AutismKB 2.0

Annotation Detail for SLC1A3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SLC1A3 ( EA6,EAAT1,FLJ25094,GLAST,GLAST1 )
Gene Full Name: solute carrier family 1 (glial high affinity glutamate transporter), member 3
Band: 5p13.2
Quick LinksEntrez ID:6507; OMIM: 600111; Uniprot ID:EAA1_HUMAN; ENSEMBL ID: ENSG00000079215; HGNC ID: 10941
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Synaptic Transmission
Transmembrane transport of small molecules
Amino acid and oligopeptide SLC transporters
No data
Pathway IDPathway Name
P00039Metabotropic glutamate receptor group III pathway
P00037Ionotropic glutamate receptor pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
1877Multiple sclerosis
2069Schizophrenia
2190Attention deficit hyperactivity disorder
No data
No data
Desease Name
Episodic ataxia, type 6
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of SLC1A3 mRNAdecreases expression 19933214
D020106 Acrylamide Acrylamide results in increased expression of SLC1A3 mRNAincreases expression 12853321
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC1A3 mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in increased oxidation of SLC1A3 mRNAincreases oxidation 18506841
C095105 bexarotene bexarotene results in decreased expression of SLC1A3 mRNAdecreases expression 16648578
C006780 bisphenol A bisphenol A affects the expression of SLC1A3 mRNAaffects expression 20170705
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of SLC1A3 proteindecreases expression 17544377
D003975 Diazepam Diazepam results in increased oxidation of SLC1A3 mRNAincreases oxidation 18506841
D003976 Diazinon Diazinon results in decreased expression of SLC1A3 mRNAdecreases expression 17452286
D004041 Dietary Fats Dietary Fats results in decreased expression of SLC1A3 mRNAdecreases expression 18042831
D004958 Estradiol Estradiol inhibits the reaction [Manganese results in decreased expression of SLC1A3 mRNA]decreases expression|decreases reaction 19453300
D004958 Estradiol Estradiol inhibits the reaction [Manganese results in decreased expression of SLC1A3 protein]decreases expression|decreases reaction 19453300
D004958 Estradiol Estradiol results in increased expression of SLC1A3 mRNAincreases expression 19453300
D004958 Estradiol Estradiol results in increased expression of SLC1A3 proteinincreases expression 19453300
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of SLC1A3 mRNAaffects expression 20170705
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of SLC1A3 mRNAdecreases expression 15834898
17557909
D006220 Haloperidol Haloperidol results in decreased expression of SLC1A3 mRNAdecreases expression 15860345
D016627 Oxidopamine Oxidopamine results in increased expression of SLC1A3 mRNAincreases expression 15518916
D008345 Manganese Estradiol inhibits the reaction [Manganese results in decreased expression of SLC1A3 mRNA]decreases expression|decreases reaction 19453300
D008345 Manganese Estradiol inhibits the reaction [Manganese results in decreased expression of SLC1A3 protein]decreases expression|decreases reaction 19453300
D008345 Manganese Manganese results in decreased expression of SLC1A3 mRNAdecreases expression 19453300
D008345 Manganese Manganese results in decreased expression of SLC1A3 proteindecreases expression 19453300
D008345 Manganese Tamoxifen inhibits the reaction [Manganese results in decreased expression of SLC1A3 mRNA]decreases expression|decreases reaction 19453300
D008345 Manganese Tamoxifen inhibits the reaction [Manganese results in decreased expression of SLC1A3 protein]decreases expression|decreases reaction 19453300
D009151 Mustard Gas Mustard Gas results in increased expression of SLC1A3 mRNAincreases expression 15674844
D015058 1-Naphthylisothiocyanate 1-Naphthylisothiocyanate results in increased expression of SLC1A3 mRNAincreases expression 12832660
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in decreased expression of SLC1A3 mRNAdecreases expression 17616710
D010126 Ozone Ozone results in decreased expression of SLC1A3 mRNAdecreases expression 17095637
C041786 palm oil palm oil results in decreased expression of SLC1A3 mRNAdecreases expression 18042831
D010656 Phenylephrine Phenylephrine results in increased expression of SLC1A3 mRNAincreases expression 18158353
C006253 pirinixic acid pirinixic acid results in increased expression of SLC1A3 mRNAincreases expression 12832660
D013629 Tamoxifen Tamoxifen inhibits the reaction [Manganese results in decreased expression of SLC1A3 mRNA]decreases expression|decreases reaction 19453300
