AutismKB 2.0

Annotation Detail for ST8SIA1


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Basic Information Top
Gene Symbol:ST8SIA1 ( GD3S,SIAT8,SIAT8A,ST8SiaI )
Gene Full Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
Band: 12p12.1
Quick LinksEntrez ID:6489; OMIM: 601123; Uniprot ID:SIA8A_HUMAN; ENSEMBL ID: ENSG00000111728; HGNC ID: 10869
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00604Glycosphingolipid biosynthesis - ganglio series
hsa00603Glycosphingolipid biosynthesis - globo series
hsa00601Glycosphingolipid biosynthesis - lacto and neolacto series
hsa01100Metabolic pathways
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1918Atherosclerosis
1997Dental plaque
2066Lung cancer
2237Neoplasm metastasis
No data
Desease Name
Non-alcoholic fatty liver disease histology (lobular)
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063609 1,2-dimethyl-4-nitrobenzene 1,2-dimethyl-4-nitrobenzene results in increased expression of ST8SIA1 mRNAincreases expression 19784758
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ST8SIA1 mRNAincreases expression 19933214
D000082 Acetaminophen Acetaminophen results in decreased expression of ST8SIA1 mRNAdecreases expression 19784758
D000082 Acetaminophen Acetaminophen results in increased expression of ST8SIA1 mRNAincreases expression 19784758
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ST8SIA1 mRNAaffects expression 16483693
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ST8SIA1 mRNAaffects cotreatment|decreases expression 18164116
D002330 Carmustine Carmustine results in increased expression of ST8SIA1 mRNAincreases expression 15980968
D003513 Cycloheximide Cycloheximide results in increased expression of ST8SIA1 mRNAincreases expression 19684285
D003513 Cycloheximide [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of ST8SIA1 mRNAaffects cotreatment|increases expression 19684285
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ST8SIA1 mRNAaffects cotreatment|decreases expression 18164116
D002117 Calcitriol Calcitriol results in increased expression of ST8SIA1 mRNAincreases expression 16002434
D004642 Emodin Emodin results in increased expression of ST8SIA1 mRNAincreases expression 16045814
D008294 Malathion Malathion results in increased expression of ST8SIA1 mRNAincreases expression 19784758
D009578 Nitrobenzenes Nitrobenzenes analog results in increased expression of ST8SIA1 mRNAincreases expression 19784758
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of ST8SIA1 mRNAaffects cotreatment|increases expression 19684285
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ST8SIA1 mRNAincreases expression 19684285
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ST8SIA1 mRNAincreases expression 20159946
19933214
D013853 Thioacetamide Thioacetamide results in increased expression of ST8SIA1 mRNAincreases expression 19784758
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9311752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D000236 Adenoma beta-Naphthoflavone 6.9819389873
MESH:D000236 Adenoma Diethylnitrosamine 6.986695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.3317162532 19061943 18056438 19052882 16434500 17620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.3316835633
MESH:D000382 Agricultural Workers' Diseases Malathion 5.0617119214 11874814
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.3312125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 9.3319483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D001932 Brain Neoplasms Carmustine 4.4416187019
MESH:D001943 Breast Neoplasms Calcitriol 2.0311237771
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.0317474063
MESH:D001943 Breast Neoplasms Malathion 2.0312762645
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0320435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.663084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.663581430 20214788 19052882 19701751 16807293 20514400 16779866 16935385 19539802 19208518 18785209 16328049 11831363 18691550 18393292 18788625 18210153 16878318 20084675 19919837 19519916 16681979 21159647 10672840 17173139 20432363 18506893 16502159 17138121 17055752 17761372 16569478 18978308 20727157 19383236 18056438 19107877 18665156 20935162 17162532 16830150 19394651 10737359 20101231 20524982 19171122 19418558 19335982 20512989 20007298 16540662 17428255 18494052 19822196 16698587 18971187 16288022 3084413 17978847
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 4.6617997003
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6411237771
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3916120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 2.6110977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.892727394 7505956 17174075 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 16.4119052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 16.4116835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 16.4118291259
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1215668235 8697196 12621046 16354765 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2620387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2617107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.1111287661 16781746 19416960 11739529 14986274 11529661 10774834 10663392 16227642 11743745 19164858 14550746 12594235 19739265 16485898 12153990 16177239 14725611 12392966 19923254 17562736 18713872 19085960 2444490 16109766 12540782 11461765 16393943 17906064 10915739 11421492 15619225 17522070 12705907 16081117 19370779 11834606 19420014 15968718 18071297 12958197
