AutismKB 2.0

Annotation Detail for TMEM135


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Basic Information Top
Gene Symbol:TMEM135 ( DKFZp686I1974,FLJ22104 )
Gene Full Name: transmembrane protein 135
Band: 11q14.2
Quick LinksEntrez ID:65084; OMIM: NA; Uniprot ID:TM135_HUMAN; ENSEMBL ID: ENSG00000166575; HGNC ID: 26167
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of TMEM135 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of TMEM135 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of TMEM135 mRNAdecreases expression 20106945
20064835
D016572 Cyclosporine Cyclosporine results in decreased expression of TMEM135 mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of TMEM135 mRNAaffects expression 17555576
D017239 Paclitaxel TMEM135 protein affects the susceptibility to Paclitaxelaffects response to substance 16217747
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TMEM135 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of TMEM135 mRNAincreases expression 17426115
D013629 Tamoxifen Tamoxifen affects the expression of TMEM135 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of TMEM135 mRNAdecreases expression 15328365
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8714745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1315322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3220127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3214692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.766695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.8716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.8716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.4619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.4612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001859 Bone Neoplasms Paclitaxel 4.7915867366
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9817474063 20146248
MESH:D001943 Breast Neoplasms Paclitaxel 1.9818323546 15136595 18234424 16244791 18223236 16115903 16273361 11325840
MESH:D001943 Breast Neoplasms Tamoxifen 1.9819084267 21138602 19221464 18997820 19115204 19289846 17440819 17242785 15565566 11161223 19011961 19487384 19142967 20135344 18815881 18629630 19200415 18425577 19189212 19066611 21152245 19244106 15668708 20065188 17893378 16273361 19189210 19059307 16873071 18351453 20544844 20859285 16202921 18821012 20390343 17049068 19155303 20005174 18984771 18855134 17261762 19410462 16818667 19103187 19288272
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9820435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7619066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.833084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.8312907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 6.8316313753
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.8316924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8117572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6612371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis Cyclosporine 14.2319486331
MESH:D002779 Cholestasis Ethinyl Estradiol 14.2317110522 16919318 15861022 17681005 11677210 16105132 17333356
MESH:D002779 Cholestasis pirinixic acid 14.2319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.188697196 12621046 16354765 15668235 15340226
MESH:D015179 Colorectal Neoplasms Paclitaxel 2.4418802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6219031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6619279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.7317562736 19739265 19164858 12705907 2444490 10915739 19370779 18071297 19923254 19416960 16109766 11287661 10774834 11461765 12958197 18713872 11834606 10663392 19420014 14725611 14550746 17906064 15619225 16781746 14986274 12594235 12540782 17522070 16081117 11529661 12153990 11421492 15968718 11739529 16177239 16393943 12392966 11743745 19085960 16485898 16227642
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema pirinixic acid 7.2312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.2311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2218230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.7512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.7519031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1716202921 20544844 19155303 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2110568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.8016530937
MESH:D004938 Esophageal Neoplasms Paclitaxel 4.8016481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Cyclosporine 20.5219224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.5215345470
MESH:D005234 Fatty Liver pirinixic acid 20.5219236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 20.5214986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3516709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4719069698
MESH:D005355 Fibrosis Cyclosporine 9.3612639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.3620067830
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7710048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly pirinixic acid 9.1416221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.1415340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3615340226 16959395 8697196 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006973 Hypertension Cyclosporine 5.1710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1718670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Tamoxifen 5.2119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2112200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.1615629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.1618776723 8314463 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 7.8812371664
MESH:D007680 Kidney Neoplasms Tamoxifen 7.8818625569
MESH:D008064 Lipidoses Tamoxifen 3.3015342952 17567588
MESH:D008080 Liposarcoma Paclitaxel 5.0417353645
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5015474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5012878042
MESH:D008107 Liver Diseases Acetaminophen 1.6716610002 16611625 11587558 12969438 19014921 19784758 12587719 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4316871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 14.9718177683 15890375 2125692 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.9720195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 14.9720007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 14.9716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.9716984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.218603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2112151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.9914755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9918569708 20064080 6695378 18520028 18816296 20869020 20135361 20464547 17053015
MESH:D008175 Lung Neoplasms Tamoxifen 4.9918625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9919555203 11884234
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 4.2614749477
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0419428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7414580682 19196723 11731420 16827153 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.8719453300
MESH:D008545 Melanoma Paclitaxel 3.6216342250 12025231 12040289
MESH:D008545 Melanoma Tamoxifen 3.6212393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D009101 Multiple Myeloma Paclitaxel 3.8314749477
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009362 Neoplasm Metastasis Paclitaxel 6.2215867366
MESH:D009362 Neoplasm Metastasis Tamoxifen 6.2219393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5719410462
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1311141357
MESH:D009369 Neoplasms pirinixic acid 5.1317405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3219200415 19189210 19196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4719348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D010014 Osteolysis Paclitaxel 5.2615867366
MESH:D010051 Ovarian Neoplasms Paclitaxel 3.0411161223
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811896295 11222880 11118676 11399792
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5717292933
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.5716729912 16356831 17136230 17172428
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5715067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.6015861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7610029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7616192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.6516709447
MESH:D013088 Spermatocele Tamoxifen 12.6516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3219457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.622093021 20155912
MESH:D013274 Stomach Neoplasms Paclitaxel 2.6218506536 18396642
MESH:D024801 Tauopathies Paclitaxel 5.1016930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2317053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.238653321 17572228 16712894
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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