AutismKB 2.0

Annotation Detail for SLC1A2


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Basic Information Top
Gene Symbol:SLC1A2 ( EAAT2,GLT-1 )
Gene Full Name: solute carrier family 1 (glial high affinity glutamate transporter), member 2
Band: 11p13
Quick LinksEntrez ID:6506; OMIM: 600300; Uniprot ID:EAA2_HUMAN; ENSEMBL ID: ENSG00000110436; HGNC ID: 10940
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05014Amyotrophic lateral sclerosis (ALS)
Pathway IDPathway Name
Synaptic Transmission
Transmembrane transport of small molecules
Amino acid and oligopeptide SLC transporters
No data
Pathway IDPathway Name
P00039Metabotropic glutamate receptor group III pathway
P00037Ionotropic glutamate receptor pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
1870Drug abuse
1877Multiple sclerosis
1914Cerebrovascular disorder
2134Amyotrophic lateral sclerosis
Desease Name
CHEMDEPENDENCY
PSYCH
smoking cessation
schizophrenia
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of SLC1A2 mRNAincreases expression 19933214
C063002 2,3-dimethoxy-1,4-naphthoquinone 2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of SLC1A2 mRNAdecreases expression 17547211
C026137 3-hydroxyacetanilide 3-hydroxyacetanilide results in decreased expression of SLC1A2 mRNAdecreases expression 18544908
D000082 Acetaminophen Acetaminophen affects the expression of SLC1A2 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of SLC1A2 mRNAdecreases expression 18544908
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC1A2 mRNAaffects expression 16483693
D000667 Ampicillin Ampicillin results in increased expression of SLC1A2 proteinincreases expression 17138558
C006632 arsenic trioxide arsenic trioxide results in decreased expression of SLC1A2 mRNAdecreases expression 17547211
D001761 Bleomycin Bleomycin results in increased expression of SLC1A2 mRNAincreases expression 15808516
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of SLC1A2 proteindecreases expression 12629582
D004390 Chlorpyrifos Chlorpyrifos results in decreased expression of SLC1A2 mRNAdecreases expression 17452286
D003024 Clozapine Clozapine results in decreased activity of SLC1A2 proteindecreases activity 11443521
D003024 Clozapine Clozapine results in decreased expression of SLC1A2 mRNAdecreases expression 12873733
D003024 Clozapine Clozapine results in decreased expression of SLC1A2 proteindecreases expression 11443521
D003345 Corticosterone Corticosterone inhibits the reaction [Hydrogen Peroxide results in decreased expression of SLC1A2 protein]decreases expression|decreases reaction 17138558
D003345 Corticosterone Corticosterone results in increased expression of SLC1A2 proteinincreases expression 17138558
D003345 Corticosterone Vitamin A promotes the reaction [Corticosterone results in increased expression of SLC1A2 protein]increases expression|increases reaction 17138558
D003345 Corticosterone Corticosterone results in increased expression of SLC1A2 proteinincreases expression 17138558
C030123 coumarin coumarin results in increased expression of SLC1A2 mRNAincreases expression 18480146
C014347 decitabine decitabine results in increased expression of SLC1A2 mRNAincreases expression 15251184
C014347 decitabine [Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of SLC1A2 mRNAaffects cotreatment|increases expression 15251184
D003976 Diazinon Diazinon results in decreased expression of SLC1A2 mRNAdecreases expression 17452286
D004958 Estradiol Estradiol results in decreased expression of SLC1A2 mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SLC1A2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC1A2 mRNAaffects cotreatment|increases expression 17942748
D006220 Haloperidol Haloperidol results in decreased expression of SLC1A2 mRNAdecreases expression 12873733
D006861 Hydrogen Peroxide Corticosterone inhibits the reaction [Hydrogen Peroxide results in decreased expression of SLC1A2 protein]decreases expression|decreases reaction 17138558
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of SLC1A2 proteindecreases expression 17138558
D008694 Methamphetamine Methamphetamine results in increased expression of SLC1A2 mRNAincreases expression 17105907
D008456 2-Methyl-4-chlorophenoxyacetic Acid 2-Methyl-4-chlorophenoxyacetic Acid affects the expression of SLC1A2 proteinaffects expression 16019039
D009151 Mustard Gas Mustard Gas results in increased expression of SLC1A2 mRNAincreases expression 15674843
D010100 Oxygen Oxygen deficiency affects the expression of SLC1A2 proteinaffects expression 15927375
D010406 Penicillins Penicillins results in increased expression of SLC1A2 proteinincreases expression 17138558
