AutismKB 2.0

Annotation Detail for SH3GL2


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Basic Information Top
Gene Symbol:SH3GL2 ( CNSA2,EEN-B1,FLJ20276,FLJ25015,SH3D2A,SH3P4 )
Gene Full Name: SH3-domain GRB2-like 2
Band: 9p22.2
Quick LinksEntrez ID:6456; OMIM: 604465; Uniprot ID:SH3G2_HUMAN; ENSEMBL ID: ENSG00000107295; HGNC ID: 10831
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04144Endocytosis
Pathway IDPathway Name
Signalling by NGF
Membrane Trafficking
Axon guidance
Signaling by EGFR
Pathway IDPathway Name
200032Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
200007RhoA signaling pathway
200146Internalization of ErbB1
No data
Pathway IDPathway Name
500097L1CAM interactions
500098Recycling pathway of L1
500645Retrograde neurotrophin signalling
500100Signal transduction by L1
500013Clathrin derived vesicle budding
500014Golgi Associated Vesicle Biogenesis
500015Lysosome Vesicle Biogenesis
500515EGFR downregulation
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1944Breast cancer
Desease Name
CHEMDEPENDENCY
multiple sclerosis
IMMUNE
NEUROLOGICAL
smoking cessation
Cognitive performance
Desease Name
Multiple sclerosis
Heart failure
Cognitive performance
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SH3GL2 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SH3GL2 mRNAaffects expression 16483693
D001104 Arbutin Arbutin results in decreased expression of SH3GL2 mRNAdecreases expression 17103032
C006632 arsenic trioxide arsenic trioxide results in increased expression of SH3GL2 mRNAincreases expression 15761015
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SH3GL2 mRNAdecreases expression 20106945
D005419 Flavonoids Flavonoids results in increased expression of SH3GL2 mRNAincreases expression 18035473
C025299 polyphenols polyphenols results in decreased expression of SH3GL2 mRNAdecreases expression 16293270
D012402 Rotenone Rotenone results in increased expression of SH3GL2 mRNAincreases expression 19013527
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SH3GL2 mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1314514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D000230 Adenocarcinoma arsenic trioxide 4.5019825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5020127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.766695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.6616206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.6612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8817474063 20146248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8820435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5511589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.1821507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.1815553829 11135700 16217749 15073043 14691202
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3112490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718850075 16120746 18670907
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.188697196 12621046 16354765 15340226 15668235
MESH:D003110 Colonic Neoplasms polyphenols 2.7016293270
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5210525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5210048152 15322242 20055451
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3215213294
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury polyphenols 4.1519370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.1520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2218230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2110568697 9294722
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5912903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5916530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver arsenic trioxide 3.4915073043
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5016904648
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7710048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1512621046 16120746 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.368697196 15340226 16959395 18606429 16354765
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718850075 18670907
MESH:D007249 Inflammation Flavonoids 8.9817296493
MESH:D007249 Inflammation polyphenols 8.9816366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.9812200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007938 Leukemia arsenic trioxide 2.9215070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0017077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1617050201 16467208 19850784 20471514 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3415213294 16331271 17649720 11468182 19075265 16330433 19035177 16112521 19642359 19225113 16823087 11161223 16891316 12018890 12712474 15336539 17869043 15748426 15622746 16966277 17217047 17712046 17107899 12679006 9834237
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5916882451
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases polyphenols 2.8216698588
MESH:D008113 Liver Neoplasms Aflatoxin B1 11.262125692 15890375 18177683 9163691
MESH:D008113 Liver Neoplasms arsenic trioxide 11.2614682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.2620195826 21137059
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.2616984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.548603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.5420377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.5412151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5115213294
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.9914755239
MESH:D008175 Lung Neoplasms arsenic trioxide 4.9919825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9917053015 18569708 20464547 20135361 18520028 18816296 20869020 20064080 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9919555203 11884234
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2514977855 11468182 15949261 19549372 19417148
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2516882451 16105982
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2016624393
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2511141357
MESH:D009410 Nerve Degeneration Rotenone 4.0417356569 15790535 18619942
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2410525206
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4612452020 19769630 16624393
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5815580305
MESH:D010235 Paraganglioma arsenic trioxide 4.3819927285
MESH:D010300 Parkinson Disease Rotenone 3.0418619942 19232380 18191903 11445065 15451049 11535288 16412576 19114014 16140633
MESH:D020734 Parkinsonian Disorders Rotenone 4.2718197244 15574749 15927086 15795934
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811222880 11118676 11399792 11896295
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.1319131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1317292933
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2016646077
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7619755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7616192470
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4117007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4120155912 2093021
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.5717997062
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2419014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2415213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.2720435036 12845720 11780464 12973940
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2717053015
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
Pathway ID Pathway Name
REACT:18266 Axon guidance
KEGG:04144 Endocytosis
REACT:11123 Membrane Trafficking
REACT:9417 Signaling by EGFR
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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