AutismKB 2.0

Annotation Detail for BLVRB


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:BLVRB ( BVRB,FLR,MGC117413,SDR43U1 )
Gene Full Name: biliverdin reductase B (flavin reductase (NADPH))
Band: 19q13.2
Quick LinksEntrez ID:645; OMIM: 600941; Uniprot ID:BLVRB_HUMAN; ENSEMBL ID: ENSG00000090013; HGNC ID: 1063
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5874heme degradation
Pathway IDPathway Name
hsa00860Porphyrin and chlorophyll metabolism
Pathway IDPathway Name
Metabolism of porphyrins
No data
No data
Pathway IDPathway Name
500861Heme degradation
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C018855 2-tert-butylhydroquinone 2-tert-butylhydroquinone results in increased expression of BLVRB mRNAincreases expression 16014739
C006632 arsenic trioxide arsenic trioxide results in increased expression of BLVRB mRNAincreases expression 15725085
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of BLVRB mRNAincreases expression 20106945
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of BLVRB mRNAdecreases expression 17484886
C057862 cyanoginosin LR cyanoginosin LR results in increased expression of BLVRB mRNAincreases expression 17654400
D016572 Cyclosporine Cyclosporine results in increased expression of BLVRB mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of BLVRB mRNAdecreases expression 18042831
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of BLVRB mRNAincreases expression 17547211
D005472 Fluorouracil BLVRB protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D008767 Methylmercury Compounds Methylmercury Compounds results in increased expression of BLVRB mRNAincreases expression 16966085
C041786 palm oil palm oil results in decreased expression of BLVRB mRNAdecreases expression 18042831
C058305 phenethyl isothiocyanate phenethyl isothiocyanate results in increased expression of BLVRB mRNAincreases expression 17616710
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of BLVRB mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of BLVRB mRNAincreases expression 19482888
C006253 pirinixic acid pirinixic acid results in increased expression of BLVRB mRNAincreases expression 18301758
D011794 Quercetin Quercetin affects the expression of BLVRB mRNAaffects expression 18178720
D012643 Selenium Selenium results in increased expression of BLVRB mRNAincreases expression 19244175
C017947 sodium arsenite sodium arsenite results in increased expression of BLVRB mRNAincreases expression 16014739
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of BLVRB mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of BLVRB mRNAaffects binding|increases expression 16214954
D014212 Tretinoin Tretinoin results in increased expression of BLVRB mRNAincreases expression 16249480
D014635 Valproic Acid Valproic Acid results in increased expression of BLVRB mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 13.706195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 13.7014514962 11752688 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 13.708875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.8419490988
MESH:D055371 Acute Lung Injury pirinixic acid 3.0318653653
MESH:D000230 Adenocarcinoma arsenic trioxide 10.0419825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 10.0420127859 20464547
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 10.0416033868
MESH:D000230 Adenocarcinoma Fluorouracil 10.0417638652
MESH:D000236 Adenoma Benzo(a)pyrene 6.726695378
MESH:D000236 Adenoma Dimethylnitrosamine 6.7219555203
MESH:D018248 Adenoma, Liver Cell Phenobarbital 16.8017620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.8016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.8016835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.6215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8216712894 17306315
MESH:D000505 Alopecia Tretinoin 3.5415955085
MESH:D000550 Amblyopia Valproic Acid 5.1517688650
MESH:D000740 Anemia Fluorouracil 8.4216511603 17963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.4211748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.1617084956
MESH:D001008 Anxiety Disorders Valproic Acid 3.5017497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9919183758
MESH:D001161 Arteriosclerosis Dietary Fats 3.8015238619
MESH:D001169 Arthritis, Experimental Tretinoin 3.0216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2416292516
MESH:D001249 Asthma Tretinoin 2.3216456186
MESH:D001260 Ataxia Telangiectasia Quercetin 4.8915336622
MESH:D001321 Autistic Disorder Valproic Acid 2.0118558336 18775368 15238991 16609825 17507914 18177632 20603192 17688650 18985861 17157402 19232924 18316065 19460635 18396377 18940202
MESH:D001327 Autoimmune Diseases Quercetin 4.3219761891
MESH:D001471 Barrett Esophagus Tretinoin 4.3216935849
MESH:D001714 Bipolar Disorder Valproic Acid 3.0320046352 17594078
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 21.2716206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 21.2719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 21.2712125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 21.2716206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.8315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.838888407