D013629 Tamoxifen Tamoxifen inhibits the reaction [Manganese results in decreased expression of SLC1A3 protein]decreases expression|decreases reaction 19453300
D013629 Tamoxifen Tamoxifen results in increased expression of SLC1A3 mRNAincreases expression 19453300
D013629 Tamoxifen Tamoxifen results in increased expression of SLC1A3 proteinincreases expression 19453300
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SLC1A3 mRNAdecreases expression 19933214
D014415 Tunicamycin Tunicamycin results in increased expression of SLC1A3 mRNAincreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3814745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6811752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.3918287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7717505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.9618653653
MESH:D000230 Adenocarcinoma Estradiol 4.0711473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.0714692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.3316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.3316835633
MESH:D000382 Agricultural Workers' Diseases Diazinon 4.1616487989
MESH:D000544 Alzheimer Disease Ozone 2.4015513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8011748828
MESH:D000756 Anemia, Sideroblastic Manganese 4.7116910769
MESH:D001008 Anxiety Disorders Diazepam 5.0616284244 18313124
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.9617460149
MESH:D001161 Arteriosclerosis Dietary Fats 9.3415238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.3411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5615885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5215570426
MESH:D001249 Asthma Mustard Gas 4.9110378619
MESH:D001249 Asthma Ozone 4.9117854713 16373670
MESH:D001289 Attention Deficit Disorder with Hyperactivity Oxidopamine 4.5414699433
MESH:D001321 Autistic Disorder marker/mechanism 11706102
MESH:D001321 Autistic Disorder Haloperidol 2.7519368416 18080171
MESH:D001768 Blister Mustard Gas 4.9919167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.2519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6515746008
MESH:D001862 Bone Resorption bisphenol A 3.7111985600
MESH:D001919 Bradycardia Phenylephrine 4.3715306635
MESH:D001943 Breast Neoplasms Acrylamide 3.6618183576 16253758
MESH:D001943 Breast Neoplasms bexarotene 3.6616344269 16818667
MESH:D001943 Breast Neoplasms bisphenol A 3.6617123778
MESH:D001943 Breast Neoplasms Dietary Fats 3.6620435547
MESH:D001943 Breast Neoplasms Estradiol 3.6617289903 19861407 17261762 12948864 14630087 16675129 17018787 18497071
MESH:D001943 Breast Neoplasms Tamoxifen 3.6619115204 18855134 18815881 16818667 15565566 19189210 19410462 19142967 19221464 19059307 21152245 18821012 20544844 18984771 17049068 19066611 20390343 16202921 21138602 11161223 19487384 16273361 17261762 20135344 17440819 19084267 19200415 20005174 19289846 19244106 19288272 15668708 20859285 19011961 17893378 17242785 19189212 18629630 16873071 19155303 18425577 20065188 19103187 18351453 18997820
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.6620435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5415516495 17626835 19059883 16777450 18315731 18417511 14754758
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.9915286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.8017687719 10378619
MESH:D002100 Cachexia Ozone 4.5716183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2916111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6116097048 16124888 16011737 15700767 3786805 18705752 16050911 15721981 16192424 15673190 10355542 16227642
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3419066611
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.4218788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.4216924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.4216924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.8217123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.1716247446
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4617572228
MESH:D006332 Cardiomegaly Phenylephrine 6.5716170337 11754973 17287366 17124262 11179087 15728586
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.5718850075 16120746 18670907
MESH:D002375 Catalepsy Haloperidol 4.7415215559 1977408
MESH:D002418 Cattle Diseases Acrylamide 5.2812510666
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.6618566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D002761 Cholangitis 1-Naphthylisothiocyanate 6.0312912871
MESH:D002779 Cholestasis 1-Naphthylisothiocyanate 12.8015913567 12927374 19486331 18164287 7624871 18590720 16629650 15500046
