AutismKB 2.0

Annotation Detail for SHBG


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SHBG ( ABP,MGC126834,MGC138391,SBP,TEBG )
Gene Full Name: sex hormone-binding globulin
Band: 17p13.1
Quick LinksEntrez ID:6462; OMIM: 182205; Uniprot ID:SHBG_HUMAN; ENSEMBL ID: ENSG00000129214; HGNC ID: 10839
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
Pathway IDPathway Name
200145Nongenotropic Androgen signaling
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1721Female reproductive system disorder
1750Endocrine system disease
1856Obesity
1864Fibroid tumor
1944Breast cancer
1955Urogenital abnormalities
1979Testicular dysfunction
2006Anorexia nervosa
2022Liver cancer
2122Protein-energy malnutrition
2138Osteoporosis
Desease Name
polycystic ovary syndrome
menarche
protein quantitative trait loci
hormone disturbance
prostate cancer
CANCER
endometrial cancer
breast cancer
overall effect
systemic lupus erythematosus
IMMUNE
METABOLIC
bone density dihydrotestosterone estradiol sex hormone binding globulin testosterone
REPRODUCTION
Desease Name
Protein quantitative trait loci
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of SHBG proteinincreases expression 3199457
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen binds to SHBG proteinaffects binding 11792437
C041594 4-nonylphenol 4-nonylphenol binds to SHBG proteinaffects binding 15081833
C080417 4-octylphenol 4-octylphenol binds to SHBG proteinaffects binding 15081833
C105260 4-tert-octylphenol 4-tert-octylphenol binds to SHBG proteinaffects binding 11792437
C105260 4-tert-octylphenol 4-tert-octylphenol binds to SHBG proteinaffects binding 15556074
C105260 4-tert-octylphenol 4-tert-octylphenol inhibits the reaction [Estradiol binds to SHBG protein]affects binding|decreases reaction 15556074
D013196 Dihydrotestosterone delta-hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone binds to SHBG protein]affects binding|decreases reaction 9171990
D013196 Dihydrotestosterone Lindane inhibits the reaction [Dihydrotestosterone binds to SHBG protein]affects binding|decreases reaction 9171990
D013196 Dihydrotestosterone nonylphenol inhibits the reaction [Dihydrotestosterone binds to SHBG protein]affects binding|decreases reaction 9171990
D013196 Dihydrotestosterone o,p'-DDT inhibits the reaction [Dihydrotestosterone binds to SHBG protein]affects binding|decreases reaction 9171990
D013196 Dihydrotestosterone Pentachlorophenol inhibits the reaction [Dihydrotestosterone binds to SHBG protein]affects binding|decreases reaction 9171990
D013196 Dihydrotestosterone Atrazine inhibits the reaction [Dihydrotestosterone binds to SHBG protein]affects binding|decreases reaction 9171990
D013196 Dihydrotestosterone DDT analog inhibits the reaction [Dihydrotestosterone binds to SHBG protein]affects binding|decreases reaction 9171990
D013196 Dihydrotestosterone DDT inhibits the reaction [Dihydrotestosterone binds to SHBG protein]affects binding|decreases reaction 9171990
D013196 Dihydrotestosterone delta-hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone binds to SHBG protein]affects binding|decreases reaction 9171990
D013196 Dihydrotestosterone Dichlorodiphenyl Dichloroethylene analog inhibits the reaction [Dihydrotestosterone binds to SHBG protein]affects binding|decreases reaction 9171990
D013196 Dihydrotestosterone Dieldrin inhibits the reaction [Dihydrotestosterone binds to SHBG protein]affects binding|decreases reaction 9171990
D013196 Dihydrotestosterone Lindane inhibits the reaction [Dihydrotestosterone binds to SHBG protein]affects binding|decreases reaction 9171990
D013196 Dihydrotestosterone Methoxychlor inhibits the reaction [Dihydrotestosterone binds to SHBG protein]affects binding|decreases reaction 9171990
D013196 Dihydrotestosterone o,p'-DDT inhibits the reaction [Dihydrotestosterone binds to SHBG protein]affects binding|decreases reaction 9171990
D013196 Dihydrotestosterone Pentachlorophenol inhibits the reaction [Dihydrotestosterone binds to SHBG protein]affects binding|decreases reaction 9171990
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SHBG mRNAaffects expression 16483693
D000728 Androgens SHBG promoter polymorphism affects the abundance of Androgensaffects abundance 16926255
D001280 Atrazine Atrazine inhibits the reaction [Dihydrotestosterone binds to SHBG protein]affects binding|decreases reaction 9171990
C006780 bisphenol A bisphenol A binds to SHBG proteinaffects binding 11792437
C006780 bisphenol A bisphenol A binds to SHBG proteinaffects binding 15556074
C006780 bisphenol A bisphenol A inhibits the reaction [Estradiol binds to SHBG protein]affects binding|decreases reaction 15556074
