AutismKB 2.0

Annotation Detail for CERK


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Basic Information Top
Gene Symbol:CERK ( DKFZp434E0211,FLJ21430,FLJ23239,KIAA1646,LK4,MGC131878,dA59H18.2,dA59H18.3,hCERK )
Gene Full Name: ceramide kinase
Band: 22q13.31
Quick LinksEntrez ID:64781; OMIM: 610307; Uniprot ID:CERK1_HUMAN; ENSEMBL ID: ENSG00000100422; HGNC ID: 19256
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00600Sphingolipid metabolism
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of CERK mRNAdecreases expression 16788091
D000082 Acetaminophen Acetaminophen affects the expression of CERK mRNAaffects expression 17562736
D002118 Calcium Calcium affects the reaction [CERK protein results in increased phosphorylation of Ceramides]affects reaction|increases phosphorylation 16269826
C065576 ceramide 1-phosphate CERK protein affects the abundance of ceramide 1-phosphateaffects abundance 15899891
D002518 Ceramides Calcium affects the reaction [CERK protein results in increased phosphorylation of Ceramides]affects reaction|increases phosphorylation 16269826
D002518 Ceramides CERK protein results in increased phosphorylation of Ceramidesincreases phosphorylation 16269826
D002518 Ceramides Magnesium affects the reaction [CERK protein results in increased phosphorylation of Ceramides]affects reaction|increases phosphorylation 16269826
D016572 Cyclosporine Cyclosporine results in decreased expression of CERK mRNAdecreases expression 20106945
D008274 Magnesium Magnesium affects the reaction [CERK protein results in increased phosphorylation of Ceramides]affects reaction|increases phosphorylation 16269826
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CERK mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of CERK mRNAdecreases expression 17426115
D014810 Vitamin E Vitamin E results in increased expression of CERK mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000236 Adenoma Magnesium 4.6517823441
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7616434500
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001321 Autistic Disorder Acetaminophen 2.4418445737
MESH:D001321 Autistic Disorder Magnesium 2.4416846101
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1916050911
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.393084413
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6612371664
MESH:D002779 Cholestasis Cyclosporine 8.2619486331
MESH:D002779 Cholestasis pirinixic acid 8.2619176532
MESH:D003111 Colonic Polyps Magnesium 6.2917823441
MESH:D015179 Colorectal Neoplasms Magnesium 3.4517823441
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D002658 Developmental Disabilities Magnesium 5.0416846101
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6314550746 19739265 16485898 18071297 19370779 16109766 10663392 14725611 17562736 15968718 12594235 16781746 16393943 10915739 11529661 11461765 19923254 11743745 2444490 18713872 12392966 19085960 12540782 19416960 19164858 16177239 12153990 11287661 14986274 17906064 19420014 11739529 11834606 16081117 16227642 12705907 15619225 10774834 17522070 11421492 12958197
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:C538011 Eales disease Vitamin E 5.029068938
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D005234 Fatty Liver Cyclosporine 8.2519224547
MESH:D005234 Fatty Liver pirinixic acid 8.2519236843 20131406
MESH:D005355 Fibrosis Cyclosporine 3.4012639820 12168785
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0816080930
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006529 Hepatomegaly pirinixic acid 3.2518467677 19772884 16221962 19176532
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7616490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.2914716179
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006973 Hypertension Cyclosporine 2.1610903974
MESH:D007251 Influenza, Human Vitamin E 4.5316624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Acetaminophen 10.6512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.658314463 18776723 10903974
MESH:D007674 Kidney Diseases Vitamin E 10.6512488133
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9012371664
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 5.3616316344
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4315474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4316169303
MESH:D008107 Liver Diseases Acetaminophen 1.6719460945 16611625 16610002 12969438 12587719 19784758 11587558 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4316871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 1.8815890375 16377806 20007298
MESH:D008171 Lung Diseases Vitamin E 3.3116863852
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D008275 Magnesium Deficiency Magnesium 6.7317823441
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D008881 Migraine Disorders Magnesium 4.9118803445
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4718481113 19348381
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D010024 Osteoporosis Calcium 3.9017882678
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2715084515
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D020521 Stroke Vitamin E 3.6816517955
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
Pathway ID Pathway Name
KEGG:00600 Sphingolipid metabolism
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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