AutismKB 2.0

Annotation Detail for TPSB2


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Basic Information Top
Gene Symbol:TPSB2 ( TPS2,tryptaseB,tryptaseC )
Gene Full Name: tryptase beta 2 (gene/pseudogene)
Band: 16p13.3
Quick LinksEntrez ID:64499; OMIM: 191081; Uniprot ID:TRYB2_HUMAN; ENSEMBL ID: ENSG00000197253; HGNC ID: 14120
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1724Vascular disease
2080Mastocytosis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of TPSB2 mRNAdecreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TPSB2 mRNAaffects expression 16483693
D001151 Arsenic Arsenic affects the expression of TPSB2 mRNAaffects expression 18414638
D011374 Progesterone Progesterone affects the expression of TPSB2 mRNAaffects expression 17251523
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.1918287403
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.963712494
MESH:D018246 Adrenocortical Adenoma Arsenic 5.9417306315
MESH:D020261 Arsenic Poisoning Arsenic 2.9518414634 16835338 12569548 16251483
MESH:D050197 Atherosclerosis Arsenic 3.4612928151 19371607
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.741440618 11289319
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 6.0617868700
MESH:D001930 Brain Injuries Progesterone 4.8215665606 15845082 15380490
MESH:D001943 Breast Neoplasms Progesterone 2.4115562024 16175315 17614352
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7817687452 15504454
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.297296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Arsenic 3.2917306315 16507464
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.837296757
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7715504454 18922899 17687452
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.4718640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.7115738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.6816973168 18022660
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 3.027505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.449022650 19486331
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.358970840 12868966 11298694 2524372 18759878 14531868 11906362 8156756
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.953621924 2952479
MESH:D003929 Diabetic Neuropathies Progesterone 5.0517187935
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.049328219 16192314 1440618 7440962 18289764 6679447 6482804 18648102 11289319 18692083 8291058 9022650 9653073
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.2817692515
MESH:D004715 Endometriosis Progesterone 4.1616134523
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.183581430
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.746705139
MESH:D005534 Foot Diseases Arsenic 6.286392382
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.507505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 4.026705139
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.8517050553
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.5015034207
MESH:D006973 Hypertension Arsenic 2.999931084 11953799 16076760
MESH:D006987 Hypesthesia Arsenic 6.2816093927
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.9615869954
MESH:D007249 Inflammation Progesterone 2.7715869954
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.748074119 9022650
MESH:D007642 Keratosis Arsenic 5.6212749816 16930632
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.316582329
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.7917339181
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4215034207 9327722
MESH:D008107 Liver Diseases Arsenic 2.6111134558
MESH:D008113 Liver Neoplasms Arsenic 2.7916368122
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.756587162 1399818 3712494 598648
MESH:D008175 Lung Neoplasms Arsenic 2.2117306315 17976673 19168569
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 3.1011408345 17203775
MESH:D017202 Myocardial Ischemia Arsenic 4.3115371236
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.593581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 8.196679447
MESH:D009436 Neural Tube Defects Arsenic 8.1916620997
MESH:D020078 Neurogenic Inflammation Arsenic 4.8417056641
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.814026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.743988306
MESH:D010051 Ovarian Neoplasms Arsenic 5.3917306315
MESH:D010051 Ovarian Neoplasms Progesterone 5.3917393432 16525653
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 4.047296757
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.6816093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.626392382 16905509 15371236
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.196228378
MESH:D011471 Prostatic Neoplasms Arsenic 3.5516140617
MESH:D011507 Proteinuria Arsenic 4.4721343184
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.673692021
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9618045962
MESH:D012871 Skin Diseases Arsenic 2.8216702368 17453740 19834688 16353154 6392382 17050553 16759981 17548696 18709164 15952646 17938729
MESH:D012878 Skin Neoplasms Arsenic 3.1617029826 19538983 17050553 17976673 16251483 15504454
MESH:D013119 Spinal Cord Injuries Progesterone 4.9115862959 16503802
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.191399818 6582329 3712494 7505956 6587162
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.638074119
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.6311144890 15987713 17306315 17976673 19322015 18640142 19429237
MESH:D014652 Vascular Diseases Arsenic 5.3717056641
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB02018 - Amido Phenyl Pyruvic Acid
DB04654 - 4-PIPERIDIN-4-YLBUTANAL
DB04764 - [4-(3-AMINOMETHYL-PHENYL)-PIPERIDIN-1-YL]-(5-PHENETHYL- PYRIDIN-3-YL)-METHANONE
DB06962 - (5-(aminomethyl)-2H-spiro[benzofuran-3,4'-piperidine]-1'-yl)(5-(phenylethynyl)furan-2-yl)methanone
No data
No data
No data

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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