AutismKB 2.0

Annotation Detail for LPIN3


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Basic Information Top
Gene Symbol:LPIN3 ( LIPN3L,SMP2,dJ450M14.2,dJ450M14.3,dJ620E11.2 )
Gene Full Name: lipin 3
Band: 20q12
Quick LinksEntrez ID:64900; OMIM: 605520; Uniprot ID:LPIN3_HUMAN; ENSEMBL ID: ENSG00000132793; HGNC ID: 14451
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Metabolism of lipids and lipoproteins
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of LPIN3 mRNAaffects expression 17562736
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of LPIN3 mRNAaffects cotreatment|increases expression 17183730
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of LPIN3 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of LPIN3 mRNAincreases expression 19482888
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of LPIN3 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 10.726195326
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 10.728875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.3519490988
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.6017620307
MESH:D000550 Amblyopia Valproic Acid 5.9617688650
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.9017497229
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8620603192 16609825 15238991 18985861 17507914 18177632 18558336 17688650 18316065 18775368 19232924 18940202 19460635 17157402 18396377
MESH:D001714 Bipolar Disorder Valproic Acid 3.2417594078 20046352
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.638888407
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.023084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 3.0220007298 20935162 1701930 17173139 6705139
MESH:D002386 Cataract Acetaminophen 2.7910977129
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.814080065
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8220734317
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9117688650 16575769 8888407
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.1012540782 14986274 11529661 18071297 11743745 19739265 16393943 19420014 18713872 17906064 2444490 11461765 10663392 19085960 19923254 11287661 17562736 19416960 12594235 15968718 16485898 10915739 14550746 12705907 11739529 11421492 14725611 17522070 19370779 16177239 16781746 12958197 12153990 16109766 19164858 11834606 12392966 15619225 10774834 16227642 16081117
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.1019641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:D004421 Dystonia Phenobarbital 12.021851702
MESH:D004421 Dystonia Valproic Acid 12.021851702
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 12.733659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 12.7317275665 3659116
MESH:D004828 Epilepsies, Partial Phenobarbital 12.523922381 11558140
MESH:D004828 Epilepsies, Partial Valproic Acid 12.523922381 16628512
MESH:D004827 Epilepsy Phenobarbital 7.2520417680
MESH:D004827 Epilepsy Valproic Acid 7.2518234410 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 10.116401628
MESH:D004832 Epilepsy, Absence Valproic Acid 10.116426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 13.247750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 13.247750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 12.683659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 12.683659116
MESH:D005234 Fatty Liver Valproic Acid 3.7219224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.6116575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.648888407 18558336
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D006529 Hepatomegaly Phenobarbital 4.0416109766
MESH:D006849 Hydrocephalus Valproic Acid 5.5017688650
MESH:D006930 Hyperalgesia Acetaminophen 3.0216870215
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 5.1916612254
MESH:D007674 Kidney Diseases Acetaminophen 2.4012587719 15629191
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.2017596541 16294345
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0821047994
MESH:D008107 Liver Diseases Acetaminophen 4.2012587719 19014921 16611625 19784758 11587558 12969438 16610002 19460945
MESH:D008107 Liver Diseases Phenobarbital 4.2019363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6316871587 17185352
MESH:D008113 Liver Neoplasms Phenobarbital 2.4219812893 19073162 19482888 8742319 15975961 21047994
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.926150874 1399818 2563599 17172636 18308698
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.9817228818
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D008881 Migraine Disorders Valproic Acid 3.4718765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.458888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3517596541
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 5.1117484760
MESH:D009436 Neural Tube Defects Valproic Acid 3.3716359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D010018 Osteomalacia Phenobarbital 5.0017016548
MESH:D010146 Pain Acetaminophen 2.7316870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.6016965848
MESH:D011230 Precancerous Conditions Phenobarbital 3.992563599
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.4620603192
MESH:D019310 Pseudolymphoma Phenobarbital 14.7412752131
MESH:D019310 Pseudolymphoma Valproic Acid 14.7412752131 11422049
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.6419155313
MESH:D012559 Schizophrenia Valproic Acid 2.1015737665 19110320
MESH:D012640 Seizures Phenobarbital 6.883137016 4039156 16876388 11442880
MESH:D012640 Seizures Valproic Acid 6.8811044598 15475178 14763951 16876388 3137016 11738929 17978042 1511512
MESH:D003294 Seizures, Febrile Phenobarbital 5.456407741
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0919490988
MESH:D013226 Status Epilepticus Valproic Acid 5.2612833885
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.361399818
MESH:D014178 Translocation, Genetic Valproic Acid 5.9617262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 5.153119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.208888407
MESH:D014581 Urticaria Acetaminophen 3.4410982225
Pathway ID Pathway Name
REACT:22258 Metabolism of lipids and lipoproteins
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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