AutismKB 2.0

Annotation Detail for MRPL41


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Basic Information Top
Gene Symbol:MRPL41 ( BMRP,MRP-L27,MRPL27,RPML27 )
Gene Full Name: mitochondrial ribosomal protein L41
Band: 9q34.3
Quick LinksEntrez ID:64975; OMIM: 611846; Uniprot ID:RM41_HUMAN; ENSEMBL ID: ENSG00000182154; HGNC ID: 14492
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of MRPL41 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of MRPL41 mRNAaffects expression 21346803
D016572 Cyclosporine Cyclosporine results in decreased expression of MRPL41 mRNAdecreases expression 20106945
D003609 Dactinomycin Dactinomycin promotes the reaction [MRPL41 protein results in increased stability of and affects the localization of TP53 protein]affects localization|increases reaction|increases stability 16024796
D008694 Methamphetamine Methamphetamine results in increased expression of MRPL41 mRNAincreases expression 19149911
D008694 Methamphetamine Valproic Acid inhibits the reaction [Methamphetamine results in increased expression of MRPL41 mRNA]decreases reaction|increases expression 19149911
D014303 Trinitrotoluene Trinitrotoluene affects the expression of MRPL41 mRNAaffects expression 21346803
D014635 Valproic Acid Valproic Acid inhibits the reaction [Methamphetamine results in increased expression of MRPL41 mRNA]decreases reaction|increases expression 19149911
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 10.167525203
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 10.168875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2119490988
MESH:D000550 Amblyopia Valproic Acid 5.6817688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.7917497229
MESH:D001321 Autistic Disorder Valproic Acid 1.9919460635 18316065 17157402 17507914 18558336 20603192 16609825 15238991 18775368 18177632 18985861 17688650 18940202 19232924 18396377
MESH:D001714 Bipolar Disorder Valproic Acid 3.2020046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.578888407
MESH:D019046 Bone Marrow Neoplasms Dactinomycin 5.9814601052
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.0616705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.0616705839
MESH:D002386 Cataract Trinitrotoluene 4.0214694615 15817613
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.196135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1912371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7920734317
MESH:D002779 Cholestasis Cyclosporine 3.1219486331
MESH:D000013 Congenital Abnormalities Trinitrotoluene 4.6515095906
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9016575769 17688650 8888407
MESH:D003490 Cyanosis 2,4-dinitrotoluene 21.0218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 21.0218551238
MESH:D003490 Cyanosis Trinitrotoluene 21.0218551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.6221346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.6218551238 21346803
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 9.6221346803 18551238
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.621733752 19641884
MESH:D004421 Dystonia Valproic Acid 4.351851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.5117275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.363922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0620417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.846426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.667750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.463659116
MESH:D005234 Fatty Liver Cyclosporine 8.7119224547
MESH:D005234 Fatty Liver Valproic Acid 8.7114986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.3316575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.468888407 18558336
MESH:D005355 Fibrosis Cyclosporine 3.5012168785 12639820
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.628708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8215720958
MESH:D006529 Hepatomegaly Trinitrotoluene 4.5915817613
MESH:D006849 Hydrocephalus Valproic Acid 5.2617688650
MESH:D006948 Hyperkinesis Methamphetamine 5.9017658665
MESH:D006973 Hypertension Cyclosporine 2.1810903974
MESH:D007248 Infertility, Male Trinitrotoluene 3.8512150543
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8815604871
MESH:D007674 Kidney Diseases Cyclosporine 2.488314463 18776723 10903974
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.7616705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.7616705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.7612371664
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1916294345 17596541
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.237678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.702876786 2876784 6135515
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.7017228818
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.2316801185
MESH:D008881 Migraine Disorders Valproic Acid 3.3818803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.318888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3017596541
MESH:D009336 Necrosis 2,4-dinitrotoluene 20.2518551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 20.2518551238 7678174
MESH:D009336 Necrosis Trinitrotoluene 20.2518551238
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5319348381 18481113
MESH:D009436 Neural Tube Defects Valproic Acid 3.3016359493 8888407
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 16.7816049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 16.7816049721
MESH:D009784 Occupational Diseases Trinitrotoluene 16.7812819281 17852074 14694615
MESH:D011230 Precancerous Conditions Cyclosporine 3.4712371664
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.2320603192
MESH:D019310 Pseudolymphoma Valproic Acid 4.9812752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4819155313
MESH:D012512 Sarcoma, Ewing's Dactinomycin 5.4114601052
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures 2,4-dinitrotoluene 15.6718551238
MESH:D012640 Seizures 2,6-dinitrotoluene 15.6718551238
MESH:D012640 Seizures Trinitrotoluene 15.6718551238
MESH:D012640 Seizures Valproic Acid 15.673137016 16876388 11044598 11738929 15475178 1511512 14763951 17978042
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9919490988
MESH:D013163 Splenomegaly Trinitrotoluene 5.5615817613
MESH:D013226 Status Epilepticus Valproic Acid 4.9812833885
MESH:D014178 Translocation, Genetic Valproic Acid 5.6817262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.923119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.3216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.3216049721
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.008888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.3510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.3510091137
MESH:D014605 Uveitis Cyclosporine 4.431336536
MESH:D014985 Xerophthalmia Cyclosporine 4.8817120751
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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