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.9220146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 2.9220435547
MESH:D001943 Breast Neoplasms Fluorouracil 2.9216110121 19217205 18357371 15136595 16595493 16557594 18608205
MESH:D001943 Breast Neoplasms Quercetin 2.9218628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9220435547
MESH:D001943 Breast Neoplasms Tretinoin 2.9216873071 16166294 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5016813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2411589617
MESH:D002105 Cadmium Poisoning Quercetin 5.4616962696
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6910355542 16192424 3786805 16050911 18705752 15673190 16124888 16227642 16097048 15721981 16011737 15700767
MESH:D002276 Carcinoid Tumor Fluorouracil 4.5916051944
MESH:D002277 Carcinoma Dimethylnitrosamine 13.5819555203
MESH:D002277 Carcinoma Fluorouracil 13.5817121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 13.5816835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.0816168501
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 13.8916217749 15553829 14691202 15073043 11135700
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.8918788625
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 13.8916799960 17088986 16332177 17971768 17045692 18930000
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 13.891701930 20007298 17173139 20935162 6705139
MESH:D006528 Carcinoma, Hepatocellular Quercetin 13.8919519916 12508355
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 13.8915276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.891917145
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.8717234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.7919014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.9818695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0412490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 14.0720419170
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 14.0716033868
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 14.0717066447 16757204 16280240 18986760
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 14.0718572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 14.0716051514 16096774
MESH:D006332 Cardiomegaly Quercetin 6.6419794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.6418670907 16120746 18850075
MESH:D002386 Cataract Tretinoin 3.0417460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.4512371664
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.4520056578 19524636
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.164080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5016129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6820734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0816835633
MESH:D002779 Cholestasis Cyclosporine 7.5419486331
MESH:D002779 Cholestasis pirinixic acid 7.5419176532
MESH:D002822 Choriocarcinoma Tretinoin 5.0816461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.6415668235 8697196 12621046 15340226 16354765
MESH:D002972 Cleft Palate Tretinoin 5.649407595
MESH:D003092 Colitis Selenium 9.2117936198
MESH:D003092 Colitis Tretinoin 9.2117035595
MESH:D003093 Colitis, Ulcerative phenethyl isothiocyanate 3.6220423518
MESH:D003110 Colonic Neoplasms Fluorouracil 3.8516510598 17172411 15001691 18772588 17725105 17016597 16340194 17287894 17018589 17169374
MESH:D003110 Colonic Neoplasms Quercetin 3.8516640504 17148506 11134977 15741050 19056647 19440933 17191121
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.4420501625
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.4416303861 17255274 16524972 17401013 18509181 17594712 20501625 15148649 17695437 17016601 16331619 18383874 18802399 14970324 17454858 17094418 18288408 18949393 18448328 16282729 15289873 16391804
MESH:D015179 Colorectal Neoplasms Quercetin 3.4418852136 18095365
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9814669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1012609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 5.3210525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.3220055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.329664655 10589399 9125849 17551590 8800419 16925845 14991402 9142499 9224671 9211117
MESH:D019465 Craniofacial Abnormalities Valproic Acid 5.328888407 17688650 16575769
MESH:D007644 Darier Disease Fluorouracil 4.7116733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.0115213294
MESH:D003704 Dementia Methylmercury Compounds 4.9116140633
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.6619496084
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6517107852
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 14.9416177239 6623471 2869522 7179309 7440962 3732212 11566570 15998439 17522070 3786805 19336974 6884620 9327722 7120509 19085960 15027814 16227642 10915739 15968718 10092053 4309450 21278145
MESH:D056486 Drug-Induced Liver Injury cyanoginosin LR 14.9417654400
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 14.948172417
