AutismKB 2.0

Annotation Detail for WNK2


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Basic Information Top
Gene Symbol:WNK2 ( KIAA1760,NY-CO-43,P/OKcl.13,PRKWNK2,SDCCAG43 )
Gene Full Name: WNK lysine deficient protein kinase 2
Band: 9q22.31
Quick LinksEntrez ID:65268; OMIM: 606249; Uniprot ID:WNK2_HUMAN; ENSEMBL ID: ENSG00000165238; HGNC ID: 14542
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006632 arsenic trioxide arsenic trioxide results in increased expression of WNK2 mRNAincreases expression 19763917
D002117 Calcitriol Calcitriol results in increased expression of WNK2 mRNAincreases expression 16002434
D002762 Cholecalciferol Cholecalciferol results in decreased expression of WNK2 mRNAdecreases expression 16508948
D019287 Zinc Sulfate Zinc Sulfate results in decreased expression of WNK2 mRNAdecreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Zinc Sulfate 5.547265320
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3619825857 11798837
MESH:D000860 Anoxia Zinc Sulfate 5.657265320
MESH:D001327 Autoimmune Diseases Cholecalciferol 5.5916142846
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 4.1016206674
MESH:D001943 Breast Neoplasms Calcitriol 2.5611237771
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.7911589617
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 1.9814691202 11135700 15073043 15553829 16217749
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.6019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.5112490120
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.7111237771
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.6912609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.5615213294
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.4415138306
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3812903497
MESH:D005234 Fatty Liver arsenic trioxide 3.7115073043
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.7716904648
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 5.5617063115
MESH:D007022 Hypotension Zinc Sulfate 4.937265320
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 4.6115237267
MESH:D007938 Leukemia arsenic trioxide 3.0015070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.2212560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.9416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.7214633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.1919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1920471514 19850784 17050201 16968895 16467208
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4611468182 16966277 16112521 19035177 16330433 17712046 16331271 16823087 12018890 16891316 15748426 19225113 15336539 15213294 9834237 12679006 11161223 15622746 17649720 19642359 17869043 17217047 17107899 19075265 12712474
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.8616882451
MESH:D008113 Liver Neoplasms arsenic trioxide 2.4614682389
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.9620377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.6615213294
MESH:D008175 Lung Neoplasms arsenic trioxide 1.8711798837 19825857
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3811468182 14977855 19549372 15949261 19417148
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.4018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3416882451 16105982
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.4716624393
MESH:D009436 Neural Tube Defects arsenic trioxide 3.3610525206
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.5016624393 12452020 19769630
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6315580305
MESH:D010235 Paraganglioma arsenic trioxide 4.6319927285
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.4115572423
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.6919131511
MESH:D011471 Prostatic Neoplasms Calcitriol 2.6916644109 16289102 18247401 15754350 12479363
MESH:D011471 Prostatic Neoplasms Cholecalciferol 2.6917024972
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.4716646077
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.3919014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.5915213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.6012973940 20435036 11780464 12845720
No data
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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