AutismKB 2.0

Annotation Detail for AEN


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Basic Information Top
Gene Symbol:AEN ( FLJ12484,FLJ12562,ISG20L1,pp12744 )
Gene Full Name: apoptosis enhancing nuclease
Band: 15q26.1
Quick LinksEntrez ID:64782; OMIM: 610177; Uniprot ID:AEN_HUMAN; ENSEMBL ID: ENSG00000181026; HGNC ID: 25722
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of AEN mRNAincreases expression 20064835
D014810 Vitamin E Vitamin E results in increased expression of AEN mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0720464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.906695378
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.8419183758
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9817474063 20146248
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.6916050911
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1520419170
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9319769572
MESH:C538011 Eales disease Vitamin E 5.779068938
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0916530937
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 7.4220471113
MESH:D006330 Heart Defects, Congenital Vitamin E 7.4216080930
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.8316490937 16863852
MESH:D019584 Hot Flashes Vitamin E 5.0414716179
MESH:D007251 Influenza, Human Vitamin E 5.2816624496
MESH:D007674 Kidney Diseases Vitamin E 3.0512488133
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9116169303
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.1820195826 21137059
MESH:D008171 Lung Diseases Vitamin E 3.4816863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.536695378 18569708 20869020 20464547 20064080 17053015 18816296 18520028 20135361
MESH:D008175 Lung Neoplasms Vitamin E 2.5311062179
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.5716381670
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3611141357
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0917292933
MESH:D011471 Prostatic Neoplasms Vitamin E 3.0915084515
MESH:D012871 Skin Diseases Vitamin E 2.5318709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5519755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D020521 Stroke Vitamin E 3.9316517955
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.3217053015
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018