MESH:D056486 Drug-Induced Liver Injury Selenium 14.9415131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.9420420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 14.941733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6911462148
MESH:D050171 Dyslipidemias Dietary Fats 3.3918367378
MESH:D004421 Dystonia Phenobarbital 10.151851702
MESH:D004421 Dystonia Valproic Acid 10.151851702
MESH:D004487 Edema pirinixic acid 6.2712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.2711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.6718230668 16714409 15322242
MESH:D004489 Edema, Cardiac Tretinoin 11.6718230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.0516569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9410568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 10.503659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 10.5017275665 3659116
MESH:D004828 Epilepsies, Partial Phenobarbital 9.703922381 11558140
MESH:D004828 Epilepsies, Partial Valproic Acid 9.703922381 16628512
MESH:D004827 Epilepsy Phenobarbital 6.5220417680
MESH:D004827 Epilepsy Valproic Acid 6.5218234410 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 8.616401628
MESH:D004832 Epilepsy, Absence Valproic Acid 8.616254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 11.017750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 11.017750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 10.193659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 10.193659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 10.2512903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 10.2516530937
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 10.2517016578
MESH:D004938 Esophageal Neoplasms Fluorouracil 10.2516337965 16785472 16481741 15173087 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.6111564622
MESH:D005124 Eye Abnormalities Tretinoin 8.619664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 29.6615073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 29.6619224547 16239168 12631006 15959796 12795759 16045604 61145 17595544
MESH:D005234 Fatty Liver Cyclosporine 29.6619224547
MESH:D005234 Fatty Liver Dietary Fats 29.6617967931 19551842 18296743 19004024
MESH:D005234 Fatty Liver pirinixic acid 29.6619236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 29.6614986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3711858732
MESH:D005315 Fetal Diseases Valproic Acid 4.8116575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.048888407 18558336
MESH:D005355 Fibrosis Carbon Tetrachloride 33.4218705752
MESH:D005355 Fibrosis Cyclosporine 33.4212168785 12639820
MESH:D005355 Fibrosis Dietary Fats 33.4218296743
MESH:D005355 Fibrosis Quercetin 33.4219474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 33.4220067830
MESH:D005355 Fibrosis Tretinoin 33.4217994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.1816904648
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5916452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.138708960
MESH:D005909 Glioblastoma Quercetin 7.0719804834
MESH:D005909 Glioblastoma Tretinoin 7.0717312396
MESH:D005910 Glioma Fluorouracil 6.0716145905
MESH:D005910 Glioma Quercetin 6.0717643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5110696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.5918337622 15102660 15162350
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.5916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.0816084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.8220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.8211294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 10.8214991402 9664655
MESH:D006333 Heart Failure pirinixic acid 6.7720558911
MESH:D006333 Heart Failure Selenium 6.7717162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2511000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.5119110552 19900420
MESH:D006529 Hepatomegaly Phenobarbital 13.8816109766
MESH:D006529 Hepatomegaly pirinixic acid 13.8818467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.8815340226 12621046 16120746
MESH:D006689 Hodgkin Disease sodium arsenite 3.0812676792
MESH:D006849 Hydrocephalus Valproic Acid 4.7817688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.968697196 16354765 15340226 18606429 16959395
MESH:D006930 Hyperalgesia Tretinoin 3.1416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4516899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.5121332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4816778211
MESH:D006943 Hyperglycemia pirinixic acid 8.9820558911
MESH:D006943 Hyperglycemia Quercetin 8.9811834736 18262572
MESH:D006949 Hyperlipidemias Dietary Fats 3.5321332399
MESH:D006973 Hypertension Cyclosporine 8.3910903974
MESH:D006973 Hypertension Quercetin 8.3918356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.3918850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0015338365
MESH:D007248 Infertility, Male sodium arsenite 2.9315346721 12646999
MESH:D007249 Inflammation Dietary Fats 4.7620412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.7612878042 12200463
