AutismKB 2.0

Annotation Detail for STIL


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Basic Information Top
Gene Symbol:STIL ( DKFZp686O09161,MCPH7,SIL )
Gene Full Name: SCL/TAL1 interrupting locus
Band: 1p33
Quick LinksEntrez ID:6491; OMIM: 181590; Uniprot ID:STIL_HUMAN; ENSEMBL ID: ENSG00000123473; HGNC ID: 10879
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200144Signaling events mediated by the Hedgehog family
No data
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Related Diseases/Disorders Top
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Desease IDDesease Name
1934Cancer
No data
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Desease Name
Microcephaly, primary autosomal recessive, 7
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of STIL proteinaffects expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of STIL mRNAdecreases expression 20382639
D016572 Cyclosporine Cyclosporine results in decreased expression of STIL mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of STIL mRNAincreases expression 20106945
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of STIL mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of STIL mRNAincreases expression 20059764
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of STIL mRNA]increases expression|increases reaction 20059764
C059514 resveratrol resveratrol results in decreased expression of STIL mRNAdecreases expression 15767336
C017947 sodium arsenite sodium arsenite results in decreased expression of STIL mRNAdecreases expression 17998272
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of STIL mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1814514962 15322242 11752688
MESH:D058186 Acute Kidney Injury resveratrol 4.0916538975
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Estradiol 2.1411473722
MESH:D000236 Adenoma resveratrol 3.4415688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.0516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.0516835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.0815276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.2816712894 17306315
MESH:D000544 Alzheimer Disease resveratrol 2.6116183991 16162502
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D001169 Arthritis, Experimental resveratrol 3.6417115116
MESH:D050197 Atherosclerosis resveratrol 3.4017967414 16873680
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.5919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.5912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D002545 Brain Ischemia resveratrol 4.6217600658
MESH:D001943 Breast Neoplasms Estradiol 1.8812948864 18497071 16675129 19861407 17289903 17018787 17261762 14630087
MESH:D001943 Breast Neoplasms resveratrol 1.8817651959 16393696 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8820435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8016111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.8712907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.8716924424
MESH:D006528 Carcinoma, Hepatocellular resveratrol 6.8716227395 19321006
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.8715276417 16507464 17306315
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.9316675471
MESH:D002294 Carcinoma, Squamous Cell resveratrol 5.0416227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 5.0418572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4916120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases resveratrol 3.6315458977
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 17.3720889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 17.3712371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 17.3718566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 17.3720056578 19524636
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis Cyclosporine 8.3519486331
MESH:D002779 Cholestasis pirinixic acid 8.3519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.198697196 15668235 16354765 12621046 15340226
MESH:D003092 Colitis resveratrol 4.4316474422
MESH:D003110 Colonic Neoplasms resveratrol 2.4916338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.8916507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.9716873680
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Estradiol 9.7419279558
MESH:D003928 Diabetic Nephropathies resveratrol 9.7416286809
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004487 Edema pirinixic acid 12.8812083418
MESH:D004487 Edema resveratrol 12.888985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.8811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2818230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 4.3117872969
MESH:D016889 Endometrial Neoplasms Estradiol 3.1311473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2510568697 9294722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 5.1617923197
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1220426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Cyclosporine 8.3819224547
MESH:D005234 Fatty Liver pirinixic acid 8.3820131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005355 Fibrosis Cyclosporine 9.5212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.5220067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.0216452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4411294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly pirinixic acid 9.3016221962 19772884 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.3012621046 16120746 15340226
MESH:D006558 Herpes Genitalis Estradiol 5.4115709030
MESH:D006561 Herpes Simplex resveratrol 4.5216876885
MESH:D006689 Hodgkin Disease sodium arsenite 3.3612676792
MESH:D019584 Hot Flashes Estradiol 4.1317088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4218606429 15340226 16354765 16959395 8697196
MESH:D006937 Hypercholesterolemia resveratrol 4.2517188708