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of SLC1A2 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of SLC1A2 mRNAincreases expression 19482888
C006253 pirinixic acid pirinixic acid results in increased expression of SLC1A2 mRNAincreases expression 12832660
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SLC1A2 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of SLC1A2 mRNAaffects cotreatment|increases expression 15251184
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC1A2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SLC1A2 mRNAincreases expression 19933214
D014050 Toluene Toluene affects the expression of SLC1A2 mRNAaffects expression 18653662
C012589 trichostatin A trichostatin A results in increased expression of SLC1A2 mRNAincreases expression 19924110
D014635 Valproic Acid Valproic Acid promotes the reaction [HIST4H4 protein modified form binds to SLC1A2 promoter]affects binding|increases reaction 19924110
D014635 Valproic Acid Valproic Acid results in increased expression of SLC1A2 mRNAincreases expression 19924110
D014635 Valproic Acid Valproic Acid results in decreased methylation of SLC1A2 promoterdecreases methylation 19924110
D014635 Valproic Acid [Valproic Acid results in decreased methylation of SLC1A2 promoter] which results in increased expression of SLC1A2 mRNAdecreases methylation|increases expression 19924110
D014635 Valproic Acid Valproic Acid results in increased expression of SLC1A2 mRNAincreases expression 19924110
D014801 Vitamin A Vitamin A promotes the reaction [Corticosterone results in increased expression of SLC1A2 protein]increases expression|increases reaction 17138558
D014801 Vitamin A Vitamin A results in increased expression of SLC1A2 proteinincreases expression 17138558
D014801 Vitamin A Vitamin A results in increased expression of SLC1A2 proteinincreases expression 17138558
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 12.486195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 12.4811752688 14514962 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 12.488875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 9.5019490988
MESH:D000015 Abnormalities, Multiple Vitamin A 9.5010992263
MESH:D000138 Acidosis Ammonium Chloride 3.2618287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6417505938
MESH:D055371 Acute Lung Injury Bleomycin 13.9017118201
MESH:D055371 Acute Lung Injury Oxygen 13.9016759491
MESH:D055371 Acute Lung Injury pirinixic acid 13.9018653653
MESH:D000230 Adenocarcinoma arsenic trioxide 6.5719825857 11798837
MESH:D000230 Adenocarcinoma Estradiol 6.5711473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.5714692618
MESH:D018248 Adenoma, Liver Cell Phenobarbital 15.5717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.5716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.5716835633
MESH:D000380 Agranulocytosis Clozapine 4.7716160616 12649775 14617031
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 8.1917119214 16611668 11874814
MESH:D000382 Agricultural Workers' Diseases Diazinon 8.1916487989
MESH:D000550 Amblyopia Valproic Acid 4.9317688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.1311748828
MESH:D000740 Anemia Vitamin A 8.1316960172
MESH:D018798 Anemia, Iron-Deficiency Vitamin A 4.5416960172
MESH:D000799 Angioedema Acetaminophen 3.5410982225
MESH:D000860 Anoxia Bleomycin 10.6715782499
MESH:D000860 Anoxia Oxygen 10.6720872349
MESH:D001008 Anxiety Disorders Valproic Acid 3.3417497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4815885639
MESH:D001249 Asthma Mustard Gas 5.0310378619
MESH:D001249 Asthma Vitamin A 5.0316732791
MESH:D050197 Atherosclerosis Oxygen 3.6316391483
MESH:D001321 Autistic Disorder Acetaminophen 2.1518445737
MESH:D001321 Autistic Disorder Haloperidol 2.1518080171 19368416
MESH:D001321 Autistic Disorder Valproic Acid 2.1518985861 17507914 19232924 18316065 18775368 17688650 18177632 18940202 20603192 18396377 16609825 17157402 19460635 18558336 15238991
MESH:D001714 Bipolar Disorder Valproic Acid 2.9320046352 17594078
MESH:D001768 Blister Mustard Gas 4.8619167455
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 13.7516206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.7519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.7512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.4015746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.408888407
MESH:D001943 Breast Neoplasms decitabine 1.9519208741 18320071
MESH:D001943 Breast Neoplasms Estradiol 1.9512948864 19861407 17018787 17289903 16675129 14630087 18497071 17261762
MESH:D001943 Breast Neoplasms Oxygen 1.9517263869
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.8615286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.6810378619 17687719
