AutismKB 2.0

Annotation Detail for SLC2A2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SLC2A2 ( GLUT2 )
Gene Full Name: solute carrier family 2 (facilitated glucose transporter), member 2
Band: 3q26.2
Quick LinksEntrez ID:6514; OMIM: 138160; Uniprot ID:GTR2_HUMAN; ENSEMBL ID: ENSG00000163581; HGNC ID: 11006
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04973Carbohydrate digestion and absorption
hsa04950Maturity onset diabetes of the young
hsa04930Type II diabetes mellitus
Pathway IDPathway Name
Metabolism of carbohydrates
Diabetes pathways
Transmembrane transport of small molecules
Regulation of beta-cell development
Metabolism of lipids and lipoproteins
Integration of energy metabolism
Pathway IDPathway Name
200073FOXA2 and FOXA3 transcription factor networks
No data
Pathway IDPathway Name
500349Facilitative Na+-independent glucose transporters
500346Glucose transport
500345Hexose transport
500522Regulation of gene expression in beta cells
Related Diseases/Disorders Top
Desease IDDesease Name
Inherited disorders of carbohydrate metabolism
H00069Glycogen storage disease (GSD)
Genetic disorders
Desease IDDesease Name
1856Obesity
1904Diabetes mellitus
Desease Name
fasting glucose-related traits
METABOLIC
diabetes, type 2
Desease Name
Fasting glucose-related traits
Desease Name
Diabetes mellitus, noninsulin-dependent
Fanconi-Bickel syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SLC2A2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SLC2A2 mRNAaffects expression 21346803
C026137 3-hydroxyacetanilide 3-hydroxyacetanilide results in decreased expression of SLC2A2 mRNAdecreases expression 18544908
C041594 4-nonylphenol 4-nonylphenol affects the expression of SLC2A2 mRNAaffects expression 15792627
D000082 Acetaminophen Acetaminophen affects the expression of SLC2A2 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of SLC2A2 mRNAdecreases expression 18544908
11264010
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SLC2A2 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC2A2 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SLC2A2 mRNAdecreases expression 20106945
C095105 bexarotene bexarotene results in increased expression of SLC2A2 mRNAincreases expression 16648578
C074702 chromium hexavalent ion chromium hexavalent ion affects the expression of SLC2A2affects expression 17022414
D003520 Cyclophosphamide Cyclophosphamide results in decreased expression of SLC2A2 mRNAdecreases expression 15331540
D016572 Cyclosporine Cyclosporine results in decreased expression of SLC2A2 mRNAdecreases expression 20106945
D003571 Cytochalasin B Cytochalasin B inhibits the reaction [SLC2A2 protein results in increased transport of Deoxyglucose]decreases reaction|increases transport 8457197
D003609 Dactinomycin Dactinomycin inhibits the reaction [Fructose results in increased expression of SLC2A2 mRNA]decreases reaction|increases expression 12787936
D003609 Dactinomycin Dactinomycin inhibits the reaction [Glucose results in increased expression of SLC2A2 mRNA]decreases reaction|increases expression 12787936
D003847 Deoxyglucose Cytochalasin B inhibits the reaction [SLC2A2 protein results in increased transport of Deoxyglucose]decreases reaction|increases transport 8457197
D003847 Deoxyglucose Fructose inhibits the reaction [SLC2A2 protein results in increased transport of Deoxyglucose]decreases reaction|increases transport 8457197
D003847 Deoxyglucose Glucose inhibits the reaction [SLC2A2 protein results in increased transport of Deoxyglucose]decreases reaction|increases transport 8457197
D003847 Deoxyglucose Maltose inhibits the reaction [SLC2A2 protein results in increased transport of Deoxyglucose]decreases reaction|increases transport 8457197
D003847 Deoxyglucose SLC2A2 protein results in increased transport of Deoxyglucoseincreases transport 8457197
D002945 Cisplatin Cisplatin results in increased expression of SLC2A2 mRNAincreases expression 18656965
D019422 Dietary Sucrose Dietary Sucrose results in increased expression of SLC2A2 proteinincreases expression 12937289
D002117 Calcitriol Calcitriol results in decreased expression of SLC2A2 mRNAdecreases expression 16002434
D004958 Estradiol Estradiol results in decreased expression of SLC2A2 mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of SLC2A2 mRNAdecreases expression 17108234
D005227 Fatty Acids Fatty Acids affects the expression of SLC2A2 mRNAaffects expression 17940560
D005419 Flavonoids Flavonoids results in decreased expression of SLC2A2 mRNAdecreases expression 18035473
D005472 Fluorouracil Fluorouracil promotes the reaction [SLC2A2 protein results in increased uptake of 3-O-Methylglucose]increases reaction|increases uptake 15986457
D005472 Fluorouracil Fluorouracil results in increased expression of SLC2A2 mRNAincreases expression 15986457
D005472 Fluorouracil Fluorouracil results in increased expression of SLC2A2 proteinincreases expression 15986457
D005472 Fluorouracil Phloretin inhibits the reaction [Fluorouracil promotes the reaction [SLC2A2 protein results in increased uptake of 3-O-Methylglucose]]decreases reaction|increases reaction|increases uptake 15986457
D005632 Fructose Fructose inhibits the reaction [SLC2A2 protein results in increased transport of Deoxyglucose]decreases reaction|increases transport 8457197
D005632 Fructose Glucose inhibits the reaction [SLC2A2 protein results in increased transport of Fructose]decreases reaction|increases transport 8457197
D005632 Fructose Maltose inhibits the reaction [SLC2A2 protein results in increased transport of Fructose]decreases reaction|increases transport 8457197
D005632 Fructose SLC2A2 protein results in increased transport of Fructoseincreases transport 8457197
17710649
D005632 Fructose Fructose results in increased expression of and affects the localization of SLC2A2 proteinaffects localization|increases expression 12937289
D005632 Fructose Fructose results in increased expression of SLC2A2 mRNAincreases expression 17786952
D005632 Fructose Dactinomycin inhibits the reaction [Fructose results in increased expression of SLC2A2 mRNA]decreases reaction|increases expression 12787936
