AutismKB 2.0

Annotation Detail for SHB


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Basic Information Top
Gene Symbol:SHB ( RP11-3J10.8,bA3J10.2 )
Gene Full Name: Src homology 2 domain containing adaptor protein B
Band: 9p13.1
Quick LinksEntrez ID:6461; OMIM: 600314; Uniprot ID:SHB_HUMAN; ENSEMBL ID: ENSG00000107338; HGNC ID: 10838
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200127PDGFR-beta signaling pathway
200140PDGFR-alpha signaling pathway
200161Signaling events mediated by VEGFR1 and VEGFR2
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Related Diseases/Disorders Top
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Desease Name
Brain structure
NEUROLOGICAL
Desease Name
Brain structure
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SHB mRNAdecreases expression 19150397
D019256 Cadmium Chloride Cadmium Chloride results in decreased expression of SHB mRNAdecreases expression 12760830
D016572 Cyclosporine Cyclosporine results in increased expression of SHB mRNAincreases expression 20106945
D028321 Plant Preparations Plant Preparations affects the expression of SHB mRNAaffects expression 16046712
D020849 Raloxifene Raloxifene affects the expression of SHB mRNAaffects expression 14699072
D012643 Selenium Selenium results in increased expression of SHB mRNAincreases expression 19244175
C017947 sodium arsenite sodium arsenite results in increased expression of SHB mRNAincreases expression 12760830
D013629 Tamoxifen Tamoxifen affects the expression of SHB mRNAaffects expression 14699072
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of SHB mRNAaffects binding|decreases expression 16214954
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8714745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1315322242 11752688 14514962
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.0215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.2216712894 17306315
MESH:D000419 Albuminuria Raloxifene 4.8317451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.5815800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001930 Brain Injuries Raloxifene 4.7316580743
MESH:D001943 Breast Neoplasms Plant Preparations 2.0417398067
MESH:D001943 Breast Neoplasms Raloxifene 2.0416912660 17049068 17893378 17242785 17261762 17440819 15758505 17595753 15775269 16837676 15572757 17952589
MESH:D001943 Breast Neoplasms Tamoxifen 2.0419142967 19487384 19289846 19084267 18629630 19288272 20544844 17049068 18351453 19200415 18425577 20859285 19066611 17242785 18821012 16873071 18997820 19059307 20005174 21138602 11161223 17893378 16818667 16273361 15565566 19189212 16202921 17261762 19155303 19221464 18855134 20390343 18984771 19244106 20065188 19103187 15668708 18815881 20135344 21152245 19011961 19115204 19189210 17440819 19410462
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0420435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7619066611
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.1416507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.1416924424
MESH:D002294 Carcinoma, Squamous Cell Plant Preparations 5.3517418620
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 5.3518572023
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 10.1517572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 10.1517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4716120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Plant Preparations 8.3616862667
MESH:D002318 Cardiovascular Diseases Raloxifene 8.3615775269
MESH:D016893 Carotid Stenosis Plant Preparations 6.4215158307
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.9820889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.9812371664
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 11.9819524636 20056578
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis Cyclosporine 3.0619486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1815668235 16354765 15340226 8697196 12621046
MESH:D003072 Cognition Disorders Raloxifene 4.8815800139
MESH:D003092 Colitis Selenium 4.0417936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D003324 Coronary Artery Disease Plant Preparations 4.0515158307
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6219031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.3417474826
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Raloxifene 9.6517308373 15920148 17451421
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.6519279558
MESH:D056486 Drug-Induced Liver Injury Selenium 3.9415131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9420420201
MESH:D004362 Drug Toxicity Plant Preparations 8.9811033412
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.9811462148
MESH:D004487 Edema Raloxifene 7.5415860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.5412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2218230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 10.0515845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.0519031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1719155303 17893378 20544844 16202921
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.219294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 5.0820426865
MESH:D004938 Esophageal Neoplasms Plant Preparations 5.0816510608
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Cyclosporine 14.4019224547
MESH:D005234 Fatty Liver Raloxifene 14.4017473493