D002569 Cerulenin Cerulenin inhibits the reaction [Fructose results in decreased expression of SHBG protein]decreases expression|decreases reaction 17992261
D002569 Cerulenin Cerulenin inhibits the reaction [Glucose results in decreased expression of SHBG protein]decreases expression|decreases reaction 17992261
D003277 Contraceptives, Oral, Combined Contraceptives, Oral, Combined results in increased expression of SHBG proteinincreases expression 16409223
D003634 DDT DDT analog inhibits the reaction [Dihydrotestosterone binds to SHBG protein]affects binding|decreases reaction 9171990
D003634 DDT DDT inhibits the reaction [Dihydrotestosterone binds to SHBG protein]affects binding|decreases reaction 9171990
C086916 delta-hexachlorocyclohexane delta-hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone binds to SHBG protein]affects binding|decreases reaction 9171990
C086916 delta-hexachlorocyclohexane delta-hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone binds to SHBG protein]affects binding|decreases reaction 9171990
D003993 Dibutyl Phthalate Dibutyl Phthalate results in increased expression of SHBG proteinincreases expression 12408638
D003633 Dichlorodiphenyl Dichloroethylene Dichlorodiphenyl Dichloroethylene analog inhibits the reaction [Dihydrotestosterone binds to SHBG protein]affects binding|decreases reaction 9171990
D004026 Dieldrin Dieldrin inhibits the reaction [Dihydrotestosterone binds to SHBG protein]affects binding|decreases reaction 9171990
D019422 Dietary Sucrose Dietary Sucrose results in decreased expression of SHBG mRNAdecreases expression 17992261
D019422 Dietary Sucrose Dietary Sucrose results in decreased expression of SHBG proteindecreases expression 17992261
D004054 Diethylstilbestrol Diethylstilbestrol binds to SHBG proteinaffects binding 11792437
D004054 Diethylstilbestrol Diethylstilbestrol binds to SHBG proteinaffects binding 15556074
D004054 Diethylstilbestrol Diethylstilbestrol inhibits the reaction [Estradiol binds to SHBG protein]affects binding|decreases reaction 15556074
C035144 drospirenone [Ethinyl Estradiol co-treated with drospirenone] results in increased expression of SHBG proteinaffects cotreatment|increases expression 11245553
D004726 Endosulfan Endosulfan binds to SHBG proteinaffects binding 15081833
D004958 Estradiol Estradiol results in increased expression of SHBG proteinincreases expression 17484513
D004958 Estradiol Estradiol binds to SHBG proteinaffects binding 15081833
D004958 Estradiol 4-tert-octylphenol inhibits the reaction [Estradiol binds to SHBG protein]affects binding|decreases reaction 15556074
D004958 Estradiol bisphenol A inhibits the reaction [Estradiol binds to SHBG protein]affects binding|decreases reaction 15556074
D004958 Estradiol Diethylstilbestrol inhibits the reaction [Estradiol binds to SHBG protein]affects binding|decreases reaction 15556074
D004958 Estradiol Estradiol binds to SHBG proteinaffects binding 15556074
D004958 Estradiol Ethinyl Estradiol inhibits the reaction [Estradiol binds to SHBG protein]affects binding|decreases reaction 15556074
D004958 Estradiol Genistein inhibits the reaction [Estradiol binds to SHBG protein]affects binding|decreases reaction 15556074
D004958 Estradiol Zearalenone inhibits the reaction [Estradiol binds to SHBG protein]affects binding|decreases reaction 15556074
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of SHBG mRNAdecreases expression 16872691
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with drospirenone] results in increased expression of SHBG proteinaffects cotreatment|increases expression 11245553
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of SHBG proteinaffects cotreatment|increases expression 10899481
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of SHBG proteinaffects cotreatment|increases expression 17519148
14981370
12586319
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with norgestimate] results in increased expression of SHBG proteinaffects cotreatment|increases expression 16982228
12586319
D004997 Ethinyl Estradiol [Ethinyl Estradiol co-treated with ST 1435] results in increased expression of SHBG proteinaffects cotreatment|increases expression 17519148
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SHBG proteinincreases expression 11907703
17374706
D004997 Ethinyl Estradiol Ethinyl Estradiol binds to SHBG proteinaffects binding 15081833
D004997 Ethinyl Estradiol Ethinyl Estradiol binds to SHBG proteinaffects binding 11792437
D004997 Ethinyl Estradiol Ethinyl Estradiol binds to SHBG proteinaffects binding 12408638
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SHBG proteinincreases expression 12408638
D004997 Ethinyl Estradiol Ethinyl Estradiol binds to SHBG proteinaffects binding 15556074