D005632 Fructose Fructose results in increased expression of SLC2A2 mRNAincreases expression 1727734
12787936
10222385
D005690 Galactose SLC2A2 protein results in increased transport of Galactoseincreases transport 8457197
D005839 Gentamicins Gentamicins results in increased expression of SLC2A2 mRNAincreases expression 18656965
D005947 Glucose Glucose inhibits the reaction [SLC2A2 protein results in increased transport of Deoxyglucose]decreases reaction|increases transport 8457197
D005947 Glucose Glucose inhibits the reaction [SLC2A2 protein results in increased transport of Fructose]decreases reaction|increases transport 8457197
D005947 Glucose SLC2A2 protein results in increased transport of Glucoseincreases transport 17710649
D005947 Glucose Glucose results in increased expression of and affects the localization of SLC2A2 proteinaffects localization|increases expression 12937289
D005947 Glucose Glucose results in increased expression of SLC2A2 mRNAincreases expression 17786952
D005947 Glucose Dactinomycin inhibits the reaction [Glucose results in increased expression of SLC2A2 mRNA]decreases reaction|increases expression 12787936
D005947 Glucose Glucose results in increased expression of SLC2A2 mRNAincreases expression 1727734
12787936
D005990 Glycerol Glycerol results in increased expression of SLC2A2 mRNAincreases expression 10222385
C117499 (glycyl-glycyl)GLP-2 (glycyl-glycyl)GLP-2 inhibits the reaction [Indomethacin results in decreased expression of SLC2A2 mRNA]decreases expression|decreases reaction 10567023
C027185 indirubin indirubin results in decreased expression of SLC2A2 mRNAdecreases expression 15056799
D007213 Indomethacin (glycyl-glycyl)GLP-2 inhibits the reaction [Indomethacin results in decreased expression of SLC2A2 mRNA]decreases expression|decreases reaction 10567023
D007213 Indomethacin Indomethacin results in decreased expression of SLC2A2 mRNAdecreases expression 10567023
D007529 Isoflavones Isoflavones affects the expression of SLC2A2 mRNAaffects expression 18522411
D008320 Maltose Maltose inhibits the reaction [SLC2A2 protein results in increased transport of Deoxyglucose]decreases reaction|increases transport 8457197
D008320 Maltose Maltose inhibits the reaction [SLC2A2 protein results in increased transport of Fructose]decreases reaction|increases transport 8457197
D008358 Mannose Mannose results in increased expression of SLC2A2 mRNAincreases expression 1727734
D019325 3-O-Methylglucose Fluorouracil promotes the reaction [SLC2A2 protein results in increased uptake of 3-O-Methylglucose]increases reaction|increases uptake 15986457
D019325 3-O-Methylglucose Phloretin inhibits the reaction [Fluorouracil promotes the reaction [SLC2A2 protein results in increased uptake of 3-O-Methylglucose]]decreases reaction|increases reaction|increases uptake 15986457
D019325 3-O-Methylglucose Phloretin inhibits the reaction [SLC2A2 protein results in increased uptake of 3-O-Methylglucose]decreases reaction|increases uptake 15986457
D019325 3-O-Methylglucose SLC2A2 protein results in increased uptake of 3-O-Methylglucoseincreases uptake 15986457
D008767 Methylmercury Compounds Methylmercury Compounds results in increased expression of SLC2A2 mRNAincreases expression 16966085
C002741 N-nitrosomorpholine N-nitrosomorpholine results in decreased expression of SLC2A2 proteindecreases expression 8364915
C025589 ochratoxin A ochratoxin A results in increased expression of SLC2A2 mRNAincreases expression 16251485
D010693 Phloretin Phloretin inhibits the reaction [Fluorouracil promotes the reaction [SLC2A2 protein results in increased uptake of 3-O-Methylglucose]]decreases reaction|increases reaction|increases uptake 15986457
D010693 Phloretin Phloretin inhibits the reaction [SLC2A2 protein results in increased uptake of 3-O-Methylglucose]decreases reaction|increases uptake 15986457
D028321 Plant Preparations Plant Preparations affects the expression of SLC2A2 mRNAaffects expression 18522411
D011794 Quercetin Quercetin results in decreased activity of SLC2A2 proteindecreases activity 11834736
C017947 sodium arsenite sodium arsenite affects the expression of SLC2A2 mRNAaffects expression 20451245
D013311 Streptozocin SLC2A2 protein results in increased susceptibility to Streptozocinincreases response to substance 11151762
D013395 Sucrose Sucrose results in increased expression of SLC2A2 mRNAincreases expression 10222385
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SLC2A2 mRNAdecreases expression 15056799
20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SLC2A2 mRNAincreases expression 15885268
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SLC2A2 mRNAdecreases expression 18465118
16054898
18796159
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SLC2A2 mRNAincreases expression 15644576
D014212 Tretinoin Tretinoin results in decreased expression of SLC2A2 mRNAdecreases expression 18230668
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.3715322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.0718287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.4517505938
MESH:D058186 Acute Kidney Injury Cisplatin 7.7012690470 17670903 15814532
MESH:D058186 Acute Kidney Injury Gentamicins 7.7011274264
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 15.1820464547 20127859
MESH:D000230 Adenocarcinoma Cisplatin 15.1817638652 11798837
MESH:D000230 Adenocarcinoma Estradiol 15.1811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 15.1814692618
MESH:D000230 Adenocarcinoma Fluorouracil 15.1817638652
MESH:D000230 Adenocarcinoma Indomethacin 15.1816537180
MESH:D000236 Adenoma Benzo(a)pyrene 5.876695378
MESH:D000236 Adenoma Indomethacin 5.8711497255
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 2.8916835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.2015276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.4016712894 17306315
MESH:D000505 Alopecia Isoflavones 8.2917569567
MESH:D000505 Alopecia Tretinoin 8.2915955085
MESH:D016301 Alveolar Bone Loss Indomethacin 4.8717225004
MESH:D000544 Alzheimer Disease Indomethacin 2.5915579461 17627676
