AutismKB 2.0

Annotation Detail for SLC1A1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SLC1A1 ( EAAC1,EAAT3 )
Gene Full Name: solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Band: 9p24.2
Quick LinksEntrez ID:6505; OMIM: 133550; Uniprot ID:EAA3_HUMAN; ENSEMBL ID: ENSG00000106688; HGNC ID: 10939
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04974Protein digestion and absorption
Pathway IDPathway Name
Synaptic Transmission
Transmembrane transport of small molecules
Amino acid and oligopeptide SLC transporters
No data
Pathway IDPathway Name
P00039Metabotropic glutamate receptor group III pathway
P00037Ionotropic glutamate receptor pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1877Multiple sclerosis
2069Schizophrenia
2185Obsessive-compulsive disorder
Desease Name
obsessive compulsive disorder
CHEMDEPENDENCY
PSYCH
smoking cessation
No data
Desease Name
Dicarboxylicaminoaciduria
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbamazepine results in increased activity of SLC1A1 protein]decreases reaction|increases activity 16150575
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in decreased expression of SLC1A1 mRNAdecreases expression 19901195
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SLC1A1 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC1A1 mRNAaffects expression 16483693
D016589 Astemizole Astemizole results in increased expression of SLC1A1 mRNAincreases expression 20221588
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC1A1 mRNAdecreases expression 19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of SLC1A1 mRNAdecreases expression 15336504
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased activity of SLC1A1 proteindecreases activity 17382927
D020122 tert-Butylhydroperoxide [Tetradecanoylphorbol Acetate co-treated with Propofol] inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of SLC1A1 protein]affects cotreatment|decreases activity|decreases reaction 17382927
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SLC1A1 mRNAaffects cotreatment|decreases expression 20360939
D002220 Carbamazepine 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbamazepine results in increased activity of SLC1A1 protein]decreases reaction|increases activity 16150575
D002220 Carbamazepine Carbamazepine results in increased activity of SLC1A1 proteinincreases activity 16150575
D002220 Carbamazepine wortmannin inhibits the reaction [Carbamazepine results in increased activity of SLC1A1 protein]decreases reaction|increases activity 16150575
C016299 chelerythrine chelerythrine results in decreased activity of SLC1A1 proteindecreases activity 17382927
D003024 Clozapine Clozapine results in decreased expression of SLC1A1 mRNAdecreases expression 12873733
D016572 Cyclosporine Cyclosporine results in decreased expression of SLC1A1 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SLC1A1 mRNAaffects cotreatment|decreases expression 20360939
D002117 Calcitriol Calcitriol results in increased expression of SLC1A1 mRNAincreases expression 16002434
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SLC1A1 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of SLC1A1 mRNAincreases expression 19619570
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SLC1A1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC1A1 mRNAaffects cotreatment|increases expression 17942748
D006220 Haloperidol Haloperidol results in decreased expression of SLC1A1 mRNAdecreases expression 12873733
D007051 Ibotenic Acid Ibotenic Acid results in decreased expression of SLC1A1 mRNAdecreases expression 12183397
D007657 Ketone Bodies Ketone Bodies results in increased expression of SLC1A1 mRNAincreases expression 16807920
D016685 Mitomycin SLC1A1 protein affects the susceptibility to Mitomycinaffects response to substance 16217747
D009151 Mustard Gas Mustard Gas results in increased expression of SLC1A1 mRNAincreases expression 15674843
D015058 1-Naphthylisothiocyanate 1-Naphthylisothiocyanate results in increased expression of SLC1A1 mRNAincreases expression 12832660
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of SLC1A1 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of SLC1A1 mRNAincreases expression 19482888
C006253 pirinixic acid pirinixic acid results in decreased expression of SLC1A1 mRNAdecreases expression 17426115
D015742 Propofol [Tetradecanoylphorbol Acetate co-treated with Propofol] inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of SLC1A1 protein]affects cotreatment|decreases activity|decreases reaction 17382927
