708 20869020 6695378 18520028 17053015 20064080 20135361
MESH:D008228 Lymphoma, Non-Hodgkin 2,4-Dichlorophenoxyacetic Acid 5.3016132792
MESH:D008881 Migraine Disorders Valproic Acid 3.3118765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2215949261 14977855 19417148 19549372 11468182
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.208888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.7216882451 16105982
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.7217596541
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0918551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1616624393
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2411141357
MESH:D009421 Nervous System Malformations bisphenol A 4.1716427766 11399458
MESH:D009436 Neural Tube Defects arsenic trioxide 7.6910525206
MESH:D009436 Neural Tube Defects Valproic Acid 7.698888407 16359493
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5916049721 12819281
OMIM:603554 OMENN SYNDROME marker/mechanism
MESH:D010049 Ovarian Diseases bisphenol A 5.2311985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4519769630 16624393 12452020
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5815580305
MESH:D010235 Paraganglioma arsenic trioxide 4.3519927285
MESH:D011248 Pregnancy Complications 2,4-Dichlorophenoxyacetic Acid 5.942087686
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 10.5510548101
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.5520603192
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.3820887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.5319131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5317292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.5316740699
MESH:D019310 Pseudolymphoma Valproic Acid 4.8111422049 12752131
MESH:D011629 Puberty, Precocious bisphenol A 5.0210548101
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3619155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1616646077
MESH:D012559 Schizophrenia Valproic Acid 2.0919110320 15737665
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3218551238
MESH:D012640 Seizures Valproic Acid 6.323137016 16876388 1511512 17978042 11044598 15475178 14763951 11738929
MESH:C537589 Severe combined immunodeficiency with sensitivity to ionizing radiation marker/mechanism
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4419755658 10029692
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8112833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4017007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4020155912 2093021
MESH:D019966 Substance-Related Disorders bisphenol A 4.2216045194 16684133
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2219014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2015213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.5017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.763119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.6416049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.6411780464 12845720 20435036 12973940
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.6417053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.868888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5510091137
MESH:D014591 Uterine Diseases bisphenol A 5.2714652134
Pathway ID Pathway Name
KEGG:03450 Non-homologous end-joining
KEGG:05340 Primary immunodeficiency
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved