AutismKB 2.0

Annotation Detail for SLC6A3


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Basic Information Top
Gene Symbol:SLC6A3 ( DAT,DAT1 )
Gene Full Name: solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
Band: 5p15.33
Quick LinksEntrez ID:6531; OMIM: 126455; Uniprot ID:SC6A3_HUMAN; ENSEMBL ID: ENSG00000142319; HGNC ID: 11049
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05012Parkinson's disease
Pathway IDPathway Name
Amine compound SLC transporters
Synaptic Transmission
Transmembrane transport of small molecules
Pathway IDPathway Name
200187Alpha-synuclein signaling
Pathway IDPathway Name
P00001Adrenaline and noradrenaline biosynthesis
P00049Parkinson disease
Pathway IDPathway Name
500357Na+/Cl- dependent neurotransmitter transporters
500155Dopamine clearance from the synaptic cleft
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1765Gilles de la Tourette syndrome
1850Herpes
1856Obesity
1870Drug abuse
1907Depression
1909Migraine
1944Breast cancer
2035Brain disease
2045Bipolar disorder
1874Stress disorder, post-traumatic
2198Psychotic disorder
2221Behavior disease
Desease Name
Parkinson's disease
CHEMDEPENDENCY
ADHD
Drug Hypersensitivity
alcohol withdrawl seizure and delirium tremens
alcohol withdrawal
CANCER
delirium tremens, alcohol-induced
PSYCH
disruptive behavior
methylphenidate response
PHARMACOGENOMIC
alcoholism
attention-deficit hyperactivity disorder
behavior problems
suicide
NEUROLOGICAL
Child hyperactivity-impulsivity and oppositional behaviors
posttraumatic stress disorder
eating behavior
attention deficit hyperactivity disorder
schizophrenia
METABOLIC
dopamine release
hyperactivity
post-traumatic stress disorder
smoking behavior
lung cancer
depression
dopamine transporter availability
externalizing behavior problems and associated temperament traits
externalizing behavior problems
No data
Desease Name
Nicotine dependence, protection against
Parkinsonism-dystonia, infantile
Attention-deficit hyperactivity disorder, susceptibility to
Major affective disorder
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C461261 (1-(2-(bis(4-fluorophenyl)methoxy)ethyl)-4-(3-hydroxy-3-phenylpropyl) piperazinyl decanoate) SLC6A3 protein affects the susceptibility to (1-(2-(bis(4-fluorophenyl)methoxy)ethyl)-4-(3-hydroxy-3-phenylpropyl) piperazinyl decanoate)affects response to substance 11312315
C021279 (1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester 1-Methyl-4-phenylpyridinium inhibits the reaction [(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester binds to SLC6A3 protein]affects binding|decreases reaction 17250655
C021279 (1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester (1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester binds to SLC6A3 proteinaffects binding 17250655
C017572 4-nitrotoluene 4-nitrotoluene results in decreased expression of SLC6A3 mRNAdecreases expression 15265578
C010643 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]affects cotreatment|decreases reaction|increases expression 12112414
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC6A3 mRNAaffects expression 16483693
D003913 Dextroamphetamine Dextroamphetamine results in increased activity of SLC6A3 proteinincreases activity 12716422
D003913 Dextroamphetamine GBR 12935 inhibits the reaction [Dextroamphetamine results in increased activity of SLC6A3 protein]decreases reaction|increases activity 12716422
D003913 Dextroamphetamine SLC6A3 protein affects the susceptibility to Dextroamphetamineaffects response to substance 11797063
D000661 Amphetamine Amphetamine affects the localization of SLC6A3 proteinaffects localization 16684900
D000661 Amphetamine [Amphetamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNAaffects cotreatment|increases expression 12112414
D000661 Amphetamine [Amphetamine co-treated with SLC6A3 protein] results in increased expression of FOS proteinaffects cotreatment|increases expression 12112414
D000661 Amphetamine [Amphetamine co-treated with Zinc] results in decreased localization of SLC6A3 proteinaffects cotreatment|decreases localization 16684900
D000661 Amphetamine Amphetamine inhibits the reaction [SLC6A3 protein mutant form results in increased export of Dopamine]decreases reaction|increases export 18614672
D000661 Amphetamine SLC6A3 3' UTR polymorphism affects the susceptibility to Amphetamineaffects response to substance 19462300
D000661 Amphetamine SLC6A3 3' UTR polymorphism results in decreased susceptibility to Amphetaminedecreases response to substance 15602501
D000661 Amphetamine SLC6A3 protein results in increased susceptibility to Amphetamineincreases response to substance 15602501
D000661 Amphetamine SLC6A3 protein promotes the reaction [Amphetamine results in increased activity of TAAR1 protein]increases activity|increases reaction 15764732
D000661 Amphetamine SLC6A3 protein affects the reaction [Amphetamine results in increased expression of FOS protein]affects reaction|increases expression 12699766
D000661 Amphetamine Amphetamine results in increased expression of SLC6A3 mRNAincreases expression 16126238
C027423 aroclor 1242 [aroclor 1242 co-treated with aroclor 1248 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of SLC6A3 proteinaffects cotreatment|decreases expression 17324953
C028617 aroclor 1248 [aroclor 1242 co-treated with aroclor 1248 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of SLC6A3 proteinaffects cotreatment|decreases expression 17324953
C026987 aroclor 1260 [Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]affects cotreatment|decreases reaction|increases uptake 16702228
C026987 aroclor 1260 [Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of SLC6A3 proteinaffects cotreatment|decreases expression 16702228
C026987 aroclor 1260 [aroclor 1242 co-treated with aroclor 1248 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of SLC6A3 proteinaffects cotreatment|decreases expression 17324953
D001590 Benztropine Benztropine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]decreases reaction|increases uptake 17250655
C070515 bisindolylmaleimide I bisindolylmaleimide I inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]affects cotreatment|decreases reaction|increases expression 12112414
C006780 bisphenol A bisphenol A results in decreased expression of SLC6A3 mRNAdecreases expression 17689037
15079872
D016642 Bupropion [Bupropion co-treated with SLC6A3 protein] results in increased expression of FOS proteinaffects cotreatment|increases expression 12112414
D016642 Bupropion Bupropion inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]affects cotreatment|decreases reaction|increases expression 12112414
D016642 Bupropion Bupropion inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]affects cotreatment|decreases reaction|increases expression 12112414
D002087 Butyrates Butyrates inhibits the reaction [Cocaine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]]decreases reaction|increases uptake 17250655
D002087 Butyrates Butyrates inhibits the reaction [Mazindol inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]]decreases reaction|increases uptake 17250655
D002087 Butyrates Butyrates results in increased expression of SLC6A3 proteinincreases expression 17250655