MESH:D001997 Bronchopulmonary Dysplasia Vitamin A 5.3017426644 17377406
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.0611589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1716111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4916050911 15721981 18705752 3786805 16097048 10355542 16011737 15700767 16192424 16227642 16124888 15673190
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5716835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.313084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 8.3116217749 11135700 15073043 14691202 15553829
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.3118788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.3116924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 8.316705139 1701930 17173139 20007298 20935162
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.5719014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.8612490120
MESH:D002294 Carcinoma, Squamous Cell Bleomycin 4.956189445
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.9519215824
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2118670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.3116936243
MESH:D002375 Catalepsy Haloperidol 4.611977408 15215559
MESH:D002386 Cataract Acetaminophen 2.4110977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.5718566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.964080065
MESH:D002547 Cerebral Palsy Toluene 5.559294310
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6020734317
MESH:D015362 Child Nutrition Disorders Vitamin A 5.1816153327
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9216835633
MESH:D002779 Cholestasis Ethinyl Estradiol 12.2815861022 11677210 17110522 17681005 17333356 16105132 16919318
MESH:D002779 Cholestasis pirinixic acid 12.2819176532
MESH:D002779 Cholestasis Vitamin A 12.2816175620
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.7215668235 8697196 15340226 16354765 12621046
MESH:D002972 Cleft Palate Vitamin A 5.7216054864
MESH:D003072 Cognition Disorders Clozapine 4.6817123785
MESH:D003110 Colonic Neoplasms decitabine 3.9717616700
MESH:D003110 Colonic Neoplasms Vitamin A 3.9716267017 17219422
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.5120501625
MESH:D015179 Colorectal Neoplasms decitabine 2.5118981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8117141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 3.9012609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 6.9710525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 6.9720055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Toluene 6.979294310
MESH:D019465 Craniofacial Abnormalities Valproic Acid 6.978888407 17688650 16575769
MESH:D019465 Craniofacial Abnormalities Vitamin A 6.9710992263
MESH:D003643 Death Toluene 5.376431079
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 10.0215213294
MESH:D016757 Death, Sudden, Cardiac Haloperidol 10.0220210726
MESH:D003704 Dementia Haloperidol 4.3211575062
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2918249437
MESH:D003922 Diabetes Mellitus, Type 1 Vitamin A 3.4216506275
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 6.8516402076
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 6.8519647726
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.8517107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.1719279558
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.2515331141
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.1818713872 19370779 16227642 16393943 11834606 19164858 16109766 2444490 19416960 19923254 18071297 12594235 11461765 11421492 11287661 15968718 19739265 16485898 16177239 17522070 14986274 17562736 10663392 11743745 12958197 12392966 10915739 15619225 17906064 10774834 12540782 19420014 16081117 12705907 12153990 11529661 19085960 14550746 11739529 16781746 14725611
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.1810092053 16227642 6884620 11566570 15027814 7440962 2869522 10915739 7179309 7120509 17522070 9327722 3732212 19336974 4309450 15998439 6623471 21278145 16177239 3786805 19085960 15968718
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.1820420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 8.1819641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8019426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5511462148
MESH:D015352 Dry Eye Syndromes Vitamin A 5.5116146918
MESH:D004381 Duodenal Ulcer Ampicillin 5.7210671773
MESH:D050171 Dyslipidemias Clozapine 3.9716402076
MESH:D004417 Dyspnea Diazinon 9.7516487989
MESH:D004417 Dyspnea Oxygen 9.7520016425
