AutismKB 2.0

Annotation Detail for SLC6A4


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Basic Information Top
Gene Symbol:SLC6A4 ( 5-HTT,5-HTTLPR,5HTT,HTT,OCD1,SERT,hSERT )
Gene Full Name: solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Band: 17q11.2
Quick LinksEntrez ID:6532; OMIM: 182138; Uniprot ID:SC6A4_HUMAN; ENSEMBL ID: ENSG00000108576; HGNC ID: 11050
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
No data
Pathway IDPathway Name
P043745HT2 type receptor mediated signaling pathway
P043765HT4 type receptor mediated signaling pathway
P043755HT3 type receptor mediated signaling pathway
P043735HT1 type receptor mediated signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1746Hypertension, Pulmonary
1799Epilepsy
1804Chronic obstructive airway disease
1836Panic disorder
1850Herpes
1856Obesity
1866Sudden infant death syndrome
1870Drug abuse
1907Depression
1909Migraine
1916Pervasive development disorder
1918Atherosclerosis
1923Generalized anxiety disorder
1954Stroke
1975Congenital heart disease
2006Anorexia nervosa
2045Bipolar disorder
2053Colon cancer
2075Heart failure
2094Ulcerative colitis
2124Autistic disorder
2144Fibromyalgia
2147Neurotic disorder
2158Pulmonary hypertension
2185Obsessive-compulsive disorder
2198Psychotic disorder
2216Chronic fatigue syndrome
2220Dermatitis
2221Behavior disease
Desease Name
alcohol use
auditory-evoked potentials
obsessive compulsive disorder
bipolar disorder
aggression
neuroticism
mood disorder
Parkinson's disease
AGING
personality traits
eating disorder
adverse neonatal outcomes birth weight neuromotor symptoms respiratory distress syndrome, neonatal
CARDIOVASCULAR
chronic fatigue syndrome
suicidal behavior
agreeableness
anxiety disorders
CHEMDEPENDENCY
ADHD
schizotypal traits
anxiety-related temperament and behavior problems
SIDS/sudden infant death syndrome
bipolar affective disorder
affective disorder
mood response
unipolar disorder
conduct disorder
PSYCH
stroke, ischemic
mania, antidepressant-induced
Depression, Postpartum
hyperkinetic disorder
pathological gambling
decision-making memory impairment
PHARMACOGENOMIC
alcoholism
migraine with aura
temporomandibular joint pain
obsessive-compulsive disorder
anxiety disorder
introversion and neuroticism
alcohol abuse substance abuse
alcohol intake
aggressive behavior
attention-deficit hyperactivity disorder
anorexia nervosa and food intake
psychosis, alcoholic
suicide
suicide, alcohol-dependent
anorexia nervosa
depressive disorder, major
cardiovascular
IMMUNE
personality disorders
violent suicide
alcohol abuse
NEUROLOGICAL
body mass bulimia harm avoidance personality disorders
serotonin
attention deficit hyperactivity disorder
Fibromyalgia
schizophrenia
loudness dependence
gastrointestinal disorders
violent suicidal behavior
Anxiety traits
METABOLIC
severe hyperkinetic disorders
migraine
Myocardial Infarction
major depression
delirium tremens
Sexual Dysfunction, Physiological
auditory evoked potential
chronic obstructive pulmonary disease/COPD
bipolar and unipolar disorder
mood disorders
chronic obstructive pulmonary disease
major and bipolar depressives
obesity
depression
illegal drug use
suicide family history
Weight Loss
substance abuse
brain function
impulse control disorder
citalopram adverse effects depressive disorder, major
dance performance
anxiety symptoms
decision making
Irritable Bowel Syndrome
REPRODUCTION
diabetes, type 2
psychoses
brain electrical response
Dementia
panic disorder
Autism
Anxiety and hostility and depression
harm avoidance behaviour in an elderly population.
