AutismKB 2.0

Annotation Detail for PDIA2


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Basic Information Top
Gene Symbol:PDIA2 ( PDA2,PDI,PDIP,PDIR )
Gene Full Name: protein disulfide isomerase family A, member 2
Band: 16p13.3
Quick LinksEntrez ID:64714; OMIM: 608012; Uniprot ID:PDIA2_HUMAN; ENSEMBL ID: ENSG00000185615; HGNC ID: 14180
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D002104 Cadmium Cadmium results in decreased expression of PDIA2 proteindecreases expression 16440303
D019256 Cadmium Chloride Cadmium Chloride results in decreased expression of PDIA2 proteindecreases expression 16440303
D016572 Cyclosporine Cyclosporine results in increased expression of PDIA2 mRNAincreases expression 20106945
D008070 Lipopolysaccharides Lipopolysaccharides affects the localization of PDIA2 proteinaffects localization 17475668
D008070 Lipopolysaccharides Vaticanol B inhibits the reaction [Lipopolysaccharides affects the localization of PDIA2 protein]affects localization|decreases reaction 17475668
C017947 sodium arsenite sodium arsenite results in decreased expression of PDIA2 proteindecreases expression 19294697
D014415 Tunicamycin Tunicamycin results in decreased expression of PDIA2 mRNAdecreases expression 17127020
C522219 Vaticanol B Vaticanol B inhibits the reaction [Lipopolysaccharides affects the localization of PDIA2 protein]affects localization|decreases reaction 17475668
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury Lipopolysaccharides 4.3318653653 11850527
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.1415276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.3516712894 17306315
MESH:D050197 Atherosclerosis Cadmium 3.7915687053
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 2.0017306315 16507464 15276417
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4418572023
MESH:D002471 Cell Transformation, Neoplastic Cadmium 12.3817332340
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 12.3812371664
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 12.3820056578 19524636
MESH:D002779 Cholestasis Cyclosporine 3.1219486331
MESH:D019446 Endotoxemia Lipopolysaccharides 4.7915328337 17637181 15821434
MESH:D005234 Fatty Liver Cyclosporine 3.1419224547
MESH:D005334 Fever Lipopolysaccharides 4.289205823 11852909
MESH:D005355 Fibrosis Cyclosporine 3.5012168785 12639820
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.0816452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.628708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8215720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.6516366002
MESH:D006689 Hodgkin Disease sodium arsenite 3.4012676792
MESH:D006973 Hypertension Cyclosporine 2.1810903974
MESH:D007248 Infertility, Male sodium arsenite 3.1612646999 15346721
MESH:D007249 Inflammation Lipopolysaccharides 2.9917255318 12878042 17963957 9205823 17237260
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.9317255318
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8815604871
MESH:D007674 Kidney Diseases Cadmium 15.7516322080 16226777 16962696
MESH:D007674 Kidney Diseases Cadmium Chloride 15.7516962696
MESH:D007674 Kidney Diseases Cyclosporine 15.7510903974 18776723 8314463
MESH:D007674 Kidney Diseases sodium arsenite 15.7520008137
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9712371664
MESH:D007970 Leukopenia Lipopolysaccharides 5.0915821434
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 2.2612878042
MESH:D008113 Liver Neoplasms sodium arsenite 2.4515276417 16712894
MESH:D008171 Lung Diseases sodium arsenite 3.3519095001
MESH:D055370 Lung Injury Lipopolysaccharides 4.3621114838
MESH:D008175 Lung Neoplasms sodium arsenite 1.8916712894 17077188 17306315 15276417 19931552
MESH:D008545 Melanoma sodium arsenite 2.0619082730 16487513
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.2316801185
MESH:D009369 Neoplasms sodium arsenite 2.6111559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.0220056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5319348381 18481113
MESH:D009436 Neural Tube Defects sodium arsenite 3.3112854658
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.5017306315 15276417
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.7815687053
MESH:D011014 Pneumonia Lipopolysaccharides 4.9511605937 12224865
MESH:D011230 Precancerous Conditions Cyclosporine 3.4712371664
MESH:D011471 Prostatic Neoplasms Cadmium 3.5117075824
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.5116039940
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.9010835634
MESH:D012878 Skin Neoplasms sodium arsenite 2.8119524636 18572023
MESH:D016135 Spinal Dysraphism sodium arsenite 4.0112854658
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.4315821434
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.5916452187 16712894 11723127 17306315
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.0311813266
MESH:D014605 Uveitis Cyclosporine 4.431336536
MESH:D014652 Vascular Diseases sodium arsenite 4.8217056641
MESH:D014985 Xerophthalmia Cyclosporine 4.8817120751
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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