MESH:D007251 Influenza, Human Quercetin 10.7916624496
MESH:D007251 Influenza, Human Selenium 10.7916624496
MESH:D007333 Insulin Resistance Dietary Fats 7.0518457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.0516306350
MESH:D007410 Intestinal Diseases Tretinoin 3.6817994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.6616580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.6615992940 17551590
MESH:D007627 Keloid Quercetin 4.8717086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3615604871
MESH:D007674 Kidney Diseases Cyclosporine 9.838314463 18776723 10903974
MESH:D007674 Kidney Diseases Quercetin 9.8316962696
MESH:D007674 Kidney Diseases sodium arsenite 9.8320008137
MESH:D007676 Kidney Failure, Chronic Selenium 3.8016518626
MESH:D007680 Kidney Neoplasms Cyclosporine 7.1512371664
MESH:D007680 Kidney Neoplasms Fluorouracil 7.1516985049
MESH:D007938 Leukemia arsenic trioxide 10.2615070760
MESH:D007938 Leukemia Quercetin 10.2617468513
MESH:D007938 Leukemia Tretinoin 10.2617143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.7117077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.2216972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3614633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.2019077051
MESH:D007951 Leukemia, Myeloid Tretinoin 9.2016932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 6.0219850784 16968895 20471514 16467208 17050201
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 6.0219850784 17596541 16294345
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 6.0217596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.4419642359 15336539 11468182 11161223 19035177 17217047 17107899 16330433 16112521 19225113 16891316 16331271 9834237 15748426 17712046 12018890 12679006 16966277 17869043 17649720 15213294 16823087 15622746 12712474 19075265
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.4415748426 17361223 16331271 16891316 17217047 16788101 12679006 17649720 17506722 16935935 17368321 19035177 16766008 16823087 17712046 19029980 16140955 17294898 9834237 17339181 19225113 17301526 17107899 19075265 19642359
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.2716882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.249224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.7516943688 11903743 17157831 16239168 17174718 16221502 21278145 17334410 11408273
MESH:D008103 Liver Cirrhosis Dietary Fats 10.7518296743
MESH:D008103 Liver Cirrhosis Phenobarbital 10.7521047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.6118412020 12445418 15730626 15931870 15338365 16136751 15362042 14620537 12632514 17869086 16192424 15959796 14724832 11481614 18339082 17922224 18210741 16097048 16027843 16033810 18156304 15052691 12445421 14716833 15876570 17481882 17631135 16011737 15057751 18054572 15996030 17900296 12898905 17976157 12741479 12649538 18429990 18395095 12546737 18420326 13678700 18472094 12667390 20821823 18705752 12609069 18317297 18263696 18205269 16638106 17944888 18277467 16248980 15925388 18481824 17698563 12632512 15818738 17766677 17761835 17557913 12389079 18418968 15370692 15650968 14512876 17721639 17708605 18187930 17823541 16116963 12666154 17640975 14748882 17525996 14716496 17565644 16015684 10355542 17714472 18395914 18251166 15893842 18376398 12586293 18472332 17805973 18006644 18166357 18279442 15673190 15123356 12958196
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 8.6115942678 17198567 16042886 16603200 18237412 15744066 12925901 15492853 15864749 15763062 14709902 17724770 18672772 15591649 18210741 18239293 17348192 17201889 14659978 15099470 15138612 18629640 15479170 18095165 17465448 16627068 17881167 16009107 15086199 18364076 15067225 15383259 17534399 14643895 16544323 17666798 17196135 15577212 15798949 15369754 18637143 17036385 15161499 17719030 15339415 15571005 16270385 17432682 15842777 14726149 12918455 15081153 15298665 15793283 18371158 14568256 18567088 17203207 15504291 15723089 15733078 16169303 15366600 17640959 16570917
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.6115474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 8.6112741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.6112878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.6118397230 16248980
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0216246199 16964402 17285989 15720792 15830285
MESH:D008107 Liver Diseases Phenobarbital 4.0219363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.5716899240 14706259
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 9.5717457977
MESH:D008113 Liver Neoplasms arsenic trioxide 33.8714682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 33.8720195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 33.8719294768
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 33.8715890375 3113478
MESH:D008113 Liver Neoplasms Fluorouracil 33.8718383874 17045692 16603448 15113037
MESH:D008113 Liver Neoplasms Phenobarbital 33.878742319 19073162 15975961 19812893 21047994 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 33.8716377806 20007298 15890375
MESH:D008113 Liver Neoplasms Quercetin 33.8718980244