MESH:D000740 Anemia Fluorouracil 7.2815504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.2811748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.8017084956
MESH:D000799 Angioedema Acetaminophen 3.3510982225
MESH:D001014 Aortic Aneurysm Indomethacin 4.3910231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 10.1319183758
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 10.1310388637
MESH:D001161 Arteriosclerosis Cyclophosphamide 8.5915014928
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.5911256880
MESH:D018771 Arthralgia Indomethacin 4.672160914
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.1615885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.1616412693
MESH:D001172 Arthritis, Rheumatoid Indomethacin 4.3011248219
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.3016292516
MESH:D001249 Asthma Tretinoin 2.1816456186
MESH:D001260 Ataxia Telangiectasia Quercetin 4.4915336622
MESH:D001321 Autistic Disorder Acetaminophen 1.4818445737
MESH:D001327 Autoimmune Diseases Quercetin 3.9319761891
MESH:D001471 Barrett Esophagus Tretinoin 3.9416935849
MESH:D001477 Bartter Syndrome Indomethacin 4.5110684365
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.4912125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 7.4916206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4415746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 10.7114601052
MESH:D019046 Bone Marrow Neoplasms Dactinomycin 10.7114601052
MESH:D001929 Brain Edema Indomethacin 4.5311481608
MESH:D002545 Brain Ischemia Indomethacin 3.9312524144
MESH:D001943 Breast Neoplasms marker/mechanism 19579870
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 11.6717474063 20146248
MESH:D001943 Breast Neoplasms bexarotene 11.6716344269 16818667
MESH:D001943 Breast Neoplasms Calcitriol 11.6711237771
MESH:D001943 Breast Neoplasms Cisplatin 11.6718382427 19526202
MESH:D001943 Breast Neoplasms Cyclophosphamide 11.6718234424 18323546 15136595 16978400 17388661 12006526 15093573 17020986 11325840
MESH:D001943 Breast Neoplasms Deoxyglucose 11.6718985042
MESH:D001943 Breast Neoplasms Estradiol 11.6716675129 17289903 14630087 12948864 18497071 17261762 17018787 19861407
MESH:D001943 Breast Neoplasms Fluorouracil 11.6716557594 16110121 16595493 18357371 15136595 18608205 19217205
MESH:D001943 Breast Neoplasms Indomethacin 11.6717401462
MESH:D001943 Breast Neoplasms ochratoxin A 11.6711921183
MESH:D001943 Breast Neoplasms Plant Preparations 11.6717398067
MESH:D001943 Breast Neoplasms Quercetin 11.6718628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 11.6720435547
MESH:D001943 Breast Neoplasms Tretinoin 11.6716873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.1016813970
MESH:D002056 Burns Indomethacin 4.2310459503
MESH:D002100 Cachexia Indomethacin 4.5215625704 16537180 15141370 11239499
MESH:D002105 Cadmium Poisoning Quercetin 5.0516962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9816111702
MESH:D002276 Carcinoid Tumor Fluorouracil 10.9916051944
MESH:D002276 Carcinoid Tumor Streptozocin 10.9916051944
MESH:D002277 Carcinoma Fluorouracil 6.9017121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.9016835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.6616168501
MESH:D006528 Carcinoma, Hepatocellular marker/mechanism 8364915
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 29.9816705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 29.9816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 29.983084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 29.9821507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 29.9817982673
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 29.9819701751
MESH:D006528 Carcinoma, Hepatocellular Estradiol 29.9816924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 29.9816799960 18930000 17088986 17045692 17971768 16332177
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 29.9816391822
MESH:D006528 Carcinoma, Hepatocellular N-nitrosomorpholine 29.9815543204 1967229 15010824 9029167 9311599 19383236 16935385 19335982 1701930 10629087 2885971 11509945 8364915 1917145 9466558
MESH:D006528 Carcinoma, Hepatocellular Quercetin 29.9819519916 12508355
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 29.9815276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 29.981917145
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 9.9116152834
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 9.9111053908
MESH:D018276 Carcinoma, Medullary Indomethacin 4.8618791128 11352223 14736730
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 5.2316247446
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 5.2312023789 16685392
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.4817234771
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 13.4616201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 13.4618695887
MESH:D002292 Carcinoma, Renal Cell Indomethacin 13.4617341418
MESH:D002292 Carcinoma, Renal Cell N-nitrosomorpholine 13.467921415 1429202
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 23.1220419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 23.1211237771
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 23.1218337622 6189445 17066447
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 23.1216757204 16280240 18986760 17066447
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 23.1215482327 12636206
MESH:D002294 Carcinoma, Squamous Cell Plant Preparations 23.1217418620
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 23.1218572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 23.1216096774 16051514
MESH:D006332 Cardiomegaly Quercetin 5.8519794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.8516120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Isoflavones 7.0217689850
MESH:D002318 Cardiovascular Diseases Plant Preparations 7.0216862667
MESH:D016893 Carotid Stenosis Plant Preparations 5.6515158307
MESH:D002386 Cataract Acetaminophen 6.2310977129