MESH:D004421 Dystonia Phenobarbital 9.531851702
MESH:D004421 Dystonia Valproic Acid 9.531851702
MESH:C538011 Eales disease Vitamin A 5.329068938
MESH:D004480 Ectromelia Vitamin A 5.5216054864
MESH:D004487 Edema Bleomycin 14.3417118201
MESH:D004487 Edema Mustard Gas 14.349260866 11428647 11402378 11428631
MESH:D004487 Edema pirinixic acid 14.3412083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.3411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6016714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9112538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 13.0319294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 13.0319294695
MESH:D016889 Endometrial Neoplasms Estradiol 2.7918566989 11473722 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.779294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 9.833659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 9.8317275665 3659116
MESH:D004828 Epilepsies, Partial Phenobarbital 8.9811558140 3922381
MESH:D004828 Epilepsies, Partial Valproic Acid 8.9816628512 3922381
MESH:D004827 Epilepsy Phenobarbital 6.1620417680
MESH:D004827 Epilepsy Valproic Acid 6.1620417680 18234410
MESH:D004832 Epilepsy, Absence Phenobarbital 8.046401628
MESH:D004832 Epilepsy, Absence Valproic Acid 8.046426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 10.347750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 10.347750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 9.503659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 9.503659116
MESH:D004890 Erythema Mustard Gas 4.869357497
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.2412903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8011564622
MESH:D005234 Fatty Liver arsenic trioxide 21.8415073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 21.8412795759 19224547 17595544 12631006 15959796 16045604 16239168 61145
MESH:D005234 Fatty Liver Ethinyl Estradiol 21.8415345470
MESH:D005234 Fatty Liver pirinixic acid 21.8419236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 21.8414986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1711858732
MESH:D005315 Fetal Diseases Valproic Acid 4.5916575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.858888407 18558336
MESH:D005327 Fetal Resorption Vitamin A 5.0616054864
MESH:D005355 Fibrosis Carbon Tetrachloride 7.6418705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.6420067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.9816904648
MESH:D005739 Gas Poisoning Oxygen 4.9220016425
MESH:D005756 Gastritis Acetaminophen 3.3816983495
MESH:D005909 Glioblastoma trichostatin A 3.6418801729
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2910696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.2919215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.3911294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin A 6.3916080930 10992263
MESH:D006333 Heart Failure pirinixic acid 2.3620558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0711000095
MESH:D006505 Hepatitis Carbon Tetrachloride 8.6819110552 19900420
MESH:D006505 Hepatitis Diazinon 8.6816487989
MESH:D006529 Hepatomegaly Phenobarbital 12.7116109766
MESH:D006529 Hepatomegaly pirinixic acid 12.7118467677 19772884 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.7116120746 12621046 15340226
MESH:D006548 Hernia, Diaphragmatic Vitamin A 3.5116292552 16863852 15707848 17436238 16490937 16877224
MESH:D006558 Herpes Genitalis Estradiol 4.7315709030
MESH:D015658 HIV Infections Vitamin A 3.6716960176
MESH:D006679 HIV Seropositivity Vitamin A 5.3017209195
MESH:D006689 Hodgkin Disease Bleomycin 4.1317606976 15147373 18501091
MESH:D019584 Hot Flashes Estradiol 3.4517088409
MESH:D006849 Hydrocephalus Valproic Acid 4.5717688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7515340226 16354765 8697196 16959395 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.4716870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2416899240
MESH:D006943 Hyperglycemia pirinixic acid 2.9320558911
MESH:D006948 Hyperkinesis Clozapine 10.8416046005
MESH:D006948 Hyperkinesis Methamphetamine 10.8417658665
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8018850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8015338365
MESH:D006986 Hypervitaminosis A Vitamin A 5.8716054864
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1912013081
MESH:D007248 Infertility, Male decitabine 10.2117581917
MESH:D007248 Infertility, Male Diazinon 10.2112948887 16466525
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.2117937319
MESH:D007249 Inflammation Bleomycin 7.6117118201
MESH:D007249 Inflammation Mustard Gas 7.6111428620 9357497 9260866 17524151 8975870 16001271 11402378 11428631 11428647
