Annotation Detail for PCDH20
Basic Information
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| Pathway ID | Pathway Name |
|---|
| P00012 | Cadherin signaling pathway |
| P00057 | Wnt signaling pathway |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D016572 |
Cyclosporine |
Cyclosporine results in decreased expression of PCDH20 mRNA | decreases expression | 20106945
|
| C006253 |
pirinixic acid |
[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PCDH20 mRNA | affects binding|decreases expression|increases activity | 19710929
|
| D014635 |
Valproic Acid |
Valproic Acid results in increased expression of PCDH20 mRNA | increases expression | 19101580
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000014 |
Abnormalities, Drug-Induced |
|
Valproic Acid |
4.23 | 8875741 |
| MESH:D000015 |
Abnormalities, Multiple |
|
Valproic Acid |
4.41 | 19490988 |
| MESH:D055371 |
Acute Lung Injury |
|
pirinixic acid |
3.64 | 18653653 |
| MESH:D018248 |
Adenoma, Liver Cell |
|
pirinixic acid |
4.22 | 16434500 |
| MESH:D000550 |
Amblyopia |
|
Valproic Acid |
6.10 | 17688650 |
| MESH:D001008 |
Anxiety Disorders |
|
Valproic Acid |
3.94 | 17497229 |
| MESH:D001321 |
Autistic Disorder |
|
Valproic Acid |
1.98 | 19460635 18775368 17688650 18177632 17157402 20603192 18396377 16609825 19232924 15238991 18985861 17507914 18558336 18940202 18316065 |
| MESH:D001714 |
Bipolar Disorder |
|
Valproic Acid |
3.26 | 17594078 20046352 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
pirinixic acid |
3.63 | 19483382 |
| MESH:D001848 |
Bone Diseases, Developmental |
|
Valproic Acid |
3.66 | 8888407 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
Cyclosporine |
2.82 | 12371664 |
| MESH:D002659 |
Child Development Disorders, Pervasive |
|
Valproic Acid |
2.83 | 20734317 |
| MESH:D002779 |
Cholestasis |
|
Cyclosporine |
8.86 | 19486331 |
| MESH:D002779 |
Cholestasis |
|
pirinixic acid |
8.86 | 19176532 |
| MESH:D019465 |
Craniofacial Abnormalities |
|
Valproic Acid |
1.91 | 16575769 8888407 17688650 |
| MESH:D003876 |
Dermatitis, Atopic |
|
pirinixic acid |
2.59 | 18249437 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Valproic Acid |
2.26 | 19641884 1733752 |
| MESH:D004421 |
Dystonia |
|
Valproic Acid |
4.58 | 1851702 |
| MESH:D004487 |
Edema |
|
pirinixic acid |
2.96 | 12083418 |
| MESH:D004831 |
Epilepsies, Myoclonic |
|
Valproic Acid |
4.81 | 3659116 17275665 |
| MESH:D004828 |
Epilepsies, Partial |
|
Valproic Acid |
4.78 | 16628512 3922381 |
| MESH:D004827 |
Epilepsy |
|
Valproic Acid |
3.12 | 18234410 20417680 |
| MESH:D004832 |
Epilepsy, Absence |
|
Valproic Acid |
4.00 | 6426943 7562514 6254150 |
| MESH:D017029 |
Epilepsy, Complex Partial |
|
Valproic Acid |
4.95 | 7750514 |
| MESH:D004830 |
Epilepsy, Tonic-Clonic |
|
Valproic Acid |
4.81 | 3659116 |
| MESH:D005234 |
Fatty Liver |
|
Cyclosporine |
16.04 | 19224547 |
| MESH:D005234 |
Fatty Liver |
|
pirinixic acid |
16.04 | 20131406 19236843 |
| MESH:D005234 |
Fatty Liver |
|
Valproic Acid |
16.04 | 14986274 19224547 |
| MESH:D005315 |
Fetal Diseases |
|
Valproic Acid |
5.75 | 16575769 |
| MESH:D005317 |
Fetal Growth Retardation |
|
Valproic Acid |
4.71 | 8888407 18558336 |
| MESH:D005355 |
Fibrosis |
|
Cyclosporine |
3.79 | 12168785 12639820 |
| MESH:D005885 |
Gingival Hyperplasia |