MESH:D008113 Liver Neoplasms sodium arsenite 33.8715276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 33.8716984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 22.6720377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 22.6712014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 22.676150874 15603536 1848544
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 22.672563599 1399818 18308698 17172636 6150874
MESH:D008114 Liver Neoplasms, Experimental Quercetin 22.6719519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 22.6712151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2815213294
MESH:D008171 Lung Diseases sodium arsenite 3.1119095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.1817228818
MESH:D008175 Lung Neoplasms arsenic trioxide 10.5511798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 10.5518520028 18816296 17053015 6695378 20869020 18569708 20064080 20135361 20464547
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 10.5516061637 11884234 19555203
MESH:D008175 Lung Neoplasms Fluorouracil 10.5515246190
MESH:D008175 Lung Neoplasms Quercetin 10.5516280456
MESH:D008175 Lung Neoplasms sodium arsenite 10.5517077188 15276417 17306315 19931552 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.5511884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.7115086387
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.7115318939
MESH:D008527 Medulloblastoma Tretinoin 2.7517453147
MESH:D008545 Melanoma sodium arsenite 3.2916487513 19082730
MESH:D008545 Melanoma Tretinoin 3.2916752155
MESH:D008569 Memory Disorders Methylmercury Compounds 4.8218436314
MESH:D008591 Meningomyelocele Tretinoin 4.3416940565
MESH:D008654 Mesothelioma Selenium 2.7615107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7116801185
MESH:D008881 Migraine Disorders Valproic Acid 3.1318765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.3016381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.3016757204 18986760
MESH:D009069 Movement Disorders Methylmercury Compounds 5.2418436314
MESH:D009101 Multiple Myeloma arsenic trioxide 3.0414977855 11468182 19417148 19549372 15949261
MESH:D009135 Muscular Diseases pirinixic acid 3.4216239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.948888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.5918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 12.0216882451 16105982
MESH:D009190 Myelodysplastic Syndromes Tretinoin 12.0217596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 12.0217596541
MESH:D009203 Myocardial Infarction pirinixic acid 5.6019151258
MESH:D009203 Myocardial Infarction Quercetin 5.6019595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9512213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.2116411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 8.2119207477
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.3917484760
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.8716624393
MESH:D009369 Neoplasms Benzo(a)pyrene 19.2511141357
MESH:D009369 Neoplasms Fluorouracil 19.2516928823 18600527 18239605
MESH:D009369 Neoplasms pirinixic acid 19.2517405874
MESH:D009369 Neoplasms Quercetin 19.2515185748
MESH:D009369 Neoplasms sodium arsenite 19.2511559025
MESH:D009369 Neoplasms Tretinoin 19.2516946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.5820056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2119348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.2214600291
MESH:D009421 Nervous System Malformations Tretinoin 9.229125849
MESH:D009436 Neural Tube Defects arsenic trioxide 16.8610525206
MESH:D009436 Neural Tube Defects sodium arsenite 16.8612854658
MESH:D009436 Neural Tube Defects Tretinoin 16.869142499
MESH:D009436 Neural Tube Defects Valproic Acid 16.868888407 16359493
MESH:D020078 Neurogenic Inflammation Quercetin 4.2817929310
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3816436463
MESH:D009765 Obesity Dietary Fats 4.3621332399 18674790 16723640 19632207 18457598 11836018 17217161 20518802 20132043
MESH:D009765 Obesity pirinixic acid 4.3620558911
MESH:D010018 Osteomalacia Phenobarbital 4.2817016548
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.1319495926
MESH:D010051 Ovarian Neoplasms arsenic trioxide 11.0912452020 16624393 19769630
MESH:D010051 Ovarian Neoplasms Quercetin 11.0919005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 11.0915276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 11.0916936753
MESH:D010146 Pain Tretinoin 2.8316870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 15.9915580305
MESH:D010190 Pancreatic Neoplasms Fluorouracil 15.9916929163 19003803 15113037 16500647
MESH:D010190 Pancreatic Neoplasms Phenobarbital 15.9916965848
MESH:D010190 Pancreatic Neoplasms Quercetin 15.9916965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 15.9915976015
MESH:D010235 Paraganglioma arsenic trioxide 4.0819927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1712520081
MESH:D010954 Plasmacytoma Selenium 4.8115087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4718163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.8912371664