D002110 Caffeine SLC6A3 gene mutant form results in increased susceptibility to Caffeineincreases response to substance 11222668
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SLC6A3 mRNAaffects expression 17805973
D020111 Chlorodiphenyl (54% Chlorine) [Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]affects cotreatment|decreases reaction|increases uptake 16702228
D020111 Chlorodiphenyl (54% Chlorine) [Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of SLC6A3 proteinaffects cotreatment|decreases expression 16702228
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in decreased expression of SLC6A3 proteindecreases expression 17229471
D020111 Chlorodiphenyl (54% Chlorine) IL6 gene mutant form inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of SLC6A3 protein]decreases expression|decreases reaction 17229471
D020111 Chlorodiphenyl (54% Chlorine) [aroclor 1242 co-treated with aroclor 1248 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] results in decreased expression of SLC6A3 proteinaffects cotreatment|decreases expression 17324953
D004390 Chlorpyrifos Chlorpyrifos affects the expression of SLC6A3 mRNAaffects expression 18812211
D003024 Clozapine SLC6A3 5' UTR affects the susceptibility to Clozapineaffects response to substance 20580759
D003042 Cocaine Butyrates inhibits the reaction [Cocaine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]]decreases reaction|increases uptake 17250655
D003042 Cocaine [Cocaine co-treated with SLC6A3 protein] results in increased expression of FOS proteinaffects cotreatment|increases expression 12112414
D003042 Cocaine Cocaine inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]affects cotreatment|decreases reaction|increases expression 12112414
D003042 Cocaine Cocaine inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]affects cotreatment|decreases reaction|increases expression 12112414
D003042 Cocaine Cocaine inhibits the reaction [SLC6A3 protein results in increased transport of phenethylamine]decreases reaction|increases transport 15764732
D003042 Cocaine Cocaine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]decreases reaction|increases uptake 17250655
D003042 Cocaine SLC6A3 protein affects the susceptibility to Cocaineaffects response to substance 11312315
C017180 decamethrin decamethrin affects the activity of SLC6A3 proteinaffects activity 16005927
C017180 decamethrin decamethrin inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]decreases reaction|increases uptake 16005927
C017180 decamethrin decamethrin results in increased expression of SLC6A3 proteinincreases expression 16005927
D003976 Diazinon Diazinon affects the expression of SLC6A3 mRNAaffects expression 18812211
D004026 Dieldrin Dieldrin results in decreased expression of SLC6A3 proteindecreases expression 17291500
D004026 Dieldrin Dieldrin results in increased expression of SLC6A3 mRNAincreases expression 16809432
D004026 Dieldrin Dieldrin results in increased expression of SLC6A3 proteinincreases expression 16809432
D004026 Dieldrin Dieldrin results in increased expression of SLC6A3 mRNAincreases expression 18812211
D004026 Dieldrin Dieldrin results in increased expression of SLC6A3 proteinincreases expression 11719704
D004041 Dietary Fats Dietary Fats results in increased expression of SLC6A3 mRNAincreases expression 18457598
D004298 Dopamine 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]affects cotreatment|decreases reaction|increases expression 12112414
D004298 Dopamine Amphetamine inhibits the reaction [SLC6A3 protein mutant form results in increased export of Dopamine]decreases reaction|increases export 18614672
D004298 Dopamine Benztropine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]decreases reaction|increases uptake 17250655
D004298 Dopamine bisindolylmaleimide I inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]affects cotreatment|decreases reaction|increases expression 12112414
D004298 Dopamine Bupropion inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]affects cotreatment|decreases reaction|increases expression 12112414
D004298 Dopamine Bupropion inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]affects cotreatment|decreases reaction|increases expression 12112414
D004298 Dopamine Butyrates inhibits the reaction [Cocaine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]]decreases reaction|increases uptake 17250655
D004298 Dopamine Butyrates inhibits the reaction [Mazindol inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]]decreases reaction|increases uptake 17250655
D004298 Dopamine Cocaine inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]affects cotreatment|decreases reaction|increases expression 12112414
D004298 Dopamine Cocaine inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]affects cotreatment|decreases reaction|increases expression 12112414
D004298 Dopamine Cocaine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]decreases reaction|increases uptake 17250655
D004298 Dopamine decamethrin inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]decreases reaction|increases uptake 16005927
D004298 Dopamine [Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNAaffects cotreatment|increases expression 12112414
D004298 Dopamine [Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS proteinaffects cotreatment|increases expression 12112414
D004298 Dopamine indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D004298 Dopamine Mazindol inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]decreases reaction|increases uptake 17250655
D004298 Dopamine Methylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]affects cotreatment|decreases reaction|increases expression 12112414
D004298 Dopamine Methylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]affects cotreatment|decreases reaction|increases expression 12112414
D004298 Dopamine Methylphenidate inhibits the reaction [SLC6A3 protein mutant form results in increased export of Dopamine]decreases reaction|increases export 18614672
D004298 Dopamine Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D004298 Dopamine Permethrin inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]decreases reaction|increases uptake 16005927
D004298 Dopamine SLC6A3 protein mutant form results in increased export of Dopamineincreases export 18614672
D004298 Dopamine SLC6A3 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]increases activity|increases reaction 17234900
D004298 Dopamine SLC6A3 protein results in increased transport of Dopamineincreases transport 11707631
D004298 Dopamine SLC6A3 protein results in increased uptake of Dopamineincreases uptake 16005927
17250655
D004298 Dopamine vanoxerine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]decreases reaction|increases uptake 17250655
D004298 Dopamine [Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]affects cotreatment|decreases reaction|increases uptake 16702228
D004298 Dopamine Heptachlor promotes the reaction [SLC6A3 protein results in increased uptake of Dopamine]increases reaction|increases uptake 11294980
D004298 Dopamine SLC6A3 protein affects the abundance of Dopamineaffects abundance 18690110
D004298 Dopamine SLC6A3 protein results in increased uptake of Dopamineincreases uptake 11719704
