AutismKB 2.0

Annotation Detail for MOSC1


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Basic Information Top
Gene Symbol:MOSC1 ( FLJ22390,MARC1 )
Gene Full Name: MOCO sulphurase C-terminal domain containing 1
Band: 1q41
Quick LinksEntrez ID:64757; OMIM: NA; Uniprot ID:MOSC1_HUMAN; ENSEMBL ID: ENSG00000186205; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of MOSC1 mRNAincreases expression 16788091
D000082 Acetaminophen Acetaminophen affects the expression of MOSC1 mRNAaffects expression 17562736
D016572 Cyclosporine Cyclosporine results in decreased expression of MOSC1 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of MOSC1 mRNAdecreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of MOSC1 mRNAdecreases expression 19638242
C041786 palm oil palm oil results in decreased expression of MOSC1 mRNAdecreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of MOSC1 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of MOSC1 mRNAdecreases expression 19482888
C006253 pirinixic acid pirinixic acid results in increased expression of MOSC1 mRNAincreases expression 18301758
17426115
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.786195326
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000236 Adenoma Diethylnitrosamine 2.9810737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 19.4418056438 19061943 17162532 19052882 17620307 16434500
MESH:D018248 Adenoma, Liver Cell Phenobarbital 19.4417620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 19.4416434500
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001161 Arteriosclerosis Dietary Fats 4.1915238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D001943 Breast Neoplasms Dietary Fats 2.1620435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.1617474063
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.723084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.7219519916 20514400 18978308 19919837 19418558 16878318 19822196 19052882 19335982 18506893 16779866 17138121 11831363 19171122 20512989 16569478 16807293 16935385 21159647 10672840 20084675 19208518 18785209 18393292 18971187 20727157 18494052 16328049 19394651 17173139 17162532 17055752 3581430 16288022 20101231 18788625 17428255 17761372 16698587 16502159 20935162 19539802 19107877 20214788 19383236 17978847 18210153 19701751 3084413 18665156 16540662 18691550 20007298 20432363 10737359 16681979 16830150 18056438 20524982
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.7217173139 6705139 1701930 20935162 20007298
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1412371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.1417174075 21159647 2727394 7505956
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.564080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9019052882
MESH:D002779 Cholestasis Cyclosporine 8.3519486331
MESH:D002779 Cholestasis pirinixic acid 8.3519176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9417522070 19739265 16177239 15619225 11421492 18713872 19416960 12153990 11834606 16393943 16227642 19370779 10915739 19420014 11461765 17562736 18071297 12540782 17906064 14550746 12705907 10663392 14986274 16485898 16109766 19923254 16081117 12392966 11287661 12594235 15968718 11739529 12958197 2444490 19085960 19164858 10774834 11529661 16781746 11743745 14725611
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 3.9419107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D050171 Dyslipidemias Dietary Fats 3.6218367378
MESH:D004421 Dystonia Phenobarbital 4.261851702
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.413659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.253922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.766401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.363659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4916302075
MESH:D005234 Fatty Liver Cyclosporine 20.8719224547
MESH:D005234 Fatty Liver Dietary Fats 20.8718296743 19551842 17967931 19004024
MESH:D005234 Fatty Liver Diethylnitrosamine 20.8720387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 20.8719236843 20131406
MESH:D005355 Fibrosis Cyclosporine 9.7312639820 12168785
MESH:D005355 Fibrosis Dietary Fats 9.7318296743
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006529 Hepatomegaly Phenobarbital 9.5216109766
MESH:D006529 Hepatomegaly pirinixic acid 9.5219772884 16221962 19176532 18467677
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8321332399
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8721332399
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D007249 Inflammation Dietary Fats 5.4820412841
MESH:D007249 Inflammation Diethylnitrosamine 5.4818785209
MESH:D007333 Insulin Resistance Dietary Fats 7.7418457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.7416306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Acetaminophen 6.2212587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.228314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9312371664
MESH:D008103 Liver Cirrhosis Dietary Fats 11.7318296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 11.7318665156 18407596 20032147 19638242 18522880
MESH:D008103 Liver Cirrhosis Phenobarbital 11.7321047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 6.8011587558 19784758 16610002 12969438 12587719 19014921 16611625 19460945
MESH:D008107 Liver Diseases Diethylnitrosamine 6.8017034775
MESH:D008107 Liver Diseases Phenobarbital 6.8019363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.8819812893 9163691 21071580 19850985 2862719 21047994 20101389 19255062 19426721 19833225 18977376 19551842 19690152 19996281 21278145 20405173 20452335 2422723 15175105 10737359 20137499 15885732 19254457 19090486 18648771 20492335 19642983 19256749 12771043 20583210 12112319 19427195 18754104 19073162 19638242 18644402 19499222 21167192 19294768 16942905 20118626 20434301 20501860 18978307
MESH:D008113 Liver Neoplasms Phenobarbital 7.8821047994 19812893 15975961 8742319 19073162 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 7.8815890375 16377806 20007298
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.4519519916 3124819 9362446 18308698 19009564 19126423 18079962 2563599 16267830 16842330 19539802 17942915 18544905 18093689 19004024 18164116 17174075 18253720 18282651 21159647 18775883 17854601
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.452563599 1399818 18308698 6150874 17172636
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.766695378 20970405 21163286 20512841
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8117484760
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.659029167 3581430
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5018481113 19348381
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.8618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.8620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4920387270
MESH:D009765 Obesity Dietary Fats 4.6011836018 17217161 18674790 21332399 18457598 20518802 19632207 16723640 20132043
MESH:D009765 Obesity pirinixic acid 4.6020558911
MESH:D010018 Osteomalacia Phenobarbital 4.7017016548
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.5116540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.5116965848
MESH:D011230 Precancerous Conditions Cyclosporine 16.5612371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 16.562563599
MESH:D011230 Precancerous Conditions Phenobarbital 16.562563599
MESH:D019310 Pseudolymphoma Phenobarbital 4.8712752131
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012640 Seizures Phenobarbital 2.8416876388 3137016 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.166407741
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.797505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.791399818
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D015430 Weight Gain Dietary Fats 3.9516723640
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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