MESH:D011230 Precancerous Conditions Phenobarbital 14.892563599
MESH:D011230 Precancerous Conditions Quercetin 14.8919056647
MESH:D011297 Prenatal Exposure Delayed Effects Methylmercury Compounds 15.8918436314
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.8911222880 11896295 11399792 11118676
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 15.8920603192
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.8719131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8717292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8719082440 18626508
MESH:D011471 Prostatic Neoplasms Quercetin 1.8717292933 14715546
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.8716039940
MESH:D011507 Proteinuria Tretinoin 3.5216636307
MESH:D019310 Pseudolymphoma Phenobarbital 11.9212752131
MESH:D019310 Pseudolymphoma Valproic Acid 11.9211422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.2016882103
MESH:D011625 Pterygium Tretinoin 4.7116723453
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9316160472 18286688 18722050 15538739
MESH:D015427 Reperfusion Injury pirinixic acid 2.3419058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7518990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.5816283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 10.5819155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.8716646077
MESH:D012554 Schistosomiasis japonica Quercetin 5.4616862918
MESH:D012559 Schizophrenia Valproic Acid 2.0619110320 15737665
MESH:D012640 Seizures Phenobarbital 5.804039156 16876388 3137016 11442880
MESH:D012640 Seizures Valproic Acid 5.8014763951 16876388 3137016 15475178 11044598 17978042 1511512 11738929
MESH:D003294 Seizures, Febrile Phenobarbital 4.746407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 13.2110029692 19755658
MESH:D012878 Skin Neoplasms sodium arsenite 13.2118572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.2116192470
MESH:D012878 Skin Neoplasms Tretinoin 13.2116467112
MESH:D016135 Spinal Dysraphism sodium arsenite 9.3112854658
MESH:D016135 Spinal Dysraphism Valproic Acid 9.3119490988
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.1912587719
MESH:D013226 Status Epilepticus Valproic Acid 4.4612833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 6.3117007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 6.312093021 20155912
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 6.3116033868
MESH:D013274 Stomach Neoplasms Fluorouracil 6.3117498489 19084572 15786421 16951190 16424979 17172411 17522103 18567086 19015929 18396642
MESH:D013274 Stomach Neoplasms Tretinoin 6.3117261132
MESH:D013733 Testicular Diseases phenethyl isothiocyanate 4.8615864552
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8212697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 11.5919014326
MESH:D013964 Thyroid Neoplasms Phenobarbital 11.591399818
MESH:D013964 Thyroid Neoplasms Tretinoin 11.5917045167 16026305
MESH:D014062 Tongue Neoplasms Fluorouracil 9.5616280240
MESH:D014062 Tongue Neoplasms Tretinoin 9.5616051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.8815213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.1517262798
MESH:D014376 Tuberculosis Tretinoin 3.1716040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.443119515
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 11.6720435036 11780464 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.6717053015
MESH:D001749 Urinary Bladder Neoplasms Quercetin 11.6716720314
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 11.6717306315 16452187 16712894 11723127
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.568888407
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 15.4016803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 15.4011813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 15.4016129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.5316752155
MESH:D014605 Uveitis Cyclosporine 3.901336536
MESH:D014652 Vascular Diseases sodium arsenite 4.3417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5112125929
MESH:D014820 Vitiligo Tretinoin 3.9716761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1715886252
MESH:D015430 Weight Gain Dietary Fats 3.6616723640
MESH:D009396 Wilms Tumor Tretinoin 3.8916287080
MESH:D014985 Xerophthalmia Cyclosporine 4.3617120751
Pathway ID Pathway Name
REACT:9431 Metabolism of porphyrins
KEGG:00860 Porphyrin and chlorophyll metabolism
KEGG:00740 Riboflavin metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25374
    • No data
    No data
    Releated drug ID Related drug Name
    PA449177cytarabine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00140 - Riboflavin Vitamins (Vitamin B Complex);Radiation-Sensitizing Agents;Photosensitizing Agents;Vitamin B Complex
    DB00157 - NADH Dietary supplement;Micronutrient
    DB02073 - Biliverdine Ix Alpha
    DB03247 - Riboflavin Monophosphate Vitamin B Complex
    DB03461 - 2'-Monophosphoadenosine 5'-Diphosphoribose
    DB04345 - 7,8-dimethylalloxazine
    DB04363 - Mesobiliverdin Iv Alpha
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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