AutismKB 2.0

Annotation Detail for MRPS5


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Basic Information Top
Gene Symbol:MRPS5 ( MRP-S5,S5mt )
Gene Full Name: mitochondrial ribosomal protein S5
Band: 2q11.1
Quick LinksEntrez ID:64969; OMIM: 611972; Uniprot ID:RT05_HUMAN; ENSEMBL ID: ENSG00000144029; HGNC ID: 14498
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of MRPS5 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of MRPS5 mRNAdecreases expression 18648102
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of MRPS5 mRNAaffects expression 17484886
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MRPS5 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MRPS5 mRNAaffects cotreatment|increases expression 17942748
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of MRPS5 mRNAaffects cotreatment|increases expression 17183730
C017947 sodium arsenite sodium arsenite results in increased expression of MRPS5 mRNAincreases expression 16014739
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MRPS5 mRNAaffects cotreatment|increases expression 17942748
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of MRPS5 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.4615322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.468875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1719490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.883712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.0815276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.2816712894 17306315
MESH:D000550 Amblyopia Valproic Acid 5.6117688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.7617497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001321 Autistic Disorder Valproic Acid 1.9918316065 18775368 15238991 18940202 20603192 16609825 18985861 18177632 18558336 17688650 19232924 17507914 17157402 19460635 18396377
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.401440618 11289319
MESH:D001714 Bipolar Disorder Valproic Acid 3.1820046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.5015746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.508888407
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6820435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.083786805 15700767 16011737 15673190 10355542 16227642 16124888 15721981 16097048 16192424 18705752 16050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.8416705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.843581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.8418788625
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.8417306315 16507464 15276417
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.777296757
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4318572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 12.156135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 12.157505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 12.1519524636 20056578
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7820734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.459022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.4516105132 17333356 17681005 11677210 16919318 17110522 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.198697196 12621046 16354765 15668235 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2714669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5310048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.538888407 17688650 16575769
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3218551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.1018759878 8156756 12868966 11298694 11906362 14531868 8970840 2524372
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.752952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.6821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.6818648102 8291058 9653073 6482804 18692083 11289319 18289764 7440962 9022650 9328219 16192314 1440618 6679447
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 12.6815027814 4309450 2869522 15998439 11566570 21278145 3732212 16227642 6884620 9327722 10092053 7440962 7179309 10915739 19336974 6623471 3786805 19085960 15968718 17522070 7120509 16177239
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.6820420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 12.6819641884 1733752
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004421 Dystonia Valproic Acid 4.311851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2815322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4712538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2510568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.463659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.293922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0418234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.806254150 6426943 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.607750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.403659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 14.5712795759 12631006 17595544 19224547 15959796 16239168 61145 16045604
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.5715345470
MESH:D005234 Fatty Liver Valproic Acid 14.5714986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005315 Fetal Diseases Valproic Acid 5.2616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.418888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.406705139
MESH:D005355 Fibrosis Carbon Tetrachloride 9.6418705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.6420067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.0216452187
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.307505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4411294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 10.186705139
MESH:D006505 Hepatitis Carbon Tetrachloride 10.1819110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2015340226 16120746 12621046
MESH:D006689 Hodgkin Disease sodium arsenite 3.3612676792
MESH:D006849 Hydrocephalus Valproic Acid 5.2017688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.428697196 16354765 15340226 16959395 18606429
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2515034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.9316612254
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.1617937319
MESH:D007248 Infertility, Male sodium arsenite 7.1612646999 15346721
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9612878042 12200463
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.408074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007674 Kidney Diseases sodium arsenite 2.9220008137
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.0416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.046582329
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1817596541 16294345
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9216943688 16239168 11408273 16221502 17174718 11903743 21278145 17334410 17157831
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3418481824 17708605 17766677 16116963 15123356 17481882 17714472 14716496 18429990 16015684 18166357 15650968 18156304 12546737 17525996 18472094 12958196 17557913 16027843 18376398 15057751 12898905 18705752 18054572 15876570 14512876 17640975 12649538 12667390 14748882 18418968 17805973 12609069 18395914 16033810 18277467 17976157 15338365 11481614 16136751 12586293 17565644 16011737 16638106 16097048 12666154 15362042 12632514 17900296 17869086 20821823 17761835 12632512 12389079 16192424 18006644 18420326 18472332 13678700 15730626 18205269 17698563 17944888 18251166 18395095 12445418 18279442 18317297 15996030 16248980 17631135 15931870 18187930 15925388 10355542 15893842 14716833 15818738 18263696 15370692 17721639 18412020 14724832 17922224 12741479 18210741 15959796 15673190 18339082 14620537 12445421 17823541 15052691
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3412878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1316246199 17285989 16964402 15830285 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9214706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.357678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.3519294768
MESH:D008113 Liver Neoplasms sodium arsenite 11.3516712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.3516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 15.292876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 15.291399818 3712494 598648 6587162
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 15.2912014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.2912151625
MESH:D008171 Lung Diseases sodium arsenite 3.3219095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.6417228818
MESH:D008175 Lung Neoplasms sodium arsenite 2.3615276417 16712894 19931552 17306315 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3611884234 19555203
MESH:D008545 Melanoma sodium arsenite 2.0619082730 16487513
MESH:D008881 Migraine Disorders Valproic Acid 3.3618803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.278888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2817596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.207678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.553581430
MESH:D009369 Neoplasms sodium arsenite 2.6011559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.9720056578
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 13.016679447
MESH:D009436 Neural Tube Defects sodium arsenite 13.0112854658
MESH:D009436 Neural Tube Defects Valproic Acid 13.0116359493 8888407
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.6516049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.654026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.403988306
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4917306315 15276417
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.797296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.856228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.6111222880 11896295 11118676 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.6120603192
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2616039940
MESH:D011537 Pruritus Ethinyl Estradiol 3.6516919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.9211422049 12752131
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.553692021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4419155313
MESH:D012559 Schizophrenia Valproic Acid 2.0919110320 15737665
MESH:D012640 Seizures 2,6-dinitrotoluene 6.4718551238
MESH:D012640 Seizures Valproic Acid 6.4716876388 3137016 15475178 14763951 11738929 11044598 1511512 17978042
MESH:D012878 Skin Neoplasms sodium arsenite 5.9319524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D016135 Spinal Dysraphism sodium arsenite 10.1612854658
MESH:D016135 Spinal Dysraphism Valproic Acid 10.1619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9212833885
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.061399818 6582329 7505956 6587162 3712494
MESH:D014178 Translocation, Genetic Valproic Acid 5.6117262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.863119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.7916049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.798074119
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.7916452187 16712894 11723127 17306315
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.958888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6610091137
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9911813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D014652 Vascular Diseases sodium arsenite 4.7617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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