MESH:D002386 Cataract Tretinoin 6.2317460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 13.206135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 13.2012371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 13.2018566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 13.2019524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.1016129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.7516835633
MESH:D002764 Cholecystitis Indomethacin 4.6711181007
MESH:D002779 Cholestasis Cyclosporine 6.5619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 6.5615861022 17681005 17333356 16105132 11677210 16919318 17110522
MESH:D002822 Choriocarcinoma Tretinoin 4.6616461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.0215668235 8697196 12621046 16354765 15340226
MESH:D002972 Cleft Palate Tretinoin 5.029407595
MESH:D003092 Colitis Tretinoin 3.2317035595
MESH:D003110 Colonic Neoplasms Fluorouracil 5.2717169374 15001691 17016597 17725105 17018589 18772588 16340194 17172411 16510598 17287894
MESH:D003110 Colonic Neoplasms Indomethacin 5.2715963497 15637740 11260862 15936596 15625704 15786552
MESH:D003110 Colonic Neoplasms Quercetin 5.2716640504 17148506 11134977 19056647 15741050 19440933 17191121
MESH:D015179 Colorectal Neoplasms Cisplatin 5.8615273666
MESH:D015179 Colorectal Neoplasms Fluorouracil 5.8617695437 20501625 17255274 17016601 16524972 18383874 18448328 16282729 16391804 18949393 14970324 17454858 15148649 15289873 16303861 18288408 18802399 16331619 17594712 17094418 17401013 18509181
MESH:D015179 Colorectal Neoplasms Indomethacin 5.8612606626 17054584 11197048 18059344
MESH:D015179 Colorectal Neoplasms Isoflavones 5.8617116718
MESH:D015179 Colorectal Neoplasms Quercetin 5.8618095365 18852136
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6514669216 17141729
MESH:D003324 Coronary Artery Disease Plant Preparations 3.8015158307
MESH:D003327 Coronary Disease Fructose 4.1518504504
MESH:D018352 Coronavirus Infections Indomethacin 5.2217302372
MESH:D019465 Craniofacial Abnormalities ochratoxin A 3.5720036863
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.5720055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.5714991402 16925845 8800419 9142499 9664655 9211117 9125849 9224671 17551590 10589399
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.3118551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.3118551238
MESH:D003556 Cystitis Cyclophosphamide 4.4916413132 10700343 18372110 15643279 10498854 16651033 16614059 12161096 12388444 18483878 18093676 11948286 15276878 12913760 18433785 16989017 18295254 17010015 17979934 18710439
MESH:D007644 Darier Disease Fluorouracil 4.3016733453
MESH:D003704 Dementia Methylmercury Compounds 4.5616140633
MESH:D003920 Diabetes Mellitus Streptozocin 4.3216285004
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 16.6711751995 10990075 15331540
MESH:D003921 Diabetes Mellitus, Experimental Fructose 16.6718603373
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 16.6719496084
MESH:D003921 Diabetes Mellitus, Experimental Streptozocin 16.6719586609 19496084 1374869 2177838 12083368 7637645 17874149 12446591 8740154 11055810 16684804 18603373 15298345 15862027 17442507 16286809 18715473 19298542 11260395 19960420 6379147 12093613 12644472 15831366
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 5.4918772604
MESH:D003922 Diabetes Mellitus, Type 1 Streptozocin 5.4918603373
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 6.5318603373
MESH:D003924 Diabetes Mellitus, Type 2 Streptozocin 6.5319647726 19586609
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.5317107852
MESH:D058065 Diabetic Cardiomyopathies Streptozocin 5.2416025228
MESH:D003928 Diabetic Nephropathies Estradiol 7.9219279558
MESH:D003928 Diabetic Nephropathies Streptozocin 7.9219682444 19960420
MESH:D003930 Diabetic Retinopathy Streptozocin 4.9617662242
MESH:D003967 Diarrhea Indomethacin 3.347237001 7907874
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 7.5318551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 7.5318551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 7.5316485898 18713872 19420014 10915739 19370779 14725611 15619225 11287661 19923254 19739265 2444490 16781746 17522070 14986274 12540782 19416960 12958197 16227642 10774834 10663392 19085960 18071297 16109766 11461765 16393943 12153990 11739529 11834606 19164858 17906064 12392966 12705907 11743745 17562736 12594235 15968718 16081117 11421492 11529661 14550746 16177239
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 7.5320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6019426721
MESH:D004362 Drug Toxicity Cisplatin 16.7212649298 19839026 15033597 12231392
MESH:D004362 Drug Toxicity Gentamicins 16.7215033597 11033412
MESH:D004362 Drug Toxicity Plant Preparations 16.7211033412
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 16.7211462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.6617190690 18446180 16133044 18043480 12774134 16326151
MESH:D004381 Duodenal Ulcer Indomethacin 3.6810671773 11535926 11991626 17202747 16699067 17045617 17351913 11595431 11595415 17329845 17151854
MESH:D004487 Edema Indomethacin 5.508273558 19703484 8985016 7907874 7990266 16100529 10653021
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.5011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.2916714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 10.2918230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 7.5615138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.5612538720
MESH:D016889 Endometrial Neoplasms Estradiol 6.3218566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 6.3216569247
MESH:D004715 Endometriosis Indomethacin 7.6715652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.679294722 10568697
MESH:D019446 Endotoxemia Indomethacin 4.0218509659
MESH:D004751 Enteritis (glycyl-glycyl)GLP-2 10.6210567023
MESH:D004751 Enteritis Indomethacin 10.6210567023 17763956 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.5117980183
MESH:D004802 Eosinophilia Cyclophosphamide 7.6611006010
MESH:D004802 Eosinophilia Indomethacin 7.6611298111
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 12.2516530937
MESH:D004938 Esophageal Neoplasms Cisplatin 12.2515173087 16481741 17638652 16785472 15464296
MESH:D004938 Esophageal Neoplasms Fluorouracil 12.2515173087 17638652 16481741 16337965 16785472