D004958 Estradiol ESR2 protein affects the reaction [Estradiol results in increased expression of SLC6A3 protein]affects reaction|increases expression 16451217
D004958 Estradiol Estradiol results in increased expression of SLC6A3 proteinincreases expression 16451217
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of SLC6A3 geneincreases mutagenesis 16495775
D005473 Fluoxetine SLC6A3 protein affects the susceptibility to Fluoxetineaffects response to substance 11797063
C044630 GBR 12935 GBR 12935 binds to SLC6A3 proteinaffects binding 11226678
C044630 GBR 12935 GBR 12935 inhibits the reaction [Dextroamphetamine results in increased activity of SLC6A3 protein]decreases reaction|increases activity 12716422
C044630 GBR 12935 NR3C1 protein inhibits the reaction [GBR 12935 binds to SLC6A3 protein]affects binding|decreases reaction 11226678
C044630 GBR 12935 GBR 12935 binds to SLC6A3 proteinaffects binding 17493592
15985715
16190885
C044630 GBR 12935 Paraquat inhibits the reaction [GBR 12935 binds to SLC6A3 protein]affects binding|decreases reaction 15985715
17493592
16190885
D005905 Glyburide Glyburide promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC6A3 protein]decreases expression|increases reaction 16725203
D006220 Haloperidol SLC6A3 protein promotes the reaction [Haloperidol results in increased expression of NTS mRNA]increases expression|increases reaction 14698760
D006533 Heptachlor Heptachlor promotes the reaction [SLC6A3 protein results in increased uptake of Dopamine]increases reaction|increases uptake 11294980
D006533 Heptachlor Heptachlor results in increased expression of SLC6A3 proteinincreases expression 11294980
16112329
10499361
12428726
D006533 Heptachlor Heptachlor results in increased expression of SLC6A3 proteinincreases expression 11719704
D016627 Oxidopamine Oxidopamine results in decreased expression of SLC6A3 mRNAdecreases expression 15518916
D016627 Oxidopamine Oxidopamine results in increased expression of SLC6A3 mRNAincreases expression 15303306
D016627 Oxidopamine SLC6A3 protein results in increased susceptibility to Oxidopamineincreases response to substance 10881039
D012701 Serotonin SLC6A3 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein]increases activity|increases reaction 17234900
D012701 Serotonin SLC6A3 protein results in increased uptake of Serotoninincreases uptake 17250655
C418119 indatraline indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
C418119 indatraline indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
C418119 indatraline indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
C418119 indatraline indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
C418119 indatraline indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D008344 Maneb [Paraquat co-treated with Maneb] results in decreased expression of SLC6A3 proteinaffects cotreatment|decreases expression 11124998
D008345 Manganese Manganese results in decreased expression of SLC6A3 proteindecreases expression 16571372
C025340 manganese chloride manganese chloride results in decreased expression of SLC6A3 proteindecreases expression 16571372
D008454 Mazindol Butyrates inhibits the reaction [Mazindol inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]]decreases reaction|increases uptake 17250655
D008454 Mazindol Mazindol inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]decreases reaction|increases uptake 17250655
D008454 Mazindol Mazindol binds to SLC6A3 proteinaffects binding 15945060
D008454 Mazindol Mazindol binds to SLC6A3 proteinaffects binding 11719704
D008694 Methamphetamine indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D008694 Methamphetamine Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D008694 Methamphetamine SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]increases activity|increases reaction 17234900
D008694 Methamphetamine SLC6A3 gene mutant form results in decreased susceptibility to Methamphetaminedecreases response to substance 11222668
D018817 N-Methyl-3,4-methylenedioxyamphetamine SLC6A3 protein promotes the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in increased activity of TAAR1 protein]increases activity|increases reaction 15764732
D008774 Methylphenidate [Methylphenidate co-treated with SLC6A3 protein] results in increased expression of FOS proteinaffects cotreatment|increases expression 12112414
D008774 Methylphenidate Methylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]affects cotreatment|decreases reaction|increases expression 12112414
D008774 Methylphenidate Methylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]affects cotreatment|decreases reaction|increases expression 12112414
D008774 Methylphenidate Methylphenidate inhibits the reaction [SLC6A3 protein mutant form results in increased export of Dopamine]decreases reaction|increases export 18614672
D008774 Methylphenidate Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D008774 Methylphenidate Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D008774 Methylphenidate Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D008774 Methylphenidate Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D008774 Methylphenidate Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D008774 Methylphenidate SLC6A3 3' UTR polymorphism affects the susceptibility to Methylphenidateaffects response to substance 19462300
D008774 Methylphenidate SLC6A3 protein affects the reaction [Methylphenidate results in increased expression of FOS protein]affects reaction|increases expression 12699766
D008774 Methylphenidate SLC6A3 protein results in increased susceptibility to Methylphenidateincreases response to substance 12699766
D015655 1-Methyl-4-phenylpyridinium 1-Methyl-4-phenylpyridinium inhibits the reaction [(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester binds to SLC6A3 protein]affects binding|decreases reaction 17250655
D015655 1-Methyl-4-phenylpyridinium SLC6A3 protein affects the susceptibility to 1-Methyl-4-phenylpyridiniumaffects response to substance 12151787
D015655 1-Methyl-4-phenylpyridinium SLC6A3 protein results in increased susceptibility to 1-Methyl-4-phenylpyridiniumincreases response to substance 12151787
D015655 1-Methyl-4-phenylpyridinium SLC6A3 protein results in increased uptake of 1-Methyl-4-phenylpyridiniumincreases uptake 17250655
D015655 1-Methyl-4-phenylpyridinium SNCA protein affects the reaction [SLC6A3 protein results in increased susceptibility to 1-Methyl-4-phenylpyridinium]affects reaction|increases response to substance 12151787
D015655 1-Methyl-4-phenylpyridinium SNCA protein mutant form promotes the reaction [SLC6A3 protein results in increased susceptibility to 1-Methyl-4-phenylpyridinium]increases reaction|increases response to substance 12151787
D015655 1-Methyl-4-phenylpyridinium SLC6A3 protein results in increased susceptibility to 1-Methyl-4-phenylpyridiniumincreases response to substance 10881039
D015632 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of SLC6A3 proteinaffects cotreatment|decreases expression 19653878
D015632 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC6A3 proteindecreases expression 16725203
