AutismKB 2.0

Annotation Detail for LMF1


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Basic Information Top
Gene Symbol:LMF1 ( C16orf26,FLJ12681,FLJ22302,HMFN1876,JFP11,TMEM112,TMEM112A )
Gene Full Name: lipase maturation factor 1
Band: 16p13.3
Quick LinksEntrez ID:64788; OMIM: 611761; Uniprot ID:LMF1_HUMAN; ENSEMBL ID: ENSG00000103227; HGNC ID: 14154
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
Lipase deficiency, combined
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of LMF1 mRNAaffects expression 17562736
D001151 Arsenic Arsenic affects the expression of LMF1 mRNAaffects expression 18414638
D004041 Dietary Fats Dietary Fats results in decreased expression of LMF1 mRNAdecreases expression 18042831
D005472 Fluorouracil [Fluorouracil co-treated with irinotecan] results in increased expression of LMF1 mRNAaffects cotreatment|increases expression 16391804
C051890 irinotecan [Fluorouracil co-treated with irinotecan] results in increased expression of LMF1 mRNAaffects cotreatment|increases expression 16391804
C041786 palm oil palm oil results in decreased expression of LMF1 mRNAdecreases expression 18042831
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Fluorouracil 2.4817638652
MESH:D018246 Adrenocortical Adenoma Arsenic 5.7317306315
MESH:D000740 Anemia Fluorouracil 4.0217963324 15504547 16511603
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D020261 Arsenic Poisoning Arsenic 2.9316251483 12569548 16835338 18414634
MESH:D001161 Arteriosclerosis Dietary Fats 4.3115238619
MESH:D050197 Atherosclerosis Arsenic 3.4212928151 19371607
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms Dietary Fats 2.2420435547
MESH:D001943 Breast Neoplasms Fluorouracil 2.2418608205 19217205 16557594 15136595 16595493 18357371 16110121
MESH:D002276 Carcinoid Tumor Fluorouracil 5.1916051944
MESH:D002277 Carcinoma Fluorouracil 3.8217121937
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7515504454 17687452
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.853084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 4.8517306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.8517045692 17971768 16799960 18930000 17088986 16332177
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1418695887
MESH:D002294 Carcinoma, Squamous Cell Arsenic 5.1315504454 18922899 17687452
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 5.1316757204 16280240 17066447 18986760
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.3818640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.6615738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.6018022660 16973168
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D003110 Colonic Neoplasms Fluorouracil 4.1216510598 18772588 15001691 17016597 17725105 17172411 17169374 17287894 16340194 17018589
MESH:D003110 Colonic Neoplasms irinotecan 4.1217725105 17287894
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.7918949393 18509181 18288408 16331619 16391804 17695437 17255274 17401013 18448328 18383874 14970324 16303861 17016601 16282729 15289873 17454858 17094418 15148649 17594712 16524972 20501625 18802399
MESH:D015179 Colorectal Neoplasms irinotecan 2.7915273666 16391804 18509181 17159606 16303861 18259882 17454858
MESH:D007644 Darier Disease Fluorouracil 5.2516733453
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6517522070 10663392 18071297 19416960 16109766 12392966 11834606 16485898 14986274 18713872 16227642 16393943 11421492 12153990 12958197 10774834 11287661 19420014 19739265 11739529 16081117 19164858 19923254 15619225 10915739 11743745 12705907 19370779 2444490 11529661 16177239 12594235 17906064 14550746 15968718 12540782 19085960 11461765 16781746 17562736 14725611
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D050171 Dyslipidemias Dietary Fats 3.6718367378
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.5117638652 16337965 16785472 15173087 16481741
MESH:D005234 Fatty Liver Dietary Fats 3.5619551842 17967931 19004024 18296743
