AutismKB 2.0

Annotation Detail for SLC6A2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SLC6A2 ( NAT1,NET,NET1,SLC6A5 )
Gene Full Name: solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
Band: 16q12.2
Quick LinksEntrez ID:6530; OMIM: 163970; Uniprot ID:SC6A2_HUMAN; ENSEMBL ID: ENSG00000103546; HGNC ID: 11048
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Amine compound SLC transporters
Transmembrane transport of small molecules
No data
Pathway IDPathway Name
P00001Adrenaline and noradrenaline biosynthesis
Pathway IDPathway Name
500357Na+/Cl- dependent neurotransmitter transporters
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1752Neuroendocrine tumor
1757Multiple endocrine neoplasia
1836Panic disorder
1870Drug abuse
1904Diabetes mellitus
2006Anorexia nervosa
2091Hypertension
2045Bipolar disorder
2221Behavior disease
Desease Name
CARDIOVASCULAR
ADHD
PSYCH
norepinephrine-transporter deficiency
PHARMACOGENOMIC
response to antidepressants
hypertension
attention-deficit hyperactivity disorder
anorexia nervosa
personality disorders
attention deficit hyperactivity disorder
gastrointestinal disorders
amphetamine response
orthostatic intolerance
left ventricular fractional shortening
No data
Desease Name
Orthostatic intolerance
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC6A2 mRNAaffects expression 16483693
D003913 Dextroamphetamine SLC6A2 gene SNP affects the susceptibility to Dextroamphetamineaffects response to substance 17239355
D000661 Amphetamine Amphetamine inhibits the reaction [nisoxetine binds to SLC6A2 protein]affects binding|decreases reaction 11082428
D000661 Amphetamine Amphetamine results in decreased activity of SLC6A2 proteindecreases activity 11082428
D000661 Amphetamine Amphetamine results in decreased expression of SLC6A2 proteindecreases expression 11082428
D000661 Amphetamine SLC6A2 SNP affects the susceptibility to Amphetamineaffects response to substance 19727679
D001151 Arsenic Arsenic results in decreased expression of SLC6A2 mRNAdecreases expression 19654921
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SLC6A2 mRNAaffects expression 12734012
D002330 Carmustine Carmustine results in increased expression of SLC6A2 mRNAincreases expression 15980968
D004390 Chlorpyrifos Chlorpyrifos affects the expression of SLC6A2 mRNAaffects expression 17452286
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of SLC6A2 mRNAincreases expression 18812211
D003024 Clozapine Clozapine results in decreased activity of SLC6A2 proteindecreases activity 11359867
D003024 Clozapine Clozapine results in increased activity of SLC6A2 proteinincreases activity 11359867
D003024 Clozapine Clozapine results in increased expression of SLC6A2 mRNAincreases expression 11359867
D003024 Clozapine Cycloheximide inhibits the reaction [Clozapine results in increased activity of SLC6A2 protein]decreases reaction|increases activity 11359867
D003024 Clozapine Dactinomycin inhibits the reaction [Clozapine results in increased activity of SLC6A2 protein]decreases reaction|increases activity 11359867
D003024 Clozapine Clozapine results in decreased expression of SLC6A2 mRNAdecreases expression 18923069
D003042 Cocaine Cocaine results in decreased activity of SLC6A2 proteindecreases activity 11082428
D003513 Cycloheximide Cycloheximide inhibits the reaction [Clozapine results in increased activity of SLC6A2 protein]decreases reaction|increases activity 11359867
D003609 Dactinomycin Dactinomycin inhibits the reaction [Clozapine results in increased activity of SLC6A2 protein]decreases reaction|increases activity 11359867
D003676 Deferoxamine Deferoxamine results in decreased expression of SLC6A2 proteindecreases expression 16650837
D003891 Desipramine Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D003891 Desipramine Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D003891 Desipramine Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D003891 Desipramine Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D003891 Desipramine Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D003891 Desipramine Desipramine results in decreased expression of SLC6A2 proteindecreases expression 18923402
D004026 Dieldrin Dieldrin affects the expression of SLC6A2 mRNAaffects expression 18812211