D012402 Rotenone Rotenone results in increased expression of SLC1A1 mRNAincreases expression 19013527
D012643 Selenium Selenium results in decreased expression of SLC1A1 mRNAdecreases expression 19244175
D019311 Staurosporine Staurosporine results in decreased activity of SLC1A1 proteindecreases activity 17382927
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SLC1A1 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SLC1A1 mRNAdecreases expression 19901195
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SLC1A1 mRNAincreases expression 19619570
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC1A1 mRNAaffects cotreatment|increases expression 17942748
D013755 Tetradecanoylphorbol Acetate [Tetradecanoylphorbol Acetate co-treated with Propofol] inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of SLC1A1 protein]affects cotreatment|decreases activity|decreases reaction 17382927
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased activity of SLC1A1 proteinincreases activity 17382927
D013849 Thimerosal Thimerosal results in increased expression of SLC1A1 proteinincreases expression 15184908
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in decreased expression of SLC1A1 mRNAdecreases expression 17982090
D014635 Valproic Acid Valproic Acid results in increased expression of SLC1A1 mRNAincreases expression 19101580
C009687 wortmannin wortmannin inhibits the reaction [Carbamazepine results in increased activity of SLC1A1 protein]decreases reaction|increases activity 16150575
C022189 zonisamide zonisamide results in increased expression of SLC1A1 proteinincreases expression 12941455
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 17.478986270
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 17.476195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 17.4714514962 15322242 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 17.478875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.6119490988
MESH:D000138 Acidosis Ammonium Chloride 3.2118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5817505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.7918653653
MESH:D000230 Adenocarcinoma Estradiol 3.8911473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 3.8914692618
MESH:D000236 Adenoma Diethylnitrosamine 2.656695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 21.9418056438 16434500 19052882 19061943 17620307 17162532
MESH:D018248 Adenoma, Liver Cell Phenobarbital 21.9417620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 21.9416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 21.9416835633
MESH:D000380 Agranulocytosis Clozapine 4.7116160616 14617031 12649775
MESH:D000550 Amblyopia Valproic Acid 4.8717688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6411748828
MESH:D000799 Angioedema Astemizole 5.302883202
MESH:D001008 Anxiety Disorders Valproic Acid 3.3017497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4515885639
MESH:D001249 Asthma Mustard Gas 2.6010378619
MESH:D001321 Autistic Disorder Haloperidol 2.3419368416 18080171
MESH:D001321 Autistic Disorder Valproic Acid 2.3417157402 18940202 17507914 18316065 17688650 15238991 19232924 18985861 19460635 18775368 18558336 18396377 18177632 20603192 16609825
MESH:D001714 Bipolar Disorder Carbamazepine 11.1617594078 20046352
MESH:D001714 Bipolar Disorder Valproic Acid 11.1620046352 17594078
MESH:D001714 Bipolar Disorder zonisamide 11.1615383137 16855456
MESH:D001768 Blister Mustard Gas 4.8019167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.7219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.7212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.2615746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.268888407
MESH:D001943 Breast Neoplasms Calcitriol 1.8911237771
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8917474063
MESH:D001943 Breast Neoplasms Estradiol 1.8919861407 16675129 17018787 12948864 18497071 17289903 14630087 17261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8920435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.8015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.6210378619 17687719
