Annotation Detail for IPPK
Basic Information
Top
| Gene Symbol: | IPPK ( C9orf12,FLJ13163,INSP5K2,IP5K,IPK1,KIAA0699,bA476B13.1 ) |
|---|
| Gene Full Name: | inositol 1,3,4,5,6-pentakisphosphate 2-kinase |
|---|
| Band: | 9q22.31 |
|---|
| Quick Links | Entrez ID:64768; OMIM: NA; Uniprot ID:IPPK_HUMAN; ENSEMBL ID: ENSG00000127080; HGNC ID: 14645 |
|---|
| Relate to Another Database: |
SFARIGene;
denovo-db |
| Pathway ID | Pathway Name |
|---|
| PWY-6554 | 1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) |
| PWY-6369 | inositol pyrophosphates biosynthesis |
| PWY-6362 | 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian) |
| Pathway ID | Pathway Name |
|---|
| hsa00562 | Inositol phosphate metabolism |
| hsa01100 | Metabolic pathways |
| hsa04070 | Phosphatidylinositol signaling system |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D000638 |
Amiodarone |
Amiodarone results in increased expression of IPPK mRNA | increases expression | 19774075
|
| C006253 |
pirinixic acid |
[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of IPPK mRNA | affects binding|decreases expression|increases activity | 19710929
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D055371 |
Acute Lung Injury |
|
pirinixic acid |
3.72 | 18653653 |
| MESH:D018248 |
Adenoma, Liver Cell |
|
pirinixic acid |
4.37 | 16434500 |
| MESH:D001145 |
Arrhythmias, Cardiac |
|
Amiodarone |
4.31 | 18218290 20041841 18057881 |
| MESH:D001281 |
Atrial Fibrillation |
|
Amiodarone |
4.27 | 19698954 18651412 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
Amiodarone |
10.97 | 19483382 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
pirinixic acid |
10.97 | 19483382 |
| MESH:D002311 |
Cardiomyopathy, Dilated |
|
Amiodarone |
3.02 | 15710769 19225199 |
| MESH:D002341 |
Carotid Artery Thrombosis |
|
Amiodarone |
5.97 | 18974383 |
| MESH:D002779 |
Cholestasis |
|
pirinixic acid |
3.19 | 19176532 |
| MESH:D003876 |
Dermatitis, Atopic |
|
pirinixic acid |
2.61 | 18249437 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Amiodarone |
2.49 | 18218290 15265979 |
| MESH:D004487 |
Edema |
|
pirinixic acid |
3.02 | 12083418 |
| MESH:D005234 |
Fatty Liver |
|
Amiodarone |
9.69 | 14986274 |
| MESH:D005234 |
Fatty Liver |
|
pirinixic acid |
9.69 | 19236843 20131406 |
| MESH:D006333 |
Heart Failure |
|
pirinixic acid |
2.81 | 20558911 |
| MESH:D006529 |
Hepatomegaly |
|
Amiodarone |
11.26 | 15265979 |
| MESH:D006529 |
Hepatomegaly |
|
pirinixic acid |
11.26 | 19176532 16221962 18467677 19772884 |
| MESH:D006937 |
Hypercholesterolemia |
|
Amiodarone |
4.42 | 9751232 8137927 |
| MESH:D006943 |
Hyperglycemia |
|
pirinixic acid |
3.69 | 20558911 |
| MESH:D007037 |
Hypothyroidism |
|
Amiodarone |
5.28 | 18020914 17991464 |
| MESH:D007333 |
Insulin Resistance |
|
pirinixic acid |
2.93 | 16306350 |
| MESH:D008064 |
Lipidoses |
|
Amiodarone |
3.85 | 17567588 15342952 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
pirinixic acid |
1.35 | 15474484 |
| MESH:D008113 |
Liver Neoplasms |
|
pirinixic acid |
1.95 | 20007298 15890375 16377806 |
| MESH:D008133 |
Long QT Syndrome |
|
Amiodarone |
3.96 | 17391786 15350150 11989578 |
| MESH:D008171 |
Lung Diseases |
|
Amiodarone |
3.68 | 12587719 |
| MESH:D017563 |
Lung Diseases, Interstitial |
|
Amiodarone |
5.55 | 18516814 |
| MESH:D009135 |
Muscular Diseases |
|
pirinixic acid |
4.27 | 16239165 |
| MESH:D009181 |
Mycoses |
|
Amiodarone |
5.97 | 17974566 12754197 |
| MESH:D009203 |
Myocardial Infarction |
|
pirinixic acid |
2.30 | 19151258 |
| MESH:D015428 |
Myocardial Reperfusion Injury |
|
pirinixic acid |
3.33 | 16411023 |
| MESH:D009369 |
Neoplasms |
|
pirinixic acid |
2.14 | 17405874 |
| MESH:D009765 |
Obesity |
|
pirinixic acid |
1.90 | 20558911 |
| MESH:D011658 |
Pulmonary Fibrosis |
|
Amiodarone |
2.99 | 12832656 12490602 11597910 |
| MESH:D015427 |
Reperfusion Injury |
|
pirinixic acid |
2.58 | 19058328 |
| OMIM:609620 |
SHORT QT SYNDROME 1 |
|
Amiodarone |
5.97 | 18724381 |
| MESH:D013276 |
Stomach Ulcer |
|
Amiodarone |
3.86 | 18087811 |
| MESH:D013610 |
Tachycardia |
|
Amiodarone |
4.96 | 11238279 |
| MESH:D017180 |
Tachycardia, Ventricular |
|
Amiodarone |
4.86 | 19225199 |
| MESH:D013959 |
Thyroid Diseases |
|
Amiodarone |
5.83 | 19731979 |
| MESH:D013971 |
Thyrotoxicosis |
|
Amiodarone |
5.62 | 18020914 19584973 |
| MESH:D016171 |
Torsades de Pointes |
|
Amiodarone |
5.08 | 11989578 17467628 |
Related Diseases/Disorders