AutismKB 2.0

Annotation Detail for PLEKHG2


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Basic Information Top
Gene Symbol:PLEKHG2 ( ARHGEF42,CLG,DKFZp667J2325,FLJ00018,FLJ22458,FLJ38638 )
Gene Full Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 2
Band: 19q13.2
Quick LinksEntrez ID:64857; OMIM: 611893; Uniprot ID:PKHG2_HUMAN; ENSEMBL ID: ENSG00000090924; HGNC ID: 29515
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Signaling by GPCR
Signalling by NGF
Signaling by Rho GTPases
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of PLEKHG2 mRNAdecreases expression 19933214
D004041 Dietary Fats Dietary Fats results in increased expression of PLEKHG2 mRNAincreases expression 18042831
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PLEKHG2 mRNAaffects cotreatment|increases expression 17942748
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of PLEKHG2 mRNAdecreases expression 20713471
C041786 palm oil palm oil results in increased expression of PLEKHG2 mRNAincreases expression 18042831
D010634 Phenobarbital Phenobarbital affects the expression of PLEKHG2 mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid affects the expression of PLEKHG2 mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid results in decreased expression of PLEKHG2 mRNAdecreases expression 17426115
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PLEKHG2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PLEKHG2 mRNAdecreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.446195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.4414514962 11752688 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D000236 Adenoma Methylcholanthrene 3.626695378 10545420
MESH:D018248 Adenoma, Liver Cell Phenobarbital 19.3717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 19.3716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 19.3716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D001161 Arteriosclerosis Dietary Fats 10.9515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D050197 Atherosclerosis Methylcholanthrene 3.5811922910
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.5919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.5912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms Dietary Fats 1.9220435547
MESH:D001943 Breast Neoplasms Methylcholanthrene 1.9217474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9220435547
MESH:D002277 Carcinoma Methylcholanthrene 8.9810545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.9816835633
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 1.9417173139 20007298 6705139 20935162 1701930
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4916120746 18850075 18670907
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 3.6616192471
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.564080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.3316105132 17333356 16919318 17110522 11677210 15861022 17681005
MESH:D002779 Cholestasis pirinixic acid 8.3319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1916354765 15340226 12621046 8697196 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2714669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D050171 Dyslipidemias Dietary Fats 3.6218367378
MESH:D004421 Dystonia Phenobarbital 4.261851702
MESH:D004487 Edema pirinixic acid 7.3512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.3512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2818230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4712538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2510568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.413659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.253922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.766401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.363659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Dietary Fats 14.5118296743 17967931 19551842 19004024
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.5115345470
MESH:D005234 Fatty Liver pirinixic acid 14.5120131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.2810962813 14633661
MESH:D005355 Fibrosis Dietary Fats 9.6618296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.6620067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4411294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly Phenobarbital 16.2516109766
MESH:D006529 Hepatomegaly pirinixic acid 16.2518467677 19772884 16221962 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 16.2512621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4216959395 15340226 16354765 18606429 8697196
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8321332399
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8721332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007249 Inflammation Dietary Fats 5.2920412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2912878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 7.7411836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.7416306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D008103 Liver Cirrhosis Dietary Fats 7.0618296743
MESH:D008103 Liver Cirrhosis Phenobarbital 7.0621047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1912878042
MESH:D008107 Liver Diseases Phenobarbital 2.2219363144
MESH:D008113 Liver Neoplasms Phenobarbital 7.8119482888 19812893 21047994 19073162 15975961 8742319
MESH:D008113 Liver Neoplasms pirinixic acid 7.8115890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.8116984957
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 10.72598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.722563599 17172636 18308698 1399818 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.7212151625
MESH:D008175 Lung Neoplasms Methylcholanthrene 2.5521163286 7750092 11893704 16337739 20512841 1399818 10545420 9230183 17909032 15390079 6695378 16271038 20970405
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.5519555203 11884234
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8117484760
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009765 Obesity Dietary Fats 4.6018457598 21332399 16723640 18674790 20132043 17217161 19632207 20518802 11836018
MESH:D009765 Obesity pirinixic acid 4.6020558911
MESH:D010018 Osteomalacia Phenobarbital 4.7017016548
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5616965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.842563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311896295 11118676 11399792 11222880
MESH:D011537 Pruritus Ethinyl Estradiol 3.6516919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.8712752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012640 Seizures Phenobarbital 2.843137016 11442880 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.166407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.231399818
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7815869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
MESH:D015430 Weight Gain Dietary Fats 3.9516723640
Pathway ID Pathway Name
REACT:14797 Signaling by GPCR
REACT:11044 Signaling by Rho GTPases
REACT:11061 Signalling by NGF
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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