MESH:D002779 Cholestasis Ethinyl Estradiol 12.8017110522 15861022 11677210 17681005 17333356 16919318 16105132
MESH:D002779 Cholestasis pirinixic acid 12.8019176532
MESH:D002780 Cholestasis, Intrahepatic 1-Naphthylisothiocyanate 5.6810220858 19407337
MESH:D002972 Cleft Palate Diazepam 6.153629520
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.1515668235 12621046 15340226 16354765 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2515322242 20055451 10048152
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.6820210726
MESH:D003704 Dementia Haloperidol 4.4211575062
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1919031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3518249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6317107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.3619279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.3619279558
MESH:D056486 Drug-Induced Liver Injury 1-Naphthylisothiocyanate 6.0317522070 20133375 18289764 7624871
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.039327722 3786805 6884620 19085960 21278145 6623471 2869522 15998439 17522070 3732212 10915739 7440962 10092053 19336974 4309450 16177239 7179309 7120509 15027814 11566570 15968718 16227642
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.0320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6311462148
MESH:D050171 Dyslipidemias Dietary Fats 3.3318367378
MESH:D004417 Dyspnea Diazinon 4.6316487989
MESH:D004421 Dystonia Diazepam 5.511851702
MESH:D004487 Edema Mustard Gas 10.5311402378 11428647 9260866 11428631
MESH:D004487 Edema pirinixic acid 10.5312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.5311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7315322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.3912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.3919031437
MESH:D016889 Endometrial Neoplasms Estradiol 7.0218566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.0216202921 20544844 19155303 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8710568697 9294722
MESH:D004828 Epilepsies, Partial Diazepam 5.373922381
MESH:D004827 Epilepsy Diazepam 4.47821787
MESH:D004832 Epilepsy, Absence Diazepam 5.066401628 6426943
OMIM:612656 EPISODIC ATAXIA, TYPE 6 marker/mechanism
MESH:D004890 Erythema Mustard Gas 4.999357497
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 2.7315878914 16510608 15623463 15547721 16704527 15264214 16805852 15150132 15547733
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8911564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 22.9817595544 16045604 16239168 12795759 19224547 61145 15959796 12631006
MESH:D005234 Fatty Liver Dietary Fats 22.9817967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 22.9815345470
MESH:D005234 Fatty Liver pirinixic acid 22.9819236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 22.9819224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1316709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2911858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3514745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.0119069698
MESH:D005355 Fibrosis Carbon Tetrachloride 13.7718705752
MESH:D005355 Fibrosis Dietary Fats 13.7718296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.7720067830
MESH:D005909 Glioblastoma Manganese 3.8117043766
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2411294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.4320558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1811000095
MESH:D006505 Hepatitis 1-Naphthylisothiocyanate 14.9718590720
MESH:D006505 Hepatitis Carbon Tetrachloride 14.9719900420 19110552
MESH:D006505 Hepatitis Diazinon 14.9716487989
MESH:D006529 Hepatomegaly pirinixic acid 7.7016221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.7015340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.8615709030
MESH:D019584 Hot Flashes Estradiol 3.5817088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8716354765 16959395 8697196 15340226 18606429
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3616899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4421332399
MESH:D006943 Hyperglycemia pirinixic acid 3.0320558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.4521332399
MESH:D006973 Hypertension Phenylephrine 5.098949925 12717712
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0918670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9215338365
MESH:D006984 Hypertrophy Phenylephrine 4.4018502941 12791704
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6416569931 16945680
MESH:D007247 Infertility, Female Acrylamide 9.8511020651
MESH:D007247 Infertility, Female Ethinyl Estradiol 9.8512013081
