AutismKB 2.0

Annotation Detail for SLC5A2


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Basic Information Top
Gene Symbol:SLC5A2 ( SGLT2 )
Gene Full Name: solute carrier family 5 (sodium/glucose cotransporter), member 2
Band: 16p11.2
Quick LinksEntrez ID:6524; OMIM: 182381; Uniprot ID:SC5A2_HUMAN; ENSEMBL ID: ENSG00000140675; HGNC ID: 11037
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Transmembrane transport of small molecules
No data
No data
Pathway IDPathway Name
500351Na+-dependent glucose transporters
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2032Kidney disease
No data
No data
Desease Name
Renal glucosuria
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC5A2 mRNAaffects expression 16483693
D002945 Cisplatin [Cisplatin results in decreased expression of HNF1A mRNA] which results in decreased expression of SLC5A2 mRNAdecreases expression 18656965
D002945 Cisplatin Cisplatin results in decreased expression of SLC5A2 mRNAdecreases expression 18656965
D002945 Cisplatin [Cisplatin results in decreased expression of SLC5A2 mRNA] which affects the transport of Glucoseaffects transport|decreases expression 18656965
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of SLC5A2 mRNAaffects expression 17555576
D005839 Gentamicins [Gentamicins results in decreased expression of HNF1A mRNA] which results in decreased expression of SLC5A2 mRNAdecreases expression 18656965
D005839 Gentamicins Gentamicins results in decreased expression of SLC5A2 mRNAdecreases expression 18656965
D005839 Gentamicins [Gentamicins results in decreased expression of SLC5A2 mRNA] which affects the transport of Glucoseaffects transport|decreases expression 18656965
D005947 Glucose [Cisplatin results in decreased expression of SLC5A2 mRNA] which affects the transport of Glucoseaffects transport|decreases expression 18656965
D005947 Glucose EDN3 protein inhibits the reaction [SLC5A2 protein results in increased uptake of Glucose]decreases reaction|increases uptake 15127950
D005947 Glucose [Gentamicins results in decreased expression of SLC5A2 mRNA] which affects the transport of Glucoseaffects transport|decreases expression 18656965
D005947 Glucose NPPA protein inhibits the reaction [SLC5A2 protein results in increased uptake of Glucose]decreases reaction|increases uptake 15127950
D012402 Rotenone Rotenone results in decreased expression of SLC5A2 mRNAdecreases expression 19013527
C446685 systhane systhane results in increased expression of SLC5A2 mRNAincreases expression 16643972
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SLC5A2 proteindecreases expression 15582352
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1814514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D058186 Acute Kidney Injury Cisplatin 9.9615814532 12690470 17670903
MESH:D058186 Acute Kidney Injury Gentamicins 9.9611274264
MESH:D000230 Adenocarcinoma Cisplatin 4.6317638652 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.6314692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.2614601052
MESH:D001943 Breast Neoplasms Cisplatin 2.1618382427 19526202
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.1620435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 2.4417982673
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.1016685392 12023789
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 2.8717066447 6189445 18337622
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918850075 18670907 16120746
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0517110522 16105132 17333356 11677210 15861022 17681005 16919318
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1915668235 15340226 12621046 8697196 16354765
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3315273666
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2714669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5920420201
MESH:D004362 Drug Toxicity Cisplatin 14.9212649298 12231392 19839026 15033597
MESH:D004362 Drug Toxicity Gentamicins 14.9215033597 11033412
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 14.9211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2818230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4712538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.259294722 10568697
MESH:D004938 Esophageal Neoplasms Cisplatin 2.8315464296 17638652 15173087 16481741 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.0515345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2520067830
MESH:D006030 Glycosuria, Renal marker/mechanism
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.8715102660 15464296
MESH:D034381 Hearing Loss Cisplatin 11.0219898482
MESH:D034381 Hearing Loss Gentamicins 11.0217868369 15968427 18024279 19130971
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.6215464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4410048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly systhane 9.9517178689 17178688
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.9515340226 16120746 12621046
MESH:D006689 Hodgkin Disease Cisplatin 3.8016170182 16200630
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4215340226 16354765 8697196 16959395 18606429
MESH:D053565 Hypercalciuria Gentamicins 6.0417652376
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9612878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007673 Kidney Cortex Necrosis Cisplatin 14.6115464296
MESH:D007673 Kidney Cortex Necrosis Gentamicins 14.6118842672
MESH:D007674 Kidney Diseases Cisplatin 7.1512649298 18289764 12231392 15190930 19839026
MESH:D007674 Kidney Diseases Gentamicins 7.1517934191 19349640 18289764
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 13.3011231351
MESH:D007683 Kidney Tubular Necrosis, Acute Gentamicins 13.3011231351
MESH:D016773 Leishmaniasis, Cutaneous Gentamicins 4.6610219319
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.7916984957
MESH:D008114 Liver Neoplasms, Experimental systhane 6.7317178689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.7312151625
MESH:D008175 Lung Neoplasms Cisplatin 2.526189445 11798837 17225452
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.5219555203 11884234
MESH:D008545 Melanoma Cisplatin 4.0318176117 17761969 18332650 16248763 12883367 16809738 12374674 12393984 17023156 15577323 11135225 18505091 16432458
MESH:D008545 Melanoma Glucose 4.0314993021
MESH:D018328 Melanoma, Amelanotic Cisplatin 5.1115990972
MESH:D008654 Mesothelioma Cisplatin 3.3217638057
MESH:D009137 Muscular Dystrophy, Animal Gentamicins 6.6518694830
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D009369 Neoplasms Cisplatin 3.0416773208
MESH:D009395 Nephritis, Interstitial Cisplatin 4.8715464296
MESH:D009410 Nerve Degeneration Rotenone 4.0617356569 18619942 15790535
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009447 Neuroblastoma Cisplatin 3.568761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 5.038761367
MESH:D010051 Ovarian Neoplasms Cisplatin 2.9319769630 17225452 15464296 6897625
MESH:D010190 Pancreatic Neoplasms Cisplatin 3.0619003803
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010300 Parkinson Disease Rotenone 3.0519232380 19114014 18619942 16140633 11445065 15451049 11535288 16412576 18191903
MESH:D020734 Parkinsonian Disorders Rotenone 4.3015927086 15574749 18197244 15795934
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.5915464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.7217638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311118676 11896295 11222880 11399792
MESH:D011507 Proteinuria Gentamicins 4.9815033597
MESH:D011537 Pruritus Ethinyl Estradiol 3.6515861022 16919318
MESH:D051437 Renal Insufficiency Cisplatin 11.7115464296
MESH:D051437 Renal Insufficiency Gentamicins 11.7115728788 17132701
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012173 Retinitis Gentamicins 6.6518644591
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.7114601052
MESH:D012878 Skin Neoplasms Glucose 6.3114993021
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.3116192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.7215464296
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D013274 Stomach Neoplasms Cisplatin 2.3318396642 17522103 15958060
MESH:D013736 Testicular Neoplasms Cisplatin 4.8917225452 15464296
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 3.0215464296 12973940 17225452
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.4316803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D014625 Vaginal Neoplasms Cisplatin 4.9215577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7815869587 14671159
MESH:D015837 Vestibular Diseases Gentamicins 5.8018776599
MESH:D014839 Vomiting Cisplatin 5.0911897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
Pathway ID Pathway Name
REACT:15518 Transmembrane transport of small molecules
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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