D015632 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Glyburide promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC6A3 protein]decreases expression|increases reaction 16725203
C048833 modafinil SLC6A3 gene mutant form results in decreased susceptibility to modafinildecreases response to substance 11222668
D005677 G(M1) Ganglioside G(M1) Ganglioside results in increased expression of SLC6A3 mRNAincreases expression 14552908
D009151 Mustard Gas Mustard Gas results in increased expression of SLC6A3 mRNAincreases expression 15674844
D009271 Naltrexone SLC6A3 gene polymorphism affects the susceptibility to Naltrexoneaffects response to substance 18552399
D009538 Nicotine Nicotine inhibits the reaction [Paraquat results in decreased expression of SLC6A3 protein]decreases expression|decreases reaction 17227438
D009627 Nomifensine Nomifensine results in decreased activity of SLC6A3 proteindecreases activity 11719704
D009638 Norepinephrine SLC6A3 protein promotes the reaction [Norepinephrine results in increased activity of TAAR1 protein]increases activity|increases reaction 17234900
D009638 Norepinephrine SLC6A3 protein results in increased uptake of Norepinephrineincreases uptake 17250655
D019301 Oleic Acid PPARA protein promotes the reaction [Oleic Acid results in increased expression of SLC6A3 mRNA]increases expression|increases reaction 18489776
D009655 Octopamine indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D009655 Octopamine Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D009655 Octopamine SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]increases activity|increases reaction 17234900
D010269 Paraquat Nicotine inhibits the reaction [Paraquat results in decreased expression of SLC6A3 protein]decreases expression|decreases reaction 17227438
D010269 Paraquat [Paraquat co-treated with Maneb] results in decreased expression of SLC6A3 proteinaffects cotreatment|decreases expression 11124998
D010269 Paraquat Paraquat results in decreased expression of SLC6A3 proteindecreases expression 17227438
D010269 Paraquat Paraquat inhibits the reaction [GBR 12935 binds to SLC6A3 protein]affects binding|decreases reaction 17493592
15985715
16190885
D026023 Permethrin Permethrin affects the activity of SLC6A3 proteinaffects activity 16005927
D026023 Permethrin Permethrin inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]decreases reaction|increases uptake 16005927
D026023 Permethrin Permethrin results in decreased expression of SLC6A3 proteindecreases expression 14555407
D026023 Permethrin Permethrin results in increased expression of SLC6A3 proteinincreases expression 14575646
16005927
12428726
C029261 phenethylamine Cocaine inhibits the reaction [SLC6A3 protein results in increased transport of phenethylamine]decreases reaction|increases transport 15764732
C029261 phenethylamine SLC6A3 protein promotes the reaction [phenethylamine results in increased activity of TAAR1 protein]increases activity|increases reaction 17234900
C029261 phenethylamine SLC6A3 protein results in increased transport of phenethylamineincreases transport 15764732
C029261 phenethylamine SLC6A3 protein promotes the reaction [phenethylamine results in increased activity of TAAR1 protein]increases activity|increases reaction 15764732
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SLC6A3 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of SLC6A3 mRNAincreases expression 17426115
D011339 Probenecid [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of SLC6A3 proteinaffects cotreatment|decreases expression 19653878
D017378 Quinolinic Acid Quinolinic Acid results in decreased expression of SLC6A3 proteindecreases expression 12207953
D017378 Quinolinic Acid Quinolinic Acid results in increased expression of SLC6A3 proteinincreases expression 12207953
D020849 Raloxifene Raloxifene results in increased expression of SLC6A3 proteinincreases expression 16451217
C074679 reboxetine SLC6A3 protein affects the susceptibility to reboxetineaffects response to substance 11312315
D012402 Rotenone Rotenone results in increased expression of SLC6A3 proteinincreases expression 18579341
C079213 RTI 121 RTI 121 binds to SLC6A3 proteinaffects binding 16451217
D013629 Tamoxifen Tamoxifen results in increased expression of SLC6A3 proteinincreases expression 16451217
D014050 Toluene Toluene affects the expression of SLC6A3 mRNAaffects expression 18653662
C030820 tryptamine indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
C030820 tryptamine Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
C030820 tryptamine SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]increases activity|increases reaction 17234900
D014439 Tyramine indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D014439 Tyramine Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D014439 Tyramine SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]increases activity|increases reaction 17234900
C043425 vanoxerine vanoxerine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]decreases reaction|increases uptake 17250655
C043425 vanoxerine SLC6A3 gene mutant form results in decreased susceptibility to vanoxerinedecreases response to substance 11222668
C043425 vanoxerine SLC6A3 protein affects the susceptibility to vanoxerineaffects response to substance 11312315
C043425 vanoxerine vanoxerine results in decreased activity of SLC6A3 proteindecreases activity 11312315
D015032 Zinc [Amphetamine co-treated with Zinc] results in decreased localization of SLC6A3 proteinaffects cotreatment|decreases localization 16684900
D015032 Zinc Zinc results in decreased activity of SLC6A3 proteindecreases activity 16684900
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.8414745880
MESH:D000014 Abnormalities, Drug-Induced Maneb 4.61982313
MESH:D000138 Acidosis Ammonium Chloride 2.8718287403
MESH:D000169 Acrodermatitis Zinc 4.7117190629 17202136 16889938
MESH:D055371 Acute Lung Injury pirinixic acid 2.4818653653
MESH:D000230 Adenocarcinoma Estradiol 1.9011473722
MESH:D000236 Adenoma Ethylnitrosourea 3.286695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 2.7916434500
MESH:D000380 Agranulocytosis Clozapine 4.3812649775 14617031 16160616
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 19.5116611668 11874814 17119214
MESH:D000382 Agricultural Workers' Diseases Diazinon 19.5116487989
MESH:D000382 Agricultural Workers' Diseases Heptachlor 19.5112661182
MESH:D000382 Agricultural Workers' Diseases Maneb 19.518807224
MESH:D000382 Agricultural Workers' Diseases Paraquat 19.5111874814
MESH:D000419 Albuminuria Raloxifene 3.9317308373 17451421
MESH:D000437 Alcoholism Naltrexone 5.4918552399 18482155
MESH:D000544 Alzheimer Disease Nicotine 5.5716627626
MESH:D000544 Alzheimer Disease Raloxifene 5.5715800139
MESH:D000544 Alzheimer Disease Zinc 5.5717119284 16325427 16410023 16580781
MESH:D019969 Amphetamine-Related Disorders Amphetamine 5.3615010207 16916582 16459022 18475255
MESH:D000755 Anemia, Sickle Cell Zinc 4.2416916123
MESH:D000756 Anemia, Sideroblastic Manganese 8.9516910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 8.9516910769
MESH:D000855 Anorexia Amphetamine 8.6412183048 16084549 16101753 12005258
MESH:D000855 Anorexia N-Methyl-3,4-methylenedioxyamphetamine 8.6415146954
MESH:D000860 Anoxia Oleic Acid 5.2015090967
MESH:D001008 Anxiety Disorders marker/mechanism 19120712
