AutismKB 2.0

Annotation Detail for ACBD3


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Basic Information Top
Gene Symbol:ACBD3 ( GCP60,GOCAP1,GOLPH1,PAP7 )
Gene Full Name: acyl-CoA binding domain containing 3
Band: 1q42.12
Quick LinksEntrez ID:64746; OMIM: 606809; Uniprot ID:GCP60_HUMAN; ENSEMBL ID: ENSG00000182827; HGNC ID: 15453
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ACBD3 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ACBD3 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of ACBD3 mRNAaffects expression 17562736
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ACBD3 mRNAaffects cotreatment|decreases expression 18164116
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ACBD3 mRNAdecreases expression 19150397
20018196
D016572 Cyclosporine Cyclosporine results in increased expression of ACBD3 mRNAincreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ACBD3 mRNAaffects cotreatment|decreases expression 18164116
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ACBD3 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ACBD3 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACBD3 mRNAaffects cotreatment|increases expression 17942748
D007501 Iron Nitric Oxide promotes the reaction [[RASD1 protein binds to ACBD3 protein binds to SLC11A2 protein] which results in increased uptake of Iron]affects binding|increases reaction|increases uptake 16908409
D009569 Nitric Oxide Nitric Oxide promotes the reaction [[RASD1 protein binds to ACBD3 protein binds to SLC11A2 protein] which results in increased uptake of Iron]affects binding|increases reaction|increases uptake 16908409
C004648 testosterone enanthate testosterone enanthate affects the expression of ACBD3 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACBD3 mRNAaffects cotreatment|increases expression 17942748
C025643 vinclozolin vinclozolin affects the expression of ACBD3 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9611752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D000236 Adenoma beta-Naphthoflavone 7.0319389873
MESH:D000236 Adenoma Diethylnitrosamine 7.0310737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.4519061943 19052882 18056438 16434500 17162532 17620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.4516835633
MESH:D019896 alpha 1-Antitrypsin Deficiency Iron 5.7716640825
MESH:D000544 Alzheimer Disease Iron 4.9216563566 16640825
MESH:D000544 Alzheimer Disease Nitric Oxide 4.9217556102
MESH:D000740 Anemia Iron 9.1816434484 16566752
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.1811748828
MESH:D018798 Anemia, Iron-Deficiency Iron 4.7217147795 17163184 16569441 17375513 17162259
MESH:D000756 Anemia, Sideroblastic Iron 4.8916910769
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001008 Anxiety Disorders vinclozolin 3.7019015723
MESH:D001145 Arrhythmias, Cardiac Iron 4.4416604332
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001260 Ataxia Telangiectasia Iron 5.5715336622
MESH:D050197 Atherosclerosis Iron 3.7516640825 16632123
MESH:D001321 Autistic Disorder Acetaminophen 2.1418445737
MESH:D001321 Autistic Disorder Iron 2.1417352947
MESH:D001424 Bacterial Infections Iron 5.3116640825
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9917474063
MESH:D001943 Breast Neoplasms Nitric Oxide 1.9915631943
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9920435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.6516705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.6516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.653084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.6516540662 17138121 16502159 19171122 20727157 18506893 18494052 16878318 18978308 19701751 19418558 18788625 18665156 10672840 20512989 19919837 16328049 20214788 20432363 16569478 20514400 16935385 16830150 17055752 16698587 16288022 18971187 17173139 10737359 19208518 17761372 17978847 20524982 19539802 11831363 16807293 16681979 16779866 18785209 18393292 19107877 20101231 17428255 18056438 19383236 20007298 19052882 19519916 19394651 17162532 21159647 3581430 20935162 19335982 3084413 18691550 20084675 19822196 18210153
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118850075 18670907 16120746
MESH:D009202 Cardiomyopathies Iron 4.0916640825
MESH:D002311 Cardiomyopathy, Dilated Iron 3.4816604332
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 16.476135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 16.4720889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 16.4712371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 16.4717174075 7505956 2727394 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.5719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.5716835633
MESH:D002779 Cholestasis Cyclosporine 13.9219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.9217333356 15861022 17110522 16105132 11677210 16919318 17681005
MESH:D002779 Cholestasis Nitric Oxide 13.9216919318
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.138697196 16354765 15340226 15668235 12621046
MESH:D003110 Colonic Neoplasms Iron 2.9016640825
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003456 Cryptorchidism vinclozolin 4.4414966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.2518551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.2518551238
MESH:D015140 Dementia, Vascular Nitric Oxide 6.0817556102
MESH:D003920 Diabetes Mellitus Iron 4.5216604332 16640825
MESH:D003922 Diabetes Mellitus, Type 1 Iron 3.3816506275
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 7.3020387270
MESH:D003924 Diabetes Mellitus, Type 2 Iron 7.3016506275
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.3017107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.2521346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.2518551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.2519085960 19416960 16485898 11287661 16227642 11461765 16081117 18071297 16393943 11739529 14986274 12540782 17522070 11743745 11834606 10915739 12392966 14550746 16109766 17906064 16177239 12705907 12958197 11529661 17562736 19739265 10774834 12594235 11421492 15619225 15968718 2444490 14725611 19923254 19370779 18713872 16781746 12153990 19420014 10663392 19164858
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 12.2519107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.2520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0416714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2812538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.109294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2516302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0920426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Cyclosporine 19.5019224547
MESH:D005234 Fatty Liver Diethylnitrosamine 19.5020387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.5015345470
MESH:D005234 Fatty Liver Iron 19.5016640825
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis Cyclosporine 8.8312639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.8320067830
MESH:D005621 Friedreich Ataxia Iron 5.5316604332 16640825
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4316417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006261 Headache Nitric Oxide 5.3111284996 11554966
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3711294989 10048152