|
Cyclosporine |
4.96 | 8708960 |
| MESH:D006333 |
Heart Failure |
|
pirinixic acid |
2.78 | 20558911 |
| MESH:D006457 |
Hemoglobinuria, Paroxysmal |
|
Cyclosporine |
5.16 | 15720958 |
| MESH:D006529 |
Hepatomegaly |
|
pirinixic acid |
3.64 | 18467677 16221962 19772884 19176532 |
| MESH:D006849 |
Hydrocephalus |
|
Valproic Acid |
5.61 | 17688650 |
| MESH:D006943 |
Hyperglycemia |
|
pirinixic acid |
3.63 | 20558911 |
| MESH:D006973 |
Hypertension |
|
Cyclosporine |
2.23 | 10903974 |
| MESH:D007333 |
Insulin Resistance |
|
pirinixic acid |
2.90 | 16306350 |
| MESH:D007638 |
Keratoconjunctivitis Sicca |
|
Cyclosporine |
5.31 | 15604871 |
| MESH:D007674 |
Kidney Diseases |
|
Cyclosporine |
2.56 | 18776723 10903974 8314463 |
| MESH:D007680 |
Kidney Neoplasms |
|
Cyclosporine |
3.12 | 12371664 |
| MESH:D015470 |
Leukemia, Myeloid, Acute |
|
Valproic Acid |
2.20 | 16294345 17596541 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
pirinixic acid |
1.35 | 15474484 |
| MESH:D008113 |
Liver Neoplasms |
|
pirinixic acid |
1.94 | 15890375 16377806 20007298 |
| MESH:D017563 |
Lung Diseases, Interstitial |
|
Valproic Acid |
5.13 | 17228818 |
| MESH:D008664 |
Metal Metabolism, Inborn Errors |
|
Cyclosporine |
5.65 | 16801185 |
| MESH:D008881 |
Migraine Disorders |
|
Valproic Acid |
3.50 | 18803445 18765137 |
| MESH:D009135 |
Muscular Diseases |
|
pirinixic acid |
4.16 | 16239165 |
| MESH:D009139 |
Musculoskeletal Abnormalities |
|
Valproic Acid |
4.51 | 8888407 |
| MESH:D009190 |
Myelodysplastic Syndromes |
|
Valproic Acid |
3.37 | 17596541 |
| MESH:D009203 |
Myocardial Infarction |
|
pirinixic acid |
2.29 | 19151258 |
| MESH:D015428 |
Myocardial Reperfusion Injury |
|
pirinixic acid |
3.29 | 16411023 |
| MESH:D009369 |
Neoplasms |
|
pirinixic acid |
2.12 | 17405874 |
| MESH:D009402 |
Nephrosis, Lipoid |
|
Cyclosporine |
5.31 | 17954296 |
| MESH:D009404 |
Nephrotic Syndrome |
|
Cyclosporine |
3.70 | 18481113 19348381 |
| MESH:D009436 |
Neural Tube Defects |
|
Valproic Acid |
3.39 | 8888407 16359493 |
| MESH:D009765 |
Obesity |
|
pirinixic acid |
1.89 | 20558911 |
| MESH:D011230 |
Precancerous Conditions |
|
Cyclosporine |
3.64 | 12371664 |
| MESH:D011297 |
Prenatal Exposure Delayed Effects |
|
Valproic Acid |
4.57 | 20603192 |
| MESH:D019310 |
Pseudolymphoma |
|
Valproic Acid |
5.41 | 12752131 11422049 |
| MESH:D011565 |
Psoriasis |
|
Cyclosporine |
2.34 | 16882103 |
| MESH:D015427 |
Reperfusion Injury |
|
pirinixic acid |
2.56 | 19058328 |
| MESH:D012208 |
Rhabdomyosarcoma |
|
Valproic Acid |
4.70 | 19155313 |
| MESH:D012559 |
Schizophrenia |
|
Valproic Acid |
2.11 | 15737665 19110320 |
| MESH:D012640 |
Seizures |
|
Valproic Acid |
3.02 | 14763951 17978042 16876388 11044598 3137016 11738929 15475178 1511512 |
| MESH:D016135 |
Spinal Dysraphism |
|
Valproic Acid |
4.13 | 19490988 |
| MESH:D013226 |
Status Epilepticus |
|
Valproic Acid |
5.41 | 12833885 |
| MESH:D014178 |
Translocation, Genetic |
|
Valproic Acid |
6.10 | 17262798 |
| MESH:D020194 |
Unverricht-Lundborg Syndrome |
|
Valproic Acid |
5.26 | 3119515 |
| MESH:D014564 |
Urogenital Abnormalities |
|
Valproic Acid |
5.30 | 8888407 |
| MESH:D014605 |
Uveitis |
|
Cyclosporine |
4.85 | 1336536 |
| MESH:D014985 |
Xerophthalmia |
|
Cyclosporine |
5.31 | 17120751 |
Related Diseases/Disorders