MESH:D001008 Anxiety Disorders Fluoxetine 4.3718083778
MESH:D001161 Arteriosclerosis Dietary Fats 3.2215238619
MESH:D001249 Asthma Mustard Gas 4.3010378619
MESH:D001249 Asthma Zinc 4.3017085522
MESH:D001289 Attention Deficit Disorder with Hyperactivity marker/mechanism 19120712 12699766
MESH:D001289 Attention Deficit Disorder with Hyperactivity Methylphenidate 7.6610490706 16919137 17276750
MESH:D001289 Attention Deficit Disorder with Hyperactivity Oxidopamine 7.6614699433
MESH:D001321 Autistic Disorder Fluoxetine 4.9918775368 19232924
MESH:D001321 Autistic Disorder Haloperidol 4.9918080171 19368416
MESH:D001321 Autistic Disorder Methylphenidate 4.9918752063 19232924 16919137
MESH:D001321 Autistic Disorder Naltrexone 4.998570775 9028057 19393386
MESH:D001321 Autistic Disorder Norepinephrine 4.998570775
MESH:D001321 Autistic Disorder Quinolinic Acid 4.9916139734
MESH:D001321 Autistic Disorder Serotonin 4.9917157402 15132762 8570775 18361446 18062943 18405062 19221690
MESH:D001768 Blister Mustard Gas 4.4719167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 2.5319483382
MESH:D001862 Bone Resorption bisphenol A 3.2411985600
MESH:D001919 Bradycardia Serotonin 4.798112388
MESH:D001927 Brain Diseases Ethylnitrosourea 4.2714991843
MESH:D001930 Brain Injuries Raloxifene 8.8816580743
MESH:D001930 Brain Injuries Zinc 8.8817109824
MESH:D001932 Brain Neoplasms Ethylnitrosourea 3.6916651633 15144691 16436596 18412241 16357521
MESH:D001943 Breast Neoplasms bisphenol A 3.1117123778
MESH:D001943 Breast Neoplasms Dieldrin 3.1111859874 15770527
MESH:D001943 Breast Neoplasms Dietary Fats 3.1120435547
MESH:D001943 Breast Neoplasms Estradiol 3.1116675129 17289903 12948864 17018787 19861407 18497071 17261762 14630087
MESH:D001943 Breast Neoplasms Heptachlor 3.118738476
MESH:D001943 Breast Neoplasms Raloxifene 3.1117440819 15572757 17595753 17952589 17049068 16912660 17242785 15775269 16837676 17893378 17261762 15758505
MESH:D001943 Breast Neoplasms Tamoxifen 3.1120135344 17242785 19059307 19189210 15668708 17893378 19103187 16873071 11161223 18984771 16202921 19011961 18351453 19115204 15565566 20005174 20544844 21152245 19244106 19288272 18629630 19221464 19142967 18821012 18855134 19410462 19155303 16273361 18815881 18425577 20065188 17261762 19200415 19189212 21138602 19066611 20390343 19289846 16818667 18997820 20859285 17049068 19084267 19487384 17440819
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.4715286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.2717687719 10378619
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.7716111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.1115700767 16097048 16192424 16124888 16011737 16050911 16227642 10355542 18705752 15673190 15721981 3786805
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.8319066611
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.6918788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.6916924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.6916924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.2917123778
MESH:D002294 Carcinoma, Squamous Cell Zinc 2.6716543248
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 7.4817572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 7.4817572228
MESH:D006332 Cardiomegaly Norepinephrine 3.9511179087
MESH:D002318 Cardiovascular Diseases Raloxifene 5.9515775269
MESH:D002318 Cardiovascular Diseases Zinc 5.9516936243
MESH:D002375 Catalepsy Haloperidol 9.3615215559 1977408
MESH:D002375 Catalepsy Norepinephrine 9.368216760
MESH:D002471 Cell Transformation, Neoplastic Estradiol 5.3518566989
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 5.3516003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.2817160924
MESH:D002547 Cerebral Palsy Toluene 5.169294310
MESH:D002659 Child Development Disorders, Pervasive Methylphenidate 6.1818752063 15319018
MESH:D002659 Child Development Disorders, Pervasive Serotonin 6.1821254450
MESH:D002779 Cholestasis pirinixic acid 2.3019176532
MESH:D021081 Chronobiology Disorders Serotonin 5.9817157402
MESH:D019970 Cocaine-Related Disorders Cocaine 10.6719606084
MESH:D019970 Cocaine-Related Disorders Methylphenidate 10.6719462300
MESH:D003072 Cognition Disorders Clozapine 9.4317123785
MESH:D003072 Cognition Disorders Raloxifene 9.4315800139
MESH:D003110 Colonic Neoplasms Butyrates 2.9415936596
MESH:D019465 Craniofacial Abnormalities decamethrin 4.7019861644
MESH:D019465 Craniofacial Abnormalities Permethrin 4.7019861644
MESH:D019465 Craniofacial Abnormalities Toluene 4.709294310
MESH:D019465 Craniofacial Abnormalities Zinc 4.7019302082
MESH:D003643 Death Toluene 4.966431079
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.2020210726
MESH:D003704 Dementia Haloperidol 3.9511575062
MESH:D003711 Demyelinating Diseases Tamoxifen 3.6819031437
MESH:D003866 Depressive Disorder Bupropion 10.6715014590
MESH:D003866 Depressive Disorder Fluoxetine 10.6715014590
MESH:D003866 Depressive Disorder reboxetine 10.6712866714
MESH:D003865 Depressive Disorder, Major Raloxifene 3.5717474826
MESH:D017449 Dermatitis, Allergic Contact Maneb 4.198807224
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.0618249437
MESH:D003877 Dermatitis, Contact Permethrin 4.3514617103
MESH:D009783 Dermatitis, Occupational Maneb 5.188807224
MESH:D003920 Diabetes Mellitus Zinc 3.6116479319
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 2.7716402076
MESH:D003928 Diabetic Nephropathies Estradiol 11.6019279558
MESH:D003928 Diabetic Nephropathies Raloxifene 11.6017308373 15920148 17451421
MESH:D003928 Diabetic Nephropathies Tamoxifen 11.6019279558
MESH:D003967 Diarrhea Serotonin 4.138112388 11488427 10446763
MESH:D006970 Disorders of Excessive Somnolence Clozapine 4.8515331141
MESH:D056486 Drug-Induced Liver Injury aroclor 1260 5.226156243
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 5.2210915739 6884620 7440962 6623471 7179309 3786805 21278145 17522070 2869522 10092053 16227642 7120509 9327722 11566570 15027814 19336974 19085960 15968718 3732212 4309450 16177239 15998439
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 5.2217851650
MESH:D050171 Dyslipidemias Clozapine 7.1216402076
MESH:D050171 Dyslipidemias Dietary Fats 7.1218367378
MESH:D004417 Dyspnea Diazinon 4.1016487989
MESH:D020821 Dystonic Disorders Nicotine 5.2317881519
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.2818357618
MESH:D004487 Edema bisindolylmaleimide I 19.118273558
MESH:D004487 Edema Fluoxetine 19.1112798668
MESH:D004487 Edema Mustard Gas 19.1111402378 11428631 9260866 11428647
MESH:D004487 Edema pirinixic acid 19.1112083418
MESH:D004487 Edema Raloxifene 19.1115860553
MESH:D004487 Edema Serotonin 19.1118841975
MESH:D020803 Encephalitis, Herpes Simplex Quinolinic Acid 6.1217174341
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 7.0715845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 7.0719031437
MESH:D016889 Endometrial Neoplasms Estradiol 5.7718566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 5.7717893378 19155303 16202921 20544844
MESH:D004827 Epilepsy Norepinephrine 3.90821787
MESH:D004890 Erythema Mustard Gas 4.479357497
MESH:D004938 Esophageal Neoplasms Zinc 2.6516543248
MESH:D005221 Fatigue Amphetamine 4.9119890266