D004298 Dopamine Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D004298 Dopamine indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D004298 Dopamine SLC6A2 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]increases activity|increases reaction 17234900
D005419 Flavonoids Flavonoids results in increased expression of SLC6A2 mRNAincreases expression 18035473
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of SLC6A2 mRNAaffects cotreatment|increases expression 17183730
C029424 hydrazine hydrazine results in decreased expression of SLC6A2 mRNAdecreases expression 15282401
D012701 Serotonin SLC6A2 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein]increases activity|increases reaction 17234900
C418119 indatraline indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
C418119 indatraline indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
C418119 indatraline indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
C418119 indatraline indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
C418119 indatraline indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D007649 Ketamine [Ketamine co-treated with Xylenes] results in decreased activity of SLC6A2 proteinaffects cotreatment|decreases activity 17934728
D007649 Ketamine Ketamine results in decreased activity of SLC6A2 proteindecreases activity 17934728
D008694 Methamphetamine Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D008694 Methamphetamine indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D008694 Methamphetamine SLC6A2 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]increases activity|increases reaction 17234900
D009532 Nickel Nickel results in decreased expression of SLC6A2 mRNAdecreases expression 18812211
C011386 nisoxetine Amphetamine inhibits the reaction [nisoxetine binds to SLC6A2 protein]affects binding|decreases reaction 11082428
C011386 nisoxetine Norepinephrine inhibits the reaction [nisoxetine binds to SLC6A2 protein]affects binding|decreases reaction 11082428
D009638 Norepinephrine Norepinephrine inhibits the reaction [nisoxetine binds to SLC6A2 protein]affects binding|decreases reaction 11082428
D009638 Norepinephrine Norepinephrine results in decreased activity of SLC6A2 proteindecreases activity 11082428
D009638 Norepinephrine Norepinephrine results in decreased expression of SLC6A2 proteindecreases expression 11082428
D009638 Norepinephrine SLC6A2 protein promotes the reaction [Norepinephrine results in increased activity of TAAR1 protein]increases activity|increases reaction 17234900
D009661 Nortriptyline SLC6A2 gene polymorphism affects the susceptibility to Nortriptylineaffects response to substance 17018806
D009655 Octopamine Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D009655 Octopamine indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D009655 Octopamine SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]increases activity|increases reaction 17234900
C029261 phenethylamine SLC6A2 protein promotes the reaction [phenethylamine results in increased activity of TAAR1 protein]increases activity|increases reaction 17234900
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SLC6A2 mRNAaffects binding|decreases expression|increases activity 19710929
D011530 Protriptyline Protriptyline results in decreased expression of SLC6A2 proteindecreases expression 18923402
C074679 reboxetine reboxetine results in decreased expression of SLC6A2 proteindecreases expression 18923402
D012643 Selenium Selenium results in decreased expression of SLC6A2 mRNAdecreases expression 19244175
C030820 tryptamine Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
C030820 tryptamine indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
C030820 tryptamine SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]increases activity|increases reaction 17234900
D014439 Tyramine Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D014439 Tyramine indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D014439 Tyramine SLC6A2 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]increases activity|increases reaction 17234900
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of SLC6A2 mRNAaffects cotreatment|increases expression 17183730