smoking
cognitive ability
depression depressive disorder, major
sleep disorders
anxiety disorder migraine
anxiety-related traits
affective psychoses
No data
Desease Name
Obsessive-compulsive disorder 1
Anxiety-related personality traits
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D019386 Alendronate Alendronate affects the expression of SLC6A4 mRNAaffects expression 16079270
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC6A4 mRNAaffects expression 16483693
D003913 Dextroamphetamine SLC6A4 gene polymorphism affects the susceptibility to Dextroamphetamineaffects response to substance 16966188
D001151 Arsenic Arsenic results in increased expression of SLC6A4 mRNAincreases expression 18315880
D010133 p-Chloroamphetamine p-Chloroamphetamine results in decreased expression of SLC6A4 mRNAdecreases expression 16054768
D010133 p-Chloroamphetamine p-Chloroamphetamine results in decreased expression of SLC6A4 proteindecreases expression 16054768
D004390 Chlorpyrifos Chlorpyrifos results in decreased expression of SLC6A4decreases expression 17035140
D004390 Chlorpyrifos Chlorpyrifos results in decreased expression of SLC6A4 mRNAdecreases expression 18835401
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of SLC6A4increases expression 17035140
D015283 Citalopram Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D015283 Citalopram Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D015283 Citalopram Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D015283 Citalopram Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D015283 Citalopram Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D003024 Clozapine [SLC6A4 gene polymorphism results in decreased uptake of Serotonin] which results in decreased susceptibility to Clozapinedecreases response to substance|decreases uptake 20452607
D003024 Clozapine SLC6A4 protein affects the susceptibility to Clozapineaffects response to substance 20452607
D003024 Clozapine Clozapine results in increased expression of SLC6A4increases expression 12007678
D003976 Diazinon Diazinon results in decreased expression of SLC6A4 mRNAdecreases expression 18835401
D003976 Diazinon Diazinon results in decreased expression of SLC6A4 proteindecreases expression 17035140
D003976 Diazinon Diazinon results in increased expression of SLC6A4 proteinincreases expression 17035140
D019259 Lamivudine [Lamivudine co-treated with IFNA2 protein] results in increased expression of SLC6A4 mRNAaffects cotreatment|increases expression 16476009
D019259 Lamivudine Lamivudine promotes the reaction [SLC6A4 protein results in increased uptake of Serotonin]increases reaction|increases uptake 16476009
D019259 Lamivudine Lamivudine results in increased expression of and results in increased activity of SLC6A4 proteinincreases activity|increases expression 16476009
D019259 Lamivudine Lamivudine results in increased expression of SLC6A4 mRNAincreases expression 16476009
D004026 Dieldrin Dieldrin results in decreased expression of SLC6A4 mRNAdecreases expression 18835401
D015116 5,7-Dihydroxytryptamine 5,7-Dihydroxytryptamine results in decreased expression of SLC6A4 proteindecreases expression 16054768
D004298 Dopamine Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D004298 Dopamine indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D004298 Dopamine SLC6A4 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]increases activity|increases reaction 17234900
C074283 estradiol 3-benzoate estradiol 3-benzoate results in increased expression of SLC6A4 proteinincreases expression 17398000
C074283 estradiol 3-benzoate Raloxifene inhibits the reaction [estradiol 3-benzoate results in increased expression of SLC6A4 protein]decreases reaction|increases expression 17398000
D004958 Estradiol [Estradiol co-treated with Sertraline] affects the expression of SLC6A4 mRNAaffects cotreatment|affects expression 18650020
D004958 Estradiol Estradiol promotes the reaction [Sertraline results in increased expression of SLC6A4 mRNA]increases expression|increases reaction 18650020
D004958 Estradiol Estradiol results in increased expression of SLC6A4 mRNAincreases expression 18650020
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of SLC6A4 mRNAaffects expression 16079270
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of SLC6A4 geneincreases mutagenesis 16495775
D006220 Haloperidol Haloperidol results in increased expression of SLC6A4increases expression 12007678
D012701 Serotonin Lamivudine promotes the reaction [SLC6A4 protein results in increased uptake of Serotonin]increases reaction|increases uptake 16476009
D012701 Serotonin Ribavirin promotes the reaction [SLC6A4 protein results in increased uptake of Serotonin]increases reaction|increases uptake 16476009
D012701 Serotonin SLC6A4 gene polymorphism affects the abundance of Serotoninaffects abundance 17203304
D012701 Serotonin [SLC6A4 gene polymorphism results in decreased uptake of Serotonin] which results in decreased susceptibility to Clozapinedecreases response to substance|decreases uptake 20452607
D012701 Serotonin SLC6A4 protein promotes the reaction [Serotonin results in increased activity of TAAR1 protein]increases activity|increases reaction 17234900
D012701 Serotonin SLC6A4 protein results in increased uptake of Serotoninincreases uptake 20452607
16476009
D012701 Serotonin SLC6A4 protein results in increased uptake of Serotoninincreases uptake 15972295
D017367 Serotonin Uptake Inhibitors SLC6A4 intron polymorphism affects the susceptibility to Serotonin Uptake Inhibitorsaffects response to substance 17018806
D017367 Serotonin Uptake Inhibitors SLC6A4 promoter polymorphism affects the susceptibility to Serotonin Uptake Inhibitorsaffects response to substance 17018806
D017367 Serotonin Uptake Inhibitors [Sertraline results in decreased expression of SLC6A4 protein] which results in decreased metabolism of Serotonin Uptake Inhibitorsdecreases expression|decreases metabolic processing 12151556
C418119 indatraline indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
C418119 indatraline indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
C418119 indatraline indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
C418119 indatraline indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
C418119 indatraline indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D008694 Methamphetamine Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D008694 Methamphetamine indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D008694 Methamphetamine SLC6A4 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]increases activity|increases reaction 17234900
D018817 N-Methyl-3,4-methylenedioxyamphetamine N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SLC6A4 mRNAdecreases expression 16054768
16489401
D018817 N-Methyl-3,4-methylenedioxyamphetamine N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SLC6A4 proteindecreases expression 16054768
D016686 Monocrotaline Monocrotaline results in increased expression of SLC6A4 mRNAincreases expression 17042913
D016686 Monocrotaline Sertraline inhibits the reaction [Monocrotaline results in increased expression of SLC6A4 mRNA]decreases reaction|increases expression 17042913
D009532 Nickel Nickel results in decreased expression of SLC6A4 mRNAdecreases expression 18835401
D009638 Norepinephrine SLC6A4 protein promotes the reaction [Norepinephrine results in increased activity of TAAR1 protein]increases activity|increases reaction 17234900
D009661 Nortriptyline SLC6A4 promoter polymorphism affects the susceptibility to Nortriptylineaffects response to substance 17018806
D009655 Octopamine Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D009655 Octopamine indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D009655 Octopamine SLC6A4 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]increases activity|increases reaction 17234900
D017374 Paroxetine Paroxetine affects the expression of SLC6A4 mRNAaffects expression 10575045
