AutismKB 2.0

Annotation Detail for CYP3A43


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Basic Information Top
Gene Symbol:CYP3A43 ( MGC119315,MGC119316 )
Gene Full Name: cytochrome P450, family 3, subfamily A, polypeptide 43
Band: 7q22.1
Quick LinksEntrez ID:64816; OMIM: 606534; Uniprot ID:CP343_HUMAN; ENSEMBL ID: ENSG00000021461; HGNC ID: 17450
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00830Retinol metabolism
hsa00140Steroid hormone biosynthesis
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa00983Drug metabolism - other enzymes
hsa01100Metabolic pathways
hsa00591Linoleic acid metabolism
Pathway IDPathway Name
Biological oxidations
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
Desease Name
prostate cancer
CANCER
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of CYP3A43 proteinaffects expression 20106945
C006632 arsenic trioxide arsenic trioxide results in increased expression of CYP3A43 mRNAincreases expression 15761015
D019207 beta Carotene beta Carotene results in increased expression of CYP3A43 mRNAincreases expression 17034753
D002220 Carbamazepine Carbamazepine results in increased expression of CYP3A43 mRNAincreases expression 17112801
D016572 Cyclosporine Cyclosporine results in decreased expression of CYP3A43 mRNAdecreases expression 20106945
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CYP3A43 mRNAaffects binding|increases activity|increases expression 19710929
D013739 Testosterone CYP3A43 protein affects the metabolism of Testosteroneaffects metabolic processing 15548719
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 4.948986270
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3419825857 11798837
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8816434500
MESH:D000987 Antisocial Personality Disorder Testosterone 6.307506515
MESH:D001714 Bipolar Disorder Carbamazepine 4.2520046352 17594078
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.9616206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.9619483382
MESH:D002545 Brain Ischemia beta Carotene 5.4916157235
MESH:D001943 Breast Neoplasms Testosterone 3.2817261762
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6311589617
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.2112907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.2114691202 15073043 16217749 11135700 15553829
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.3219014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3812490120
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7112371664
MESH:D002659 Child Development Disorders, Pervasive Testosterone 3.7620678186
MESH:D002779 Cholestasis Cyclosporine 8.4419486331
MESH:D002779 Cholestasis pirinixic acid 8.4419176532
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5112609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.1610525206
MESH:D019465 Craniofacial Abnormalities Carbamazepine 3.169014606
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4015213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
OMIM:607208 DRAVET SYNDROME Carbamazepine 5.8011748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.5616538176 16538175 20216337 15057820
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 3.2917465707
MESH:D004362 Drug Toxicity Carbamazepine 4.6620216337
MESH:D004487 Edema pirinixic acid 2.7612083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 5.0617654737
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 5.5818855540 20485159 16538176 16415921 19915237
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 5.5717275665
MESH:D004828 Epilepsies, Partial Carbamazepine 5.4217116037 16628512 15008574
MESH:D004827 Epilepsy Carbamazepine 4.117988514 9014606 18234410 19700373 17178248 821787 19620853 17465707 19439326 20417680
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 5.717750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 5.5215276670 3659116
MESH:D004916 Erythromelalgia Carbamazepine 6.1219549232
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3612903497
MESH:D005076 Exanthema Carbamazepine 5.8620485159
MESH:D005234 Fatty Liver arsenic trioxide 14.7615073043
MESH:D005234 Fatty Liver Cyclosporine 14.7619224547
MESH:D005234 Fatty Liver pirinixic acid 14.7619236843 20131406
MESH:D005355 Fibrosis Cyclosporine 3.5012639820 12168785
MESH:D005391 Firesetting Behavior Testosterone 6.307506515
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5916904648
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.628708960
MESH:D005909 Glioblastoma Testosterone 4.2117162496
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8215720958
MESH:D006529 Hepatomegaly pirinixic acid 3.3516221962 19772884 18467677 19176532
MESH:D006628 Hirsutism Testosterone 6.1017019078
MESH:D015658 HIV Infections beta Carotene 4.1716960176
MESH:D017588 Hyperandrogenism Testosterone 5.7517019078
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D020138 Hyperhomocysteinemia Carbamazepine 4.9710459572
MESH:D006965 Hyperplasia Carbamazepine 5.5718773962
MESH:D006973 Hypertension Cyclosporine 2.1810903974
MESH:D007006 Hypogonadism Testosterone 4.7712002444
MESH:D007018 Hypopituitarism Testosterone 6.6417426086
MESH:D007174 Impulse Control Disorders Testosterone 6.307506515
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8815604871
MESH:D007674 Kidney Diseases Cyclosporine 2.488314463 18776723 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9712371664
MESH:D007938 Leukemia arsenic trioxide 2.9515070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0817077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1716467208 20471514 16968895 19850784 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3819035177 16966277 19642359 12018890 17107899 11161223 16330433 15748426 15622746 16331271 9834237 15336539 15213294 12679006 12712474 17217047 16112521 19225113 17869043 16823087 16891316 17712046 19075265 11468182 17649720