D004997 Ethinyl Estradiol Ethinyl Estradiol inhibits the reaction [Estradiol binds to SHBG protein]affects binding|decreases reaction 15556074
C442659 ethinyl estradiol-desogestrel combination ethinyl estradiol-desogestrel combination results in increased expression of SHBG proteinincreases expression 14981370
D015025 Zearalenone Zearalenone binds to SHBG proteinaffects binding 11792437
D015025 Zearalenone Zearalenone binds to SHBG proteinaffects binding 15556074
D015025 Zearalenone Zearalenone inhibits the reaction [Estradiol binds to SHBG protein]affects binding|decreases reaction 15556074
D005632 Fructose Cerulenin inhibits the reaction [Fructose results in decreased expression of SHBG protein]decreases expression|decreases reaction 17992261
D005632 Fructose Fructose affects the reaction [NR2F1 protein binds to SHBG promoter]affects binding|affects reaction 17992261
D005632 Fructose Fructose results in decreased expression of SHBG proteindecreases expression 17992261
D019833 Genistein Genistein results in increased expression of SHBG mRNAincreases expression 18847459
D019833 Genistein Genistein binds to SHBG proteinaffects binding 11792437
D019833 Genistein Genistein binds to SHBG proteinaffects binding 15556074
D019833 Genistein Genistein inhibits the reaction [Estradiol binds to SHBG protein]affects binding|decreases reaction 15556074
C033273 Gestodene [Ethinyl Estradiol co-treated with Gestodene] results in increased expression of SHBG proteinaffects cotreatment|increases expression 10899481
D005947 Glucose Cerulenin inhibits the reaction [Glucose results in decreased expression of SHBG protein]decreases expression|decreases reaction 17992261
D005947 Glucose Glucose affects the reaction [HNF4A protein binds to SHBG promoter]affects binding|affects reaction 17992261
D005947 Glucose Glucose affects the reaction [NR2F1 protein binds to SHBG promoter]affects binding|affects reaction 17992261
D005947 Glucose Glucose results in decreased expression of SHBG proteindecreases expression 17992261
D001556 Lindane Lindane inhibits the reaction [Dihydrotestosterone binds to SHBG protein]affects binding|decreases reaction 9171990
D001556 Lindane Lindane inhibits the reaction [Dihydrotestosterone binds to SHBG protein]affects binding|decreases reaction 9171990
C013598 methoxyacetic acid methoxyacetic acid results in increased expression of SHBG mRNAincreases expression 18486176
12606434
C013598 methoxyacetic acid methoxyacetic acid results in increased expression of SHBG proteinincreases expression 12606434
C013598 methoxyacetic acid methoxyacetic acid results in increased expression of SHBG mRNAincreases expression 12606434
D008731 Methoxychlor Methoxychlor inhibits the reaction [Dihydrotestosterone binds to SHBG protein]affects binding|decreases reaction 9171990
C025256 nonylphenol nonylphenol inhibits the reaction [Dihydrotestosterone binds to SHBG protein]affects binding|decreases reaction 9171990
C017576 norgestimate [Ethinyl Estradiol co-treated with norgestimate] results in increased expression of SHBG proteinaffects cotreatment|increases expression 12586319
16982228
D016912 Levonorgestrel [Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of SHBG proteinaffects cotreatment|increases expression 17519148
12586319
14981370
D016912 Levonorgestrel Levonorgestrel binds to SHBG proteinaffects binding 12586319
C016340 o,p'-DDT o,p'-DDT inhibits the reaction [Dihydrotestosterone binds to SHBG protein]affects binding|decreases reaction 9171990
C016340 o,p'-DDT o,p'-DDT binds to SHBG proteinaffects binding 11792437
C016340 o,p'-DDT o,p'-DDT inhibits the reaction [Dihydrotestosterone binds to SHBG protein]affects binding|decreases reaction 9171990
C511292 Ortho Evra Ortho Evra results in increased expression of SHBG proteinincreases expression 16982228
D010171 Palmitoyl Coenzyme A Palmitoyl Coenzyme A results in decreased expression of SHBG mRNAdecreases expression 17992261
D010171 Palmitoyl Coenzyme A Palmitoyl Coenzyme A results in decreased expression of SHBG proteindecreases expression 17992261
D010416 Pentachlorophenol Pentachlorophenol inhibits the reaction [Dihydrotestosterone binds to SHBG protein]affects binding|decreases reaction 9171990
D010416 Pentachlorophenol Pentachlorophenol inhibits the reaction [Dihydrotestosterone binds to SHBG protein]affects binding|decreases reaction 9171990
D020849 Raloxifene Raloxifene results in increased expression of SHBG proteinincreases expression 16775175
16912660
C017947 sodium arsenite sodium arsenite results in increased expression of SHBG mRNAincreases expression 17451858
C029167 ST 1435 [Ethinyl Estradiol co-treated with ST 1435] results in increased expression of SHBG proteinaffects cotreatment|increases expression 17519148