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.6112200463 12878042
MESH:D007333 Insulin Resistance Estradiol 6.5616627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.5616306350
MESH:D019586 Intracranial Hypertension Vitamin A 5.5215955940
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0716580747
MESH:D007674 Kidney Diseases Acetaminophen 5.3215629191 12587719
MESH:D007674 Kidney Diseases Estradiol 5.3215618244
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.0116518626
MESH:D007680 Kidney Neoplasms Estradiol 2.7515610895
MESH:D007938 Leukemia arsenic trioxide 5.9615070760
MESH:D007938 Leukemia decitabine 5.9618980019 19235587
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.5312560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.0116972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2114633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.7119077051
MESH:D007951 Leukemia, Myeloid decitabine 8.7118454857 19117987 17236224
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 8.3119850784 20471514 16968895 17050201 16467208
MESH:D015470 Leukemia, Myeloid, Acute decitabine 8.3117679729 18460780 19387464 18704418 19010910 18206229
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 8.3118206229
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 8.3117596541 16294345
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.1618055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.029834237 15336539 11161223 15748426 19035177 17217047 12679006 12018890 19225113 16330433 19642359 15622746 16891316 17107899 16823087 17712046 17649720 12712474 16112521 17869043 15213294 16331271 11468182 16966277 19075265
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.0716882451
MESH:D017880 Limb Deformities, Congenital Vitamin A 4.1116054864
MESH:D008064 Lipidoses Clozapine 3.7517567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.2116221502 17174718 16943688 17334410 11408273 11903743 21278145 17157831 16239168
MESH:D008103 Liver Cirrhosis Phenobarbital 10.2121047994
MESH:D008103 Liver Cirrhosis Vitamin A 10.2116256175
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.3112389079 17714472 17805973 12632512 18054572 17631135 14512876 12741479 15052691 18187930 18210741 17976157 15893842 17761835 18006644 12609069 17922224 18395095 14716496 18418968 16015684 20821823 12649538 12667390 17698563 18166357 18472332 17525996 17481882 17640975 18317297 12445421 15650968 18420326 18395914 15876570 15931870 11481614 17565644 16027843 16116963 15362042 12445418 12586293 16248980 18339082 16638106 15123356 18412020 18251166 18472094 15818738 17869086 15996030 15338365 18481824 15370692 15959796 12666154 14716833 15925388 18263696 14748882 15730626 14620537 16192424 18277467 17900296 16136751 16097048 17823541 12898905 15057751 18705752 17721639 16033810 10355542 12546737 17708605 18376398 18279442 15673190 12958196 17766677 18156304 13678700 14724832 18205269 16011737 17557913 12632514 18429990 17944888
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.3114659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.3115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.3112878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin A 6.3116248980
MESH:D008107 Liver Diseases Acetaminophen 11.6716610002 12587719 12969438 16611625 19014921 11587558 19460945 19784758
MESH:D008107 Liver Diseases Carbon Tetrachloride 11.6715720792 16246199 17285989 16964402 15830285
MESH:D008107 Liver Diseases Chlorpyrifos 11.6715991261
MESH:D008107 Liver Diseases Phenobarbital 11.6719363144
MESH:D008107 Liver Diseases Vitamin A 11.6716175620
MESH:D008108 Liver Diseases, Alcoholic Vitamin A 4.8716762690
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.5617185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.5614706259 16899240
MESH:D008113 Liver Neoplasms arsenic trioxide 12.9914682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 12.9919294768
MESH:D008113 Liver Neoplasms Phenobarbital 12.9915975961 8742319 19482888 19073162 19812893 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 12.9920007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 12.9916984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 16.7120377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 16.7115583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 16.7118308698 1399818 6150874 17172636 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 16.7112151625
MESH:D008114 Liver Neoplasms, Experimental Vitamin A 16.7117113696
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1315213294
MESH:D008171 Lung Diseases Mustard Gas 7.2318161513 18702808