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1116111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5216835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.0521507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.0518665156 17761372 10737359 19394651 16540662 10672840 16779866 19701751 19107877 19519916 19383236 17978847 20007298 17055752 17162532 16807293 16698587 19539802 20101231 18785209 16502159 3084413 16569478 16288022 16830150 17173139 16681979 18506893 19335982 18210153 16935385 20084675 3581430 17138121 20432363 20524982 21159647 19919837 18971187 18393292 18494052 11831363 20727157 19052882 16878318 17428255 18056438 20935162 18978308 19171122 20214788 20514400 19822196 19208518 19418558 18788625 20512989 18691550 16328049
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.0516924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.056705139 20007298 17173139 1701930 20935162
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.6511237771
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 4.6518922899
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1718670907 18850075 16120746
MESH:D002375 Catalepsy Haloperidol 4.561977408 15215559
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 14.0020889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 14.0012371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 14.002727394 7505956 17174075 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.0018566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.914080065
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5820734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.3419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.3416835633
MESH:D002761 Cholangitis 1-Naphthylisothiocyanate 5.8412912871
MESH:D002779 Cholestasis 1-Naphthylisothiocyanate 17.1312927374 15913567 18590720 19486331 16629650 15500046 7624871 18164287
MESH:D002779 Cholestasis Cyclosporine 17.1319486331
MESH:D002779 Cholestasis Ethinyl Estradiol 17.1315861022 17681005 17110522 16105132 17333356 16919318 11677210
MESH:D002779 Cholestasis pirinixic acid 17.1319176532
MESH:D002780 Cholestasis, Intrahepatic 1-Naphthylisothiocyanate 5.4910220858 19407337
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9512621046 16354765 15668235 8697196 15340226
MESH:D003072 Cognition Disorders Clozapine 4.6217123785
MESH:D003092 Colitis Selenium 8.6617936198
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 8.6616474422 18200517 16804969 16782535 18023891 17991707 17936198 16867261 11698051
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.3217276891
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7617141729 14669216
MESH:D019465 Craniofacial Abnormalities Carbamazepine 3.679014606
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6715322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.678888407 16575769 17688650
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.5220210726
MESH:D003704 Dementia Haloperidol 4.2611575062
MESH:D003866 Depressive Disorder zonisamide 4.6616855456
MESH:D017449 Dermatitis, Allergic Contact Thimerosal 4.2016958921 15932584
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2618249437
MESH:D002658 Developmental Disabilities Thimerosal 4.6015764492
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 6.6016402076
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.6020387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.6017107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.1219279558
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.1915331141
MESH:D004244 Dizziness Astemizole 6.103105558
OMIM:607208 DRAVET SYNDROME Carbamazepine 11.5011748493
OMIM:607208 DRAVET SYNDROME zonisamide 11.5011748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.1916538175 15057820 20216337 16538176
MESH:D056486 Drug-Induced Liver Injury 1-Naphthylisothiocyanate 13.7717522070 18289764 7624871 20133375
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 13.7717465707
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 13.7719107877
MESH:D056486 Drug-Induced Liver Injury Selenium 13.7715131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 13.7720420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 13.7719641884 1733752
MESH:D004362 Drug Toxicity Carbamazepine 7.5320216337
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.5311462148
MESH:D050171 Dyslipidemias Clozapine 3.9316402076
MESH:D004421 Dystonia Phenobarbital 9.351851702
MESH:D004421 Dystonia Valproic Acid 9.351851702
MESH:D004487 Edema Mustard Gas 18.349260866 11428631 11428647 11402378
MESH:D004487 Edema pirinixic acid 18.3412083418
MESH:D004487 Edema Staurosporine 18.348273558
MESH:D004487 Edema Tetrachlorodibenzodioxin 18.3411000095 12711302
MESH:D004487 Edema Tetradecanoylphorbol Acetate 18.347812673 15177302 8273558 9599246 16716910 11698051 8113982