D014810 Vitamin E Vitamin E results in decreased expression of SLC6A2 mRNAdecreases expression 19244175
D014992 Xylenes [Ketamine co-treated with Xylenes] results in decreased activity of SLC6A2 proteinaffects cotreatment|decreases activity 17934728
D014992 Xylenes Xylenes results in decreased activity of SLC6A2 proteindecreases activity 17934728
D019287 Zinc Sulfate Zinc Sulfate results in increased expression of SLC6A2 mRNAincreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.108875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.5819490988
MESH:D000138 Acidosis Ammonium Chloride 9.3118287403
MESH:D000138 Acidosis Zinc Sulfate 9.317265320
MESH:D055371 Acute Lung Injury Nickel 8.0416166738
MESH:D055371 Acute Lung Injury pirinixic acid 8.0418653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.0916434500
MESH:D018246 Adrenocortical Adenoma Arsenic 4.8117306315
MESH:D000380 Agranulocytosis Clozapine 4.6712649775 16160616 14617031
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 3.9617119214 16611668 11874814
MESH:D000550 Amblyopia Valproic Acid 4.8317688650
MESH:D019969 Amphetamine-Related Disorders Amphetamine 5.6616459022 16916582 18475255 15010207
MESH:D000855 Anorexia Amphetamine 4.6716101753 12183048 16084549 12005258
MESH:D000860 Anoxia Zinc Sulfate 4.627265320
MESH:D001008 Anxiety Disorders Valproic Acid 3.2617497229
MESH:D001145 Arrhythmias, Cardiac Xylenes 5.20513065
MESH:D020261 Arsenic Poisoning Arsenic 2.7516835338 18414634 16251483 12569548
MESH:D050197 Atherosclerosis Arsenic 3.0119371607 12928151
MESH:D001321 Autistic Disorder Norepinephrine 2.498570775
MESH:D001321 Autistic Disorder Serotonin 2.4918405062 15132762 18361446 17157402 19221690 18062943 8570775
MESH:D001321 Autistic Disorder Valproic Acid 2.4920603192 16609825 17157402 18775368 15238991 19460635 17507914 17688650 18316065 19232924 18940202 18396377 18985861 18177632 18558336
MESH:D001714 Bipolar Disorder Valproic Acid 2.8717594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 2.8019483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.158888407
MESH:D019046 Bone Marrow Neoplasms Dactinomycin 5.1414601052
MESH:D001919 Bradycardia Serotonin 5.088112388
MESH:D001932 Brain Neoplasms Carmustine 4.0516187019
MESH:D001943 Breast Neoplasms Deferoxamine 2.4015993339
MESH:D001943 Breast Neoplasms Dieldrin 2.4015770527 11859874
MESH:D001943 Breast Neoplasms Nickel 2.4015986119
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 8.6618705752 15721981 15673190 3786805 16227642 15700767 10355542 16192424 16097048 16011737 16124888 16050911
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 8.6616050911
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.3617687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Arsenic 2.9717306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 2.9718788625
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.5717687452 18922899 15504454
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.7418640142
MESH:D006332 Cardiomegaly Norepinephrine 4.1511179087
MESH:D002318 Cardiovascular Diseases Arsenic 3.1815738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 3.9818022660 16973168
MESH:D002375 Catalepsy Norepinephrine 5.148216760
MESH:D002659 Child Development Disorders, Pervasive Serotonin 5.9321254450
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 5.9320734317
MESH:D002779 Cholestasis pirinixic acid 2.5419176532
MESH:D021081 Chronobiology Disorders Serotonin 6.2917157402
MESH:D019970 Cocaine-Related Disorders Cocaine 5.3219606084
MESH:D003072 Cognition Disorders Clozapine 4.5817123785
MESH:D003092 Colitis Selenium 3.4017936198
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.5816575769 8888407 17688650
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5819769572
MESH:D003866 Depressive Disorder Desipramine 8.4115014590 3690436
MESH:D003866 Depressive Disorder reboxetine 8.4112866714
MESH:D017449 Dermatitis, Allergic Contact Nickel 3.5817244072 19470301 17100760
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2418249437
MESH:D003877 Dermatitis, Contact Nickel 4.282952479
MESH:D017453 Dermatitis, Irritant Xylenes 6.4317574719
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 2.8716402076
MESH:D003967 Diarrhea Serotonin 4.408112388 11488427 10446763