MESH:D008171 Lung Diseases Vitamin A 7.2316863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.9617228818
MESH:D055370 Lung Injury Oxygen 4.2218339021
MESH:D008175 Lung Neoplasms arsenic trioxide 4.6111798837 19825857
MESH:D008175 Lung Neoplasms Bleomycin 4.616189445
MESH:D008175 Lung Neoplasms Mustard Gas 4.613148597 8781369
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.6111884234 19555203
MESH:D008223 Lymphoma decitabine 3.2119470736
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 5.7212807724
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.7211408345 16891317 17203775 11807958
MESH:D020149 Manganese Poisoning Estradiol 4.1819453300
MESH:D008545 Melanoma Bleomycin 5.0915577320
MESH:D008545 Melanoma decitabine 5.0917785578 16505122
MESH:D008545 Melanoma trichostatin A 5.0916505122
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2819513568
MESH:D001523 Mental Disorders Clozapine 7.3916856516
MESH:D001523 Mental Disorders Haloperidol 7.3916856516
MESH:D008607 Mental Retardation Toluene 3.559294310
MESH:D024821 Metabolic Syndrome X Clozapine 4.1719142101
MESH:D008881 Migraine Disorders Valproic Acid 2.9818803445 18765137
MESH:D019957 Motor Skills Disorders Toluene 4.969294310
MESH:D009101 Multiple Myeloma arsenic trioxide 15.6314977855 19549372 15949261 11468182 19417148
MESH:D009101 Multiple Myeloma decitabine 15.6318172295
MESH:D009101 Multiple Myeloma trichostatin A 15.6318172295
MESH:D009101 Multiple Myeloma Vitamin A 15.6316374440
MESH:D009135 Muscular Diseases pirinixic acid 3.2216239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.768888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.3718349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 11.3716105982 16882451
MESH:D009190 Myelodysplastic Syndromes decitabine 11.3719010910 18608210 19157545 16882708
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 11.3717596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7912213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.5116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.5116411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.1817484760
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.6816624393
MESH:D009369 Neoplasms decitabine 4.5319470736 17925555 19116145
MESH:D009369 Neoplasms pirinixic acid 4.5317405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4417289903
MESH:D009421 Nervous System Malformations Estradiol 8.5311399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.5314600291
MESH:D009436 Neural Tube Defects arsenic trioxide 11.1810525206
MESH:D009436 Neural Tube Defects Valproic Acid 11.188888407 16359493
MESH:D009436 Neural Tube Defects Vitamin A 11.1817400914
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6318514411
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 3.9715081274
MESH:D009503 Neutropenia Mustard Gas 3.707688884 16761898
MESH:D009765 Obesity Clozapine 4.4418515891 19142110
MESH:D009765 Obesity pirinixic acid 4.4420558911
MESH:D010018 Osteomalacia Phenobarbital 4.0717016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 10.5316624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms decitabine 10.5319259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 10.5319401270
MESH:D010051 Ovarian Neoplasms trichostatin A 10.5319331143
MESH:D010146 Pain Acetaminophen 2.1616870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 11.4815580305
MESH:D010190 Pancreatic Neoplasms decitabine 11.4819294695
MESH:D010190 Pancreatic Neoplasms Phenobarbital 11.4816965848
MESH:D010190 Pancreatic Neoplasms trichostatin A 11.4819294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4111578682
MESH:D010212 Papilloma Hydrogen Peroxide 3.8012065085
MESH:D010235 Paraganglioma arsenic trioxide 3.8919927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9512520081
MESH:D011014 Pneumonia Bleomycin 5.1118024389 16317386 17071938
MESH:D011041 Poisoning Diazinon 8.1217603234
MESH:D011041 Poisoning Mustard Gas 8.1215727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2818163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.382563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.4811399792 11896295 11222880 11118676
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 8.4820603192
MESH:D055728 Primary Myelofibrosis decitabine 11.4617616702
MESH:D055728 Primary Myelofibrosis trichostatin A 11.4617616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6220887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.7619131511
MESH:D011471 Prostatic Neoplasms Estradiol 2.7616740699
MESH:D011471 Prostatic Neoplasms trichostatin A 2.7619789329 18798265
MESH:D011537 Pruritus Ethinyl Estradiol 8.5416919318 15861022