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.1119107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.1120420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 9.1112963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0016714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.0015138306
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.079294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2116302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005218 Fat Necrosis Thioacetamide 5.8216456712
MESH:D005234 Fatty Liver Diethylnitrosamine 3.2421071580 20387270
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005355 Fibrosis Emodin 9.3419474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.3420067830
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D005909 Glioblastoma Carmustine 3.9616187019
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3610048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.6315929193 18665440 17276928
MESH:D006505 Hepatitis Thioacetamide 4.2816456712
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9616120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1415340226 18606429 8697196 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.7416870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9218850075 18670907
MESH:D007249 Inflammation Diethylnitrosamine 4.9818785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.9812200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2315629191 12587719
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Emodin 5.0817077332
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8518407596 18665156 19638242 18522880 20032147
MESH:D008106 Liver Cirrhosis, Experimental Emodin 3.7415288473
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.7412878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 3.7411172339 16248980 16511523 17629604 18606216 15288472 11682029 15158331 15362042 18380797 15078482 15716488 17127702 17292413 15334695 18458672 18263696 16097051 11481614 10677585 18615449 16343077 14739098 18031379 12085344 17355460 18416461 15288473 15075984 15316131 12891558 16489207 12175628 16098781 16126171 12531686 12679928 18295389 15465738 17050028 15474484 18395095 18032466 12557150 15095483
MESH:D008107 Liver Diseases marker/mechanism 19784758
MESH:D008107 Liver Diseases Acetaminophen 6.6311587558 12969438 12587719 19784758 19014921 19460945 16611625 16610002
MESH:D008107 Liver Diseases Diethylnitrosamine 6.6317034775
MESH:D008107 Liver Diseases Thioacetamide 6.6318374380 15158337 16337175
MESH:D017114 Liver Failure, Acute Acetaminophen 9.8117185352 16871587
MESH:D017114 Liver Failure, Acute Thioacetamide 9.8112479984 15313186 17276928 15633222
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 7.5721295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.5718754104 18648771 19427195 19638242 21167192 2862719 9163691 15175105 19073162 20501860 19812893 21071580 20452335 19254457 19690152 19090486 21278145 20118626 20583210 18978307 19833225 20101389 2422723 19642983 18644402 18977376 20137499 19499222 20434301 19294768 19255062 19850985 19996281 19256749 12771043 15885732 20405173 21047994 12112319 16942905 19426721 19551842 10737359 20492335
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.5716984957
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 10.0618164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.069362446 3124819 19004024 18253720 19539802 18164116 16267830 18308698 17174075 18282651 19009564 2563599 19519916 18775883 17854601 16842330 21159647 18079962 19126423 17942915 18093689 18544905
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.0612151625
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.2720970405 6695378 20512841 21163286
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2719555203 11884234
MESH:D008545 Melanoma Carmustine 2.8712393984
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.593581430 9029167
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2814600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.3318514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.3320387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2120387270
MESH:D020258 Neurotoxicity Syndromes marker/mechanism 19784758
MESH:D020258 Neurotoxicity Syndromes Malathion 4.8315081274
MESH:D010146 Pain Acetaminophen 2.4316870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4416540662
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.602563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2711222880 11896295 11399792 11118676
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.8615572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.5412479363 15754350 16644109 18247401 16289102
MESH:D012135 Respiratory Sounds Malathion 5.3411874814 17119214
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012140 Respiratory Tract Diseases Malathion 5.6217119214
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0716192470
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.027505956
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
Pathway ID Pathway Name
KEGG:00604 Glycosphingolipid biosynthesis - ganglio series
KEGG:00603 Glycosphingolipid biosynthesis - globo series
KEGG:00601 Glycosphingolipid biosynthesis - lacto and neolacto series
KEGG:01100 Metabolic pathways
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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