D013629 Tamoxifen Tamoxifen results in increased expression of SHBG proteinincreases expression 20332317
D014212 Tretinoin Tretinoin results in decreased expression of SHBG mRNAdecreases expression 18230668
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of SHBG mRNAincreases expression 17982090
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.0614745880
MESH:D000014 Abnormalities, Drug-Induced methoxyacetic acid 4.3812805644 1761404 3652986 1761407 15959878
MESH:D000138 Acidosis Ammonium Chloride 3.0818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 10.7017505938
MESH:D000152 Acne Vulgaris norgestimate 10.7017505938
MESH:D000230 Adenocarcinoma Estradiol 6.2311473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.2314692618
MESH:D000230 Adenocarcinoma Genistein 6.2311473722
MESH:D018248 Adenoma, Liver Cell DDT 4.7512597452
MESH:D000310 Adrenal Gland Neoplasms Pentachlorophenol 11.6810696769
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 11.6815276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.4217306315 16712894
MESH:D000382 Agricultural Workers' Diseases Atrazine 16.6711874814
MESH:D000382 Agricultural Workers' Diseases DDT 16.6712584743 16487989
MESH:D000382 Agricultural Workers' Diseases Dichlorodiphenyl Dichloroethylene 16.6716487989
MESH:D000382 Agricultural Workers' Diseases Lindane 16.6712661182
MESH:D000419 Albuminuria Raloxifene 4.1417451421 17308373
MESH:D000505 Alopecia Tretinoin 3.2415955085
MESH:D000544 Alzheimer Disease Androgens 4.3717182789 17917157
MESH:D000544 Alzheimer Disease Raloxifene 4.3715800139
MESH:D000686 Amyloidosis Diethylstilbestrol 4.0315469931
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.0011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.1915885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.1916412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1416292516
MESH:D001249 Asthma Tretinoin 2.1916456186
MESH:D001471 Barrett Esophagus Tretinoin 3.9516935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.1916197459 16206674
MESH:D001862 Bone Resorption bisphenol A 3.4411985600
MESH:D001930 Brain Injuries Raloxifene 4.0116580743
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 10.2411921183
MESH:D001943 Breast Neoplasms Androgens 10.2417018787
MESH:D001943 Breast Neoplasms bisphenol A 10.2417123778
MESH:D001943 Breast Neoplasms DDT 10.2416792888 12709520
MESH:D001943 Breast Neoplasms Dichlorodiphenyl Dichloroethylene 10.2415061365
MESH:D001943 Breast Neoplasms Dieldrin 10.2411859874 15770527
MESH:D001943 Breast Neoplasms Diethylstilbestrol 10.2415324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 10.2418497071 12948864 19861407 16675129 14630087 17289903 17261762 17018787
MESH:D001943 Breast Neoplasms Genistein 10.2416873071 17200150 16541309
MESH:D001943 Breast Neoplasms Lindane 10.2414688026
MESH:D001943 Breast Neoplasms Raloxifene 10.2417595753 15572757 17049068 16837676 17952589 16912660 17261762 17242785 15775269 17893378 15758505 17440819
MESH:D001943 Breast Neoplasms Tamoxifen 10.2416273361 15565566 19487384 19084267 18984771 19011961 20005174 16873071 18629630 19221464 19103187 19189212 17261762 18855134 17242785 20859285 21152245 19115204 20065188 17893378 17049068 18351453 19288272 19189210 16818667 15668708 21138602 18815881 19244106 17440819 19155303 20544844 19066611 19410462 11161223 18821012 19289846 19200415 19059307 20135344 19142967 20390343 18425577 16202921 18997820
MESH:D001943 Breast Neoplasms Tretinoin 10.2416443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.1116813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9916111702
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.0419066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.6716168501
MESH:D006528 Carcinoma, Hepatocellular DDT 12.6012597452
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 12.6016924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 12.6016924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 12.6016924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 12.6015276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 12.6016924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 12.601917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.5117123778
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.1518572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.1516051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.1317572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.1317572228
MESH:D002318 Cardiovascular Diseases Genistein 6.3916332659
MESH:D002318 Cardiovascular Diseases Raloxifene 6.3915775269
MESH:D002386 Cataract Tretinoin 2.8017460283