MESH:D004938 Esophageal Neoplasms Indomethacin 12.2511005569
MESH:D004938 Esophageal Neoplasms Plant Preparations 12.2516510608
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.6111564622
MESH:D005124 Eye Abnormalities Tretinoin 7.619664655 16938888
OMIM:227810 FANCONI-BICKEL SYNDROME marker/mechanism 11810292
MESH:D005234 Fatty Liver Cyclosporine 15.3519224547
MESH:D005234 Fatty Liver Dietary Sucrose 15.3517967931
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.3515345470
MESH:D005234 Fatty Liver Fructose 15.3518641190 19196556 18395287
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9811858732
MESH:D005334 Fever Indomethacin 3.7017627676 11852909 10431976
MESH:D005354 Fibrosarcoma Indomethacin 4.4110962813
MESH:D005355 Fibrosis Cyclosporine 28.3612168785 12639820
MESH:D005355 Fibrosis Fructose 28.3618504504
MESH:D005355 Fibrosis Indomethacin 28.3617994277
MESH:D005355 Fibrosis Quercetin 28.3619474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 28.3620067830
MESH:D005355 Fibrosis Tretinoin 28.3617994277
MESH:D005499 Folliculitis Indomethacin 4.6711298111
MESH:D005756 Gastritis Acetaminophen 9.5016983495
MESH:D005756 Gastritis Indomethacin 9.5015046732
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.1916452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.738708960
MESH:D005909 Glioblastoma Indomethacin 10.0812870263
MESH:D005909 Glioblastoma Quercetin 10.0819804834
MESH:D005909 Glioblastoma Tretinoin 10.0817312396
MESH:D005910 Glioma Fluorouracil 8.7516145905
MESH:D005910 Glioma Indomethacin 8.7518371953 16487511
MESH:D005910 Glioma Quercetin 8.7517643826
MESH:D018316 Gliosarcoma Cyclophosphamide 5.0311389073
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.9011849393
MESH:D018149 Glucose Intolerance Fructose 4.8719165636
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1010696789
MESH:D006073 Gout Indomethacin 4.8611248219
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.5616376943 11014644 15172196
MESH:D006258 Head and Neck Neoplasms Cisplatin 15.7215464296 15102660
MESH:D006258 Head and Neck Neoplasms Fluorouracil 15.7215162350 15102660 18337622
MESH:D006258 Head and Neck Neoplasms Indomethacin 15.7215482327
MESH:D006258 Head and Neck Neoplasms Tretinoin 15.7216096774
MESH:D034381 Hearing Loss Cisplatin 8.9219898482
MESH:D034381 Hearing Loss Gentamicins 8.9219130971 15968427 17868369 18024279
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.6616084493
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.0215464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 9.5020471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.5011294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 9.509664655 14991402
MESH:D006331 Heart Diseases Streptozocin 3.9312093613
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.9315720958
MESH:D006467 Hemophilia A Cyclophosphamide 4.8111918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9011000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.1315633222
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.0414986274
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.2215135802
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.4312621046 16120746 15340226
MESH:D006558 Herpes Genitalis Estradiol 4.5315709030
MESH:D006689 Hodgkin Disease Cisplatin 10.0416170182 16200630
MESH:D006689 Hodgkin Disease Cyclophosphamide 10.0417606976 16135485
MESH:D006689 Hodgkin Disease sodium arsenite 10.0412676792
MESH:D019584 Hot Flashes Estradiol 8.7717088409
MESH:D019584 Hot Flashes Isoflavones 8.7717290160 14716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5516354765 15340226 18606429 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 10.8416870215
MESH:D006930 Hyperalgesia Indomethacin 10.8412727271
MESH:D006930 Hyperalgesia Tretinoin 10.8416870215
MESH:D034321 Hyperamylasemia Indomethacin 5.2217883296
MESH:D053565 Hypercalciuria Gentamicins 5.2217652376
MESH:D006940 Hyperemia Indomethacin 4.5212524144
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.0916778211
MESH:D006943 Hyperglycemia Quercetin 3.6118262572 11834736
MESH:D006946 Hyperinsulinism Fructose 4.4914757778 18563319 18360027 19008412 15752949
MESH:D006949 Hyperlipidemias Fructose 8.2715752949
MESH:D006949 Hyperlipidemias Indomethacin 8.2717546600
MESH:D006968 Hypersensitivity, Delayed indirubin 5.4411275354
MESH:D006973 Hypertension Cyclosporine 10.6910903974
MESH:D006973 Hypertension Fructose 10.6914573337 19008412 14633139 14568997 16843071
MESH:D006973 Hypertension Quercetin 10.6918356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 10.6918850075 18670907
MESH:D015228 Hypertriglyceridemia Fructose 4.6519799862 19342510
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3316569931 16945680
MESH:D007077 Ileal Diseases Indomethacin 4.5318306037 10574470
MESH:D007079 Ileitis Indomethacin 4.8616133968 10647630 10651667
MESH:D007154 Immune System Diseases Cyclophosphamide 4.8316076520
MESH:D007235 Infant, Premature, Diseases Indomethacin 4.8716133044
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0112013081
MESH:D007248 Infertility, Male Cyclophosphamide 9.357193160 16517039
MESH:D007248 Infertility, Male Ethinyl Estradiol 9.3517937319
MESH:D007248 Infertility, Male sodium arsenite 9.3512646999 15346721
MESH:D007249 Inflammation Flavonoids 6.8217296493
MESH:D007249 Inflammation Indomethacin 6.827812673 3291741 12568917
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 6.8212878042 12200463
MESH:D007251 Influenza, Human Quercetin 4.0116624496
MESH:D007333 Insulin Resistance Estradiol 6.7016393666 16627594
MESH:D007333 Insulin Resistance Fructose 6.7019799862 14757778 14633139 17133782 18057795 19586609 18563319 19008412 18981581 19342510 14573337
MESH:D007410 Intestinal Diseases Indomethacin 8.3111713966 11686837 17329856 17994277 15831440 11855677 10210152 18236018 15610444
MESH:D007410 Intestinal Diseases Tretinoin 8.3117994277
MESH:D019586 Intracranial Hypertension Indomethacin 4.8715241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.4816580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.4817551590 15992940