D017374 Paroxetine Paroxetine results in decreased expression of SLC6A4 mRNAdecreases expression 10575045
C029261 phenethylamine SLC6A4 protein promotes the reaction [phenethylamine results in increased activity of TAAR1 protein]increases activity|increases reaction 17234900
C006253 pirinixic acid pirinixic acid results in decreased expression of SLC6A4 mRNAdecreases expression 17426115
C006253 pirinixic acid pirinixic acid results in increased expression of SLC6A4 mRNAincreases expression 18301758
D020849 Raloxifene Raloxifene affects the expression of SLC6A4 mRNAaffects expression 16079270
D020849 Raloxifene Raloxifene inhibits the reaction [estradiol 3-benzoate results in increased expression of SLC6A4 protein]decreases reaction|increases expression 17398000
D012254 Ribavirin Ribavirin promotes the reaction [SLC6A4 protein results in increased uptake of Serotonin]increases reaction|increases uptake 16476009
D012254 Ribavirin Ribavirin results in increased expression of and results in increased activity of SLC6A4 proteinincreases activity|increases expression 16476009
D012254 Ribavirin Ribavirin results in increased expression of SLC6A4 mRNAincreases expression 16476009
C069723 RTI 55 RTI 55 binds to SLC6A4 proteinaffects binding 15972295
D020280 Sertraline Sertraline inhibits the reaction [Monocrotaline results in increased expression of SLC6A4 mRNA]decreases reaction|increases expression 17042913
D020280 Sertraline SLC6A4 promoter polymorphism results in increased susceptibility to Sertralineincreases response to substance 12955294
D020280 Sertraline SLC6A4 protein affects the susceptibility to Sertralineaffects response to substance 12955294
D020280 Sertraline Sertraline results in decreased expression of SLC6A4 proteindecreases expression 18923402
D020280 Sertraline [Estradiol co-treated with Sertraline] affects the expression of SLC6A4 mRNAaffects cotreatment|affects expression 18650020
D020280 Sertraline Estradiol promotes the reaction [Sertraline results in increased expression of SLC6A4 mRNA]increases expression|increases reaction 18650020
D020280 Sertraline Sertraline results in decreased expression of SLC6A4 proteindecreases expression 12151556
D020280 Sertraline [Sertraline results in decreased expression of SLC6A4 protein] which results in decreased metabolism of Serotonin Uptake Inhibitorsdecreases expression|decreases metabolic processing 12151556
D020280 Sertraline Sertraline results in increased expression of SLC6A4 mRNAincreases expression 18650020
C030820 tryptamine Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
C030820 tryptamine indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
C030820 tryptamine SLC6A4 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]increases activity|increases reaction 17234900
D014439 Tyramine Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D014439 Tyramine indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]decreases reaction|increases activity|increases reaction 17234900
D014439 Tyramine SLC6A4 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]increases activity|increases reaction 17234900
C047426 venlafaxine SLC6A4 gene polymorphism affects the susceptibility to venlafaxineaffects response to substance 17503984
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.1718287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5417505938
MESH:D055371 Acute Lung Injury Nickel 8.0416166738
MESH:D055371 Acute Lung Injury pirinixic acid 8.0418653653
MESH:D000230 Adenocarcinoma Estradiol 3.8511473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 3.8514692618
MESH:D000236 Adenoma Ethylnitrosourea 3.496695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.0916434500
MESH:D018246 Adrenocortical Adenoma Arsenic 4.8117306315
MESH:D000380 Agranulocytosis Clozapine 4.6712649775 14617031 16160616
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 7.8717119214 16611668 11874814
MESH:D000382 Agricultural Workers' Diseases Diazinon 7.8716487989
MESH:D000419 Albuminuria Raloxifene 4.2217308373 17451421
