AutismKB 2.0

Annotation Detail for SLC4A2


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Basic Information Top
Gene Symbol:SLC4A2 ( AE2,BND3L,EPB3L1,HKB3,NBND3 )
Gene Full Name: solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)
Band: 7q36.1
Quick LinksEntrez ID:6522; OMIM: 109280; Uniprot ID:B3A2_HUMAN; ENSEMBL ID: ENSG00000164889; HGNC ID: 11028
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04970Salivary secretion
hsa04972Pancreatic secretion
hsa04971Gastric acid secretion
Pathway IDPathway Name
Transmembrane transport of small molecules
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1779Cervical cancer
1841Stomach cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of SLC4A2 mRNAaffects expression 21346803
C000188 alachlor alachlor results in increased expression of SLC4A2 mRNAincreases expression 12419858
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC4A2 mRNAaffects expression 16483693
D016718 Arachidonic Acid Arachidonic Acid results in increased expression of SLC4A2 mRNAincreases expression 16623957
D001639 Bicarbonates SLC4A2 protein affects the transport of [Chlorides co-treated with Bicarbonates]affects cotreatment|affects transport 11852051
C055494 caffeic acid phenethyl ester caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of SLC4A2 mRNA]decreases expression|decreases reaction 20360939
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of SLC4A2 mRNAincreases expression 16644059
D002712 Chlorides SLC4A2 protein affects the transport of [Chlorides co-treated with Bicarbonates]affects cotreatment|affects transport 11852051
D002713 Chlorine [Ozone co-treated with Chlorine] results in decreased expression of SLC4A2 mRNAaffects cotreatment|decreases expression 18636392
D003622 Dapsone Dapsone metabolite results in decreased expression of SLC4A2 proteindecreases expression 15863252
D004052 Diethylnitrosamine caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of SLC4A2 mRNA]decreases expression|decreases reaction 20360939
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of SLC4A2 mRNAdecreases expression 20360939
D000431 Ethanol Ethanol results in increased expression of SLC4A2 mRNAincreases expression 15353170
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SLC4A2 mRNAincreases expression 17942748
D010126 Ozone [Ozone co-treated with Chlorine] results in decreased expression of SLC4A2 mRNAaffects cotreatment|decreases expression 18636392
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 9.157525203
MESH:D000014 Abnormalities, Drug-Induced Ethanol 9.1518926900 17676605
MESH:D000138 Acidosis Ammonium Chloride 10.7518287403
MESH:D000138 Acidosis Ethanol 10.7511192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0417505938
MESH:D055371 Acute Lung Injury Chlorine 4.3820601635
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8214692618
MESH:D000236 Adenoma Diethylnitrosamine 2.8810737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 3.9817620307 18056438 19061943 17162532 19052882 16434500
MESH:D000380 Agranulocytosis Dapsone 6.6615999287
MESH:D000382 Agricultural Workers' Diseases alachlor 4.7414769641 11874814
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.4215451039 15451040
MESH:D000544 Alzheimer Disease Ozone 2.4515513908
MESH:D000853 Anophthalmos Ethanol 4.8915513904
MESH:D001008 Anxiety Disorders Ethanol 4.0511141031
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6915885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5715570426
MESH:D001249 Asthma Ozone 2.6517854713 16373670
MESH:D001321 Autistic Disorder Arachidonic Acid 3.0218582451
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2317474063
MESH:D016535 Bronchial Hyperreactivity Ozone 3.7216777450 18417511 19059883 15516495 14754758 17626835 18315731
MESH:D002056 Burns Ethanol 4.7216374292
MESH:D002100 Cachexia Ozone 4.8216183385
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.853786805 16124888 10355542 16011737 16192424 18705752 15721981 16097048 16050911 15673190 15700767 16227642
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7118788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.7120084675 20524982 20432363 20727157 16807293 19052882 18665156 17428255 17055752 17761372 18978308 18393292 19519916 17138121 16328049 19701751 18788625 20935162 21159647 17978847 18056438 18210153 19418558 19394651 10672840 16288022 10737359 16935385 19919837 20214788 16779866 3084413 17162532 18506893 16681979 19539802 18785209 17173139 19107877 11831363 20514400 16569478 19822196 19171122 19208518 18494052 16830150 16540662 18971187 20101231 16878318 16502159 16698587 19335982 20007298 18691550 3581430 20512989 19383236
MESH:D006528 Carcinoma, Hepatocellular Ethanol 4.7115289165 18788625 15763234
MESH:D006332 Cardiomegaly Ethanol 3.4619332462
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.6614694615
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.897505956 2727394 17174075 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7319052882
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9116919318 17333356 16105132 15861022 17681005 17110522 11677210
MESH:D002971 Cleft Lip Ethanol 3.6115513904
MESH:D002972 Cleft Palate Ethanol 3.1915513904
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.2115095906
MESH:D019465 Craniofacial Abnormalities Ethanol 2.3315513904 19302082 15451040 11198716 11873399 15451039 10194807
MESH:D017449 Dermatitis, Allergic Contact alachlor 4.268428444
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2020387270
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 9.1821346803
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.1821278145 19336974 3786805 7440962 7120509 9327722 7179309 16227642 15998439 11566570 15027814 15968718 10092053 2869522 6623471 19085960 6884620 3732212 4309450 16177239 10915739 17522070
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.1819107877
MESH:D056486 Drug-Induced Liver Injury Ethanol 9.1811566570
MESH:D004417 Dyspnea Chlorine 4.7220016425
MESH:D004487 Edema Arachidonic Acid 4.099599246 11698051 7990266 16716910 15177302 9831321
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2512538720
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2116302075
MESH:D004938 Esophageal Neoplasms Ethanol 2.7716704527
MESH:D005234 Fatty Liver Carbon Tetrachloride 19.2716239168 17595544 15959796 61145 19224547 12631006 12795759 16045604