MESH:D006432 Hemochromatosis Iron 4.5516640825 16574947 17236123 17053826 16604332 17255318
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006486 Hemosiderosis Iron 5.3516604332
MESH:D006525 Hepatitis, Viral, Human Iron 5.6016640825
MESH:D006527 Hepatolenticular Degeneration Iron 5.0417182432
MESH:D006529 Hepatomegaly Iron 9.1016890145
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.1012621046 16120746 15340226
MESH:D015658 HIV Infections Iron 3.7116597321
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.8817440010
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1816959395 16354765 8697196 18606429 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006940 Hyperemia Nitric Oxide 5.7311156591
MESH:D006973 Hypertension Cyclosporine 5.0410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0418670907 18850075
MESH:D006976 Hypertension, Pulmonary Nitric Oxide 4.4715838368
MESH:D007006 Hypogonadism Iron 4.4616640825
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116945680 16569931
MESH:D007037 Hypothyroidism Iron 5.1916640825
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.8417937319
MESH:D007248 Infertility, Male vinclozolin 6.8416467254
MESH:D007249 Inflammation Diethylnitrosamine 5.0318785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0312878042 12200463
MESH:D007410 Intestinal Diseases Nitric Oxide 5.0411574821 11713966 10210152
MESH:D019189 Iron Metabolism Disorders Iron 5.1217163184
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Acetaminophen 5.9415629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 5.9418776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.7716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.7716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.7712371664
MESH:D007896 Leishmaniasis Nitric Oxide 4.7317218153
MESH:D020961 Lewy Body Disease Iron 5.5316563566
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8516417039
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 7.0918665156 18407596 18522880 20032147 19638242
MESH:D008103 Liver Cirrhosis Iron 7.0916640825
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Acetaminophen 3.9719460945 11587558 19014921 16611625 19784758 12587719 12969438 16610002
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9717034775
MESH:D008108 Liver Diseases, Alcoholic Iron 5.1117207112 16737972
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3117185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.577678174
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 14.5721295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.5720118626 19690152 20452335 18977376 15885732 19426721 18644402 21278145 20492335 18648771 10737359 19638242 19427195 19499222 19256749 15175105 16942905 19254457 20501860 12771043 18754104 20137499 19833225 12112319 19073162 20101389 9163691 20583210 19812893 21071580 21047994 19996281 18978307 19551842 20405173 21167192 20434301 2862719 2422723 19090486 19255062 19294768 19642983 19850985
MESH:D008113 Liver Neoplasms Iron 14.5720302851 16640825
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.5716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.542876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 14.5418164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.5419539802 21159647 16267830 18079962 19009564 19004024 17854601 18775883 16842330 18093689 9362446 18164116 18308698 19126423 19519916 18544905 18282651 18253720 2563599 17942915 17174075 3124819
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.5412151625
MESH:D055370 Lung Injury Nitric Oxide 4.8211395602
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.546695378 20970405 20512841 21163286
MESH:D008175 Lung Neoplasms Iron 3.5416640825
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5419555203 11884234
MESH:D008223 Lymphoma Nitric Oxide 4.3416166326
MESH:D008268 Macular Degeneration Iron 4.0216640825
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D008881 Migraine Disorders Nitric Oxide 4.3411701602
MESH:D020326 Migraine without Aura Nitric Oxide 5.2111304026 14659530
MESH:D020528 Multiple Sclerosis, Chronic Progressive Iron 5.8117086897
MESH:D009181 Mycoses Iron 5.6016640825
MESH:D017202 Myocardial Ischemia Iron 9.3916604332
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.3912213967
MESH:D015428 Myocardial Reperfusion Injury Iron 4.3316604332
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.7418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.7418551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.599029167 3581430
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 9.7319348381 18481113
MESH:D009404 Nephrotic Syndrome Iron 9.7317178036
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 14.5218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 14.5220387270
MESH:D019636 Neurodegenerative Diseases Iron 14.5216604332 17296847
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2520387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.1416049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.1416049721
MESH:D010003 Osteoarthritis Iron 4.0116640825
MESH:D010024 Osteoporosis Iron 3.9016648989 16640825
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4516540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010212 Papilloma Iron 4.5912065085
MESH:D020447 Parasomnias Iron 6.1517352947
MESH:D010300 Parkinson Disease Iron 3.3516640825 16563566
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010900 Pituitary Diseases Iron 5.8116604332
MESH:D011015 Pneumonia, Aspiration Nitric Oxide 5.4518573544
MESH:D011041 Poisoning Iron 4.3816604332
MESH:D017119 Porphyria Cutanea Tarda Iron 11.3416640825
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 11.3418163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.1912371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.192563599
MESH:D011225 Pre-Eclampsia Iron 4.4816640825
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.8811896295 11222880 11118676 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.8818220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.0518220299
MESH:D011472 Prostatitis vinclozolin 5.0518629315
MESH:D011528 Protozoan Infections Iron 6.1516640825
MESH:D011537 Pruritus Ethinyl Estradiol 3.4315861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012148 Restless Legs Syndrome Iron 4.6116930377
MESH:D012555 Schistosomiasis mansoni Nitric Oxide 5.529673227
MESH:D012640 Seizures 2,4-dinitrotoluene 6.0518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.0518551238
MESH:D012878 Skin Neoplasms Iron 6.0012065085
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.0016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0816709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013276 Stomach Ulcer Nitric Oxide 4.2715138204
MESH:D013398 Sudden Infant Death Iron 5.5716640825
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.047505956
MESH:D014376 Tuberculosis Iron 4.1316597321
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.1116049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.1116049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.3910091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.3910091137
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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