MESH:D005234 Fatty Liver Carbon Tetrachloride 18.1012631006 16239168 16045604 17595544 12795759 15959796 19224547 61145
MESH:D005234 Fatty Liver Dietary Fats 18.1019004024 18296743 19551842 17967931
MESH:D005234 Fatty Liver pirinixic acid 18.1019236843 20131406
MESH:D005234 Fatty Liver Raloxifene 18.1017473493
MESH:D005234 Fatty Liver Tamoxifen 18.1019224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.7716709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.8314745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.4919069698
MESH:D005355 Fibrosis Carbon Tetrachloride 6.5818705752
MESH:D005355 Fibrosis Dietary Fats 6.5818296743
MESH:D005756 Gastritis Zinc 4.0917241300
MESH:D005909 Glioblastoma Ethylnitrosourea 6.1416436596
MESH:D005909 Glioblastoma Manganese 6.1417043766
MESH:D005910 Glioma Ethylnitrosourea 3.1716357521 16651633 18412241
MESH:D005911 Gliosis Maneb 12.0811124998
MESH:D005911 Gliosis Paraquat 12.0811124998
MESH:D006130 Growth Disorders Zinc 3.4817217573
MESH:D006331 Heart Diseases Raloxifene 3.0311110106
MESH:D006333 Heart Failure pirinixic acid 5.6020558911
MESH:D006333 Heart Failure Zinc 5.6017162251
MESH:D006335 Heart Injuries Zinc 5.0617074742
MESH:D016481 Helicobacter Infections Zinc 3.8917241300
MESH:D006505 Hepatitis Caffeine 12.1711394713
MESH:D006505 Hepatitis Carbon Tetrachloride 12.1719110552 19900420
MESH:D006505 Hepatitis Diazinon 12.1716487989
MESH:D006527 Hepatolenticular Degeneration Zinc 4.0117276780
MESH:D006529 Hepatomegaly pirinixic acid 2.3316221962 19176532 18467677 19772884
MESH:D006558 Herpes Genitalis Estradiol 4.3215709030
MESH:D019584 Hot Flashes Estradiol 8.2117088409
MESH:D019584 Hot Flashes Fluoxetine 8.2114716179
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 3.8416899240
MESH:D006937 Hypercholesterolemia Dietary Fats 2.9721332399
MESH:D006943 Hyperglycemia pirinixic acid 2.5820558911
MESH:D006946 Hyperinsulinism Naltrexone 5.6516901484
MESH:D006948 Hyperkinesis Amphetamine 21.761977408 14960337
MESH:D006948 Hyperkinesis Clozapine 21.7616046005
MESH:D006948 Hyperkinesis Methamphetamine 21.7617658665
MESH:D006948 Hyperkinesis Nomifensine 21.761977408
MESH:D006949 Hyperlipidemias Dietary Fats 2.9821332399
MESH:D006973 Hypertension Raloxifene 2.5717577099 15787275
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.4115338365
MESH:D007003 Hypoglycemia Glyburide 5.3110918110
MESH:D007022 Hypotension Dopamine 7.916740701
MESH:D007022 Hypotension Norepinephrine 7.916740701
MESH:D007247 Infertility, Female Dieldrin 4.3010630421
MESH:D007248 Infertility, Male Diazinon 5.6012948887 16466525
MESH:D007248 Infertility, Male Paraquat 5.604850670
MESH:D007249 Inflammation bisindolylmaleimide I 11.578273558
MESH:D007249 Inflammation Dietary Fats 11.5720412841
MESH:D007249 Inflammation Fluoxetine 11.5712798668
MESH:D007249 Inflammation Mustard Gas 11.5711402378 11428620 16001271 9260866 11428631 9357497 11428647 17524151 8975870
MESH:D007249 Inflammation Tamoxifen 11.5719457130
MESH:D007299 Insect Bites and Stings decamethrin 10.8015189238
MESH:D007299 Insect Bites and Stings Permethrin 10.8012749493 12971516 15189238
MESH:D007333 Insulin Resistance bisphenol A 13.6416393666
MESH:D007333 Insulin Resistance Dietary Fats 13.6411836018 18457598
MESH:D007333 Insulin Resistance Estradiol 13.6416393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 13.6416306350
MESH:D007511 Ischemia Zinc 3.9616584753
MESH:D007674 Kidney Diseases Estradiol 4.8415618244
MESH:D007674 Kidney Diseases Zinc 4.8416960431
MESH:D007676 Kidney Failure, Chronic Zinc 3.8016518626
MESH:D007680 Kidney Neoplasms Estradiol 9.2315610895
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 9.2317379185
MESH:D007680 Kidney Neoplasms Tamoxifen 9.2318625569
MESH:D007889 Leiomyoma Raloxifene 3.8516973256
MESH:D007938 Leukemia Permethrin 3.7412937054
MESH:D008064 Lipidoses Clozapine 10.3617567588
MESH:D008064 Lipidoses Fluoxetine 10.3617567588 15342952
MESH:D008064 Lipidoses Tamoxifen 10.3615342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 5.2017174718 16943688 17334410 11903743 11408273 16221502 16239168 17157831 21278145
MESH:D008103 Liver Cirrhosis Dietary Fats 5.2018296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.9518317297 15673190 12666154 12445418 12667390 17766677 20821823 18210741 17525996 15931870 18395095 15123356 15052691 18205269 12445421 12958196 12609069 16248980 11481614 13678700 18156304 18395914 18472332 15996030 14748882 18412020 14716833 15338365 18705752 15370692 15959796 14512876 17640975 10355542 17823541 17761835 16011737 17631135 16027843 18251166 18166357 18054572 16116963 16638106 16015684 17869086 14716496 16136751 18429990 17698563 17565644 17922224 17944888 12632512 18277467 17708605 17976157 17557913 16033810 18472094 17900296 15362042 16097048 17481882 18420326 12389079 18481824 18187930 18263696 18376398 15057751 15925388 15893842 17805973 15876570 12741479 14724832 18279442 15650968 12632514 18418968 12898905 12586293 15818738 18006644 12649538 17714472 12546737 18339082 14620537 17721639 15730626 16192424
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.9514659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.9515474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.9518564211
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.6616964402 15830285 16246199 17285989 15720792
MESH:D008107 Liver Diseases Chlorpyrifos 3.6615991261
MESH:D017093 Liver Failure Carbon Tetrachloride 3.4915123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.0816899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 10.8419294768
MESH:D008113 Liver Neoplasms Dieldrin 10.848742319 9539021
MESH:D008113 Liver Neoplasms Heptachlor 10.842422723 9544696
MESH:D008113 Liver Neoplasms pirinixic acid 10.8416377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 10.8416684651
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.1815583823 12014681
MESH:D008171 Lung Diseases Mustard Gas 2.9618702808 18161513
MESH:D055370 Lung Injury Oleic Acid 4.6815090967
MESH:D008175 Lung Neoplasms Ethylnitrosourea 2.9916271038 16019985 17703301 6695378
MESH:D008175 Lung Neoplasms Mustard Gas 2.998781369 3148597
MESH:D008175 Lung Neoplasms Tamoxifen 2.9918625569
MESH:D008223 Lymphoma Ethylnitrosourea 3.4315790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 4.3715375218
OMIM:125480 MAJOR AFFECTIVE DISORDER 1 marker/mechanism
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.0719428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.4016891317 17203775 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 10.4018041768 10767621 10838139
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 10.4014580682 11731420 16827153 19196723 19196722
MESH:D008325 Mammary Neoplasms, Experimental Zinc 10.4012773700
MESH:D020149 Manganese Poisoning Estradiol 18.3219453300
MESH:D020149 Manganese Poisoning Manganese 18.3219453300 16551646 16568477
MESH:D020149 Manganese Poisoning Tamoxifen 18.3219453300
MESH:D008545 Melanoma 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid 3.3717992120
MESH:D008545 Melanoma Tamoxifen 3.3719393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.4915990972
MESH:D008579 Meningioma Ethylnitrosourea 5.2817943659
MESH:D001523 Mental Disorders Clozapine 13.3016856516