MESH:D000437 Alcoholism marker/mechanism 15520362
MESH:D000544 Alzheimer Disease Raloxifene 2.4515800139
MESH:D000855 Anorexia N-Methyl-3,4-methylenedioxyamphetamine 4.9815146954
MESH:D001008 Anxiety Disorders marker/mechanism
MESH:D001008 Anxiety Disorders Citalopram 9.0418083778
MESH:D001008 Anxiety Disorders Sertraline 9.0418822694
MESH:D020261 Arsenic Poisoning Arsenic 2.7516251483 16835338 18414634 12569548
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.0811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4215885639
MESH:D020817 Asperger Syndrome marker/mechanism 18197083
MESH:D050197 Atherosclerosis Arsenic 3.0119371607 12928151
MESH:D001321 Autistic Disorder marker/mechanism 16721604 17203304 17280648 9152989 20649385
MESH:D001321 Autistic Disorder Citalopram 3.4219232924 18775368
MESH:D001321 Autistic Disorder Haloperidol 3.4218080171 19368416
MESH:D001321 Autistic Disorder Norepinephrine 3.428570775
MESH:D001321 Autistic Disorder Serotonin 3.428570775 15132762 18361446 18405062 19221690 17157402 18062943
MESH:D001321 Autistic Disorder Sertraline 3.4218775368
MESH:D001778 Blood Coagulation Disorders pirinixic acid 2.8019483382
MESH:D001919 Bradycardia Serotonin 5.088112388
MESH:D001927 Brain Diseases Ethylnitrosourea 4.5414991843
MESH:D001930 Brain Injuries Raloxifene 4.0916580743
MESH:D001932 Brain Neoplasms Ethylnitrosourea 3.9516436596 15144691 16651633 16357521 18412241
MESH:D001943 Breast Neoplasms Dieldrin 2.0211859874 15770527
MESH:D001943 Breast Neoplasms Estradiol 2.0216675129 19861407 17018787 18497071 12948864 17289903 14630087 17261762
MESH:D001943 Breast Neoplasms Nickel 2.0215986119
MESH:D001943 Breast Neoplasms Raloxifene 2.0217049068 17261762 17242785 15775269 16837676 15572757 17595753 16912660 17440819 17952589 17893378 15758505
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0716111702
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.3615504454 17687452
MESH:D006528 Carcinoma, Hepatocellular Arsenic 2.9416507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Estradiol 2.9416924424
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.5715504454 18922899 17687452
MESH:D002295 Carcinoma, Transitional Cell Arsenic 8.5418640142
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.5417572228
MESH:D006332 Cardiomegaly Norepinephrine 4.1511179087
MESH:D002318 Cardiovascular Diseases Arsenic 6.6515738583 17938729 19152805
MESH:D002318 Cardiovascular Diseases Raloxifene 6.6515775269
MESH:D002340 Carotid Artery Diseases Arsenic 3.9816973168 18022660
MESH:D002375 Catalepsy Haloperidol 10.3415215559 1977408
MESH:D002375 Catalepsy Norepinephrine 10.348216760
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.1118566989
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 6.1116003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.5817160924
MESH:D002659 Child Development Disorders, Pervasive Citalopram 6.6115782081
MESH:D002659 Child Development Disorders, Pervasive Serotonin 6.6121254450
MESH:D002779 Cholestasis Ethinyl Estradiol 6.7711677210 17681005 16105132 17110522 15861022 17333356 16919318
MESH:D002779 Cholestasis pirinixic acid 6.7719176532
MESH:D021081 Chronobiology Disorders Serotonin 6.2917157402
MESH:D003072 Cognition Disorders Clozapine 10.4017123785
MESH:D003072 Cognition Disorders Raloxifene 10.4015800139
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.4820210726
MESH:D003704 Dementia Haloperidol 4.2311575062
MESH:D003866 Depressive Disorder Citalopram 16.3515014590
MESH:D003866 Depressive Disorder Paroxetine 16.3517072103 15014590
MESH:D003866 Depressive Disorder Sertraline 16.3515014590 18822694 20305041
MESH:D003866 Depressive Disorder venlafaxine 16.3520305041
MESH:D003865 Depressive Disorder, Major Raloxifene 9.3217474826
MESH:D003865 Depressive Disorder, Major Sertraline 9.3216968574
MESH:D017449 Dermatitis, Allergic Contact Nickel 3.5817100760 17244072 19470301
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2418249437
MESH:D003877 Dermatitis, Contact Nickel 4.282952479