MESH:D007579 Jejunal Diseases Indomethacin 4.5316133968 10574470 18306037
MESH:D007627 Keloid Quercetin 4.4817086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.9415604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 11.6715464296
MESH:D007673 Kidney Cortex Necrosis Gentamicins 11.6718842672
MESH:D007674 Kidney Diseases Acetaminophen 38.1212587719 15629191
MESH:D007674 Kidney Diseases Cisplatin 38.1212649298 18289764 15190930 12231392 19839026
MESH:D007674 Kidney Diseases Cyclosporine 38.128314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 38.1215618244
MESH:D007674 Kidney Diseases Gentamicins 38.1219349640 17934191 18289764
MESH:D007674 Kidney Diseases Indomethacin 38.1217190690
MESH:D007674 Kidney Diseases ochratoxin A 38.1211409539
MESH:D007674 Kidney Diseases Quercetin 38.1216962696
MESH:D007674 Kidney Diseases sodium arsenite 38.1220008137
MESH:D007674 Kidney Diseases Streptozocin 38.1212093613
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 23.9716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 23.9716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 23.9712371664
MESH:D007680 Kidney Neoplasms Estradiol 23.9715610895
MESH:D007680 Kidney Neoplasms Fluorouracil 23.9716985049
MESH:D007680 Kidney Neoplasms ochratoxin A 23.9716251485
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 10.3611231351
MESH:D007683 Kidney Tubular Necrosis, Acute Gentamicins 10.3611231351
MESH:D016773 Leishmaniasis, Cutaneous Gentamicins 7.5510219319
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 7.5512228301 10320625 11703811
MESH:D007938 Leukemia Cyclophosphamide 9.0910602166
MESH:D007938 Leukemia Quercetin 9.0917468513
MESH:D007938 Leukemia Tretinoin 9.0917143497
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.2717802794 17296974 17008537 18587576 18172266 17658394
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 7.5810373061
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 7.5815631656 10785260 16572323
MESH:D007951 Leukemia, Myeloid Tretinoin 3.2619285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 3.7018360721
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.7017596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.8319075265 16331271 16935935 17107899 17294898 17506722 16891316 17339181 9834237 17368321 17649720 19035177 16788101 19225113 17301526 17712046 17361223 12679006 16823087 19029980 19642359 16140955 16766008 15748426 17217047
MESH:D007964 Leukocytosis Indomethacin 4.8716537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.2217980183
MESH:D007970 Leukopenia Cyclophosphamide 4.4811830472 10052129
MESH:D017880 Limb Deformities, Congenital Tretinoin 2.959224671
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.2211479899
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 7.7414716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 7.7418194892
MESH:D008106 Liver Cirrhosis, Experimental Plant Preparations 7.7417724770
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 7.7412741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 7.7412878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 7.7418397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 1.5012969438 11587558 19014921 12587719 19460945 16611625 19784758 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 2.8116871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 18.697678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 18.692125692 15890375 9163691 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 18.6920195826 21137059
MESH:D008113 Liver Neoplasms Fluorouracil 18.6915113037 16603448 17045692 18383874
MESH:D008113 Liver Neoplasms Quercetin 18.6918980244
MESH:D008113 Liver Neoplasms sodium arsenite 18.6915276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 18.6916984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 11.532876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 11.538603461
MESH:D008114 Liver Neoplasms, Experimental Quercetin 11.5319519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 11.5312151625
MESH:D008171 Lung Diseases chromium hexavalent ion 6.8616775837
MESH:D008171 Lung Diseases sodium arsenite 6.8619095001
MESH:D008175 Lung Neoplasms Aflatoxin B1 16.2114755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 16.2118569708 17053015 20135361 18520028 18816296 20464547 20869020 20064080 6695378
MESH:D008175 Lung Neoplasms bexarotene 16.2117849452
MESH:D008175 Lung Neoplasms chromium hexavalent ion 16.2116570259 16876463
MESH:D008175 Lung Neoplasms Cisplatin 16.216189445 11798837 17225452
MESH:D008175 Lung Neoplasms Fluorouracil 16.2115246190
MESH:D008175 Lung Neoplasms Indomethacin 16.2111497255 11053908 16537180
MESH:D008175 Lung Neoplasms Quercetin 16.2116280456
MESH:D008175 Lung Neoplasms sodium arsenite 16.2115276417 16712894 17306315 19931552 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 16.2119555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.3015086387
MESH:D008223 Lymphoma Cyclophosphamide 3.4912854902
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.1516675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 3.7711911406
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.6711161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 8.3715591091 19196723 19196722
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.3711408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental ochratoxin A 8.3711921183
MESH:D020149 Manganese Poisoning Estradiol 3.9919453300
MESH:D008527 Medulloblastoma Tretinoin 2.5717453147
MESH:D008545 Melanoma Cisplatin 6.4718332650 18176117 17761969 18505091 12883367 16432458 17023156 16809738 11135225 15577323 12393984 16248763 12374674
MESH:D008545 Melanoma Glucose 6.4714993021
MESH:D008545 Melanoma sodium arsenite 6.4719082730 16487513
MESH:D008545 Melanoma Tretinoin 6.4716752155
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.2915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 9.2519513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 9.2516388313
MESH:D008569 Memory Disorders Methylmercury Compounds 4.4518436314