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.1515331141
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 5.546884620 7120509 7179309 19336974 21278145 3732212 10915739 19085960 17522070 15968718 2869522 16227642 4309450 16177239 10092053 9327722 15027814 3786805 11566570 15998439 6623471 7440962
MESH:D056486 Drug-Induced Liver Injury Selenium 5.5415131321
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 5.5419641884 1733752
MESH:D004409 Dyskinesia, Drug-Induced Desipramine 5.783690436
MESH:D050171 Dyslipidemias Clozapine 3.9016402076
MESH:D004421 Dystonia Valproic Acid 3.691851702
MESH:C538011 Eales disease Vitamin E 4.309068938
MESH:D004487 Edema pirinixic acid 6.1712083418
MESH:D004487 Edema Serotonin 6.1718841975
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.7717275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.523922381 16628512
MESH:D004827 Epilepsy Norepinephrine 6.48821787
MESH:D004827 Epilepsy Valproic Acid 6.4818234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.267562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.917750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.673659116
MESH:D005221 Fatigue Amphetamine 5.2019890266
MESH:D005234 Fatty Liver Carbon Tetrachloride 11.0812631006 19224547 12795759 15959796 16239168 16045604 61145 17595544
MESH:D005234 Fatty Liver pirinixic acid 11.0820131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 11.0819224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 4.4816575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.768888407 18558336
MESH:D005355 Fibrosis Carbon Tetrachloride 3.0818705752
MESH:D005534 Foot Diseases Arsenic 5.166392382
MESH:D005909 Glioblastoma Carmustine 3.6716187019
MESH:D006261 Headache Ketamine 5.6111554966
MESH:D006330 Heart Defects, Congenital Vitamin E 2.7816080930
MESH:D006333 Heart Failure pirinixic acid 6.1320558911
MESH:D006333 Heart Failure Selenium 6.1317162251
MESH:D006505 Hepatitis Carbon Tetrachloride 3.2219110552 19900420
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 4.6117063115
MESH:D006529 Hepatomegaly pirinixic acid 2.6219772884 16221962 18467677 19176532
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.5616863852 16490937
MESH:D015658 HIV Infections Nickel 3.6117263646
MESH:D019584 Hot Flashes Vitamin E 3.5714716179
MESH:D006849 Hydrocephalus Valproic Acid 4.4717688650
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1416899240
MESH:D006943 Hyperglycemia pirinixic acid 2.8420558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.1117050553
MESH:D006948 Hyperkinesis Amphetamine 17.0314960337 1977408
MESH:D006948 Hyperkinesis Clozapine 17.0316046005
MESH:D006948 Hyperkinesis Methamphetamine 17.0317658665
MESH:D006973 Hypertension Arsenic 2.7211953799 9931084 16076760
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7015338365
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.2416612254
MESH:D006987 Hypesthesia Arsenic 5.1616093927
MESH:D007022 Hypotension Dopamine 13.506740701
MESH:D007022 Hypotension Norepinephrine 13.506740701
MESH:D007022 Hypotension Zinc Sulfate 13.507265320
MESH:D007247 Infertility, Female Dieldrin 4.5810630421
MESH:D007249 Inflammation Flavonoids 4.8817296493
MESH:D007249 Inflammation Nickel 4.8816166738
MESH:D007251 Influenza, Human Selenium 9.6216624496
MESH:D007251 Influenza, Human Vitamin E 9.6216624496
MESH:D007333 Insulin Resistance pirinixic acid 2.3716306350
MESH:D007642 Keratosis Arsenic 4.6016930632 12749816
MESH:D007674 Kidney Diseases Vitamin E 2.5812488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.5316518626
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 3.9515237267
MESH:D015470 Leukemia, Myeloid, Acute Deferoxamine 4.1420368581
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.1417596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.2917339181
MESH:D008064 Lipidoses Clozapine 3.6817567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.5916943688 17334410 11903743 17174718 11408273 21278145 16239168 17157831 16221502
