AutismKB 2.0

Annotation Detail for FNDC4


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Basic Information Top
Gene Symbol:FNDC4 ( FLJ22362,FRCP1 )
Gene Full Name: fibronectin type III domain containing 4
Band: 2p23.3
Quick LinksEntrez ID:64838; OMIM: 611905; Uniprot ID:FNDC4_HUMAN; ENSEMBL ID: ENSG00000115226; HGNC ID: 20239
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of FNDC4 mRNAaffects expression 18281256
D000638 Amiodarone Amiodarone results in increased expression of FNDC4 mRNAincreases expression 17567588
D000639 Amitriptyline Amitriptyline results in increased expression of FNDC4 mRNAincreases expression 15342952
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of FNDC4 mRNAincreases expression 20064835
C084597 chlorcyclizine chlorcyclizine results in increased expression of FNDC4 mRNAincreases expression 15342952
D002746 Chlorpromazine Chlorpromazine results in increased expression of FNDC4 mRNAincreases expression 15342952
D003024 Clozapine Clozapine results in increased expression of FNDC4 mRNAincreases expression 15342952
D016572 Cyclosporine Cyclosporine results in increased expression of FNDC4 mRNAincreases expression 20106945
D005424 Flecainide Flecainide results in increased expression of FNDC4 mRNAincreases expression 15342952
D005473 Fluoxetine Fluoxetine results in increased expression of FNDC4 mRNAincreases expression 17567588
15342952
D007099 Imipramine Imipramine results in increased expression of FNDC4 mRNAincreases expression 15342952
17567588
D007654 Ketoconazole Ketoconazole results in increased expression of FNDC4 mRNAincreases expression 17567588
15342952
D010419 Pentamidine Pentamidine results in increased expression of FNDC4 mRNAincreases expression 15342952
D010480 Perhexiline Perhexiline results in increased expression of FNDC4 mRNAincreases expression 15342952
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FNDC4 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of FNDC4 mRNAincreases expression 18445702
D020280 Sertraline Sertraline results in increased expression of FNDC4 mRNAincreases expression 17567588
15342952
D013629 Tamoxifen Tamoxifen results in increased expression of FNDC4 mRNAincreases expression 15342952
D013881 Thioridazine Thioridazine results in increased expression of FNDC4 mRNAincreases expression 15342952
D015031 Zimeldine Zimeldine results in increased expression of FNDC4 mRNAincreases expression 15342952
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4914745880
MESH:D055371 Acute Lung Injury pirinixic acid 3.0518653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 1.9720127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.616695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.4216434500
MESH:D000380 Agranulocytosis Clozapine 4.9914617031 16160616 12649775
MESH:D017088 AIDS-Related Opportunistic Infections Pentamidine 6.2911806628
MESH:D001008 Anxiety Disorders Fluoxetine 9.7118083778
MESH:D001008 Anxiety Disorders Sertraline 9.7118822694
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0119183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.7420041841 18218290 18057881
MESH:D001281 Atrial Fibrillation Amiodarone 3.8518651412 19698954
MESH:D001321 Autistic Disorder Fluoxetine 3.1319232924 18775368
MESH:D001321 Autistic Disorder Sertraline 3.1318775368
MESH:D001778 Blood Coagulation Disorders Amiodarone 8.8819483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.8819483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0920146248 17474063
MESH:D001943 Breast Neoplasms Tamoxifen 2.0920390343 18629630 19289846 19189212 17049068 15565566 18821012 11161223 18997820 18351453 17440819 19288272 19487384 19221464 19244106 20544844 21152245 18855134 16818667 17893378 19066611 19115204 18425577 19155303 17242785 15668708 18984771 20135344 20859285 19011961 20005174 19189210 16873071 18815881 19200415 19142967 17261762 19084267 21138602 16273361 19410462 19059307 20065188 16202921 19103187
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4419066611
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 1.8216924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0320419170
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.5517572228
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8719225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.0218974383
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.4812371664
MESH:D002779 Cholestasis Cyclosporine 7.5919486331
MESH:D002779 Cholestasis pirinixic acid 7.5919176532
MESH:D003072 Cognition Disorders Clozapine 4.9017123785
MESH:D016757 Death, Sudden, Cardiac Thioridazine 5.7820210726
MESH:D003704 Dementia Thioridazine 5.5111575062
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3019031437