MESH:D005234 Fatty Liver Diethylnitrosamine 19.2720387270 21071580
MESH:D005234 Fatty Liver Ethanol 19.2718620774 19236843 16409862
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.2715345470
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.7617920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.3816946407 15513904 10194807 15451040
MESH:D005334 Fever Arachidonic Acid 4.7111852909
MESH:D005355 Fibrosis Carbon Tetrachloride 3.5318705752
MESH:D005739 Gas Poisoning Chlorine 5.1120016425
MESH:D005756 Gastritis Ethanol 4.7915046732
MESH:D016460 Granuloma Annulare Dapsone 7.5315999287
MESH:D006486 Hemosiderosis Dapsone 6.7217053738
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6619110552 19900420
MESH:D006930 Hyperalgesia Ethanol 3.7618783367
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6116899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1615338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5212013081
MESH:D007248 Infertility, Male alachlor 7.1812948887 16466525 17049205
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.1817937319
MESH:D007249 Inflammation Arachidonic Acid 5.6017371808 9831321 15177302
MESH:D007249 Inflammation Diethylnitrosamine 5.6018785209
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.6410783313
MESH:D007569 Jaw Abnormalities Ethanol 4.4615513904
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 3.5815369732
MESH:D007859 Learning Disorders Ethanol 4.2815451040
MESH:D007938 Leukemia alachlor 4.0414769641
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 4.0216766008
MESH:D017880 Limb Deformities, Congenital Ethanol 3.8517676605
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 11.2517174718 16221502 11408273 11903743 16239168 17157831 21278145 17334410 16943688
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 11.2518665156 20032147 19638242 18522880 18407596
MESH:D008103 Liver Cirrhosis Ethanol 11.2515289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.1818295389
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.6915052691 12958196 17698563 10355542 12389079 15996030 14620537 15338365 15925388 18705752 16015684 15057751 18006644 16116963 18263696 15876570 16638106 18418968 17481882 12898905 12666154 17721639 17922224 17944888 15931870 18279442 17823541 17761835 17714472 20821823 15893842 17631135 16136751 12632512 18277467 16192424 17565644 18156304 15370692 18187930 12649538 18317297 16011737 15730626 17869086 18395914 14748882 18210741 17976157 12546737 18054572 15362042 18376398 15673190 14716496 16027843 18472332 17766677 14512876 16248980 15959796 18339082 18251166 11481614 12445418 16033810 15650968 14716833 18472094 17640975 18481824 18166357 12632514 12741479 17525996 18412020 17900296 13678700 14724832 18395095 12667390 12609069 17557913 17708605 12586293 15123356 12445421 15818738 17805973 18429990 16097048 18420326 18205269
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 2.6918166357
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.9315830285 16246199 16964402 17285989 15720792
MESH:D008107 Liver Diseases Dapsone 6.9317053738
MESH:D008107 Liver Diseases Diethylnitrosamine 6.9317034775
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.7217347304 17207112
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2415123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7416899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.6519294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 4.659163691 20583210 18977376 19850985 18754104 20492335 19499222 10737359 19812893 2862719 20137499 21167192 19690152 19642983 12112319 2422723 18644402 20405173 20452335 19427195 19426721 20101389 19638242 18648771 19256749 18978307 21278145 20501860 12771043 19090486 19294768 19833225 21047994 21071580 19255062 19996281 19254457 15885732 16942905 19551842 20118626 15175105 20434301 19073162
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.0615583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.0618164116 9362446 18253720 16842330 18544905 19004024 18079962 17174075 18775883 18308698 19009564 2563599 16267830 3124819 17854601 19126423 18093689 21159647 19539802 19519916 17942915 18282651
MESH:D008171 Lung Diseases Ozone 3.418266340 19066396
MESH:D055370 Lung Injury Ozone 3.9220417186
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.586695378 21163286 20512841 20970405
MESH:D008175 Lung Neoplasms Ozone 2.587614698 8597069
MESH:D008569 Memory Disorders Ethanol 4.2518411066 15451040
MESH:D008679 Metaplasia Ozone 5.2010496685
MESH:D009101 Multiple Myeloma alachlor 4.3214769641
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.593581430 9029167
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.3920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2120387270
MESH:D009669 Nose Neoplasms alachlor 4.9016698726 11127290 14563481 15580706 16178123
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 4.1514694615
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.5016540662
MESH:D010190 Pancreatic Neoplasms Ethanol 5.5012384795
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7511578682
MESH:D010538 Peritonitis Ozone 4.2016369182
MESH:D011014 Pneumonia Ozone 4.4818381685 18007984 18929643
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.602563599
MESH:D011537 Pruritus Ethinyl Estradiol 3.3916919318 15861022
MESH:D012120 Respiration Disorders Chlorine 5.3118579056
MESH:D012135 Respiratory Sounds alachlor 5.0211874814
MESH:D012640 Seizures Ethanol 3.209754883
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0416709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.6218456281
MESH:D013274 Stomach Neoplasms Ethanol 2.6218456281
MESH:D013276 Stomach Ulcer Ethanol 3.589562338 16755016 17189318 17918041 9211565 11906479
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.309754883
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2015669648
MESH:D013964 Thyroid Neoplasms alachlor 7.778812207
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.777505956
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3614692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5915869587 14671159
Pathway ID Pathway Name
KEGG:04976 Bile secretion
KEGG:04971 Gastric acid secretion
KEGG:04972 Pancreatic secretion
KEGG:04970 Salivary secretion
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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