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5416714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 13.5615138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 13.5617654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 13.5612538720
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 7.0119148513
MESH:D016889 Endometrial Neoplasms Estradiol 7.0118566989 11473722 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.729294722 10568697
MESH:D004802 Eosinophilia Astemizole 4.461355641
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 4.9216415921 19915237 16538176 20485159 18855540
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 23.5417275665
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 23.543659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 23.5417275665 3659116
MESH:D004831 Epilepsies, Myoclonic zonisamide 23.543691417 3659116
MESH:D004828 Epilepsies, Partial Carbamazepine 21.1717116037 16628512 15008574
MESH:D004828 Epilepsies, Partial Phenobarbital 21.1711558140 3922381
MESH:D004828 Epilepsies, Partial Valproic Acid 21.173922381 16628512
MESH:D004828 Epilepsies, Partial zonisamide 21.1711558140 15140322 3691417
MESH:D004827 Epilepsy marker/mechanism 12151515
MESH:D004827 Epilepsy Carbamazepine 14.337988514 19620853 821787 9014606 18234410 17465707 19700373 17178248 20417680 19439326
MESH:D004827 Epilepsy Phenobarbital 14.3320417680
MESH:D004827 Epilepsy Valproic Acid 14.3320417680 18234410
MESH:D004827 Epilepsy zonisamide 14.3320196486
MESH:D004832 Epilepsy, Absence Phenobarbital 7.886401628
MESH:D004832 Epilepsy, Absence Valproic Acid 7.886426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 17.427750514
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 17.427750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 17.427750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 22.5815276670 3659116
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 22.583659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 22.583659116
MESH:D004830 Epilepsy, Tonic-Clonic zonisamide 22.583691417 3659116
MESH:D004890 Erythema Mustard Gas 4.809357497
MESH:D004916 Erythromelalgia Carbamazepine 5.3719549232
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.7616302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 1.9820426865
MESH:D020329 Essential Tremor zonisamide 5.8317149715 18297619
MESH:D005076 Exanthema Carbamazepine 11.5420485159
MESH:D005076 Exanthema zonisamide 11.5415140322
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7511564622
MESH:D005221 Fatigue zonisamide 5.7217149715
MESH:D005234 Fatty Liver Cyclosporine 21.2919224547
MESH:D005234 Fatty Liver Diethylnitrosamine 21.2921071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 21.2915345470
MESH:D005234 Fatty Liver pirinixic acid 21.2920131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 21.2919224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1111858732
MESH:D005315 Fetal Diseases Valproic Acid 4.5316575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.798888407 18558336
MESH:D005355 Fibrosis Cyclosporine 12.8312168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.8320067830
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 12.8317994277
MESH:D005499 Folliculitis Astemizole 5.561671328
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.868708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2310696789
MESH:D006261 Headache zonisamide 5.3917149715
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1411294989 10048152
MESH:D006333 Heart Failure pirinixic acid 6.2220558911
MESH:D006333 Heart Failure Selenium 6.2217162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0211000095
MESH:D006505 Hepatitis 1-Naphthylisothiocyanate 4.3618590720
MESH:D006529 Hepatomegaly Phenobarbital 12.3816109766
MESH:D006529 Hepatomegaly pirinixic acid 12.3818467677 19176532 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.3816120746 12621046 15340226
MESH:D006558 Herpes Genitalis Estradiol 4.6715709030
MESH:D019584 Hot Flashes Estradiol 3.3917088409
MESH:D006849 Hydrocephalus Valproic Acid 4.5117688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6818606429 16959395 15340226 16354765 8697196
MESH:D006943 Hyperglycemia pirinixic acid 2.8820558911
MESH:D020138 Hyperhomocysteinemia Carbamazepine 4.4310459572
MESH:D006948 Hyperkinesis Clozapine 4.5616046005
MESH:D006965 Hyperplasia Carbamazepine 4.8618773962