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.1820821823 15673190 18263696 17698563 12586293 15730626 14748882 18205269 18317297 17525996 16097048 18429990 15650968 16192424 16033810 12632512 15996030 15818738 17565644 17631135 14724832 17761835 18277467 15925388 14716833 16638106 18395095 12649538 18472332 15123356 15057751 14620537 18705752 17481882 17976157 17869086 18166357 18006644 17944888 15876570 15893842 17721639 16011737 17922224 15959796 16027843 12958196 18395914 16116963 16248980 12609069 14716496 18481824 13678700 17900296 15362042 16015684 18210741 12741479 12445418 11481614 18472094 15052691 12445421 18420326 15370692 14512876 18279442 17823541 12666154 12632514 17557913 17708605 18418968 17805973 18251166 18412020 18376398 18156304 17714472 12898905 15931870 18054572 17766677 12546737 17640975 18339082 12389079 10355542 12667390 16136751 18187930 15338365
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.1815474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.1816169303
MESH:D008107 Liver Diseases Arsenic 6.0511134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.0515720792 16246199 17285989 15830285 16964402
MESH:D008107 Liver Diseases Chlorpyrifos 6.0515991261
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.3514706259 16899240
MESH:D008113 Liver Neoplasms Arsenic 9.4416368122
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 9.4419294768
MESH:D008113 Liver Neoplasms Dieldrin 9.448742319 9539021
MESH:D008113 Liver Neoplasms pirinixic acid 9.4416377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.3715583823 12014681
MESH:D008171 Lung Diseases Vitamin E 2.9116863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.8617228818
MESH:D008175 Lung Neoplasms Arsenic 2.5317306315 17976673 19168569
MESH:D008175 Lung Neoplasms Vitamin E 2.5311062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.5215318939
MESH:D008545 Melanoma Carmustine 2.8112393984
MESH:D001523 Mental Disorders Clozapine 15.7916856516
MESH:D001523 Mental Disorders Desipramine 15.7916856516
MESH:D001523 Mental Disorders Nortriptyline 15.7916856516
MESH:D001523 Mental Disorders reboxetine 15.7916856516
MESH:D008654 Mesothelioma Selenium 2.6315107826
MESH:D024821 Metabolic Syndrome X Clozapine 4.0919142101
MESH:D008881 Migraine Disorders Tyramine 7.4010792367
MESH:D008881 Migraine Disorders Valproic Acid 7.4018765137 18803445
MESH:D009041 Motion Sickness Dextroamphetamine 5.121613127
MESH:D009135 Muscular Diseases pirinixic acid 3.1216239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.688888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 2.9217596541
MESH:D009203 Myocardial Infarction Cocaine 5.5118072171
MESH:D009203 Myocardial Infarction pirinixic acid 5.5119151258
MESH:D017202 Myocardial Ischemia Arsenic 3.6715371236
MESH:D015428 Myocardial Reperfusion Injury Norepinephrine 7.8215642760
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.8216411023
MESH:D009369 Neoplasms Dieldrin 4.638820588
MESH:D009369 Neoplasms pirinixic acid 4.6317405874
MESH:D009436 Neural Tube Defects Arsenic 6.5916620997
MESH:D009436 Neural Tube Defects Valproic Acid 6.5916359493 8888407
MESH:D019636 Neurodegenerative Diseases Amphetamine 4.3315183010
MESH:D020078 Neurogenic Inflammation Arsenic 10.0817056641
MESH:D020078 Neurogenic Inflammation Xylenes 10.0819159661
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 3.9015081274
MESH:D009765 Obesity Clozapine 4.3319142110 18515891
MESH:D009765 Obesity pirinixic acid 4.3320558911
MESH:D054971 Orthostatic Intolerance marker/mechanism
MESH:D010051 Ovarian Neoplasms Arsenic 2.6217306315
MESH:D010146 Pain Xylenes 4.6219159661 3412491
MESH:D010149 Pain, Postoperative Ketamine 5.7211554966
MESH:D010300 Parkinson Disease Desipramine 5.8310965161
MESH:D010300 Parkinson Disease Dieldrin 5.8316809432 16112328 11181820 11445065 17291500
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.8116093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.606392382 15371236 16905509
MESH:D010954 Plasmacytoma Selenium 4.4915087411
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 3.4420603192
MESH:D011471 Prostatic Neoplasms Arsenic 3.5816140617
MESH:D011471 Prostatic Neoplasms Vitamin E 3.5815084515
MESH:D011507 Proteinuria Arsenic 3.6421343184
MESH:D019310 Pseudolymphoma Valproic Acid 4.1412752131 11422049
MESH:D011618 Psychotic Disorders Clozapine 8.4215331141
MESH:D011618 Psychotic Disorders Cocaine 8.4216134406