MESH:D002471 Cell Transformation, Neoplastic Estradiol 5.6418566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 5.6419524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.1116129372
MESH:D002779 Cholestasis Ethinyl Estradiol 7.3417333356 16105132 11677210 16919318 15861022 17681005 17110522
MESH:D002779 Cholestasis Levonorgestrel 7.3415861022
MESH:D002822 Choriocarcinoma Tretinoin 4.6716461808
MESH:D002972 Cleft Palate Tretinoin 2.469407595
MESH:D003072 Cognition Disorders Raloxifene 4.1515800139
MESH:D003092 Colitis Tretinoin 8.2417035595
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 8.2416867261 18200517 16474422 16804969 16782535 11698051 18023891 17936198 17991707
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.2717276891
MESH:D003110 Colonic Neoplasms Genistein 2.2017182828
MESH:D000013 Congenital Abnormalities DDT 4.5015095906
MESH:D003327 Coronary Disease Fructose 4.1618504504
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.808800419 16925845 14991402 10589399 9142499 17551590 9211117 9125849 9224671 9664655
MESH:D016638 Critical Illness Androgens 5.5816670151
MESH:D003456 Cryptorchidism Dibutyl Phthalate 10.2716037377
MESH:D003456 Cryptorchidism Diethylstilbestrol 10.2712952375 16002989
MESH:D003490 Cyanosis Endosulfan 5.087900959
MESH:D003711 Demyelinating Diseases Tamoxifen 3.9019031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.7617474826
MESH:D003921 Diabetes Mellitus, Experimental Fructose 4.1118603373
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 4.5018603373
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.5016647724
MESH:D003928 Diabetic Nephropathies Estradiol 12.7019279558
MESH:D003928 Diabetic Nephropathies Raloxifene 12.7015920148 17451421 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 12.7019279558
MESH:D004417 Dyspnea DDT 14.7716487989
MESH:D004417 Dyspnea Dichlorodiphenyl Dichloroethylene 14.7716487989
MESH:D004417 Dyspnea Endosulfan 14.773388749 7900959
MESH:D004487 Edema Raloxifene 2.9315860553
MESH:D004489 Edema, Cardiac Tretinoin 3.9818230668
MESH:D004646 Emphysema Endosulfan 6.077900959
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 12.7412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 12.7415845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 12.7419031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 10.3116402032
MESH:D004714 Endometrial Hyperplasia Genistein 10.3116402032
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 24.9619148513
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 24.9615700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 24.9611473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 24.9611473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 24.9617893378 16202921 20544844 19155303
MESH:D016889 Endometrial Neoplasms Tretinoin 24.9616569247
MESH:D005124 Eye Abnormalities Tretinoin 3.2216938888 9664655
MESH:D005234 Fatty Liver Dietary Sucrose 20.2217967931
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.2215345470
MESH:D005234 Fatty Liver Fructose 20.2218641190 19196556 18395287
MESH:D005234 Fatty Liver Raloxifene 20.2217473493
MESH:D005234 Fatty Liver Tamoxifen 20.2214986274 19224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.2116611131 16513791 16534752 16002989 15751030
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.2116709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.0514745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.7119069698
MESH:D005355 Fibrosis Fructose 12.4318504504
MESH:D005355 Fibrosis Tretinoin 12.4317994277
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 12.4317994277
MESH:D005532 Foot Deformities, Congenital methoxyacetic acid 5.273652986
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 11.2316452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 11.2316452187
MESH:D005909 Glioblastoma Genistein 6.1516598420
MESH:D005909 Glioblastoma Tretinoin 6.1517312396
MESH:D018149 Glucose Intolerance Fructose 4.8819165636
MESH:D006258 Head and Neck Neoplasms Tretinoin 2.8616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.6716084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.639664655 14991402
MESH:D006331 Heart Diseases Raloxifene 3.2011110106
MESH:D006394 Hemangiosarcoma Pentachlorophenol 4.6315200160
MESH:D006470 Hemorrhage Endosulfan 4.877900959
MESH:D006505 Hepatitis DDT 8.7816487989
MESH:D006505 Hepatitis Dichlorodiphenyl Dichloroethylene 8.7816487989
MESH:D006529 Hepatomegaly DDT 4.282387028
MESH:D006558 Herpes Genitalis Estradiol 4.5515709030
MESH:D006628 Hirsutism Androgens 5.5916914592 17019078
MESH:D006689 Hodgkin Disease sodium arsenite 2.7712676792
MESH:D019584 Hot Flashes Estradiol 3.2717088409