MESH:D003866 Depressive Disorder Amitriptyline 18.2318083778 15014590
MESH:D003866 Depressive Disorder Fluoxetine 18.2315014590
MESH:D003866 Depressive Disorder Imipramine 18.2320305041
MESH:D003866 Depressive Disorder Sertraline 18.2315014590 18822694 20305041
MESH:D003865 Depressive Disorder, Major Sertraline 5.3016968574
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3918249437
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 2.9616402076
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.4219279558
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.5015331141
MESH:D056486 Drug-Induced Liver Injury Amiodarone 6.5918218290 15265979
MESH:D056486 Drug-Induced Liver Injury Chlorpromazine 6.5911461765
MESH:D056486 Drug-Induced Liver Injury Ketoconazole 6.5918289764
MESH:D050171 Dyslipidemias Clozapine 4.1316402076
MESH:D004487 Edema Amitriptyline 16.1712798668
MESH:D004487 Edema Fluoxetine 16.1712798668
MESH:D004487 Edema Imipramine 16.1712798668
MESH:D004487 Edema pirinixic acid 16.1712083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 3.4719031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.0020544844 16202921 17893378 19155303
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9916530937
MESH:D005234 Fatty Liver Amiodarone 18.2614986274
MESH:D005234 Fatty Liver Cyclosporine 18.2619224547
MESH:D005234 Fatty Liver pirinixic acid 18.2619236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 18.2614986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1916709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1219069698
MESH:D005355 Fibrosis Cyclosporine 3.0812639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.168708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6220471113
MESH:D006333 Heart Failure pirinixic acid 2.5020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3615720958
MESH:D006529 Hepatomegaly 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 14.3016109766
MESH:D006529 Hepatomegaly Amiodarone 14.3015265979
MESH:D006529 Hepatomegaly pirinixic acid 14.3018467677 19176532 19772884 16221962
MESH:D006561 Herpes Simplex Chlorpromazine 5.231682908
MESH:D019584 Hot Flashes Fluoxetine 5.2514716179
MESH:D006816 Huntington Disease Sertraline 5.9618403212
MESH:D006937 Hypercholesterolemia Amiodarone 3.819751232 8137927
MESH:D006943 Hyperglycemia pirinixic acid 3.1220558911
MESH:D006948 Hyperkinesis Clozapine 4.8516046005
MESH:D006973 Hypertension Cyclosporine 2.0710903974
MESH:D007037 Hypothyroidism Amiodarone 4.4518020914 17991464
MESH:D007249 Inflammation Amitriptyline 11.9312798668
MESH:D007249 Inflammation Fluoxetine 11.9312798668
MESH:D007249 Inflammation Imipramine 11.9312798668
MESH:D007249 Inflammation Tamoxifen 11.9319457130
MESH:D007333 Insulin Resistance pirinixic acid 2.5916306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3915604871
MESH:D007674 Kidney Diseases Cyclosporine 2.3018776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 7.1112371664
MESH:D007680 Kidney Neoplasms Tamoxifen 7.1118625569
MESH:D007896 Leishmaniasis Pentamidine 5.3315340016
MESH:D016773 Leishmaniasis, Cutaneous Ketoconazole 9.278889330 2166429 1311351 19744259
MESH:D016773 Leishmaniasis, Cutaneous Pentamidine 9.278889330 11806628 12453009 10617787
MESH:D007897 Leishmaniasis, Mucocutaneous Pentamidine 6.0110881086
MESH:D007898 Leishmaniasis, Visceral Ketoconazole 8.7711332679
MESH:D007898 Leishmaniasis, Visceral Pentamidine 8.771659303 12803856 16131481 7715298 7498017 10467834
MESH:D008064 Lipidoses marker/mechanism 15342952 16919414
MESH:D008064 Lipidoses Amiodarone 77.0015342952 17567588
MESH:D008064 Lipidoses Amitriptyline 77.0017567588 15342952
MESH:D008064 Lipidoses chlorcyclizine 77.0015342952
MESH:D008064 Lipidoses Chlorpromazine 77.0017567588 15342952
MESH:D008064 Lipidoses Clozapine 77.0017567588
MESH:D008064 Lipidoses Fluoxetine 77.0015342952 17567588
MESH:D008064 Lipidoses Imipramine 77.0015342952 17567588
MESH:D008064 Lipidoses Ketoconazole 77.0017567588
MESH:D008064 Lipidoses Perhexiline 77.0015342952 17567588
MESH:D008064 Lipidoses Sertraline 77.0017567588
MESH:D008064 Lipidoses Tamoxifen 77.0017567588 15342952
MESH:D008064 Lipidoses Thioridazine 77.0015342952 17567588
MESH:D008064 Lipidoses Zimeldine 77.0015342952
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3015474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3018564211
MESH:D008107 Liver Diseases Chlorpromazine 3.6614986274
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.2320195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 7.2320007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 7.2316684651
MESH:D008133 Long QT Syndrome Amiodarone 8.6717391786 15350150 11989578
