AutismKB 2.0

Annotation Detail for SIM1


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Basic Information Top
Gene Symbol:SIM1 ( bHLHe14 )
Gene Full Name: single-minded homolog 1 (Drosophila)
Band: 6q16.3
Quick LinksEntrez ID:6492; OMIM: 603128; Uniprot ID:SIM1_HUMAN; ENSEMBL ID: ENSG00000112246; HGNC ID: 10882
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1856Obesity
1986Eating disorder
No data
No data
Desease Name
Obesity, severe
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of SIM1 geneincreases mutagenesis 18056790
D009151 Mustard Gas Mustard Gas results in increased expression of SIM1 mRNAincreases expression 15674843
D011374 Progesterone Progesterone affects the expression of SIM1 mRNAaffects expression 17251523
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SIM1 mRNAincreases expression 14660629
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.4714514962 15322242 11752688
MESH:D000236 Adenoma Ethylnitrosourea 3.926695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.0116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.3411748828
MESH:D001249 Asthma Mustard Gas 2.8010378619
MESH:D001768 Blister Mustard Gas 5.7919167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0015746008
MESH:D001927 Brain Diseases Ethylnitrosourea 5.2814991843
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 6.0617868700
MESH:D001930 Brain Injuries Progesterone 4.8215665606 15845082 15380490
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.6816357521 15144691 18412241 16436596 16651633
MESH:D001943 Breast Neoplasms marker/mechanism 15818620
MESH:D001943 Breast Neoplasms Progesterone 2.0117614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0120435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.7915286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.7017687719 10378619
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5618670907 16120746 18850075
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 3.9816003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.7117160924
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5316835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.248697196 15340226 15668235 12621046 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2710048152 20055451 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7417107852
MESH:D003929 Diabetic Neuropathies Progesterone 5.0517187935
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0511462148
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.7118357618
MESH:D004487 Edema Mustard Gas 8.2811402378 9260866 11428631 11428647
MESH:D004487 Edema Tetrachlorodibenzodioxin 8.2812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.6218230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.2817692515
MESH:D004715 Endometriosis Progesterone 10.2716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 10.279294722 10568697
MESH:D004890 Erythema Mustard Gas 5.799357497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3111564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.0211858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.5120067830
MESH:D005909 Glioblastoma Ethylnitrosourea 4.0716436596
MESH:D005910 Glioma Ethylnitrosourea 3.6216357521 18412241 16651633
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.3210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5110048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.4515340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.778697196 16354765 15340226 16959395 18606429
MESH:D006943 Hyperglycemia marker/mechanism 18056790
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0218850075 18670907
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.9615869954
MESH:D007249 Inflammation Mustard Gas 9.4311428631 17524151 11402378 8975870 9357497 9260866 11428647 16001271 11428620
MESH:D007249 Inflammation Progesterone 9.4315869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 9.4312878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7616580747
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 4.2717379185
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8316984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3312151625
MESH:D008171 Lung Diseases Mustard Gas 3.7018702808 18161513
MESH:D008175 Lung Neoplasms Ethylnitrosourea 3.7316271038 6695378 17703301 16019985
MESH:D008175 Lung Neoplasms Mustard Gas 3.738781369 3148597
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.7311884234 19555203
MESH:D008223 Lymphoma Ethylnitrosourea 4.2215790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.6115375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 7.2110767621 18041768 10838139
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 7.2117203775 11408345
MESH:D008579 Meningioma Ethylnitrosourea 6.7117943659
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3412213967
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.9616707424
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.7214600291
MESH:D009442 Neurilemmoma Ethylnitrosourea 6.0516651423 16003739 17160924
MESH:D009503 Neutropenia Mustard Gas 4.437688884 16761898
MESH:D009765 Obesity marker/mechanism
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.7117160924
MESH:D010051 Ovarian Neoplasms Progesterone 2.6217393432 16525653
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.9712520081
MESH:D011041 Poisoning Mustard Gas 4.2615727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0718163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.8211118676 11399792 11896295 11222880
MESH:D011537 Pruritus Mustard Gas 4.7218058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 3.0510334151 17894541 17266442 17720292 17620002
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.3518990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9618045962
MESH:D012871 Skin Diseases Mustard Gas 2.7915451306 12880345 16961503
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.2016192470
MESH:D013119 Spinal Cord Injuries Progesterone 4.9115862959 16503802
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.7915790496
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.6212697716
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.3212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.9715886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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