MESH:D006930 Hyperalgesia Tretinoin 2.8416870215
MESH:D017588 Hyperandrogenism Androgens 5.2517019078
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.1016778211
MESH:D006946 Hyperinsulinism Fructose 4.5015752949 18360027 14757778 18563319 19008412
MESH:D006949 Hyperlipidemias Fructose 4.3215752949
MESH:D006965 Hyperplasia Diethylstilbestrol 3.9714722030 12960047
MESH:D006973 Hypertension Fructose 5.1914633139 14568997 16843071 19008412 14573337
MESH:D006973 Hypertension Raloxifene 5.1917577099 15787275
MESH:D015228 Hypertriglyceridemia Fructose 4.6619342510 19799862
MESH:D007021 Hypospadias Diethylstilbestrol 9.7016002989
MESH:D007021 Hypospadias Ethinyl Estradiol 9.7016569931 16945680
MESH:D007246 Infertility Diethylstilbestrol 3.9015036965
MESH:D007247 Infertility, Female Dieldrin 8.8310630421
MESH:D007247 Infertility, Female Ethinyl Estradiol 8.8312013081
MESH:D007248 Infertility, Male Atrazine 26.8312948887
MESH:D007248 Infertility, Male DDT 26.8317157474 17192596
MESH:D007248 Infertility, Male Dichlorodiphenyl Dichloroethylene 26.8312948891 17192596
MESH:D007248 Infertility, Male Endosulfan 26.838588293 9432128
MESH:D007248 Infertility, Male Ethinyl Estradiol 26.8317937319
MESH:D007248 Infertility, Male Methoxychlor 26.8316467254 11955947
MESH:D007248 Infertility, Male sodium arsenite 26.8312646999 15346721
MESH:D007249 Inflammation Tamoxifen 2.1219457130
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 3.3718200517
MESH:D007333 Insulin Resistance bisphenol A 10.6816393666
MESH:D007333 Insulin Resistance Estradiol 10.6816393666 16627594
MESH:D007333 Insulin Resistance Fructose 10.6818981581 19342510 18057795 14757778 19799862 14633139 19586609 14573337 19008412 17133782 18563319
MESH:D007410 Intestinal Diseases Tretinoin 8.4517994277
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 8.4517994277
MESH:D007569 Jaw Abnormalities Tretinoin 3.4715992940 17551590
MESH:D007674 Kidney Diseases Estradiol 5.1615618244
MESH:D007674 Kidney Diseases sodium arsenite 5.1620008137
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 10.2416762066 14681315 15003126
MESH:D007680 Kidney Neoplasms Estradiol 10.2415610895
MESH:D007680 Kidney Neoplasms Tamoxifen 10.2418625569
MESH:D007859 Learning Disorders DDT 13.707589230
MESH:D007859 Learning Disorders Diethylstilbestrol 13.7017184923
MESH:D007859 Learning Disorders Endosulfan 13.708157075
MESH:D007889 Leiomyoma Raloxifene 4.0616973256
MESH:D007938 Leukemia Genistein 5.5617468513 18980019
MESH:D007938 Leukemia Tretinoin 5.5617143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.2716932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 1.9919850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.8317294898 15748426 19642359 19225113 16823087 17339181 16935935 16766008 17361223 19029980 16788101 17712046 17649720 17107899 16891316 9834237 17301526 16331271 19075265 17217047 19035177 12679006 17506722 16140955 17368321
MESH:D017880 Limb Deformities, Congenital Dichlorodiphenyl Dichloroethylene 12.0012745335
MESH:D017880 Limb Deformities, Congenital methoxyacetic acid 12.0015959878 12805644
MESH:D017880 Limb Deformities, Congenital Tretinoin 12.009224671
MESH:D008064 Lipidoses Tamoxifen 2.8117567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.3914659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 4.3917823541
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.3918564211
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.3916248980 18397230
MESH:D008107 Liver Diseases DDT 4.4615729006
MESH:D008107 Liver Diseases Lindane 4.461715830
MESH:D008113 Liver Neoplasms DDT 15.3711948501 15975961
MESH:D008113 Liver Neoplasms Dieldrin 15.379539021 8742319
MESH:D008113 Liver Neoplasms Diethylstilbestrol 15.3716712894 15890375
MESH:D008113 Liver Neoplasms Pentachlorophenol 15.3710696769
MESH:D008113 Liver Neoplasms sodium arsenite 15.3716712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 15.3716684651
MESH:D008171 Lung Diseases sodium arsenite 2.8519095001
MESH:D008175 Lung Neoplasms sodium arsenite 2.3217306315 19931552 15276417 16712894 17077188
MESH:D008175 Lung Neoplasms Tamoxifen 2.3218625569
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.6715166399
MESH:D008223 Lymphoma Diethylstilbestrol 7.0215700306
MESH:D008223 Lymphoma Pentachlorophenol 7.0212669308
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.0316002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.2919428831
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 11.7211921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 11.7211807958 11408345 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Genistein 11.7212929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 11.7219196722 11731420 16827153 14580682 19196723