MESH:D005234 Fatty Liver Tamoxifen 14.4014986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3516709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4719069698
MESH:D005355 Fibrosis Cyclosporine 9.3612639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.3620067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.9616452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4311294989 10048152
MESH:D006331 Heart Diseases Raloxifene 3.6711110106
MESH:D006333 Heart Failure Selenium 3.1917162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1515340226 12621046 16120746
MESH:D006689 Hodgkin Disease sodium arsenite 3.3312676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.368697196 15340226 16959395 18606429 16354765
MESH:D006973 Hypertension Cyclosporine 8.9810903974
MESH:D006973 Hypertension Raloxifene 8.9817577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.9818670907 18850075
MESH:D007248 Infertility, Male sodium arsenite 3.1215346721 12646999
MESH:D007249 Inflammation Tamoxifen 5.2119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2112200463 12878042
MESH:D007251 Influenza, Human Selenium 4.5116624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Cadmium Chloride 10.8216962696
MESH:D007674 Kidney Diseases Cyclosporine 10.828314463 10903974 18776723
MESH:D007674 Kidney Diseases sodium arsenite 10.8220008137
MESH:D007676 Kidney Failure, Chronic Selenium 4.0916518626
MESH:D007680 Kidney Neoplasms Cyclosporine 7.8812371664
MESH:D007680 Kidney Neoplasms Tamoxifen 7.8818625569
MESH:D007889 Leiomyoma Raloxifene 4.7216973256
MESH:D008064 Lipidoses Tamoxifen 3.3015342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Plant Preparations 3.7417724770
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.7418564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.7412878042
MESH:D008113 Liver Neoplasms sodium arsenite 7.8116712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 7.8116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.8116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2212151625
MESH:D008171 Lung Diseases sodium arsenite 3.3019095001
MESH:D008175 Lung Neoplasms sodium arsenite 3.4917077188 16712894 19931552 17306315 15276417
MESH:D008175 Lung Neoplasms Tamoxifen 3.4918625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4911884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0419428831
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.4615318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.4616827153 14580682 19196723 11731420 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.8719453300
MESH:D008545 Melanoma sodium arsenite 3.4116487513 19082730
MESH:D008545 Melanoma Tamoxifen 3.4119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4715990972
MESH:D008654 Mesothelioma Selenium 2.8615107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.8715863610
MESH:D009062 Mouth Neoplasms Plant Preparations 4.9317418620
MESH:D009101 Multiple Myeloma Raloxifene 3.5816497877
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D009232 Myxoma Raloxifene 5.8716343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5719410462
MESH:D009369 Neoplasms sodium arsenite 2.5811559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.9220056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3219200415 19189210 19196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4718481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.2712854658
MESH:D010024 Osteoporosis Raloxifene 3.5115775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.4515758505 17823083 17893378 15579764
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4917306315 15276417
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D010954 Plasmacytoma Selenium 5.2115087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms Raloxifene 2.5815731164 16220300 16536755
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.5816039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5815067354
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D011693 Purpura Raloxifene 5.8715770314
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012878 Skin Neoplasms sodium arsenite 5.8819524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8816192470
MESH:D013088 Spermatocele Tamoxifen 4.6116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3219457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9512854658
MESH:D020521 Stroke Raloxifene 3.9816837676
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013978 Tibial Fractures Raloxifene 5.5319048282
MESH:D001749 Urinary Bladder Neoplasms Plant Preparations 12.6111251952
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 12.6117572228
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 12.6116452187 11723127 17306315 16712894
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 12.6116712894 8653321 17572228
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9611813266
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D014652 Vascular Diseases sodium arsenite 4.7117056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.5316837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.8716343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35744
    • No data
    No data
    Releated drug ID Related drug Name
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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