MESH:D015427 Reperfusion Injury pirinixic acid 2.1919058328
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.2517119214 11874814 16611668
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.4916611668 17119214
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.8119155313
MESH:D012512 Sarcoma, Ewing's Dactinomycin 4.7114601052
MESH:D012559 Schizophrenia Clozapine 5.4620521326 16141801 11763009 20107430 19369910 17667964 18855531 20168265 17123785 17726453 20452607 11151749 18806925 20580759 20521320
MESH:D012559 Schizophrenia Ketamine 5.4620000043
MESH:D012559 Schizophrenia Valproic Acid 5.4615737665 19110320
MESH:D012640 Seizures Cocaine 5.6110454489
MESH:D012640 Seizures Valproic Acid 5.611511512 16876388 17978042 3137016 14763951 15475178 11044598 11738929
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.696418539
MESH:D012871 Skin Diseases Arsenic 4.6619834688 16759981 18709164 6392382 16353154 16702368 17938729 15952646 17548696 17050553 17453740
MESH:D012871 Skin Diseases Vitamin E 4.6618709164
MESH:D012878 Skin Neoplasms Arsenic 2.8217050553 15504454 17029826 17976673 16251483 19538983
MESH:D016135 Spinal Dysraphism Valproic Acid 3.4819490988
MESH:D013226 Status Epilepticus Valproic Acid 4.1412833885
MESH:D019956 Stereotypic Movement Disorder Amphetamine 6.021977408
MESH:D020521 Stroke Vitamin E 3.2116517955
MESH:D013610 Tachycardia Norepinephrine 5.063261545
MESH:D013733 Testicular Diseases Xylenes 5.5310048760 10514026
MESH:D014178 Translocation, Genetic Valproic Acid 4.8317262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.133119515
MESH:D001749 Urinary Bladder Neoplasms Arsenic 2.6617306315 11144890 19429237 19322015 18640142 17976673 15987713
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.268888407
MESH:D014652 Vascular Diseases Arsenic 4.3417056641
MESH:D015430 Weight Gain Clozapine 4.1416141801 17502770 20107430 20521320 20564506 16402076
MESH:D015431 Weight Loss Clozapine 4.6817933447
Pathway ID Pathway Name
REACT:20679 Amine compound SLC transporters
KEGG:00232 Caffeine metabolism
KEGG:00983 Drug metabolism - other enzymes
KEGG:01100 Metabolic pathways
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA310
    • Releated gene ID Related gene Name
    PA310SLC6A2
    Releated disease ID Related disease Name
    PA447278Depression
    PA443632Cardiomyopathy, Dilated
    PA447197Attention Deficit Disorder with Hyperactivity
    Releated drug ID Related drug Name
    PA452229antidepressants
    PA450657nortriptyline
    PA10066duloxetine
    PA451866venlafaxine
    PA164752812milnacipran
    PA449233desipramine
    PA450649norepinephrine
    PA134688071atomoxetine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00191 antagonist Fen-phen Adrenergic Agents;Central Nervous System Stimulants;Sympathomimetics;Central Nervous System Agents;Appetite Depressants;Anorexigenic Agents;Stimulants
    DB00193 antagonist Tramadol Narcotics;Analgesics;Analgesics, Opioid
    DB00226 partial agonist Guanadrel Sulfate Antihypertensive Agents
    DB00234 antagonist Reboxetine Adrenergic Uptake Inhibitors;Antidepressive Agents
    DB00285 antagonist Venlafaxine Antidepressants;Analgesics;Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB00289 - Atomoxetine Antidepressants;Adrenergic Uptake Inhibitors;Central Nervous System Agents
    DB00321 antagonist Triavil Tab Adrenergic Uptake Inhibitors;Analgesics, Non-Narcotic;Antidepressive Agents, Tricyclic
    DB00344 antagonist Protriptyline Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors;Antidepressive Agents
    DB00422 antagonist Methylphenidate Adrenergic Agents;Dopamine Uptake Inhibitors;Adrenergic Uptake Inhibitors;Central Nervous System Stimulants;Sympathomimetics
    DB00458 antagonist Imipramine Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00476 antagonist Duloxetine Dopamine Uptake Inhibitors;Adrenergic Uptake Inhibitors;Antidepressive Agents;Serotonin Uptake Inhibitors
    DB00540 antagonist Nortriptyline Antidepressants;Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00543 antagonist Amoxapine Adrenergic Uptake Inhibitors;Dopamine Antagonists;Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation;Neurotransmitter Uptake Inhibitors
    DB00579 antagonist Mazindol Dopamine Uptake Inhibitors;Adrenergic Uptake Inhibitors;Central Nervous System Stimulants
