AutismKB 2.0

Annotation Detail for SLC30A5


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Basic Information Top
Gene Symbol:SLC30A5 ( FLJ12496,FLJ12756,MGC5499,ZNT5,ZNTL1,ZTL1,ZnT-5 )
Gene Full Name: solute carrier family 30 (zinc transporter), member 5
Band: 5q13.1-q13.2
Quick LinksEntrez ID:64924; OMIM: 607819; Uniprot ID:ZNT5_HUMAN; ENSEMBL ID: ENSG00000145740; HGNC ID: 19089
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Diabetes pathways
Transmembrane transport of small molecules
No data
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Pathway IDPathway Name
500355Zinc efflux and compartmentalization by the SLC30 family
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1997Dental plaque
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SLC30A5 mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of SLC30A5 mRNAdecreases expression 12958071
D000082 Acetaminophen Acetaminophen affects the expression of SLC30A5 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SLC30A5 mRNAdecreases expression 20127859
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC30A5 mRNAdecreases expression 19150397
C099555 CD 437 CD 437 results in decreased expression of SLC30A5 mRNAdecreases expression 12958071
D016572 Cyclosporine Cyclosporine results in increased expression of SLC30A5 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC30A5 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC30A5 mRNAaffects cotreatment|increases expression 17942748
D014810 Vitamin E Vitamin E results in decreased expression of SLC30A5 mRNAdecreases expression 19244175
D015032 Zinc SLC30A5 protein results in increased transport of Zincincreases transport 18326752
D015032 Zinc SLC30A5 protein results in increased export of Zincincreases export 17126599
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0415322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D000169 Acrodermatitis Zinc 5.6016889938 17190629 17202136
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2820464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2814692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.736695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D000544 Alzheimer Disease Zinc 2.7816325427 16410023 17119284 16580781
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D000755 Anemia, Sickle Cell Zinc 5.0616916123
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D001249 Asthma Zinc 2.9917085522
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001930 Brain Injuries Zinc 4.8617109824
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8817474063 20146248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8820435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1116050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 2.8816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.883084413
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.9120419170
MESH:D002294 Carcinoma, Squamous Cell Zinc 4.9116543248
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Zinc 3.7516936243
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.696135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.6920889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.6912371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Cyclosporine 8.1219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.1217333356 16919318 17681005 17110522 15861022 16105132 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1515340226 12621046 16354765 15668235 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.9220055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.9219769572
MESH:D019465 Craniofacial Abnormalities Zinc 3.9219302082
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1918551238
MESH:D003920 Diabetes Mellitus Zinc 4.3316479319
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.3321346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3316177239 14550746 11834606 17906064 12594235 11529661 16227642 12540782 19085960 10915739 16109766 16781746 11421492 10774834 19370779 19923254 19164858 2444490 16485898 19420014 18071297 14725611 19416960 12153990 17562736 11287661 16393943 11743745 12958197 12392966 16081117 11739529 11461765 12705907 15968718 19739265 17522070 18713872 14986274 10663392 15619225
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:C538011 Eales disease Vitamin E 4.929068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1215322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3512538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1510568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.4820426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.4816530937
MESH:D004938 Esophageal Neoplasms Zinc 7.4816543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Cyclosporine 8.0519224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.0515345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Cyclosporine 9.0712639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.0720067830
MESH:D005756 Gastritis Acetaminophen 11.9116983495
MESH:D005756 Gastritis Zinc 11.9117241300
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006130 Growth Disorders Zinc 4.0517217573
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.5020471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.5010048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 11.5016080930
MESH:D006333 Heart Failure Zinc 3.6917162251
MESH:D006335 Heart Injuries Zinc 5.9917074742
MESH:D016481 Helicobacter Infections Zinc 4.6817241300
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006527 Hepatolenticular Degeneration Zinc 4.8617276780
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0716120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7416490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.1914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2616959395 15340226 16354765 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006973 Hypertension Cyclosporine 5.1010903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1018850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5717937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9212878042 12200463
MESH:D007251 Influenza, Human Vitamin E 4.4316624496
MESH:D007511 Ischemia Zinc 4.8116584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Acetaminophen 15.0912587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 15.098314463 10903974 18776723
MESH:D007674 Kidney Diseases Vitamin E 15.0912488133
MESH:D007674 Kidney Diseases Zinc 15.0916960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.5616518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.6716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.6712371664
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3812878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.3816169303
MESH:D008107 Liver Diseases Acetaminophen 1.6616611625 19014921 11587558 12969438 19784758 12587719 19460945 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3716871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.637678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.6320195826 21137059
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.6316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.012876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.0112151625
MESH:D008171 Lung Diseases Vitamin E 3.2716863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4420869020 18569708 17053015 18816296 20135361 18520028 20064080 20464547 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4419555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 3.4411062179
MESH:D008325 Mammary Neoplasms, Experimental Zinc 3.3812773700
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.057678174 18551238
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2311141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4118481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5616049721
MESH:D010051 Ovarian Neoplasms CD 437 3.3517474084
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D011225 Pre-Eclampsia Zinc 4.2817114810
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811222880 11118676 11399792 11896295
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6017292933
MESH:D011471 Prostatic Neoplasms Vitamin E 2.6015084515
MESH:D011471 Prostatic Neoplasms Zinc 2.6012429649 16606632 16517595 16700911
MESH:D011537 Pruritus Ethinyl Estradiol 3.5115861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012162 Retinal Degeneration Zinc 4.2316584753
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6218551238
MESH:D012871 Skin Diseases Vitamin E 2.4718709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.6719755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1616709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D020521 Stroke Vitamin E 3.6316517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D014062 Tongue Neoplasms Zinc 4.5316543248
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.7016049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.7017053015
MESH:D001749 Urinary Bladder Neoplasms CD 437 8.7016720286
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5110091137
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
Pathway ID Pathway Name
REACT:15380 Diabetes pathways
REACT:15518 Transmembrane transport of small molecules
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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