MESH:D001523 Mental Disorders Fluoxetine 13.3016856516
MESH:D001523 Mental Disorders Haloperidol 13.3016856516
MESH:D001523 Mental Disorders reboxetine 13.3016856516
MESH:D008607 Mental Retardation Toluene 3.379294310
MESH:D024821 Metabolic Syndrome X Clozapine 3.8319142101
MESH:D008881 Migraine Disorders Tyramine 4.8410792367
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 4.8515863610
MESH:D009041 Motion Sickness Dextroamphetamine 4.821613127
MESH:D019957 Motor Skills Disorders Toluene 4.599294310
MESH:D009069 Movement Disorders Manganese 4.3716551646
MESH:D009101 Multiple Myeloma Raloxifene 2.9316497877
MESH:D009135 Muscular Diseases pirinixic acid 2.8316239165
MESH:D009203 Myocardial Infarction Cocaine 4.9418072171
MESH:D009203 Myocardial Infarction pirinixic acid 4.9419151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 11.1516810080
MESH:D015428 Myocardial Reperfusion Injury Norepinephrine 11.1515642760
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 11.1516411023
MESH:D009207 Myoclonus Fluoxetine 5.188041377
MESH:D009232 Myxoma Raloxifene 4.8516343187
MESH:D009290 Narcolepsy modafinil 5.7115260124
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.2319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.2419410462
MESH:D009369 Neoplasms Dieldrin 6.258820588
MESH:D009369 Neoplasms Nicotine 6.2516365874
MESH:D009369 Neoplasms pirinixic acid 6.2517405874
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 3.7416707424
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.3019200415 19196722 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 8.0717289903
MESH:D009389 Neovascularization, Pathologic Nicotine 8.0716365874
MESH:D009410 Nerve Degeneration 1-Methyl-4-phenylpyridinium 20.4317433543
MESH:D009410 Nerve Degeneration Maneb 20.4315350641 16893418
MESH:D009410 Nerve Degeneration Manganese 20.4316551646
MESH:D009410 Nerve Degeneration Paraquat 20.4316893418
MESH:D009410 Nerve Degeneration Rotenone 20.4317356569 18619942 15790535
MESH:D009421 Nervous System Malformations bisphenol A 7.5611399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 7.5616427766 11399458
MESH:D009442 Neurilemmoma Ethylnitrosourea 4.7216003739 17160924 16651423
MESH:D019636 Neurodegenerative Diseases 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 15.6812349958
MESH:D019636 Neurodegenerative Diseases 1-Methyl-4-phenylpyridinium 15.6816353238
MESH:D019636 Neurodegenerative Diseases Amphetamine 15.6815183010
MESH:D019636 Neurodegenerative Diseases Oxidopamine 15.6818514411
MESH:D020258 Neurotoxicity Syndromes 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 10.9816725203
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 10.9815081274
MESH:D020258 Neurotoxicity Syndromes Glyburide 10.9816725203
MESH:D009503 Neutropenia Mustard Gas 3.337688884 16761898
MESH:D009765 Obesity Clozapine 6.0919142110 18515891
MESH:D009765 Obesity Dietary Fats 6.0921332399 11836018 20518802 16723640 20132043 19632207 17217161 18457598 18674790
MESH:D009765 Obesity pirinixic acid 6.0920558911
MESH:D009771 Obsessive-Compulsive Disorder Fluoxetine 4.8120418887
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.2817160924
MESH:D010024 Osteoporosis Raloxifene 2.9419059307 15775268 17882678
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.5915758505 15579764 17823083 17893378
MESH:D010049 Ovarian Diseases bisphenol A 4.2911985600
MESH:D010051 Ovarian Neoplasms Estradiol 1.9719401270
MESH:D010146 Pain Fluoxetine 3.7912798668
MESH:D010300 Parkinson Disease marker/mechanism 16112329
MESH:D010300 Parkinson Disease 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 19.9511181820 15451049 16140633
MESH:D010300 Parkinson Disease 1-Methyl-4-phenylpyridinium 19.9517433543
MESH:D010300 Parkinson Disease Dieldrin 19.9511181820 17291500 11445065 16112328 16809432
MESH:D010300 Parkinson Disease Maneb 19.9515824117 12911755 16510128 11124998 16140633
MESH:D010300 Parkinson Disease Manganese 19.9511181820
MESH:D010300 Parkinson Disease Paraquat 19.9512911755 16140633 11445065 11124998 15451049 11181820 15824117 16510128
MESH:D010300 Parkinson Disease Rotenone 19.9516412576 11445065 19232380 18191903 18619942 15451049 16140633 19114014 11535288
MESH:D010302 Parkinson Disease, Secondary Oxidopamine 9.1515893579 11771942
MESH:D010302 Parkinson Disease, Secondary Paraquat 9.1516190885
MESH:D020734 Parkinsonian Disorders 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 12.0712349958
MESH:D020734 Parkinsonian Disorders Manganese 12.0716140633
MESH:D020734 Parkinsonian Disorders Rotenone 12.0715574749 18197244 15927086 15795934
OMIM:613135 PARKINSONISM-DYSTONIA, INFANTILE marker/mechanism
MESH:D020774 Pick Disease of the Brain Fluoxetine 5.328041377
MESH:D011014 Pneumonia Paraquat 3.7612504350
MESH:D011041 Poisoning Diazinon 6.9017603234
MESH:D011041 Poisoning Mustard Gas 6.9015727166
MESH:D011225 Pre-Eclampsia Zinc 3.6217114810
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 3.2710548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 8.4720887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 8.4720887781
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8916740699
MESH:D011471 Prostatic Neoplasms Estradiol 1.8916740699
MESH:D011471 Prostatic Neoplasms Heptachlor 1.8912661182
MESH:D011471 Prostatic Neoplasms Raloxifene 1.8916536755 16220300 15731164
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8915067354
MESH:D011471 Prostatic Neoplasms Zinc 1.8916517595 12429649 16606632 16700911
MESH:D011537 Pruritus Mustard Gas 8.3018058305
MESH:D011537 Pruritus Naltrexone 8.3015861022 19657356
MESH:D011595 Psychomotor Agitation Haloperidol 9.8411575062
MESH:D011595 Psychomotor Agitation Methylphenidate 9.8418752063
MESH:D011618 Psychotic Disorders Clozapine 11.7915331141
MESH:D011618 Psychotic Disorders Cocaine 11.7916134406
MESH:D011618 Psychotic Disorders Haloperidol 11.7911575062
MESH:D011629 Puberty, Precocious bisphenol A 4.0910548101
MESH:D011654 Pulmonary Edema Oleic Acid 5.1015090967
MESH:D011658 Pulmonary Fibrosis Mustard Gas 4.7917620002 17266442 10334151 17894541 17720292
MESH:D011658 Pulmonary Fibrosis Paraquat 4.7916324872 17997886
MESH:D011693 Purpura Raloxifene 4.8515770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.0019058328
MESH:D012128 Respiratory Distress Syndrome, Adult Oleic Acid 7.6318549715
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 7.6311700416
MESH:D012135 Respiratory Sounds Chlorpyrifos 7.7111874814 16611668 17119214
MESH:D012135 Respiratory Sounds Paraquat 7.7111874814
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.1916611668 17119214
MESH:D012162 Retinal Degeneration Paraquat 7.4016458197
MESH:D012162 Retinal Degeneration Zinc 7.4016584753
MESH:D012559 Schizophrenia Clozapine 3.6117667964 11151749 16141801 17123785 18806925 11763009 18855531 20521326 20580759 20452607 20168265 19369910 20107430 17726453 20521320
MESH:D012559 Schizophrenia Haloperidol 3.6118513383 20107430 19369910 1830565
MESH:D012640 Seizures Cocaine 10.3010454489
MESH:D012640 Seizures modafinil 10.3015260124
MESH:D012640 Seizures Nicotine 10.3017873105
MESH:D012640 Seizures Toluene 10.309294310 6431079
MESH:D020230 Serotonin Syndrome Fluoxetine 11.138704074
MESH:D020230 Serotonin Syndrome Methylphenidate 11.137854515
