AutismKB 2.0

Annotation Detail for NOL6


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Basic Information Top
Gene Symbol:NOL6 ( FLJ21959,MGC14896,MGC14921,MGC20838,NRAP,UTP22,bA311H10.1 )
Gene Full Name: nucleolar protein family 6 (RNA-associated)
Band: 9p13.3
Quick LinksEntrez ID:65083; OMIM: 611532; Uniprot ID:NOL6_HUMAN; ENSEMBL ID: ENSG00000165271; HGNC ID: 19910
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of NOL6 mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone results in increased expression of NOL6 mRNAincreases expression 19774075
C006632 arsenic trioxide arsenic trioxide results in increased expression of NOL6 mRNAincreases expression 20458559
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of NOL6 mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of NOL6 mRNAaffects cotreatment|affects expression 17602206
C025643 vinclozolin vinclozolin affects the expression of NOL6 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3419825857 11798837
MESH:D000236 Adenoma Diethylnitrosamine 3.0110737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.3619061943 18056438 17162532 17620307 16434500 19052882
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001008 Anxiety Disorders vinclozolin 3.8919015723
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.1120041841 18057881 18218290
MESH:D001281 Atrial Fibrillation Amiodarone 4.1319698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 10.3819483382
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 10.3816206674
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2017474063
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6811589617
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.773084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.7715553829 14691202 15073043 16217749 11135700
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.7717978847 20101231 18210153 18978308 16328049 16569478 20935162 19394651 16288022 19208518 17173139 21159647 20514400 16830150 16502159 19107877 18393292 20084675 17055752 20524982 17138121 19519916 17428255 18494052 19171122 18665156 17761372 20214788 18788625 17162532 19539802 16807293 3084413 16779866 18506893 20432363 16878318 10737359 20727157 20512989 19701751 16540662 19052882 16681979 10672840 16935385 16698587 19418558 18691550 18971187 19822196 20007298 18056438 19335982 11831363 18785209 3581430 19919837 19383236
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.4019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.4212490120
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9815710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.5518974383
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.0621159647 7505956 2727394 17174075
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9719052882
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D003456 Cryptorchidism vinclozolin 4.7214966744
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4515213294
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2520387270
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6917522070 12540782 11287661 12594235 10915739 19370779 11461765 11739529 16109766 19420014 10663392 16393943 16781746 11743745 17906064 10774834 11834606 12392966 19739265 15968718 12705907 16081117 11421492 16485898 12958197 17562736 16227642 16177239 18071297 19085960 14986274 15619225 19416960 11529661 14725611 14550746 12153990 19164858 18713872 19923254 2444490
MESH:D056486 Drug-Induced Liver Injury Amiodarone 6.6915265979 18218290
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.6919107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.6416302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3712903497
MESH:D005234 Fatty Liver Amiodarone 15.1814986274
MESH:D005234 Fatty Liver arsenic trioxide 15.1815073043
MESH:D005234 Fatty Liver Diethylnitrosamine 15.1821071580 20387270
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.6416904648
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.4016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.8216417039
MESH:D006529 Hepatomegaly Amiodarone 4.1615265979
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006937 Hypercholesterolemia Amiodarone 4.209751232 8137927
MESH:D007037 Hypothyroidism Amiodarone 4.9317991464 18020914
MESH:D007248 Infertility, Male vinclozolin 3.2416467254
MESH:D007249 Inflammation Diethylnitrosamine 2.5218785209
MESH:D007674 Kidney Diseases Acetaminophen 2.3612587719 15629191
MESH:D007938 Leukemia arsenic trioxide 2.9615070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.1212560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6614633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1816467208 16968895 17050201 20471514 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4112712474 16966277 16823087 16331271 15213294 16330433 19075265 19225113 15622746 17217047 19035177 15336539 16112521 12679006 19642359 15748426 17649720 17869043 17107899 17712046 11468182 12018890 9834237 11161223 16891316
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.7316882451
MESH:D007984 Leydig Cell Tumor vinclozolin 5.1916417039
MESH:D008064 Lipidoses Amiodarone 3.7315342952 17567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9819638242 18665156 18522880 20032147 18407596
MESH:D008107 Liver Diseases Acetaminophen 4.1219784758 16611625 19014921 16610002 12587719 12969438 19460945 11587558
MESH:D008107 Liver Diseases Diethylnitrosamine 4.1217034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5417185352 16871587
MESH:D008113 Liver Neoplasms arsenic trioxide 8.1314682389
MESH:D008113 Liver Neoplasms Clofibric Acid 8.1317602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 8.1321167192 19638242 19073162 20137499 18977376 12771043 20434301 18644402 20405173 19294768 15885732 19690152 21071580 19812893 2862719 19833225 18978307 12112319 20118626 9163691 19254457 10737359 21047994 21278145 18648771 19256749 19996281 19426721 19551842 20452335 19255062 19499222 20501860 18754104 20583210 20492335 20101389 16942905 2422723 19642983 19850985 19427195 15175105 19090486
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.6120377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.6118253720 18079962 18164116 18544905 19519916 18775883 21159647 19009564 19126423 16267830 3124819 18093689 17942915 19539802 17174075 18308698 18282651 17854601 19004024 16842330 2563599 9362446
MESH:D008133 Long QT Syndrome Amiodarone 9.0117391786 11989578 15350150
MESH:D008133 Long QT Syndrome arsenic trioxide 9.0115213294
MESH:D008171 Lung Diseases Amiodarone 3.5712587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 5.0018516814
MESH:D008175 Lung Neoplasms arsenic trioxide 2.5611798837 19825857
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.5620970405 6695378 20512841 21163286
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3214977855 19549372 19417148 11468182 15949261
MESH:D009181 Mycoses Amiodarone 5.4212754197 17974566
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3016882451 16105982
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.3416624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.673581430 9029167
MESH:D009436 Neural Tube Defects arsenic trioxide 3.3110525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 9.0918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 9.0920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.6420387270
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4819769630 16624393 12452020
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.5815580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.5816540662
MESH:D010235 Paraganglioma arsenic trioxide 4.5119927285
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.842563599
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.3618042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.4018220299
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2219131511
MESH:D011472 Prostatitis vinclozolin 5.4018629315
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9512832656 11597910 12490602
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.3416646077
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.5518724381
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.5017007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.5018456281
MESH:D013276 Stomach Ulcer Amiodarone 3.6418087811
MESH:D013610 Tachycardia Amiodarone 4.6711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.5719225199
MESH:D013959 Thyroid Diseases Amiodarone 5.2819731979
MESH:D013964 Thyroid Neoplasms arsenic trioxide 8.0019014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 8.007505956
MESH:D013971 Thyrotoxicosis Amiodarone 5.2818020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 11.8511989578 17467628
MESH:D016171 Torsades de Pointes arsenic trioxide 11.8515213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5820435036 12973940 12845720 11780464
MESH:D014581 Urticaria Acetaminophen 3.3310982225
Pathway ID Pathway Name
KEGG:03008 Ribosome biogenesis in eukaryotes
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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