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006949 Hyperlipidemias resveratrol 4.2916873680
MESH:D006973 Hypertension Cyclosporine 5.2110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2118670907 18850075
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.5317488730
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.9517600658
MESH:D007248 Infertility, Male sodium arsenite 3.1415346721 12646999
MESH:D007249 Inflammation resveratrol 5.4416366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4412878042 12200463
MESH:D007251 Influenza, Human resveratrol 4.9216624496
MESH:D007333 Insulin Resistance Estradiol 7.6916393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 7.6916306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Cyclosporine 10.8018776723 8314463 10903974
MESH:D007674 Kidney Diseases Estradiol 10.8015618244
MESH:D007674 Kidney Diseases sodium arsenite 10.8020008137
MESH:D007680 Kidney Neoplasms Cyclosporine 7.9512371664
MESH:D007680 Kidney Neoplasms Estradiol 7.9515610895
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.7216087638
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5014659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5012878042
MESH:D008113 Liver Neoplasms Aflatoxin B1 15.1018177683 15890375 2125692 9163691
MESH:D008113 Liver Neoplasms pirinixic acid 15.1015890375 16377806 20007298
MESH:D008113 Liver Neoplasms resveratrol 15.1019321006 19812893 20405173 19073162
MESH:D008113 Liver Neoplasms sodium arsenite 15.1016712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 15.1016984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.288603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2812151625
MESH:D008171 Lung Diseases sodium arsenite 3.3219095001
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.5314755239
MESH:D008175 Lung Neoplasms sodium arsenite 3.5317306315 17077188 15276417 19931552 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5311884234 19555203
MESH:D016393 Lymphoma, B-Cell resveratrol 4.5617088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 4.0714749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.5815688416
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.6411408345 16891317 17203775 11807958
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 6.6411606380 8985016
MESH:D020149 Manganese Poisoning Estradiol 4.8619453300
MESH:D008545 Melanoma resveratrol 3.6117992120
MESH:D008545 Melanoma sodium arsenite 3.6116487513 19082730
MESH:D008659 Metabolic Diseases resveratrol 4.6217112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
OMIM:612703 MICROCEPHALY, PRIMARY AUTOSOMAL RECESSIVE, 7 marker/mechanism
MESH:D009101 Multiple Myeloma resveratrol 3.6316490592 17164350 17049120 16267019 14749477 17935668
MESH:D009134 Muscular Atrophy, Spinal resveratrol 5.2117962980
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 6.0319151258
MESH:D009203 Myocardial Infarction resveratrol 6.0316525036 17015251 17125593 16456233 17188708 16317513
MESH:D017202 Myocardial Ischemia resveratrol 9.6617015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.6612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.8716810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.8716411023
MESH:D009205 Myocarditis resveratrol 5.1017322642
MESH:D009369 Neoplasms pirinixic acid 5.2917405874
MESH:D009369 Neoplasms sodium arsenite 5.2911559025
MESH:D009374 Neoplasms, Experimental resveratrol 10.278985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 10.2720056578
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 10.4211399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.4214600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.2912854658
MESH:D019636 Neurodegenerative Diseases resveratrol 4.0117652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.6617929310
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.5217513867
MESH:D010051 Ovarian Neoplasms Estradiol 5.0519401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.0517306315 15276417
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 10.7416679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.7411399792 11118676 11222880 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1320887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.5716740699
MESH:D011471 Prostatic Neoplasms resveratrol 2.5717718901 17636462 17675339 17804756 15767336 16731767
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.5716039940
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.9616325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.9219058328
MESH:D015427 Reperfusion Injury resveratrol 6.9217520802 15827377 16317513 17058453 16314181
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012878 Skin Neoplasms resveratrol 10.078985016 15837718
MESH:D012878 Skin Neoplasms sodium arsenite 10.0718572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 10.0716192470
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9812854658
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.7116321402
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013978 Tibial Fractures Estradiol 5.0619048282
MESH:D014062 Tongue Neoplasms resveratrol 4.4416227395
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.5816452187 11723127 17306315 16712894
MESH:D002583 Uterine Cervical Neoplasms resveratrol 10.3417473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 10.3411813266
MESH:D014594 Uterine Neoplasms resveratrol 4.4217044934
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D014652 Vascular Diseases sodium arsenite 4.7617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.6117488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35780
    • No data
    Releated disease ID Related disease Name
    PA446714Neoplasm, Residual
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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