AutismKB 2.0

Annotation Detail for SH3BP2


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Basic Information Top
Gene Symbol:SH3BP2 ( 3BP2,CRBM,CRPM,FLJ42079,FLJ54978 )
Gene Full Name: SH3-domain binding protein 2
Band: 4p16.3
Quick LinksEntrez ID:6452; OMIM: 602104; Uniprot ID:3BP2_HUMAN; ENSEMBL ID: ENSG00000087266; HGNC ID: 10825
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04650Natural killer cell mediated cytotoxicity
No data
Pathway IDPathway Name
200022TCR signaling in naive CD4+ T cells
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1824Bone disease
No data
No data
Desease Name
Cherubism
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SH3BP2 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of SH3BP2 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of SH3BP2 mRNAaffects expression 17562736
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SH3BP2 mRNAincreases expression 17555576
C013038 hydroxyhydroquinone hydroxyhydroquinone results in increased expression of SH3BP2 mRNAincreases expression 17572062
D010634 Phenobarbital Phenobarbital results in increased expression of SH3BP2 mRNAincreases expression 19270015
C006253 pirinixic acid NCF1 protein inhibits the reaction [pirinixic acid results in decreased expression of SH3BP2 mRNA]decreases expression|decreases reaction 17950772
C006253 pirinixic acid pirinixic acid results in decreased expression of SH3BP2 mRNAdecreases expression 17950772
D011794 Quercetin Quercetin results in increased expression of SH3BP2 mRNAincreases expression 15309432
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.786195326
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.883712494
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.2717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.2716434500
MESH:D000743 Anemia, Hemolytic Quercetin 4.4817084956
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001260 Ataxia Telangiectasia Quercetin 5.3115336622
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001327 Autoimmune Diseases Quercetin 4.7119761891
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.4011289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D001943 Breast Neoplasms Quercetin 2.6318628248
MESH:D002105 Cadmium Poisoning Quercetin 5.9216962696
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.2216705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 9.227296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.223084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 9.2220007298 1701930 17173139 6705139 20935162
MESH:D006528 Carcinoma, Hepatocellular Quercetin 9.2219519916 12508355
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.2617234771
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.777296757
MESH:D006332 Cardiomegaly Quercetin 3.4419794523
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.917505956
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.564080065
MESH:D002636 Cherubism marker/mechanism
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 14.4119486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 14.4111677210 16919318 16105132 17333356 17681005 15861022 17110522
MESH:D002779 Cholestasis pirinixic acid 14.4119176532
MESH:D003110 Colonic Neoplasms Quercetin 2.4515741050 11134977 17148506 17191121 16640504 19056647 19440933
MESH:D015179 Colorectal Neoplasms Quercetin 2.1918852136 18095365
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.3218551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.1011298694 12868966 8970840 11906362 18759878 8156756 14531868 2524372
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.753621924 2952479
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.9319496084
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.5318551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.5311289319 16192314 9653073 6679447 1440618 18289764 6482804 7440962 9022650 18648102 9328219 8291058 18692083
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5311461765 19420014 11529661 18071297 12540782 15968718 10774834 19085960 19370779 16485898 11739529 11421492 12153990 12705907 18713872 12594235 11743745 2444490 14725611 16081117 16781746 10915739 17562736 12958197 10663392 16109766 14550746 14986274 19416960 17522070 11834606 19164858 17906064 16393943 15619225 19923254 16227642 19739265 16177239 11287661 12392966
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004421 Dystonia Phenobarbital 4.261851702
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4712538720
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.413659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.253922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.766401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.363659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.3615345470
MESH:D005234 Fatty Liver pirinixic acid 8.3620131406 19236843
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.406705139
MESH:D005355 Fibrosis Quercetin 4.2019474275
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005909 Glioblastoma Quercetin 3.5419804834
MESH:D005910 Glioma Quercetin 3.1317643826
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.307505956
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.796705139
MESH:D006529 Hepatomegaly Phenobarbital 9.5216109766
MESH:D006529 Hepatomegaly pirinixic acid 9.5216221962 19176532 18467677 19772884
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006943 Hyperglycemia pirinixic acid 10.0120558911
MESH:D006943 Hyperglycemia Quercetin 10.0118262572 11834736
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2515034207
MESH:D006973 Hypertension Quercetin 2.9318356687
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007251 Influenza, Human Quercetin 4.8816624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.408074119 9022650
MESH:D007627 Keloid Quercetin 5.2617086741
MESH:D007674 Kidney Diseases Acetaminophen 6.5015629191 12587719
MESH:D007674 Kidney Diseases Quercetin 6.5016962696
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.0416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.046582329
MESH:D007938 Leukemia Quercetin 3.2617468513
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0121047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5415474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 2.5412741479
MESH:D008107 Liver Diseases Acetaminophen 4.1012969438 12587719 19784758 11587558 16611625 16610002 19460945 19014921
MESH:D008107 Liver Diseases Phenobarbital 4.1019363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms Phenobarbital 7.948742319 19812893 21047994 19482888 19073162 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 7.9420007298 16377806 15890375
MESH:D008113 Liver Neoplasms Quercetin 7.9418980244
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.756587162 1399818 3712494 598648
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.7517172636 6150874 18308698 1399818 2563599
MESH:D008114 Liver Neoplasms, Experimental Quercetin 10.7519519916
MESH:D008175 Lung Neoplasms Quercetin 2.1916280456
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 6.0119151258
MESH:D009203 Myocardial Infarction Quercetin 6.0119595682
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 9.0616411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 9.0619207477
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8117484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.2018551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.553581430
MESH:D009369 Neoplasms pirinixic acid 5.4017405874
MESH:D009369 Neoplasms Quercetin 5.4015185748
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.066679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D020078 Neurogenic Inflammation Quercetin 4.6217929310
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.6512819281 16049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.654026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.403988306
MESH:D010018 Osteomalacia Phenobarbital 4.7017016548
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.4819495926
MESH:D010051 Ovarian Neoplasms Quercetin 2.7919005980
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.6616965848
MESH:D010190 Pancreatic Neoplasms Quercetin 5.6616965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.797296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.856228378
MESH:D011230 Precancerous Conditions Phenobarbital 9.972563599
MESH:D011230 Precancerous Conditions Quercetin 9.9719056647
MESH:D011471 Prostatic Neoplasms Quercetin 3.5617292933 14715546
MESH:D011537 Pruritus Ethinyl Estradiol 3.6516919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.8712752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.553692021
MESH:D012554 Schistosomiasis japonica Quercetin 5.9216862918
MESH:D012640 Seizures 2,4-dinitrotoluene 6.4518551238
MESH:D012640 Seizures Phenobarbital 6.453137016 11442880 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 5.166407741
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.761399818 3712494 6587162 6582329 7505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.761399818
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.8316049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.838074119
MESH:D001749 Urinary Bladder Neoplasms Quercetin 8.8316720314
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6510091137
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7814671159 15869587
Pathway ID Pathway Name
KEGG:04650 Natural killer cell mediated cytotoxicity
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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