MESH:D006973 Hypertension Cyclosporine 4.4710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.4718670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4616569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1412013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.2517937319
MESH:D007249 Inflammation Diethylnitrosamine 10.4418785209
MESH:D007249 Inflammation Mustard Gas 10.449260866 11402378 8975870 9357497 11428647 11428631 11428620 17524151 16001271
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.4412200463 12878042
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 10.447562506 15177302 11698051 7812673 8273558
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 3.4318200517
MESH:D007251 Influenza, Human Selenium 3.8416624496
MESH:D007333 Insulin Resistance Estradiol 6.4216393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 6.4216306350
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 4.2617994277
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.2810783313
MESH:D002546 Ischemic Attack, Transient zonisamide 6.549372210
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0815604871
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 8.9615369732
MESH:D007674 Kidney Diseases Cyclosporine 8.968314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 8.9615618244
MESH:D007676 Kidney Failure, Chronic Selenium 3.5716518626
MESH:D007680 Kidney Neoplasms Cyclosporine 6.3312371664
MESH:D007680 Kidney Neoplasms Estradiol 6.3315610895
MESH:D007938 Leukemia 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 3.6212970779
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.0917596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 3.7616766008
MESH:D017513 Lichen Nitidus Astemizole 6.102563723
MESH:D008064 Lipidoses Clozapine 3.7117567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 5.9818665156 18407596 20032147 19638242 18522880
MESH:D008103 Liver Cirrhosis Phenobarbital 5.9821047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.1214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.1215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.1212878042
MESH:D008107 Liver Diseases 1-Naphthylisothiocyanate 6.1017184895
MESH:D008107 Liver Diseases Diethylnitrosamine 6.1017034775
MESH:D008107 Liver Diseases Phenobarbital 6.1019363144
MESH:D008113 Liver Neoplasms Aflatoxin B1 16.1318177683 2125692 15890375 9163691
MESH:D008113 Liver Neoplasms Diethylnitrosamine 16.1319690152 19850985 20405173 18978307 12112319 19254457 19638242 20118626 19499222 21047994 20137499 19642983 19426721 16942905 20452335 20501860 18644402 19294768 12771043 19255062 19812893 15175105 21278145 19427195 10737359 21167192 19256749 19090486 18754104 15885732 20492335 18648771 9163691 19996281 18977376 2422723 20101389 19833225 21071580 2862719 19551842 19073162 20434301 20583210
MESH:D008113 Liver Neoplasms Mitomycin 16.1315113037
MESH:D008113 Liver Neoplasms Phenobarbital 16.1319812893 21047994 15975961 19073162 19482888 8742319
MESH:D008113 Liver Neoplasms pirinixic acid 16.1320007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 16.1316984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 12.288603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 12.2818544905 19126423 18775883 16842330 18079962 9362446 17942915 21159647 17174075 18308698 18282651 3124819 19009564 19539802 18253720 18164116 19519916 18093689 19004024 16267830 2563599 17854601
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 12.286150874 1399818 17172636 2563599 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.2812151625
MESH:D008133 Long QT Syndrome Astemizole 4.3318472280 11989578
MESH:D008171 Lung Diseases Mustard Gas 3.2118161513 18702808
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 10.6017228818
MESH:D017563 Lung Diseases, Interstitial zonisamide 10.6017228818
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.0814755239
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.086695378 20512841 21163286 20970405
MESH:D008175 Lung Neoplasms Mustard Gas 6.083148597 8781369
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.0811884234 19555203
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 6.0811807781
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.4616628512
MESH:D008288 Malaria Astemizole 4.5016816845
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.7311807958 17203775 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 8.7315318939
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 8.738985016
MESH:D020149 Manganese Poisoning Estradiol 4.1219453300
