AutismKB 2.0

Annotation Detail for ALDH8A1


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Basic Information Top
Gene Symbol:ALDH8A1 ( ALDH12,DJ352A20.2,DKFZp779D2315,MGC138650 )
Gene Full Name: aldehyde dehydrogenase 8 family, member A1
Band: 6q23.3
Quick LinksEntrez ID:64577; OMIM: 606467; Uniprot ID:AL8A1_HUMAN; ENSEMBL ID: ENSG00000118514; HGNC ID: 15471
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P043725-Hydroxytryptamine degredation
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of ALDH8A1 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of ALDH8A1 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ALDH8A1 proteinaffects expression 20106945
D019324 beta-Naphthoflavone beta-Naphthoflavone results in decreased expression of ALDH8A1 mRNAdecreases expression 19737606
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ALDH8A1 mRNAdecreases expression 20106945
19737606
D016572 Cyclosporine Cyclosporine results in decreased expression of ALDH8A1 mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in decreased expression of ALDH8A1 mRNAdecreases expression 20106945
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ALDH8A1 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of ALDH8A1 mRNAdecreases expression 18445702
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ALDH8A1 mRNAdecreases expression 17884332
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of ALDH8A1 mRNAaffects expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ALDH8A1 mRNAincreases expression 16267337
D014212 Tretinoin Tretinoin results in decreased expression of ALDH8A1 mRNAdecreases expression 18230668
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0814514962 15322242 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4120127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.4111473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 11.743712494
MESH:D000236 Adenoma Benzo(a)pyrene 11.746695378
MESH:D000236 Adenoma beta-Naphthoflavone 11.7419389873
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.7116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.7116835633
MESH:D000505 Alopecia Tretinoin 3.7515955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001169 Arthritis, Experimental Tretinoin 3.1816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001471 Barrett Esophagus Tretinoin 4.6016935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.2811289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 16.3019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 16.3012125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 16.3016206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9417474063 20146248
MESH:D001943 Breast Neoplasms Estradiol 1.9418497071 12948864 19861407 16675129 17289903 17018787 17261762 14630087
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9416873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8316813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7016111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4216168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 9.123581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.123084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 9.1221507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Estradiol 9.1216924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 9.121917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.757296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7120419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.7116051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 7.5410977129
MESH:D002386 Cataract Tretinoin 7.5417460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.827505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.8212371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.8218566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8316129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 14.129022650 19486331
MESH:D002779 Cholestasis Cyclosporine 14.1219486331
MESH:D002779 Cholestasis pirinixic acid 14.1219176532
MESH:D002822 Choriocarcinoma Tretinoin 5.4216461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.9812621046 8697196 15340226 16354765 15668235
MESH:D002972 Cleft Palate Tretinoin 5.989407595
MESH:D003092 Colitis Tretinoin 3.9217035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4910048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.4917551590 8800419 16925845 9211117 10589399 14991402 9664655 9125849 9142499 9224671
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0114531868 8156756 2524372 12868966 18759878 11906362 8970840 11298694
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.672952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.5619279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.386679447 18648102 9328219 9653073 16192314 8291058 1440618 6482804 18692083 11289319 9022650 7440962 18289764
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3810663392 12958197 19164858 12392966 12594235 11461765 11739529 11421492 12153990 17522070 11743745 11834606 19420014 16485898 17562736 10774834 18713872 16227642 2444490 19085960 19923254 16081117 15619225 19370779 14550746 15968718 19739265 16109766 16781746 16177239 14725611 19416960 11287661 14986274 11529661 18071297 12540782 16393943 12705907 17906064 10915739
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004487 Edema pirinixic acid 7.1112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.1111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.8516714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 12.8518230668
MESH:D016889 Endometrial Neoplasms Estradiol 7.7718566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 7.7716569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.493581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4916530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.2611564622
MESH:D005124 Eye Abnormalities Tretinoin 9.2616938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 8.1419224547
MESH:D005234 Fatty Liver pirinixic acid 8.1420131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.286705139
MESH:D005355 Fibrosis Cyclosporine 16.0312168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.0320067830
MESH:D005355 Fibrosis Tretinoin 16.0317994277
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D005909 Glioblastoma Tretinoin 3.1117312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.227505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4216084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.5720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.5710048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 11.5714991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.716705139