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.386418539
MESH:D012871 Skin Diseases Mustard Gas 2.4912880345 16961503 15451306
MESH:D012893 Sleep Disorders Caffeine 4.6319395429
MESH:D007319 Sleep Initiation and Maintenance Disorders Caffeine 4.4017225163
MESH:D013088 Spermatocele Tamoxifen 3.5916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.3519457130
MESH:D019956 Stereotypic Movement Disorder Amphetamine 5.721977408
MESH:D020521 Stroke Raloxifene 3.2616837676
MESH:D019966 Substance-Related Disorders bisphenol A 3.3016045194 16684133
MESH:D013610 Tachycardia Norepinephrine 4.783261545
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.0520210726
MESH:D013733 Testicular Diseases Toluene 4.2710048760 10514026
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 4.4715790496
MESH:D013964 Thyroid Neoplasms Butyrates 3.5417967635
MESH:D013978 Tibial Fractures Estradiol 11.3719048282
MESH:D013978 Tibial Fractures Raloxifene 11.3719048282
MESH:D013981 Tic Disorders marker/mechanism 19120712
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO marker/mechanism
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Bupropion 8.6116785264
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Nicotine 8.6116785264 16720336 11259349
MESH:D014029 Tobacco Use Disorder Bupropion 10.6120388087
MESH:D014029 Tobacco Use Disorder Nicotine 10.6115735609 17979512 18305452 18041664
MESH:D014062 Tongue Neoplasms Zinc 3.7916543248
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 4.1517572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 4.158653321 16712894 17572228
MESH:D014570 Urologic Diseases Diazinon 4.5716487989
MESH:D014591 Uterine Diseases bisphenol A 4.3014652134
MESH:D054556 Venous Thromboembolism Raloxifene 4.5016837676
MESH:D014846 Vulvar Neoplasms Raloxifene 4.8516343187
MESH:D015430 Weight Gain Clozapine 7.8516141801 20107430 20564506 20521320 16402076 17502770
MESH:D015430 Weight Gain Dietary Fats 7.8516723640
MESH:D015431 Weight Loss Clozapine 4.3817933447
Pathway ID Pathway Name
REACT:20679 Amine compound SLC transporters
KEGG:05012 Parkinson's disease
REACT:13685 Synaptic Transmission
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA311
    • Releated gene ID Related gene Name
    PA311SLC6A3
    Releated disease ID Related disease Name
    PA445254Parkinson Disease
    PA447278Depression
    PA446878Cocaine-Related Disorders
    PA443309Alcoholism
    PA446876Substance-Related Disorders
    PA447197Attention Deficit Disorder with Hyperactivity
    PA443560Breast Neoplasms
    PA447199Bipolar Disorder
    PA443959Dyskinesia, Drug-Induced
    PA443970Dystonia
    PA446736Hypokinesia
    PA444993Muscle Rigidity
    PA447216Schizophrenia
    PA445917Tremor
    Releated drug ID Related drug Name
    PA10066duloxetine
    PA164752812milnacipran
    PA449092colchicine
    PA451578tacrolimus
    PA452229antidepressants
    PA450522mirtazapine
    PA10389non-selective monoamine reuptake inhibitors
    PA451866venlafaxine
    PA449233desipramine
    PA450464methylphenidate
    PA452233antipsychotics
    PA451257risperidone
    PA449396dopamine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00182 negative modulator Adderall XR 5mg Adrenergic Agents;Dopamine Agents;Dopamine Uptake Inhibitors;Adrenergic Uptake Inhibitors;Central Nervous System Stimulants;Amphetamines;Sympathomimetics
    DB00191 antagonist Fen-phen Adrenergic Agents;Central Nervous System Stimulants;Sympathomimetics;Central Nervous System Agents;Appetite Depressants;Anorexigenic Agents;Stimulants
    DB00245 inhibitor Benztropine Antiparkinson Agents;Antidyskinetics;Muscarinic Antagonists;Parasympatholytics
    DB00285 antagonist Venlafaxine Antidepressants;Analgesics;Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB00422 antagonist Methylphenidate Adrenergic Agents;Dopamine Uptake Inhibitors;Adrenergic Uptake Inhibitors;Central Nervous System Stimulants;Sympathomimetics
    DB00476 antagonist Duloxetine Dopamine Uptake Inhibitors;Adrenergic Uptake Inhibitors;Antidepressive Agents;Serotonin Uptake Inhibitors
    DB00579 antagonist Mazindol Dopamine Uptake Inhibitors;Adrenergic Uptake Inhibitors;Central Nervous System Stimulants
    DB00721 antagonist Procaine Anesthetics;Local Anesthetics;Anesthetics, Local
    DB00726 antagonist Trimipramine Antidepressants;Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00745 antagonist Modafinil Central Nervous System Stimulants;Central Nervous System Agents;Anorexigenic Agents;Stimulants;Neuroprotective Agents
    DB00830 antagonist Phenmetrazine Central Nervous System Stimulants;Sympathomimetics;Central Nervous System Agents;Appetite Depressants
    DB00852 antagonist Tussin Cough Medicine DM Antitussive Expectorant Decongestant Vasoconstrictor Agents;Adrenergic Agents;Sympathomimetics;Central Nervous System Agents;Bronchodilator Agents;Nasal Decongestants
    DB00865 antagonist Benzphetamine Adrenergic Agents;Dopamine Agents;Dopamine Uptake Inhibitors;Adrenergic Uptake Inhibitors;Central Nervous System Stimulants;Sympathomimetics;Central Nervous System Agents
    DB00907 blocker Cocaine Vasoconstrictor Agents;Dopamine Uptake Inhibitors;Anesthetics;Local Anesthetics;Anesthetics, Local
    DB00937 antagonist Diethylpropion Appetite Depressants;Anorexigenic Agents;Stimulants
    DB00988 agonist Dopamine Dopamine Agents;Sympathomimetics;Cardiotonic Agents;Sympathomimetic
    DB01104 antagonist Sertraline Antidepressants;Selective Serotonin Reuptake Inhibitors (SSRIs);Antidepressive Agents;Serotonin Uptake Inhibitors
    DB01105 antagonist Sibutramine Antidepressants;Appetite Depressants;Anorexigenic Agents;Stimulants;Antidepressive Agents
    DB01114 antagonist Triaminicol Dm Syrup Antipruritics;Anti-Allergic Agents;Histamine H1 Antagonists;Antihistamines
    DB01146 antagonist Vito Bronches Sirop Antihistamines
    DB01149 antagonist Nefazodone Antidepressants;Analgesics;Antidepressive Agents, Second-Generation;Serotonin Agents
    DB01156 antagonist Bupropion Dopamine Uptake Inhibitors;Antidepressive Agents;Antidepressive Agents, Second-Generation
    DB01161 blocker Chloroprocaine Anesthetics, Local
    DB01175 antagonist Escitalopram Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB01255 antagonist Lisdexamfetamine Central Nervous System Agents
    DB01363 negative modulator Tartephedreel
    DB01442 negative modulator MMDA Psychotropic Drugs
    DB01454 negative modulator 3,4-Methylenedioxymethamphetamine Adrenergic Uptake Inhibitors;Hallucinogens;Serotonin Agents
    DB01463 antagonist Fencamfamine Central Nervous System Stimulants;Antipsychotic Agents
    DB01472 antagonist 4-Methoxyamphetamine Hallucinogens
    DB01576 negative modulator Adderall XR Adrenergic Agents;Dopamine Agents;Dopamine Uptake Inhibitors;Adrenergic Uptake Inhibitors;Central Nervous System Stimulants;Sympathomimetics
    DB01577 negative modulator Methamphetamine Adrenergic Agents;Dopamine Agents;Dopamine Uptake Inhibitors;Adrenergic Uptake Inhibitors;Central Nervous System Stimulants;Sympathomimetics
    DB04821 - Nomifensine Dopamine Uptake Inhibitors
    DB06701 antagonist Dexmethylphenidate
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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