AutismKB 2.0

Annotation Detail for GIGYF1


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Basic Information Top
Gene Symbol:GIGYF1 ( GYF1,PERQ1 )
Gene Full Name: GRB10 interacting GYF protein 1
Band: 7q22.1
Quick LinksEntrez ID:64599; OMIM: 612064; Uniprot ID:PERQ1_HUMAN; ENSEMBL ID: ENSG00000146830; HGNC ID: 9126
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of GIGYF1 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of GIGYF1 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GIGYF1 mRNAdecreases expression 20018196
C025643 vinclozolin vinclozolin affects the expression of GIGYF1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.963712494
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D001008 Anxiety Disorders vinclozolin 3.9719015723
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.741440618 11289319
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.967296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.963084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.837296757
MESH:D002386 Cataract Acetaminophen 2.7910977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.537505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.5320889678
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.449022650 19486331
MESH:D003456 Cryptorchidism vinclozolin 4.8514966744
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.3511906362 8156756 8970840 18759878 14531868 12868966 11298694 2524372
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.952952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.029653073 18289764 6679447 18692083 1440618 8291058 6482804 18648102 9022650 11289319 9328219 7440962 16192314
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0215619225 14986274 17522070 18071297 11421492 19416960 10774834 16177239 16393943 14725611 19164858 17906064 12153990 12705907 11743745 16781746 10663392 11461765 14550746 16109766 11529661 11834606 11739529 16227642 19420014 12958197 17562736 16081117 19923254 10915739 16485898 11287661 18713872 19739265 12540782 19085960 2444490 15968718 12594235 19370779 12392966
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.653581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.6520426865
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.746705139
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.5716973722
MESH:D005832 Genital Diseases, Male vinclozolin 6.0216417039
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.507505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 4.026705139
MESH:D006930 Hyperalgesia Acetaminophen 3.0216870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.5015034207
MESH:D007248 Infertility, Male vinclozolin 3.2916467254
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.749022650 8074119
MESH:D007674 Kidney Diseases Acetaminophen 2.4012587719 15629191
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.316582329
MESH:D007984 Leydig Cell Tumor vinclozolin 5.3616417039
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.429327722 15034207
MESH:D008107 Liver Diseases Acetaminophen 1.7016611625 12969438 12587719 19784758 16610002 19460945 19014921 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6317185352 16871587
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.75598648 6587162 1399818 3712494
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.593581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.156679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.816482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.743988306
MESH:D010146 Pain Acetaminophen 2.7316870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 4.047296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.196228378
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.5318042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.5718220299
MESH:D011472 Prostatitis vinclozolin 5.5718629315
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.673692021
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.193712494 6582329 7505956 1399818 6587162
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.408074119
MESH:D014581 Urticaria Acetaminophen 3.4410982225
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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