MESH:D006529 Hepatomegaly pirinixic acid 8.9919176532 19772884 18467677 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.9912621046 16120746 15340226
MESH:D006558 Herpes Genitalis Estradiol 5.3015709030
MESH:D019584 Hot Flashes Estradiol 4.0217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3116959395 16354765 8697196 15340226 18606429
MESH:D006930 Hyperalgesia Acetaminophen 8.0916870215
MESH:D006930 Hyperalgesia Tretinoin 8.0916870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7816778211
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1515034207
MESH:D006973 Hypertension Cyclosporine 5.1410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1418670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312200463 12878042
MESH:D007333 Insulin Resistance Estradiol 7.5516627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.5516306350
MESH:D007410 Intestinal Diseases Tretinoin 3.9817994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.289022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.5116580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.5115992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Acetaminophen 10.5212587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.5218776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 10.5215618244
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 13.226582329
MESH:D007680 Kidney Neoplasms Cyclosporine 13.2212371664
MESH:D007680 Kidney Neoplasms Estradiol 13.2215610895
MESH:D007938 Leukemia Tretinoin 2.8417143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8716482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1017596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.269834237 17649720 16823087 16891316 17107899 12679006 17294898 16788101 17339181 17506722 16140955 19075265 19642359 19225113 17361223 16766008 17712046 17301526 17217047 15748426 19035177 19029980 16331271 16935935 17368321
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.439224671
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.309327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.0614659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.0615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0612878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 5.0616248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 1.6616611625 12969438 12587719 19014921 16610002 19460945 11587558 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4017185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 14.872125692 9163691 18177683 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.8720195826 21137059
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 14.8721295105 19389873
MESH:D008113 Liver Neoplasms pirinixic acid 14.8715890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.8716984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 14.996587162 3712494 598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 14.998603461
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 14.9918164116
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.9912151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.4514755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4518569708 20135361 20464547 20064080 18816296 18520028 6695378 17053015 20869020
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4519555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6611807958 17203775 16891317 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.7519453300
MESH:D008527 Medulloblastoma Tretinoin 2.8417453147
MESH:D008545 Melanoma Tretinoin 1.9616752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008591 Meningomyelocele Tretinoin 4.6416940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1717596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.6916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.6916411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.533581430
MESH:D009369 Neoplasms Benzo(a)pyrene 8.6511141357
MESH:D009369 Neoplasms pirinixic acid 8.6517405874
MESH:D009369 Neoplasms Tretinoin 8.6516594593 16946489
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4418481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 17.5316427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 17.5314600291
MESH:D009421 Nervous System Malformations Tretinoin 17.539125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.596679447
MESH:D009436 Neural Tube Defects Tretinoin 7.599142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.584026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.283988306
MESH:D010051 Ovarian Neoplasms Estradiol 4.9619401270
MESH:D010051 Ovarian Neoplasms Tretinoin 4.9616936753
MESH:D010146 Pain Acetaminophen 7.0716870215
MESH:D010146 Pain Tretinoin 7.0716870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5115976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.707296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.736228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311399792 11896295 11222880 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0620887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0717292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.0716740699
MESH:D011507 Proteinuria Tretinoin 3.7916636307
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D011625 Pterygium Tretinoin 5.0316723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.503692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2816283617 16116481
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.8219755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.8216192470
MESH:D012878 Skin Neoplasms Tretinoin 9.8216467112
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.3820155912 2093021
MESH:D013274 Stomach Neoplasms Tretinoin 2.3817261132
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.576582329 6587162 1399818 3712494 7505956
MESH:D013964 Thyroid Neoplasms Tretinoin 7.5717045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.9519048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.9516051514
MESH:D014376 Tuberculosis Tretinoin 3.3316040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.178074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.1717053015
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8416129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.8816752155
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D014820 Vitiligo Tretinoin 4.2516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D009396 Wilms Tumor Tretinoin 4.1216287080
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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