MESH:D008591 Meningomyelocele Tretinoin 3.9516940565
MESH:D008654 Mesothelioma Cisplatin 3.0417638057
MESH:D024821 Metabolic Syndrome X Fructose 4.4218497449 19165636 16815490 17261469 17098227
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.2916801185
MESH:D008850 Microphthalmos ochratoxin A 5.3320036863
MESH:D008881 Migraine Disorders Indomethacin 3.3211903285
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 17.4916381670
MESH:D009062 Mouth Neoplasms Fluorouracil 17.4916757204 18986760
MESH:D009062 Mouth Neoplasms Indomethacin 17.4912636206
MESH:D009062 Mouth Neoplasms Plant Preparations 17.4917418620
MESH:D009069 Movement Disorders Methylmercury Compounds 4.8818436314
MESH:D009137 Muscular Dystrophy, Animal Gentamicins 5.7818694830
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.7917596541
MESH:D009203 Myocardial Infarction Quercetin 2.7819595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.3116810080
MESH:D015428 Myocardial Reperfusion Injury Quercetin 7.3119207477
MESH:D009336 Necrosis 2,4-dinitrotoluene 8.7318551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 8.7318551238 7678174
MESH:D009362 Neoplasm Metastasis Indomethacin 2.9611239499 16537180 11053908
MESH:D009369 Neoplasms Benzo(a)pyrene 20.0511141357
MESH:D009369 Neoplasms Cisplatin 20.0516773208
MESH:D009369 Neoplasms Cyclophosphamide 20.0518854779
MESH:D009369 Neoplasms Fluorouracil 20.0516928823 18600527 18239605
MESH:D009369 Neoplasms Quercetin 20.0515185748
MESH:D009369 Neoplasms sodium arsenite 20.0511559025
MESH:D009369 Neoplasms Tretinoin 20.0516946489 16594593
MESH:D009374 Neoplasms, Experimental Indomethacin 7.7015625704 10663608
MESH:D009374 Neoplasms, Experimental sodium arsenite 7.7020056578
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.2919196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.2517289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.0015464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.9417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.8718481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 13.6616427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 13.6614600291
MESH:D009421 Nervous System Malformations Tretinoin 13.669125849
MESH:D009436 Neural Tube Defects ochratoxin A 10.4320036863
MESH:D009436 Neural Tube Defects sodium arsenite 10.4312854658
MESH:D009436 Neural Tube Defects Tretinoin 10.439142499
MESH:D009447 Neuroblastoma Cisplatin 6.398761367
MESH:D009447 Neuroblastoma Cyclophosphamide 6.3915176712 8761367 16115947
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.0818514411
MESH:D019636 Neurodegenerative Diseases Indomethacin 7.0812349958
MESH:D017599 Neuroectodermal Tumors Cisplatin 9.908761367
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 9.908761367 12837982
MESH:D020078 Neurogenic Inflammation Quercetin 3.9117929310
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.1016436463
MESH:D009503 Neutropenia Cyclophosphamide 3.888291058
MESH:D009669 Nose Neoplasms chromium hexavalent ion 4.6316876463
MESH:D009765 Obesity Fructose 3.2917707055 18585860
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.676374098
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 7.4812819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 7.4816049721
MESH:D009845 Oligospermia Cyclophosphamide 4.2316517039
MESH:D010003 Osteoarthritis Indomethacin 3.367009135
MESH:D010024 Osteoporosis Isoflavones 3.7916562857
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 3.7719495926
MESH:D010051 Ovarian Neoplasms Cisplatin 13.086897625 19769630 17225452 15464296
MESH:D010051 Ovarian Neoplasms Estradiol 13.0819401270
MESH:D010051 Ovarian Neoplasms Quercetin 13.0819005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 13.0815276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 13.0816936753
MESH:D010146 Pain Acetaminophen 12.9116870215
MESH:D010146 Pain Cyclophosphamide 12.9118093676 12161096
MESH:D010146 Pain Indomethacin 12.9113679232 17627676 3291741 17440234
MESH:D010146 Pain Tretinoin 12.9116870215
MESH:D010149 Pain, Postoperative Indomethacin 4.1818702446 12538197
MESH:D010190 Pancreatic Neoplasms Cisplatin 14.2219003803
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 14.2211332152
MESH:D010190 Pancreatic Neoplasms Fluorouracil 14.2215113037 16500647 19003803 16929163
MESH:D010190 Pancreatic Neoplasms Quercetin 14.2216965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 14.2215976015
MESH:D010195 Pancreatitis Indomethacin 3.4817883296 15028970
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2411578682
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.2216537180
MESH:D020734 Parkinsonian Disorders Indomethacin 3.7012349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.2211903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7512520081
MESH:D010437 Peptic Ulcer Indomethacin 4.6611148446
MESH:D010518 Periodontitis Indomethacin 4.4217225004
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 3.8515464296
MESH:D010997 Pleural Neoplasms Cisplatin 4.8517638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1018163543
MESH:D011230 Precancerous Conditions Cyclosporine 7.7412371664
MESH:D011230 Precancerous Conditions Quercetin 7.7419056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.5221297632
MESH:D047928 Premature Birth Indomethacin 4.6517000239
MESH:D011297 Prenatal Exposure Delayed Effects Methylmercury Compounds 8.2718436314
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.2711222880 11896295 11399792 11118676
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.2915572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.4520887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.7317292933
MESH:D011471 Prostatic Neoplasms Calcitriol 2.7316644109 16289102 12479363 18247401 15754350
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.7317136230
MESH:D011471 Prostatic Neoplasms Deoxyglucose 2.7318985042
MESH:D011471 Prostatic Neoplasms Estradiol 2.7316740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.7318626508 19082440
MESH:D011471 Prostatic Neoplasms Isoflavones 2.7317374662 17571952 17219775 16365062