MESH:D020149 Manganese Poisoning Estradiol 11.0319453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.0319453300
MESH:D008527 Medulloblastoma Tretinoin 2.5817453147
MESH:D008545 Melanoma Cerulenin 8.7120805790
MESH:D008545 Melanoma Glucose 8.7114993021
MESH:D008545 Melanoma sodium arsenite 8.7116487513 19082730
MESH:D008545 Melanoma Tamoxifen 8.7112393984 19393235
MESH:D008545 Melanoma Tretinoin 8.7116752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.7115990972
MESH:D008591 Meningomyelocele Tretinoin 3.9616940565
MESH:D008654 Mesothelioma Atrazine 3.321916698
MESH:D024821 Metabolic Syndrome X marker/mechanism 17992261 16968811
MESH:D024821 Metabolic Syndrome X Fructose 4.4319165636 17261469 18497449 17098227 16815490
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.0715863610
MESH:D009101 Multiple Myeloma Raloxifene 3.1016497877
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.8017596541
MESH:D009203 Myocardial Infarction Genistein 2.6517141266
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.2916810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 7.2917141266
MESH:D009232 Myxoma Raloxifene 5.0716343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.3419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3519410462
MESH:D009369 Neoplasms DDT 16.528820588
MESH:D009369 Neoplasms Dieldrin 16.528820588
MESH:D009369 Neoplasms Diethylstilbestrol 16.5215313581
MESH:D009369 Neoplasms Lindane 16.5212807735 16818664
MESH:D009369 Neoplasms sodium arsenite 16.5211559025
MESH:D009369 Neoplasms Tretinoin 16.5216946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.2120056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.5219200415 19196722 19189210
MESH:D018301 Neoplasms, Mesothelial Pentachlorophenol 6.1710696769
MESH:D009389 Neovascularization, Pathologic Estradiol 3.2617289903
MESH:D009421 Nervous System Malformations bisphenol A 25.9616427766 11399458
MESH:D009421 Nervous System Malformations Diethylstilbestrol 25.9611399458
MESH:D009421 Nervous System Malformations Estradiol 25.9616427766 11399458
MESH:D009421 Nervous System Malformations Genistein 25.9616427766
MESH:D009421 Nervous System Malformations Tretinoin 25.969125849
MESH:D009436 Neural Tube Defects sodium arsenite 6.2512854658
MESH:D009436 Neural Tube Defects Tretinoin 6.259142499
MESH:D009765 Obesity Fructose 3.2918585860 17707055
MESH:D010024 Osteoporosis Genistein 10.3619401787
MESH:D010024 Osteoporosis Levonorgestrel 10.3612665316
MESH:D010024 Osteoporosis Raloxifene 10.3619059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Genistein 8.6816169203
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 8.6815579764 17893378 17823083 15758505
MESH:D010049 Ovarian Diseases bisphenol A 4.5111985600
MESH:D010051 Ovarian Neoplasms Estradiol 9.8619401270
MESH:D010051 Ovarian Neoplasms Genistein 9.8619005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 9.8615276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 9.8616936753
MESH:D010146 Pain Tretinoin 2.5316870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.2815976015
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 3.7717698068
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2511578682
MESH:D010300 Parkinson Disease Atrazine 5.2917218051
MESH:D010300 Parkinson Disease Dieldrin 5.2916809432 17291500 16112328 11445065 11181820
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.6814722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.2115687265 16977796
MESH:D011085 Polycystic Ovary Syndrome ethinyl estradiol-desogestrel combination 5.1817105841
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 8.2710548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 8.2717184923
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.1320887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.1320887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 17220347
MESH:D011471 Prostatic Neoplasms Androgens 3.2817909013 16998812 15389811
MESH:D011471 Prostatic Neoplasms bisphenol A 3.2816740699
MESH:D011471 Prostatic Neoplasms DDT 3.2812584743
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.2817136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 3.2816740699
MESH:D011471 Prostatic Neoplasms Genistein 3.2815378649 15256057 16925846
MESH:D011471 Prostatic Neoplasms Lindane 3.2814688026 12661182
MESH:D011471 Prostatic Neoplasms Raloxifene 3.2816536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2816039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2815067354
MESH:D011507 Proteinuria Tretinoin 3.1716636307
MESH:D011537 Pruritus Ethinyl Estradiol 8.4215861022 16919318