MESH:D007248 Infertility, Male Acrylamide 10.8215355880 11020651 12507653 15749267
MESH:D007248 Infertility, Male Diazinon 10.8212948887 16466525
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.8217937319
MESH:D007249 Inflammation Dietary Fats 11.2320412841
MESH:D007249 Inflammation Mustard Gas 11.2317524151 11428647 8975870 9357497 9260866 16001271 11402378 11428620 11428631
MESH:D007249 Inflammation Tamoxifen 11.2319457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.2312200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 16.7316393666
MESH:D007333 Insulin Resistance Dietary Fats 16.7311836018 18457598
MESH:D007333 Insulin Resistance Estradiol 16.7316627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 16.7316306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1816580747
MESH:D007674 Kidney Diseases Estradiol 2.4915618244
MESH:D007680 Kidney Neoplasms Estradiol 6.9215610895
MESH:D007680 Kidney Neoplasms Tamoxifen 6.9218625569
MESH:D008064 Lipidoses Tamoxifen 3.0317567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.3211408273 16221502 11903743 17334410 16943688 17174718 21278145 16239168 17157831
MESH:D008103 Liver Cirrhosis Dietary Fats 6.3218296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.4918418968 18429990 15959796 16027843 18277467 17714472 15052691 15673190 17766677 18339082 12609069 12898905 17922224 12586293 16638106 17708605 15123356 12546737 13678700 17557913 18166357 18279442 16097048 15818738 18481824 18251166 18472332 15996030 17900296 18205269 16116963 12445418 17640975 18395914 12666154 12632514 15925388 15338365 12667390 18210741 17698563 17805973 17565644 18054572 17869086 18376398 16011737 16248980 17944888 17761835 16192424 16015684 12632512 12741479 17631135 15730626 17976157 18412020 18156304 14716496 18263696 10355542 16033810 17721639 12389079 15057751 18317297 12958196 15876570 14512876 12649538 18705752 14724832 15370692 18420326 15893842 16136751 17481882 14748882 15650968 17525996 18395095 14716833 15931870 18006644 20821823 17823541 18472094 18187930 12445421 15362042 11481614 14620537
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.4914716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.4915474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.4918564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.4912878042
MESH:D008107 Liver Diseases 1-Naphthylisothiocyanate 4.3217184895
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.3216246199 15830285 15720792 16964402 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9915123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.5416899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 10.1319294768
MESH:D008113 Liver Neoplasms pirinixic acid 10.1316377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 10.1316684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.1316984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.4112014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.4112151625
MESH:D008171 Lung Diseases Mustard Gas 7.2418702808 18161513
MESH:D008171 Lung Diseases Ozone 7.2419066396 8266340
MESH:D055370 Lung Injury Ozone 3.6820417186
MESH:D008175 Lung Neoplasms bexarotene 6.3817849452
MESH:D008175 Lung Neoplasms Mustard Gas 6.388781369 3148597
MESH:D008175 Lung Neoplasms Ozone 6.387614698 8597069
MESH:D008175 Lung Neoplasms Tamoxifen 6.3818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.3819555203 11884234
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.9811161223
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5919428831
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 9.4119196722 15591091 19196723
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.4111807958 17203775 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.4116827153 19196722 19196723 14580682 11731420
MESH:D020149 Manganese Poisoning Estradiol 21.3919453300
MESH:D020149 Manganese Poisoning Manganese 21.3916551646 19453300 16568477
MESH:D020149 Manganese Poisoning Tamoxifen 21.3919453300
MESH:D008545 Melanoma Tamoxifen 1.8619393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.0115990972
MESH:D001523 Mental Disorders Haloperidol 3.8416856516
MESH:D008679 Metaplasia Ozone 4.9310496685
MESH:D009069 Movement Disorders Manganese 4.8516551646
MESH:D009135 Muscular Diseases pirinixic acid 3.3416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.0719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.8116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.8116411023
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4619410462
MESH:D009369 Neoplasms pirinixic acid 1.8717405874
