AutismKB 2.0

Annotation Detail for CREB3L2


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Basic Information Top
Gene Symbol:CREB3L2 ( BBF2H7,MGC131709,MGC71006 )
Gene Full Name: cAMP responsive element binding protein 3-like 2
Band: 7q33
Quick LinksEntrez ID:64764; OMIM: 608834; Uniprot ID:CR3L2_HUMAN; ENSEMBL ID: ENSG00000182158; HGNC ID: 23720
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04916Melanogenesis
hsa04962Vasopressin-regulated water reabsorption
hsa05016Huntington's disease
hsa05215Prostate cancer
No data
No data
Pathway IDPathway Name
P00055Transcription regulation by bZIP transcription factor
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of CREB3L2 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of CREB3L2 mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CREB3L2 mRNAdecreases expression 20018196
D016572 Cyclosporine Cyclosporine results in increased expression of CREB3L2 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of CREB3L2 mRNAaffects expression 17555576
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of CREB3L2 mRNAincreases expression 17560707
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CREB3L2 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of CREB3L2 mRNAdecreases expression 17426115
D013629 Tamoxifen Tamoxifen affects the expression of CREB3L2 mRNAaffects expression 17555576
D014415 Tunicamycin Tunicamycin results in increased expression of CREB3L2 mRNAincreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8714745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3220127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3214692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.766695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7616434500
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0620146248 17474063
MESH:D001943 Breast Neoplasms Tamoxifen 2.0618997820 18629630 21138602 19155303 19142967 19011961 20065188 20135344 20390343 11161223 19487384 18351453 16873071 15668708 19289846 19084267 18425577 18855134 18821012 19189212 18984771 19221464 19066611 19200415 19059307 21152245 17049068 19288272 19244106 20859285 19103187 17261762 16273361 17893378 19410462 18815881 16202921 19189210 16818667 19115204 20005174 20544844 17242785 15565566 17440819
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7619066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.923084413
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 2.9216924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8117572228
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.0120889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.0112371664
MESH:D002779 Cholestasis Cyclosporine 14.2319486331
MESH:D002779 Cholestasis Ethinyl Estradiol 14.2317333356 16919318 17110522 11677210 15861022 17681005 16105132
MESH:D002779 Cholestasis pirinixic acid 14.2319176532
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6219031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6619279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6311529661 10663392 2444490 10915739 18713872 17906064 16393943 12540782 19370779 12153990 16485898 11287661 11743745 18071297 16109766 14550746 15619225 14725611 12392966 17522070 16177239 11421492 12594235 16781746 10774834 19085960 16081117 12958197 19164858 12705907 19923254 19416960 11739529 14986274 17562736 11461765 19420014 19739265 15968718 11834606 16227642
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004487 Edema perfluorooctanoic acid 7.6712083418 17259670
MESH:D004487 Edema pirinixic acid 7.6712083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.7512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.7519031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1717893378 16202921 20544844 19155303
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5020426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5016530937
MESH:D005234 Fatty Liver Cyclosporine 20.5219224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.5215345470
MESH:D005234 Fatty Liver pirinixic acid 20.5220131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 20.5214986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3516709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4719069698
MESH:D005355 Fibrosis Cyclosporine 3.4012639820 12168785
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7520471113
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006529 Hepatomegaly perfluorooctanoic acid 9.583609246
MESH:D006529 Hepatomegaly pirinixic acid 9.5819176532 18467677 16221962 19772884
MESH:D006930 Hyperalgesia Acetaminophen 8.4116870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 8.4112083418
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006973 Hypertension Cyclosporine 2.1610903974
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation perfluorooctanoic acid 5.6512083418
MESH:D007249 Inflammation Tamoxifen 5.6519457130
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.1615629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.1618776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 7.8812371664
MESH:D007680 Kidney Neoplasms Tamoxifen 7.8818625569
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.518812269
MESH:D008064 Lipidoses Tamoxifen 3.3015342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3715474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3718564211
MESH:D008107 Liver Diseases Acetaminophen 1.6716611625 19014921 12587719 19460945 16610002 12969438 11587558 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4317185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.2920195826 21137059
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 11.2918709148 14757943
MESH:D008113 Liver Neoplasms pirinixic acid 11.2915890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 11.2916684651
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4220135361 20464547 18520028 18816296 6695378 18569708 17053015 20064080 20869020
MESH:D008175 Lung Neoplasms Tamoxifen 2.4218625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0419428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7414580682 16827153 11731420 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.8719453300
MESH:D008545 Melanoma Tamoxifen 1.9012393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5719410462
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1311141357
MESH:D009369 Neoplasms pirinixic acid 5.1317405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3219200415 19189210 19196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4718481113 19348381
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 5.219802331
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 4.6817132714
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0817292933
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.0815067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.6015861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4519755658 10029692
MESH:D013088 Spermatocele Ethinyl Estradiol 12.6516709447
MESH:D013088 Spermatocele Tamoxifen 12.6516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3219457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2317053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.2316712894 17572228 8653321
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7515869587 14671159
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
Pathway ID Pathway Name
KEGG:05016 Huntington's disease
KEGG:04916 Melanogenesis
KEGG:05215 Prostate cancer
KEGG:04962 Vasopressin-regulated water reabsorption
Pharmacogenomics Knowledge Base Top
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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