    DB00696 antagonist Wigraine Tab Vasoconstrictor Agents;Sympatholytics;Adrenergic alpha-Agonists;Analgesics, Non-Narcotic
    DB00715 antagonist Paroxetine Antidepressants;Selective Serotonin Reuptake Inhibitors (SSRIs);Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB00726 antagonist Trimipramine Antidepressants;Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00830 antagonist Phenmetrazine Central Nervous System Stimulants;Sympathomimetics;Central Nervous System Agents;Appetite Depressants
    DB00852 antagonist Tussin Cough Medicine DM Antitussive Expectorant Decongestant Vasoconstrictor Agents;Adrenergic Agents;Sympathomimetics;Central Nervous System Agents;Bronchodilator Agents;Nasal Decongestants
    DB00907 blocker Cocaine Vasoconstrictor Agents;Dopamine Uptake Inhibitors;Anesthetics;Local Anesthetics;Anesthetics, Local
    DB00934 antagonist Maprotiline Antidepressants;Adrenergic Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB00937 antagonist Diethylpropion Appetite Depressants;Anorexigenic Agents;Stimulants
    DB01105 antagonist Sibutramine Antidepressants;Appetite Depressants;Anorexigenic Agents;Stimulants;Antidepressive Agents
    DB01114 antagonist Triaminicol Dm Syrup Antipruritics;Anti-Allergic Agents;Histamine H1 Antagonists;Antihistamines
    DB01142 antagonist Doxepin Antidepressants;Anti-anxiety Agents;Antipruritics;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors;Histamine Antagonists
    DB01149 antagonist Nefazodone Antidepressants;Analgesics;Antidepressive Agents, Second-Generation;Serotonin Agents
    DB01151 antagonist Desipramine Antidepressants;Adrenergic Uptake Inhibitors;Enzyme Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB01156 antagonist Bupropion Dopamine Uptake Inhibitors;Antidepressive Agents;Antidepressive Agents, Second-Generation
    DB01170 agonist Guanethidine Antihypertensive Agents;Adrenergic Agents;Sympatholytics
    DB01173 antagonist Orphenadrine Skeletal Muscle Relaxants;Antiparkinson Agents;Antidyskinetics;Muscarinic Antagonists;Muscle Relaxants, Central;Parasympatholytics
    DB01175 antagonist Escitalopram Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB01242 antagonist Clomipramine Antidepressive Agents, Tricyclic;Serotonin Uptake Inhibitors
    DB01363 negative modulator Tartephedreel
    DB01364 inverse agonist Ephedrine Vasoconstrictor Agents;Adrenergic Agents;Central Nervous System Stimulants;Sympathomimetics
    DB01381 antagonist Ginkgo biloba
    DB01442 negative modulator MMDA Psychotropic Drugs
    DB01454 negative modulator 3,4-Methylenedioxymethamphetamine Adrenergic Uptake Inhibitors;Hallucinogens;Serotonin Agents
    DB01576 negative modulator Adderall XR Adrenergic Agents;Dopamine Agents;Dopamine Uptake Inhibitors;Adrenergic Uptake Inhibitors;Central Nervous System Stimulants;Sympathomimetics
    DB01577 negative modulator Methamphetamine Adrenergic Agents;Dopamine Agents;Dopamine Uptake Inhibitors;Adrenergic Uptake Inhibitors;Central Nervous System Stimulants;Sympathomimetics
    DB01579 negative modulator Phendimetrazine Anorexigenic Agents
    DB04821 - Nomifensine Dopamine Uptake Inhibitors
    DB04836 - Amineptine Antidepressive Agents, Tricyclic;Psychotropic Drugs
    DB04840 agonist Debrisoquin Antihypertensive Agents;Adrenergic Agents;Sympatholytics
    DB04896 antagonist Milnacipran Adrenergic Uptake Inhibitors;Antidepressive Agents;Serotonin Uptake Inhibitors
    DB06148 blocker Mianserin Serotonin Antagonists;Histamine H1 Antagonists;Adrenergic alpha-Antagonists;Antidepressive Agents, Second-Generation
    DB06700 antagonist Desvenlafaxine Antidepressants;Antidepressive Agents;Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs)
    DB06701 antagonist Dexmethylphenidate
    DB06707 antagonist Levonordefrin Vasoconstrictor Agents;Nasal Decongestants
    No data
    Drugbank ID Action Drug Name Description
    DB00368 substrate Norepinephrine Vasoconstrictor Agents;Sympathomimetics;Adrenergic alpha-Agonists
    DB06262 substrate Droxidopa Vasoconstrictor Agents;Sympathomimetics;Adrenergic alpha-Agonists
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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