MESH:D011537 Pruritus Levonorgestrel 8.4215861022
MESH:D011625 Pterygium Tretinoin 4.3216723453
MESH:D011629 Puberty, Precocious bisphenol A 4.3110548101
MESH:D011693 Purpura Raloxifene 5.0715770314
MESH:D012135 Respiratory Sounds Atrazine 4.0611874814
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.6616116481 16283617
MESH:D012640 Seizures Endosulfan 5.7410698677 7539098
MESH:D012640 Seizures Lindane 5.7412842176 7539098 15475178
MESH:D012878 Skin Neoplasms Glucose 8.2514993021
MESH:D012878 Skin Neoplasms sodium arsenite 8.2518572023 19524636
MESH:D012878 Skin Neoplasms Tretinoin 8.2516467112
MESH:D013088 Spermatocele Diethylstilbestrol 17.3216002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 17.3216709447
MESH:D013088 Spermatocele Tamoxifen 17.3216709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.5619457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.4312854658
MESH:D013160 Splenic Neoplasms Pentachlorophenol 5.8210696769
MESH:D013274 Stomach Neoplasms Tretinoin 1.7917261132
MESH:D020521 Stroke Raloxifene 3.4516837676
MESH:D019966 Substance-Related Disorders bisphenol A 3.5116045194 16684133
MESH:D013576 Syndactyly methoxyacetic acid 5.181761404 1761407
MESH:D013733 Testicular Diseases methoxyacetic acid 4.866499806 18486176
MESH:D019851 Thrombophilia Ethinyl Estradiol 15.9311994571
MESH:D019851 Thrombophilia ethinyl estradiol-desogestrel combination 15.9311994571
MESH:D019851 Thrombophilia Gestodene 15.9311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 8.2215669648
MESH:D013927 Thrombosis Gestodene 8.2215669648
MESH:D013964 Thyroid Neoplasms Tretinoin 2.6716026305 17045167
MESH:D013978 Tibial Fractures Estradiol 12.0919048282
MESH:D013978 Tibial Fractures Raloxifene 12.0919048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.3716051514
MESH:D014376 Tuberculosis Tretinoin 2.9216040207
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 10.2517306315 16452187 16712894
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 10.2517572228
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 10.2516712894 16452187 17306315 11723127
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 10.2516712894 8653321 17572228
MESH:D014570 Urologic Diseases DDT 11.1016487989
MESH:D014570 Urologic Diseases Dichlorodiphenyl Dichloroethylene 11.1016487989
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 13.4916175088
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 13.4911813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 13.4916129372
MESH:D014591 Uterine Diseases bisphenol A 12.2014652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 12.2014652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 7.9715809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 7.9714692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.1216752155
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 3.9716002989 16513791
MESH:D014652 Vascular Diseases sodium arsenite 3.9517056641
MESH:D054556 Venous Thromboembolism Raloxifene 4.7216837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 15.4714671159 15869587
MESH:D020246 Venous Thrombosis ethinyl estradiol-desogestrel combination 15.4715869587
MESH:D020246 Venous Thrombosis Levonorgestrel 15.4715869587
MESH:D018487 Ventricular Dysfunction, Left Dietary Sucrose 5.4418551017
MESH:D014820 Vitiligo Tretinoin 3.6016761959
MESH:D014846 Vulvar Neoplasms Raloxifene 5.0716343187
MESH:D009396 Wilms Tumor Tretinoin 3.5616287080
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35745
    • No data
    Releated disease ID Related disease Name
    PA443890Diabetes Mellitus, Type 2
    Releated drug ID Related drug Name
    PA165290929norelgestromin/ethinyl estradiol
    Drug Bank Top
    No data
    No data
    No data
    Drugbank ID Action Drug Name Description
    DB00624 other/unknown Uni-Bol Androgens
    DB00648 - Mitotane Antineoplastic Agents;Antineoplastic Agents, Hormonal
    DB00741 - Vosol Hc Anti-inflammatory Agents
    DB00783 - Triquilar 21 Anticholesteremic Agents;Estrogens;Anti-menopausal Agents
    DB00858 - Dromostanolone Anabolic Agents;Antineoplastic Agents, Hormonal
    DB01185 - Fluoxymesterone Anabolic Agents;Antineoplastic Agents, Hormonal
    DB01406 - Danazol Estrogen Antagonists
    DB02901 - Dihydrotestosterone Androgens;Steroidal
    DB03882 - 5-Alpha-Androstane-3-Beta,17beta-Diol
    DB03926 - 5-Alpha-Androstane-3-Beta,17-Alpha-Diol Anabolic Agents
    DB04402 - 2-Propanol, Isopropanol Solvents
    DB04574 - Estropipate Hormone Replacement Agents;Estrogens
    DB06710 - Methyltestosterone Anabolic Agents;Hormone Replacement Agents;Androgens

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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