AutismKB 2.0

Annotation Detail for NDRG4


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Basic Information Top
Gene Symbol:NDRG4 ( DKFZp686I1615,FLJ30586,FLJ42011,KIAA1180,MGC19632,SMAP-8 )
Gene Full Name: NDRG family member 4
Band: 16q21
Quick LinksEntrez ID:65009; OMIM: NA; Uniprot ID:NDRG4_HUMAN; ENSEMBL ID: ENSG00000103034; HGNC ID: 14466
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
CARDIOVASCULAR
QT interval
Desease Name
Electrocardiographic traits
QT interval
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000499 Allylamine Allylamine affects the expression of NDRG4 mRNAaffects expression 15910882
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NDRG4 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of NDRG4 mRNAincreases expression 20106945
C002791 bismuth tripotassium dicitrate bismuth tripotassium dicitrate results in decreased expression of NDRG4 mRNAdecreases expression 15912405
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of NDRG4 mRNAdecreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of NDRG4 mRNAaffects expression 17484886
D004041 Dietary Fats Dietary Fats results in increased expression of NDRG4 mRNAincreases expression 18042831
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of NDRG4 mRNAincreases expression 20713471
C041786 palm oil palm oil results in increased expression of NDRG4 mRNAincreases expression 18042831
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of NDRG4 mRNAaffects cotreatment|decreases expression 19059307
D018038 Sodium Selenite Sodium Selenite results in decreased expression of NDRG4 mRNAdecreases expression 18175754
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of NDRG4 mRNAaffects cotreatment|decreases expression 19059307
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NDRG4 mRNAincreases expression 20106945
D014501 Uranium Uranium results in increased expression of NDRG4 mRNAincreases expression 15672453
C005460 uranyl acetate uranyl acetate results in increased expression of NDRG4 mRNAincreases expression 15672453
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.6114745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9011752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 1.9920464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 6.926695378
MESH:D000236 Adenoma Methylcholanthrene 6.926695378 10545420
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4316835633
MESH:D000419 Albuminuria Raloxifene 4.6317308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5515800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1219183758
MESH:D001161 Arteriosclerosis Dietary Fats 3.9315238619
MESH:D050197 Atherosclerosis Methylcholanthrene 3.4711922910
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7815746008
MESH:D001930 Brain Injuries Raloxifene 4.5216580743
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.9720146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 2.9720435547
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.9717474063
MESH:D001943 Breast Neoplasms Raloxifene 2.9715572757 15758505 16837676 17049068 17595753 17242785 17893378 17261762 16912660 15775269 17440819 17952589
MESH:D001943 Breast Neoplasms Tamoxifen 2.9716273361 19200415 21138602 11161223 17261762 18629630 19142967 18351453 19288272 19084267 16202921 15565566 19059307 17893378 17242785 19155303 18425577 18815881 19487384 19189212 19289846 17440819 16873071 15668708 19103187 20859285 19066611 18855134 19244106 19221464 16818667 20544844 20390343 19189210 18997820 19011961 18821012 20135344 20005174 19115204 18984771 21152245 20065188 17049068 19410462
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9720435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8216192424 3786805 16124888 15721981 18705752 15673190 10355542 15700767 16011737 16227642 16097048 16050911
MESH:D002277 Carcinoma Methylcholanthrene 8.4110545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.4116835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.5519066611
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.0218788625
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.0216924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0620419170
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 9.5917572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.5917572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3818850075 16120746 18670907
MESH:D002318 Cardiovascular Diseases Raloxifene 3.4615775269
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 3.5216192471
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1916835633
MESH:D019457 Chromosome Breakage Sodium Selenite 4.7915894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.118697196 15340226 16354765 15668235 12621046
MESH:D003072 Cognition Disorders Raloxifene 4.6615800139
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 15322242 20055451
MESH:D003711 Demyelinating Diseases Tamoxifen 4.4019031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.1917474826
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8016285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D003928 Diabetic Nephropathies Raloxifene 9.1217451421 17308373 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.1219279558
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.263732212 16177239 3786805 15968718 10092053 10915739 6884620 17522070 2869522 16227642 7179309 19085960 15027814 6623471 19336974 15998439 7120509 4309450 11566570 9327722 7440962 21278145
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.2615131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.2620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7811462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4718367378
MESH:D004487 Edema Raloxifene 6.9515860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.9512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9616714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 9.3615845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.3619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.0620544844 16202921 17893378 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0510568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0116530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0311564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 19.0712631006 19224547 12795759 61145 15959796 17595544 16045604 16239168
MESH:D005234 Fatty Liver Dietary Fats 19.0719551842 17967931 18296743 19004024
MESH:D005234 Fatty Liver Raloxifene 19.0717473493