MESH:D011537 Pruritus Mustard Gas 8.5418058305
MESH:D019310 Pseudolymphoma Phenobarbital 11.1912752131
MESH:D019310 Pseudolymphoma Valproic Acid 11.1912752131 11422049
MESH:D011595 Psychomotor Agitation Haloperidol 4.6711575062
MESH:D011618 Psychotic Disorders Clozapine 8.4615331141
MESH:D011618 Psychotic Disorders Haloperidol 8.4611575062
MESH:D011654 Pulmonary Edema Bleomycin 5.0215808516
MESH:D011658 Pulmonary Fibrosis Bleomycin 5.8318162602 15541506 21435439 17434272 16115399 17241526 12574379 14609568 16314464 15322207 18008008 11554783 17177178 12624602
MESH:D011658 Pulmonary Fibrosis Mustard Gas 5.8317266442 17720292 17620002 17894541 10334151
MESH:D015427 Reperfusion Injury pirinixic acid 2.2419058328
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 4.2418339021 17627322
MESH:D012127 Respiratory Distress Syndrome, Newborn Vitamin A 5.5116877224
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.3516611668 11874814 17119214
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5618990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.5916611668 17119214
MESH:D012208 Rhabdomyosarcoma decitabine 10.0719155313
MESH:D012208 Rhabdomyosarcoma Valproic Acid 10.0719155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.6816646077
MESH:D012559 Schizophrenia Clozapine 5.4218855531 20521326 20168265 19369910 20107430 17123785 16141801 11151749 20580759 20452607 11763009 17667964 17726453 20521320 18806925
MESH:D012559 Schizophrenia Haloperidol 5.4220107430 19369910 1830565 18513383
MESH:D012559 Schizophrenia Valproic Acid 5.4219110320 15737665
MESH:D012640 Seizures Phenobarbital 8.8416876388 11442880 4039156 3137016
MESH:D012640 Seizures Toluene 8.846431079 9294310
MESH:D012640 Seizures Valproic Acid 8.8414763951 11044598 15475178 3137016 11738929 16876388 1511512 17978042
MESH:D003294 Seizures, Febrile Phenobarbital 4.536407741
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.796418539
MESH:D012852 Sinusitis Ampicillin 6.227327846
MESH:D012871 Skin Diseases Mustard Gas 5.0912880345 15451306 16961503
MESH:D012871 Skin Diseases Vitamin A 5.0918709164
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 5.2612065085
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.2616192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6416709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.5619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.2412833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4917007042
MESH:D013274 Stomach Neoplasms decitabine 2.4919037991
MESH:D013398 Sudden Infant Death Oxygen 5.2512563064
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.4320210726
MESH:D013733 Testicular Diseases Toluene 4.6610514026 10048760
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6012697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 10.7419014326
MESH:D013964 Thyroid Neoplasms decitabine 10.7417967635
MESH:D013964 Thyroid Neoplasms Phenobarbital 10.741399818
MESH:D013978 Tibial Fractures Estradiol 4.3919048282
MESH:D016171 Torsades de Pointes arsenic trioxide 3.6715213294
MESH:D014178 Translocation, Genetic Valproic Acid 4.9317262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.233119515
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 4.8512973940 11780464 12845720 20435036
MESH:D001749 Urinary Bladder Neoplasms decitabine 4.8517616700 19087683
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.358888407
MESH:D014570 Urologic Diseases Diazinon 4.9816487989
MESH:D014581 Urticaria Acetaminophen 2.7110982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0214692618
MESH:D014604 Uveal Neoplasms decitabine 4.6117785578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2912125929
MESH:D014689 Venous Insufficiency coumarin 5.4812708602
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2815869587 14671159
MESH:D014802 Vitamin A Deficiency Vitamin A 5.0016960172 16146918 16175781
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9515886252
MESH:D015430 Weight Gain Clozapine 4.2220521320 20107430 20564506 17502770 16141801 16402076
MESH:D015431 Weight Loss Bleomycin 11.4312624602
MESH:D015431 Weight Loss Clozapine 11.4317933447
Pathway ID Pathway Name
REACT:19419 Amino acid and oligopeptide SLC transporters
KEGG:05014 Amyotrophic lateral sclerosis (ALS)
KEGG:04724 Glutamatergic synapse
REACT:13685 Synaptic Transmission
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35827
    • No data
    No data
    Releated drug ID Related drug Name
    PA452229antidepressants
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00142 - L-Glutamic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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