AutismKB 2.0

Annotation Detail for SLC1A6


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Basic Information Top
Gene Symbol:SLC1A6 ( EAAT4,MGC33092,MGC43671 )
Gene Full Name: solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
Band: 19p13.12
Quick LinksEntrez ID:6511; OMIM: 600637; Uniprot ID:EAA4_HUMAN; ENSEMBL ID: ENSG00000105143; HGNC ID: 10944
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Synaptic Transmission
Transmembrane transport of small molecules
Amino acid and oligopeptide SLC transporters
No data
Pathway IDPathway Name
P00039Metabotropic glutamate receptor group III pathway
P00037Ionotropic glutamate receptor pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2069Schizophrenia
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC1A6 mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SLC1A6 mRNAaffects expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SLC1A6 mRNAaffects expression 12734012
D002713 Chlorine [Ozone co-treated with Chlorine] affects the expression of SLC1A6 mRNAaffects cotreatment|affects expression 18636392
D002117 Calcitriol Calcitriol results in increased expression of SLC1A6 mRNAincreases expression 16002434
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC1A6 mRNAaffects cotreatment|increases expression 17942748
D015525 Fatty Acids, Omega-3 Fatty Acids, Omega-3 results in increased expression of SLC1A6 mRNAincreases expression 16823509
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of SLC1A6 mRNAincreases expression 12057914
D009151 Mustard Gas Mustard Gas results in increased expression of SLC1A6 mRNAincreases expression 15674843
D043371 Fatty Acids, Omega-6 Fatty Acids, Omega-6 results in decreased expression of SLC1A6 mRNAdecreases expression 16823509
D010126 Ozone [Ozone co-treated with Chlorine] affects the expression of SLC1A6 mRNAaffects cotreatment|affects expression 18636392
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC1A6 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0415322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D055371 Acute Lung Injury Chlorine 9.9920601635
MESH:D055371 Acute Lung Injury Lipopolysaccharides 9.9911850527 18653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8414692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D000544 Alzheimer Disease Ozone 2.4615513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5815570426
MESH:D001249 Asthma Mustard Gas 5.2210378619
MESH:D001249 Asthma Ozone 5.2216373670 17854713
MESH:D001289 Attention Deficit Disorder with Hyperactivity Fatty Acids, Omega-3 9.5718448859
MESH:D001289 Attention Deficit Disorder with Hyperactivity Fatty Acids, Omega-6 9.5718448859
MESH:D001321 Autistic Disorder Fatty Acids, Omega-3 3.4716920077
MESH:D001768 Blister Mustard Gas 5.3519167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms Calcitriol 2.0911237771
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0920435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.7917626835 15516495 19059883 18417511 14754758 18315731 16777450
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.3515286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.1917687719 10378619
MESH:D002100 Cachexia Ozone 4.9316183385
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9516011737 15673190 16124888 16097048 10355542 16050911 18705752 3786805 15700767 15721981 16227642 16192424
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8418788625
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6611237771
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4416120746 18670907 18850075
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9817333356 17110522 11677210 15861022 17681005 16919318 16105132
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1512621046 8697196 15340226 15668235 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.8421278145 4309450 16177239 19336974 10915739 15998439 15968718 3786805 2869522 11566570 19085960 3732212 10092053 7179309 15027814 6884620 17522070 7120509 16227642 7440962 6623471 9327722
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004417 Dyspnea Chlorine 4.8420016425
MESH:D004487 Edema Mustard Gas 7.3111428631 9260866 11428647 11402378
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.3112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1218230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 9.6415138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.6412538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1510568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 4.5915328337 17637181 15821434
MESH:D004890 Erythema Mustard Gas 5.359357497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.1612795759 16045604 61145 16239168 12631006 17595544 15959796 19224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.1615345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005334 Fever Lipopolysaccharides 4.149205823 11852909
MESH:D005355 Fibrosis Carbon Tetrachloride 9.1918705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.1920067830
MESH:D005739 Gas Poisoning Chlorine 5.2320016425
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4011294989 10048152
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.5216366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7619900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0715340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.268697196 16959395 18606429 15340226 16354765
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7316899240
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2615338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5717937319
MESH:D007249 Inflammation Fatty Acids, Omega-3 12.6417296493
MESH:D007249 Inflammation Lipopolysaccharides 12.6417237260 17255318 12878042 17963957 9205823
MESH:D007249 Inflammation Mustard Gas 12.6411402378 17524151 11428647 8975870 11428620 9260866 11428631 16001271 9357497
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 12.6412200463 12878042
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.7817255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007970 Leukopenia Lipopolysaccharides 4.8915821434
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8817157831 16239168 16943688 11903743 11408273 21278145 17174718 17334410 16221502
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5911481614 16136751 17721639 18412020 17698563 17525996 12609069 15338365 15057751 17766677 18420326 18472332 14620537 17869086 18166357 18429990 12445418 12898905 14724832 12632514 16638106 14716496 14716833 18376398 16033810 17557913 15931870 15362042 17944888 12445421 15052691 17481882 17565644 17631135 15925388 16027843 15893842 15673190 18317297 15123356 16097048 17714472 20821823 15818738 16011737 18187930 18705752 12958196 10355542 12632512 15959796 12546737 17976157 18277467 18481824 12667390 17900296 17761835 18263696 18472094 18205269 15876570 15370692 12649538 16116963 15730626 12389079 17823541 18395095 12741479 14512876 18395914 15650968 12666154 18279442 18156304 18054572 18339082 17922224 15996030 18006644 16248980 13678700 18210741 17640975 16192424 16015684 12586293 14748882 17708605 18418968 18251166 17805973
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 3.5912878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5912878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1117285989 16964402 16246199 15720792 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3415123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8214706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.5519294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5516984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.0415583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.0412151625
MESH:D008171 Lung Diseases Mustard Gas 7.9218702808 18161513
MESH:D008171 Lung Diseases Ozone 7.9219066396 8266340
MESH:D055370 Lung Injury Lipopolysaccharides 9.8321114838
MESH:D055370 Lung Injury Ozone 9.8320417186
MESH:D008175 Lung Neoplasms Mustard Gas 3.553148597 8781369
MESH:D008175 Lung Neoplasms Ozone 3.558597069 7614698
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5519555203 11884234
MESH:D008679 Metaplasia Ozone 5.3210496685
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D009503 Neutropenia Mustard Gas 4.1216761898 7688884
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D010538 Peritonitis Ozone 4.3116369182
MESH:D011014 Pneumonia Lipopolysaccharides 11.7612224865 11605937
MESH:D011014 Pneumonia Ozone 11.7618007984 18929643 18381685
MESH:D011041 Poisoning Mustard Gas 3.9415727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811118676 11222880 11896295 11399792
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.9715572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.5216289102 15754350 12479363 18247401 16644109
MESH:D011537 Pruritus Ethinyl Estradiol 10.1815861022 16919318
MESH:D011537 Pruritus Mustard Gas 10.1818058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9717720292 17894541 17620002 10334151 17266442
MESH:D012120 Respiration Disorders Chlorine 5.4318579056
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.8210835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012871 Skin Diseases Mustard Gas 2.7415451306 16961503 12880345
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1616709447
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.3015821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
Pathway ID Pathway Name
REACT:19419 Amino acid and oligopeptide SLC transporters
KEGG:04724 Glutamatergic synapse
REACT:13685 Synaptic Transmission
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35831
    • No data
    Releated disease ID Related disease Name
    PA445218Pancreatic Neoplasms
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00142 - L-Glutamic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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