MESH:D001523 Mental Disorders Clozapine 7.2016856516
MESH:D001523 Mental Disorders Haloperidol 7.2016856516
MESH:D008607 Mental Retardation Carbamazepine 3.609014606
MESH:D008654 Mesothelioma Selenium 2.6515107826
MESH:D024821 Metabolic Syndrome X Clozapine 4.1219142101
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4316801185
MESH:D008881 Migraine Disorders Valproic Acid 2.9418765137 18803445
MESH:D009101 Multiple Myeloma zonisamide 4.5411868602
MESH:D009135 Muscular Diseases pirinixic acid 3.1616239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.718888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 2.9517596541
MESH:D009203 Myocardial Infarction pirinixic acid 1.9919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.3516810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.3516411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 11.5517484760
MESH:D020191 Myoclonic Epilepsies, Progressive zonisamide 11.559477142
MESH:D009224 Myotonia Congenita Carbamazepine 5.1120399394
MESH:D009325 Nausea zonisamide 5.6516855456
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.423581430 9029167
MESH:D009369 Neoplasms pirinixic acid 1.7817405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3817289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.9919348381 18481113
MESH:D009410 Nerve Degeneration Rotenone 3.6118619942 15790535 17356569
MESH:D009421 Nervous System Malformations Carbamazepine 14.5416990009
MESH:D009421 Nervous System Malformations Estradiol 14.5411399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.5414600291
MESH:D009436 Neural Tube Defects Valproic Acid 2.908888407 16359493
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.0620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.7620387270
MESH:D009503 Neutropenia Mustard Gas 3.6516761898 7688884
MESH:D009759 Nystagmus, Pathologic Astemizole 6.106135121
MESH:D009765 Obesity Clozapine 4.3819142110 18515891
MESH:D009765 Obesity pirinixic acid 4.3820558911
MESH:D010018 Osteomalacia Carbamazepine 10.9117016548
MESH:D010018 Osteomalacia Phenobarbital 10.9117016548
MESH:D010051 Ovarian Neoplasms 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 4.7916211241
MESH:D010051 Ovarian Neoplasms Estradiol 4.7919401270
MESH:D010146 Pain Carbamazepine 6.9015215642
MESH:D010146 Pain zonisamide 6.9015140322 17666864 16217643
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.2916540662
MESH:D010190 Pancreatic Neoplasms Mitomycin 11.2915113037
MESH:D010190 Pancreatic Neoplasms Phenobarbital 11.2916965848
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 11.2915976015
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 3.8817698068
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3611578682
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 3.9518922899 8330346 12065085 18404319
MESH:D010267 Parapsoriasis Carbamazepine 5.3516538176
MESH:D010292 Paresthesia zonisamide 6.5417149715
MESH:D010300 Parkinson Disease Rotenone 5.6318191903 18619942 15451049 11535288 16140633 11445065 16412576 19232380 19114014
MESH:D010300 Parkinson Disease zonisamide 5.6320196486 13677302 19594199 17200492 11755227
MESH:D020734 Parkinsonian Disorders Rotenone 3.7715795934 15574749 15927086 18197244
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 5.5717145499 17679678
MESH:D010382 Peliosis Hepatis 1-Naphthylisothiocyanate 12.5920133375
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 12.5912520081
MESH:D010954 Plasmacytoma Selenium 4.5315087411
MESH:D011041 Poisoning Mustard Gas 3.4815727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2218163543
MESH:D011230 Precancerous Conditions Cyclosporine 13.5612371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 13.562563599
MESH:D011230 Precancerous Conditions Phenobarbital 13.562563599
MESH:D011248 Pregnancy Complications Carbamazepine 4.819014606
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 14.329014606
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.3211896295 11118676 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 14.3220603192
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.4215572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5720887781
MESH:D011471 Prostatic Neoplasms Calcitriol 3.4616289102 18247401 15754350 12479363 16644109
MESH:D011471 Prostatic Neoplasms Estradiol 3.4616740699
MESH:D011537 Pruritus Ethinyl Estradiol 8.3515861022 16919318
MESH:D011537 Pruritus Mustard Gas 8.3518058305
MESH:D019310 Pseudolymphoma Carbamazepine 19.0812752131 9591791
MESH:D019310 Pseudolymphoma Phenobarbital 19.0812752131