MESH:D011471 Prostatic Neoplasms Quercetin 2.7314715546 17292933
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.7316039940
MESH:D011507 Proteinuria Gentamicins 13.0115033597
MESH:D011507 Proteinuria Indomethacin 13.0111849393
MESH:D011507 Proteinuria Tretinoin 13.0116636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.8315861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.0416882103
MESH:D011625 Pterygium Tretinoin 4.3016723453
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.0816636934
MESH:D012004 Rectal Neoplasms Fluorouracil 3.6018722050 15538739 16160472 18286688
MESH:D051437 Renal Insufficiency Cisplatin 9.0815464296
MESH:D051437 Renal Insufficiency Gentamicins 9.0817132701 15728788
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3718990726
MESH:D012173 Retinitis Gentamicins 5.7818644591
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.6516116481 16283617
MESH:D012512 Sarcoma, Ewing's Cisplatin 9.2214601052
MESH:D012512 Sarcoma, Ewing's Dactinomycin 9.2214601052
MESH:D012554 Schistosomiasis japonica Quercetin 5.0516862918
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.3716636934
MESH:D012640 Seizures 2,4-dinitrotoluene 8.1118551238
MESH:D012640 Seizures 2,6-dinitrotoluene 8.1118551238
MESH:D012640 Seizures Deoxyglucose 8.1117978042
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 15.2819755658 10029692
MESH:D012878 Skin Neoplasms Glucose 15.2814993021
MESH:D012878 Skin Neoplasms sodium arsenite 15.2818572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 15.2816192470
MESH:D012878 Skin Neoplasms Tretinoin 15.2816467112
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 4.8515464296
MESH:D013088 Spermatocele Ethinyl Estradiol 3.4516709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.0316517039
MESH:D016135 Spinal Dysraphism sodium arsenite 3.4212854658
MESH:D013272 Stomach Diseases Indomethacin 3.9316113693 17207306 16184426 17160473 18545984 10486359 17638125 10215738 16280098 18209964 15472012 10192188 15038085
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 5.7320155912 2093021
MESH:D013274 Stomach Neoplasms Cisplatin 5.7317522103 18396642 15958060
MESH:D013274 Stomach Neoplasms Fluorouracil 5.7318396642 17498489 16424979 18567086 17172411 19015929 15786421 16951190 19084572 17522103
MESH:D013274 Stomach Neoplasms Indomethacin 5.7315609394
MESH:D013274 Stomach Neoplasms Tretinoin 5.7317261132
MESH:D013276 Stomach Ulcer Indomethacin 3.1712498302 16252198 17657623 16755016 1323529 17135157 18209962 11595415 11906479 17895592 17654042 15255614 18726076 18543354 17918041 11729361 16934674 16397915 18193104 18299717 14567935 15138204 12467913 12077510 12787963 18431645 18181030 15104355 11595431 10878458 16169175 18237397 12500499 17627676 11145282 17977527 16150113 10750652 10423059 16631530 18087811 11523592
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.5712837982
MESH:D013736 Testicular Neoplasms Cisplatin 4.1815464296 17225452
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7415669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4112697716
MESH:D013964 Thyroid Neoplasms Indomethacin 6.1611352223 18791128 14736730
MESH:D013964 Thyroid Neoplasms Tretinoin 6.1617045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.1919048282
MESH:D014062 Tongue Neoplasms Fluorouracil 8.4216280240
MESH:D014062 Tongue Neoplasms Tretinoin 8.4216051514
MESH:D014376 Tuberculosis Tretinoin 2.9116040207
MESH:D014456 Ulcer Indomethacin 4.4117380554 10574470
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 24.7716049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 24.7716049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 24.7717053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 24.7717225452 12973940 15464296
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 24.7714692829
MESH:D001749 Urinary Bladder Neoplasms Plant Preparations 24.7711251952
MESH:D001749 Urinary Bladder Neoplasms Quercetin 24.7716720314
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 24.7716712894 16452187 11723127 17306315
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.3710091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.3710091137
MESH:D014581 Urticaria Acetaminophen 2.5310982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 19.1716803524
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 19.1716803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 19.1711813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 19.1716129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.8414692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.1116752155
MESH:D014605 Uveitis Cyclosporine 3.491336536
MESH:D014625 Vaginal Neoplasms Cisplatin 4.1315577323
MESH:D014652 Vascular Diseases sodium arsenite 3.9417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1012125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1015869587 14671159
MESH:D018487 Ventricular Dysfunction, Left Dietary Sucrose 5.4318551017
MESH:D015837 Vestibular Diseases Gentamicins 5.0518776599
MESH:D014820 Vitiligo Tretinoin 3.5916761959
MESH:D014839 Vomiting Cisplatin 9.8811897121
MESH:D014839 Vomiting Indomethacin 9.8811897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7515886252
MESH:D009396 Wilms Tumor Tretinoin 3.5616287080
MESH:D014985 Xerophthalmia Cyclosporine 3.9417120751
Pathway ID Pathway Name
KEGG:04973 Carbohydrate digestion and absorption
REACT:15380 Diabetes pathways
REACT:1505 Integration of energy metabolism
KEGG:04950 Maturity onset diabetes of the young
REACT:474 Metabolism of carbohydrates
REACT:22258 Metabolism of lipids and lipoproteins
REACT:13698 Regulation of beta-cell development
REACT:13641 Regulation of Beta-Cell Development
REACT:15518 Transmembrane transport of small molecules
KEGG:04930 Type II diabetes mellitus
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35876
    • No data
    Releated disease ID Related disease Name
    PA443890Diabetes Mellitus, Type 2
    Releated drug ID Related drug Name
    PA448625biotin
    PA449773glucose
    PA164749238exenatide
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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