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6816882451
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.9618177683 2125692 15890375 9163691
MESH:D008113 Liver Neoplasms arsenic trioxide 7.9614682389
MESH:D008113 Liver Neoplasms pirinixic acid 7.9620007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 11.028603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 11.0220377131
MESH:D008114 Liver Neoplasms, Experimental beta Carotene 11.0217113696
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5615213294
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.7814755239
MESH:D008175 Lung Neoplasms arsenic trioxide 3.7819825857 11798837
MESH:D008175 Lung Neoplasms beta Carotene 3.7816401635
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.6316628512
MESH:D008607 Mental Retardation Carbamazepine 3.809014606
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.2316801185
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2919417148 19549372 15949261 11468182 14977855
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2816105982 16882451
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009224 Myotonia Congenita Carbamazepine 5.8620399394
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2916624393
MESH:D009369 Neoplasms beta Carotene 5.7717051425
MESH:D009369 Neoplasms pirinixic acid 5.7717405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5318481113 19348381
MESH:D009421 Nervous System Malformations Carbamazepine 5.2416990009
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2810525206
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010018 Osteomalacia Carbamazepine 5.8617016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4719769630 12452020 16624393
MESH:D010146 Pain Carbamazepine 4.2615215642
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6015580305
MESH:D010235 Paraganglioma arsenic trioxide 4.4719927285
MESH:D010267 Parapsoriasis Carbamazepine 6.0616538176
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 6.3217145499 17679678
MESH:D011230 Precancerous Conditions Cyclosporine 3.4712371664
MESH:D011248 Pregnancy Complications Carbamazepine 5.519014606
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 5.289014606
MESH:D019048 Prostatic Intraepithelial Neoplasia Testosterone 5.3420887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 15894682
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2319131511
MESH:D019310 Pseudolymphoma Carbamazepine 6.049591791 12752131
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2916646077
MESH:D012640 Seizures Carbamazepine 3.979046859 19414003 16876388 9844417 15946322 16938433 16180713
MESH:D012735 Sexual Dysfunction, Physiological Testosterone 6.6416631401
MESH:D012893 Sleep Disorders Carbamazepine 5.5219414003
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 5.5715057820 16538176 20485159 19915237 16415921 19694795 18855540
MESH:D013272 Stomach Diseases beta Carotene 5.4917638125
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013276 Stomach Ulcer beta Carotene 4.5312500499
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2919014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3615213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5711780464 12973940 12845720 20435036
MESH:D014605 Uveitis Cyclosporine 4.431336536
MESH:D014985 Xerophthalmia Cyclosporine 4.8817120751
Pathway ID Pathway Name
REACT:13433 Biological oxidations
KEGG:00982 Drug metabolism - cytochrome P450
KEGG:00983 Drug metabolism - other enzymes
KEGG:00591 Linoleic acid metabolism
KEGG:01100 Metabolic pathways
KEGG:00980 Metabolism of xenobiotics by cytochrome P450
KEGG:00830 Retinol metabolism
KEGG:00140 Steroid hormone biosynthesis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA427
    • Releated gene ID Related gene Name
    PA427CYP3A43
    Releated disease ID Related disease Name
    PA445204Ovarian Neoplasms
    PA445425Prostatic Neoplasms
    PA445424Prostatic Hyperplasia
    Releated drug ID Related drug Name
    PA449512estrone
    PA449247dexamethasone
    PA450180lansoprazole
    PA450774pantoprazole
    PA451216rabeprazole
    PA448333alprazolam
    Drug Bank Top
    No data
    Drugbank ID Action Drug Name Description
    DB00254 - Doxycycline Anti-Bacterial Agents;Antimalarials;Tetracyclines
    DB00341 - Cetirizine Anti-Allergic Agents;Antihistamines;Histamine H1 Antagonists, Non-Sedating
    DB00593 substrate Ethosuximide Anticonvulsants;Succinimides
    DB00624 substrate Uni-Bol Androgens
    DB00780 inhibitor Phenelzine Antidepressants;Antidepressive Agents;Monoamine Oxidase Inhibitors
    DB00842 substrate Oxazepam Anti-anxiety Agents;Hypnotics and Sedatives;GABA Modulators
    DB00943 substrate Zalcitabine Anti-HIV Agents;Antimetabolites;Nucleoside and Nucleotide Reverse Transcriptase Inhibitors;Reverse Transcriptase Inhibitors
    DB01045 inducer Rifater Enzyme Inhibitors;Antituberculosis Agents;Nucleic Acid Synthesis Inhibitors;Leprostatic Agents;Antibiotics;Antibiotics, Antitubercular
    DB01058 substrate Drontal Tab Anthelmintics
    DB01201 inducer Rifapentine Leprostatic Agents;Antimycobacterials;Antibiotics, Antitubercular
    DB01234 inducer Tresaderm Dermatologic Solution Anti-inflammatory Agents;Adrenergic Agents;Antiemetics;Antineoplastic Agents, Hormonal;Glucocorticoids
    DB01361 inducer Troleandomycin Anti-Bacterial Agents;Antibacterial Agents;Macrolides
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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