MESH:D019310 Pseudolymphoma Valproic Acid 19.0811422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.1016882103
MESH:D011595 Psychomotor Agitation Haloperidol 4.6111575062
MESH:D011618 Psychotic Disorders Clozapine 8.3115331141
MESH:D011618 Psychotic Disorders Haloperidol 8.3111575062
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.7917266442 17620002 17894541 17720292 10334151
MESH:D015427 Reperfusion Injury pirinixic acid 2.2119058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5018990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.8519155313
MESH:D012221 Rhinitis, Allergic, Perennial Astemizole 5.0710822083
MESH:D012559 Schizophrenia Clozapine 5.3520521320 18855531 17667964 20521326 11151749 20107430 19369910 20580759 20452607 17726453 17123785 16141801 20168265 11763009 18806925
MESH:D012559 Schizophrenia Haloperidol 5.3518513383 20107430 19369910 1830565
MESH:D012559 Schizophrenia Valproic Acid 5.3515737665 19110320
MESH:D012640 Seizures Carbamazepine 12.259046859 19414003 15946322 9844417 16876388 16938433 16180713
MESH:D012640 Seizures Phenobarbital 12.254039156 3137016 16876388 11442880
MESH:D012640 Seizures Valproic Acid 12.2514763951 15475178 17978042 16876388 11738929 11044598 1511512 3137016
MESH:D012640 Seizures zonisamide 12.2511442880 11755227 18455367 11879338 11518630 10029267 9806000 11044598 16876388 9844417 9046859 16180713 12941455 16938433 15946322
MESH:D003294 Seizures, Febrile Phenobarbital 4.476407741
MESH:D012871 Skin Diseases Mustard Gas 2.6216961503 15451306 12880345
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 8.518532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.5116192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 8.518330346 12065085 18404319 11807781 8985016
MESH:D012893 Sleep Disorders Carbamazepine 4.7719414003
MESH:D013088 Spermatocele Ethinyl Estradiol 3.5816709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.5119490988
MESH:D013226 Status Epilepticus Valproic Acid 11.6212833885
MESH:D013226 Status Epilepticus zonisamide 11.6212833885
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 10.6615057820 19694795 16538176 19915237 18855540 20485159 16415921
MESH:D013262 Stevens-Johnson Syndrome zonisamide 10.6612239465
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.3720210726
MESH:D013742 Tetanus Propofol 6.072903605
MESH:D013921 Thrombocytopenia 1-Naphthylisothiocyanate 4.4520133375
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2911994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8615669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5412697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.307505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.301399818
MESH:D013978 Tibial Fractures Estradiol 4.3219048282
MESH:D016171 Torsades de Pointes Astemizole 4.859583453 8256756
MESH:D014178 Translocation, Genetic Valproic Acid 4.8717262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 11.573119515
MESH:D020194 Unverricht-Lundborg Syndrome zonisamide 11.5711814737
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.308888407
MESH:D014581 Urticaria Astemizole 4.471976298 2568189 2147912 1683191 2883202 3080510 3097109 2565098 2859714 3134034 2885854 2568013
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.9614692618
MESH:D014605 Uveitis Cyclosporine 3.621336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2214671159 15869587
MESH:D014717 Vertigo Astemizole 6.103105558
MESH:D014839 Vomiting zonisamide 5.5717157078
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8915886252
MESH:D015430 Weight Gain Clozapine 4.1716402076 16141801 20564506 20107430 20521320 17502770
MESH:D015431 Weight Loss Clozapine 4.7217933447
MESH:D014985 Xerophthalmia Cyclosporine 4.0817120751
Pathway ID Pathway Name
REACT:19419 Amino acid and oligopeptide SLC transporters
KEGG:04724 Glutamatergic synapse
KEGG:04974 Protein digestion and absorption
REACT:13685 Synaptic Transmission
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35826
    • No data
    Releated disease ID Related disease Name
    PA447211Obsessive-Compulsive Disorder
    PA447216Schizophrenia
    Releated drug ID Related drug Name
    PA449061clozapine
    PA450688olanzapine
    PA451257risperidone
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00128 - L-Aspartic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
    DB00142 - L-Glutamic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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