MESH:D005234 Fatty Liver Tamoxifen 19.0714986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2516709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.2319069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.9914633661 10962813
MESH:D005355 Fibrosis Carbon Tetrachloride 15.0218705752
MESH:D005355 Fibrosis Dietary Fats 15.0218296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.0220067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.4920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.4910048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.5511110106
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6319110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9316120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1116959395 8697196 18606429 15340226 16354765
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5816899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6221332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.6521332399
MESH:D006973 Hypertension Raloxifene 5.2615787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2618850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1315338365
MESH:D007249 Inflammation Dietary Fats 8.3620412841
MESH:D007249 Inflammation Tamoxifen 8.3619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.3612200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 7.5418457598 11836018
MESH:D007333 Insulin Resistance Sodium Selenite 7.5414714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3616580747
MESH:D007680 Kidney Neoplasms Tamoxifen 3.0718625569
MESH:D007889 Leiomyoma Raloxifene 4.5316973256
MESH:D008064 Lipidoses Tamoxifen 3.1717567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.6816943688 11903743 11408273 17157831 16239168 17174718 21278145 17334410 16221502
MESH:D008103 Liver Cirrhosis Dietary Fats 6.6818296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.4614512876 15052691 17805973 16033810 14716496 12667390 14748882 15362042 15818738 18395095 16116963 20821823 17714472 18420326 17698563 17708605 16638106 17976157 12546737 18429990 15057751 17900296 17922224 11481614 18210741 15893842 18006644 13678700 17823541 17631135 16248980 18156304 15931870 17761835 14620537 15673190 18481824 12632512 17944888 17640975 18395914 15650968 12445418 15876570 17565644 12586293 18472094 17525996 18054572 15996030 16015684 16192424 17557913 18339082 18166357 12741479 18277467 14716833 12666154 18418968 12389079 15959796 18317297 18279442 15370692 12958196 12898905 14724832 12649538 18205269 18376398 15123356 18412020 15730626 17481882 10355542 15925388 12609069 17869086 12445421 18472332 16027843 18251166 16097048 16136751 17721639 18705752 16011737 12632514 17766677 15338365 18187930 18263696
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.4618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4612878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0917285989 16246199 16964402 15720792 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2115123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7216899240 14706259
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.7721137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 10.7719294768
MESH:D008113 Liver Neoplasms Tamoxifen 10.7716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.7716984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.9815583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 9.981399818 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.9812151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.8817053015 20869020 18520028 6695378 20135361 20064080 18816296 18569708 20464547
MESH:D008175 Lung Neoplasms Methylcholanthrene 4.8817909032 9230183 20512841 1399818 6695378 16271038 11893704 7750092 10545420 15390079 16337739 21163286 20970405
MESH:D008175 Lung Neoplasms Tamoxifen 4.8818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.8811884234 19555203
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.0914737004
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.8119428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.6411731420 19196722 14580682 19196723 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.6119453300
MESH:D008545 Melanoma Tamoxifen 1.8812393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.2315990972
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.6215863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2116381670
MESH:D009101 Multiple Myeloma Raloxifene 3.4616497877
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D009232 Myxoma Raloxifene 5.6216343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5219410462
MESH:D009369 Neoplasms Benzo(a)pyrene 2.1811141357
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0619189210 19196722 19200415
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2514600291
MESH:D009765 Obesity Dietary Fats 2.2917217161 20132043 21332399 11836018 18457598 18674790 20518802 16723640 19632207
MESH:D010024 Osteoporosis Raloxifene 3.4117882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.2617823083 15758505 17893378 15579764
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2411896295 11222880 11118676 11399792
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0817292933
MESH:D011471 Prostatic Neoplasms Raloxifene 2.0816220300 16536755 15731164
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.0818760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0815067354
MESH:D011693 Purpura Raloxifene 5.6215770314
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.4710029692 19755658
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.478532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.4716192470
MESH:D013088 Spermatocele Tamoxifen 4.3516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0919457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D020521 Stroke Raloxifene 3.8416837676
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D013978 Tibial Fractures Raloxifene 5.2719048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.4117053015
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 8.4117572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.4116712894 17572228 8653321
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.2716837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.6216343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
MESH:D015430 Weight Gain Dietary Fats 3.7616723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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