MESH:D005355 Fibrosis Dietary Fats 3.9418296743
MESH:D005534 Foot Diseases Arsenic 6.086392382
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D005910 Glioma Fluorouracil 2.9716145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5915102660 15162350 18337622
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.9221332399
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.7617050553
MESH:D006949 Hyperlipidemias Dietary Fats 3.9721332399
MESH:D006973 Hypertension Arsenic 2.9616076760 11953799 9931084
MESH:D015228 Hypertriglyceridemia marker/mechanism 17994020
MESH:D006987 Hypesthesia Arsenic 6.0816093927
MESH:D007249 Inflammation Dietary Fats 2.5720412841
MESH:D007333 Insulin Resistance Dietary Fats 3.3011836018 18457598
MESH:D007642 Keratosis Arsenic 5.4512749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 2.3612587719 15629191
MESH:D007680 Kidney Neoplasms Fluorouracil 3.5716985049
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.7417339181
OMIM:246650 LIPASE DEFICIENCY, COMBINED marker/mechanism
MESH:D008103 Liver Cirrhosis Dietary Fats 3.0318296743
MESH:D008107 Liver Diseases Acetaminophen 4.2912969438 19460945 19784758 16611625 12587719 11587558 16610002 19014921
MESH:D008107 Liver Diseases Arsenic 4.2911134558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5417185352 16871587
MESH:D008113 Liver Neoplasms Arsenic 5.1816368122
MESH:D008113 Liver Neoplasms Fluorouracil 5.1817045692 18383874 16603448 15113037
MESH:D008175 Lung Neoplasms Arsenic 2.7717976673 17306315 19168569
MESH:D008175 Lung Neoplasms Fluorouracil 2.7715246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.2515086387
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D009062 Mouth Neoplasms Fluorouracil 3.8716757204 18986760
MESH:D052016 Mucositis irinotecan 5.4717159606
MESH:D017202 Myocardial Ischemia Arsenic 4.2415371236
MESH:D009362 Neoplasm Metastasis irinotecan 3.2718259882
MESH:D009369 Neoplasms Fluorouracil 2.7416928823 18239605 18600527
MESH:D009436 Neural Tube Defects Arsenic 3.6416620997
MESH:D009447 Neuroblastoma irinotecan 3.628761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D017599 Neuroectodermal Tumors irinotecan 5.198761367
MESH:D020078 Neurogenic Inflammation Arsenic 4.7317056641
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6416436463
MESH:D009765 Obesity Dietary Fats 2.3418457598 11836018 21332399 20518802 16723640 19632207 17217161 18674790 20132043
MESH:D010051 Ovarian Neoplasms Arsenic 2.8217306315
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7516929163 15113037 19003803 16500647
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.5616093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.4516905509 6392382 15371236
MESH:D011471 Prostatic Neoplasms Arsenic 3.4016140617
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.4019082440 18626508
MESH:D011507 Proteinuria Arsenic 4.3521343184
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3015538739 16160472 18722050 18286688
MESH:D012871 Skin Diseases Arsenic 2.8115952646 19834688 17938729 6392382 17050553 16759981 16353154 16702368 18709164 17453740 17548696
MESH:D012878 Skin Neoplasms Arsenic 3.1317976673 17050553 17029826 19538983 16251483 15504454
MESH:D013274 Stomach Neoplasms Fluorouracil 2.7718396642 16424979 17522103 17172411 18567086 19015929 19084572 16951190 15786421 17498489
MESH:D013274 Stomach Neoplasms irinotecan 2.7715723263
MESH:D014062 Tongue Neoplasms Fluorouracil 4.2916280240
MESH:D001749 Urinary Bladder Neoplasms Arsenic 2.9115987713 11144890 17976673 19322015 19429237 17306315 18640142
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.1816803524
MESH:D014652 Vascular Diseases Arsenic 5.2017056641
MESH:D015430 Weight Gain Dietary Fats 4.0216723640
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25540
    • No data
    Releated disease ID Related disease Name
    PA446120Hypertriglyceridemia
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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