AutismKB 2.0

Annotation Detail for KLC2


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Basic Information Top
Gene Symbol:KLC2 ( FLJ12387 )
Gene Full Name: kinesin light chain 2
Band: 11q13.2
Quick LinksEntrez ID:64837; OMIM: 611729; Uniprot ID:KLC2_HUMAN; ENSEMBL ID: ENSG00000174996; HGNC ID: 20716
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00003Alzheimer disease-amyloid secretase pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of KLC2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of KLC2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of KLC2 mRNAaffects expression 17562736
D004041 Dietary Fats Dietary Fats results in decreased expression of KLC2 mRNAdecreases expression 18042831
C041786 palm oil palm oil results in decreased expression of KLC2 mRNAdecreases expression 18042831
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001161 Arteriosclerosis Dietary Fats 4.3715238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms Dietary Fats 2.2520435547
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7616705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.763084413
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 3.006135515
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.5618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.5618551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.6721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.6718551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6711461765 19416960 16781746 19085960 14725611 16227642 14550746 11287661 10774834 11834606 12540782 16109766 19923254 14986274 12594235 15968718 11739529 12958197 17562736 12705907 11743745 10915739 11529661 16177239 10663392 16081117 19164858 11421492 15619225 17522070 12392966 18071297 19370779 17906064 19739265 16393943 12153990 2444490 16485898 19420014 18713872
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D050171 Dyslipidemias Dietary Fats 3.7018367378
MESH:D005234 Fatty Liver Dietary Fats 3.6117967931 19004024 18296743 19551842
MESH:D005355 Fibrosis Dietary Fats 4.0118296743
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.9721332399
MESH:D006949 Hyperlipidemias Dietary Fats 4.0221332399
MESH:D007249 Inflammation Dietary Fats 2.5920412841
MESH:D007333 Insulin Resistance Dietary Fats 3.3211836018 18457598
MESH:D007674 Kidney Diseases Acetaminophen 2.3812587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.3916705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.3916705839
MESH:D008103 Liver Cirrhosis Dietary Fats 3.0518296743
MESH:D008107 Liver Diseases Acetaminophen 1.6912969438 11587558 19014921 16611625 19784758 16610002 19460945 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5817185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.257678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.742876784 2876786 6135515
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D009336 Necrosis 2,4-dinitrotoluene 12.2118551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 12.2118551238 7678174
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D009765 Obesity Dietary Fats 2.3511836018 21332399 16723640 17217161 18457598 19632207 20518802 20132043 18674790
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 10.0616049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 10.0616049721
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D012640 Seizures 2,4-dinitrotoluene 6.6518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.6518551238
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.3916049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.3916049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.8610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.8610091137
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D015430 Weight Gain Dietary Fats 4.0616723640
Pathway ID Pathway Name
REACT:604 Hemostasis
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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