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 10.3619196722
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 10.3619189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5617289903
MESH:D009410 Nerve Degeneration Acrylamide 8.7111264303 12387366 12387367
MESH:D009410 Nerve Degeneration Manganese 8.7116551646
MESH:D009422 Nervous System Diseases Acrylamide 4.8412164553 12507653
MESH:D009421 Nervous System Malformations bisphenol A 15.3911399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 15.3911399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.3914600291
MESH:D019636 Neurodegenerative Diseases Oxidopamine 4.6218514411
MESH:D009503 Neutropenia Mustard Gas 3.817688884 16761898
MESH:D009765 Obesity Dietary Fats 4.2920132043 18457598 21332399 18674790 11836018 16723640 17217161 20518802 19632207
MESH:D009765 Obesity pirinixic acid 4.2920558911
MESH:D010049 Ovarian Diseases bisphenol A 4.8211985600
MESH:D010051 Ovarian Neoplasms Estradiol 2.1719401270
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5311578682
MESH:D010300 Parkinson Disease Manganese 3.3111181820
MESH:D010302 Parkinson Disease, Secondary Oxidopamine 5.2915893579 11771942
MESH:D020734 Parkinsonian Disorders Manganese 4.3216140633
MESH:D010382 Peliosis Hepatis 1-Naphthylisothiocyanate 13.2120133375
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 13.2112520081
MESH:D010523 Peripheral Nervous System Diseases Acrylamide 4.9411510240
MESH:D010538 Peritonitis Ozone 3.9616369182
MESH:D011014 Pneumonia Ozone 4.2218381685 18929643 18007984
MESH:D011041 Poisoning Diazinon 8.4817603234
MESH:D011041 Poisoning Mustard Gas 8.4815727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3918163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 8.9310548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.9311896295 11222880 11118676 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.0320887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.0320887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.6116740699
MESH:D011471 Prostatic Neoplasms Estradiol 2.6116740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.6115067354
MESH:D011537 Pruritus Ethinyl Estradiol 8.9515861022 16919318
MESH:D011537 Pruritus Mustard Gas 8.9518058305
MESH:D011595 Psychomotor Agitation Haloperidol 4.7811575062
MESH:D011618 Psychotic Disorders Haloperidol 4.1311575062
MESH:D011629 Puberty, Precocious bisphenol A 4.6110548101
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8617720292 17894541 17266442 10334151 17620002
MESH:D015427 Reperfusion Injury pirinixic acid 2.3019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6718990726
MESH:D012559 Schizophrenia Haloperidol 2.7820107430 18513383 1830565 19369910
MESH:D012640 Seizures Diazepam 4.259754883 15946322 10087439
MESH:D012852 Sinusitis Phenylephrine 4.537327846
MESH:D012871 Skin Diseases Mustard Gas 2.6715451306 16961503 12880345
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.9716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 10.9816709447
MESH:D013088 Spermatocele Tamoxifen 10.9816709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8719457130
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.3212958204 17575124
MESH:D019966 Substance-Related Disorders bisphenol A 3.8116045194 16684133
MESH:D013375 Substance Withdrawal Syndrome Diazepam 5.299754883
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.5420210726
MESH:D013733 Testicular Diseases Acrylamide 5.0615864552
MESH:D013921 Thrombocytopenia 1-Naphthylisothiocyanate 4.6020133375
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7312697716
MESH:D013978 Tibial Fractures Estradiol 4.5119048282
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.2917572228 16712894 8653321
MESH:D014570 Urologic Diseases Diazinon 5.1016487989
MESH:D014591 Uterine Diseases bisphenol A 4.8414652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1314692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0815886252
MESH:D015430 Weight Gain Dietary Fats 3.5916723640
Pathway ID Pathway Name
REACT:19419 Amino acid and oligopeptide SLC transporters
KEGG:04724 Glutamatergic synapse
REACT:13685 Synaptic Transmission
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35828
    • Releated gene ID Related gene Name
    PA120CRP
    Releated disease ID Related disease Name
    PA447216Schizophrenia
    Releated drug ID Related drug Name
    PA452347glucocorticoids
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00142 - L-Glutamic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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