MESH:D008133 Long QT Syndrome Thioridazine 8.6720210726
MESH:D008171 Lung Diseases Amiodarone 3.3312587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.4218516814
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.3518569708 20135361 20869020 18520028 20464547 6695378 18816296 17053015 20064080
MESH:D008175 Lung Neoplasms Tamoxifen 2.3518625569
MESH:D016778 Malaria, Falciparum Perhexiline 11.5616882315
MESH:D016778 Malaria, Falciparum Thioridazine 11.5616882315
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.5811731420 16827153 14580682 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.4919453300
MESH:D008545 Melanoma Tamoxifen 1.8719393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1215990972
MESH:D001523 Mental Disorders Amitriptyline 35.8916856516
MESH:D001523 Mental Disorders Chlorpromazine 35.8916856516
MESH:D001523 Mental Disorders Clozapine 35.8916856516
MESH:D001523 Mental Disorders Fluoxetine 35.8916856516
MESH:D001523 Mental Disorders Imipramine 35.8916856516
MESH:D001523 Mental Disorders Sertraline 35.8916856516
MESH:D001523 Mental Disorders Thioridazine 35.8916856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.3519142101
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7316801185
MESH:D008881 Migraine Disorders Amitriptyline 4.7418803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1416381670
MESH:D009135 Muscular Diseases pirinixic acid 3.4416239165
MESH:D009175 Mycoplasma Infections Chlorpromazine 5.9410773494
MESH:D009181 Mycoses Amiodarone 4.8512754197 17974566
MESH:D009203 Myocardial Infarction pirinixic acid 2.1119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8916411023
MESH:D009207 Myoclonus Fluoxetine 5.828041377
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5219393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4919410462
MESH:D009369 Neoplasms Benzo(a)pyrene 4.7111141357
MESH:D009369 Neoplasms pirinixic acid 4.7117405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.9419200415 19189210 19196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2318481113 19348381
MESH:D009765 Obesity Clozapine 4.6518515891 19142110
MESH:D009765 Obesity pirinixic acid 4.6520558911
MESH:D009771 Obsessive-Compulsive Disorder Fluoxetine 5.3820418887
MESH:D010146 Pain Amitriptyline 11.5812798668
MESH:D010146 Pain Fluoxetine 11.5812798668
MESH:D010146 Pain Imipramine 11.5812798668
MESH:D020774 Pick Disease of the Brain Fluoxetine 5.948041377
MESH:D011020 Pneumonia, Pneumocystis Pentamidine 6.6615340016
MESH:D011230 Precancerous Conditions Cyclosporine 3.1612371664
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.7217292933
MESH:D011471 Prostatic Neoplasms Ketoconazole 2.7217404083
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.7215067354
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D011618 Psychotic Disorders Clozapine 9.3615331141
MESH:D011618 Psychotic Disorders Thioridazine 9.3616882315
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8312832656 12490602 11597910
MESH:D015427 Reperfusion Injury pirinixic acid 2.3519058328
MESH:D012559 Schizophrenia Clozapine 2.7320168265 20521326 18806925 16141801 17667964 17726453 20521320 20580759 17123785 20107430 19369910 18855531 11151749 11763009 20452607
MESH:D020230 Serotonin Syndrome Fluoxetine 5.848704074
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.0218724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.3410029692 19755658
MESH:D012892 Sleep Deprivation Imipramine 6.1319798453
MESH:D007319 Sleep Initiation and Maintenance Disorders Amitriptyline 5.3915341891
MESH:D013088 Spermatocele Tamoxifen 4.2416709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.9819457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013276 Stomach Ulcer Amiodarone 3.2618087811
MESH:D013610 Tachycardia Amiodarone 4.2211238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 10.6919225199
MESH:D017180 Tachycardia, Ventricular Thioridazine 10.6920210726
MESH:D013959 Thyroid Diseases Amiodarone 4.7019731979
MESH:D013971 Thyrotoxicosis Amiodarone 4.8018020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 10.8317467628 11989578
MESH:D016171 Torsades de Pointes Flecainide 10.8317467628
MESH:D014352 Trypanosomiasis Pentamidine 6.4615340016
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.9117053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 4.918653321 17572228 16712894
MESH:D014605 Uveitis Cyclosporine 3.931336536
MESH:D015430 Weight Gain Clozapine 4.4120521320 20107430 20564506 17502770 16141801 16402076
MESH:D015431 Weight Loss Clozapine 5.0217933447
MESH:D014985 Xerophthalmia Cyclosporine 4.3917120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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