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 2.8716402076
MESH:D003928 Diabetic Nephropathies Estradiol 7.9119279558
MESH:D003928 Diabetic Nephropathies Raloxifene 7.9117451421 17308373 15920148
MESH:D003967 Diarrhea Serotonin 4.4011488427 8112388 10446763
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.1515331141
MESH:D004362 Drug Toxicity Lamivudine 3.9815040536
MESH:D050171 Dyslipidemias Clozapine 3.9016402076
MESH:D004417 Dyspnea Diazinon 4.4016487989
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.5818357618
MESH:D004487 Edema pirinixic acid 9.7012083418
MESH:D004487 Edema Raloxifene 9.7015860553
MESH:D004487 Edema Serotonin 9.7018841975
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.8712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 7.8715845917
MESH:D016889 Endometrial Neoplasms Estradiol 2.7211473722 18566989 19148513
MESH:D004827 Epilepsy Norepinephrine 4.09821787
MESH:D005234 Fatty Liver Ethinyl Estradiol 11.0815345470
MESH:D005234 Fatty Liver pirinixic acid 11.0820131406 19236843
MESH:D005234 Fatty Liver Raloxifene 11.0817473493
MESH:D005534 Foot Diseases Arsenic 5.166392382
MESH:D005909 Glioblastoma Ethylnitrosourea 3.5716436596
MESH:D005910 Glioma Ethylnitrosourea 3.3318412241 16357521 16651633
MESH:D006331 Heart Diseases Raloxifene 3.2611110106
MESH:D006333 Heart Failure pirinixic acid 2.2920558911
MESH:D006505 Hepatitis Diazinon 4.2016487989
MESH:D006509 Hepatitis B Lamivudine 4.7517703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 4.7512044531 15631357 15309715 16476009 15274664
MESH:D019698 Hepatitis C, Chronic Ribavirin 6.1719749757 16476009 19749758
MESH:D006529 Hepatomegaly pirinixic acid 2.6218467677 19772884 16221962 19176532
MESH:D006558 Herpes Genitalis Estradiol 4.6315709030
MESH:D015658 HIV Infections Lamivudine 6.479296927 20032539 17530837 11141242
MESH:D015658 HIV Infections Nickel 6.4717263646
MESH:D019584 Hot Flashes Estradiol 15.1817088409
MESH:D019584 Hot Flashes Paroxetine 15.1814716179
MESH:D019584 Hot Flashes venlafaxine 15.1814716179
MESH:D006816 Huntington Disease Sertraline 5.6418403212
MESH:D006930 Hyperalgesia Alendronate 4.4116769263
MESH:D006943 Hyperglycemia pirinixic acid 2.8420558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.1117050553
MESH:D006948 Hyperkinesis Clozapine 10.5216046005
MESH:D006948 Hyperkinesis Methamphetamine 10.5217658665
MESH:D006973 Hypertension Arsenic 5.059931084 16076760 11953799
MESH:D006973 Hypertension Raloxifene 5.0515787275 17577099
MESH:D006976 Hypertension, Pulmonary Monocrotaline 5.2016936438 17042913 14726295
MESH:D006987 Hypesthesia Arsenic 5.1616093927
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4216945680 16569931
MESH:D007022 Hypotension Dopamine 8.836740701
MESH:D007022 Hypotension Norepinephrine 8.836740701
MESH:D007247 Infertility, Female Dieldrin 9.0810630421
MESH:D007247 Infertility, Female Ethinyl Estradiol 9.0812013081
MESH:D007248 Infertility, Male Diazinon 6.0716466525 12948887
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.0717937319
MESH:D007249 Inflammation Nickel 3.2316166738
MESH:D007333 Insulin Resistance Estradiol 6.3316393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 6.3316306350
MESH:D007642 Keratosis Arsenic 4.6012749816 16930632
MESH:D007674 Kidney Diseases Estradiol 2.3615618244
MESH:D007680 Kidney Neoplasms Estradiol 6.6615610895
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 6.6617379185
MESH:D007889 Leiomyoma Raloxifene 4.1316973256
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.2917339181
MESH:D008064 Lipidoses Citalopram 12.0417567588
MESH:D008064 Lipidoses Clozapine 12.0417567588
MESH:D008064 Lipidoses Sertraline 12.0417567588
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.1614659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1615474484
MESH:D008107 Liver Diseases Arsenic 4.2211134558
MESH:D008107 Liver Diseases Chlorpyrifos 4.2215991261
MESH:D017114 Liver Failure, Acute venlafaxine 5.0619857765
MESH:D008113 Liver Neoplasms Arsenic 6.6816368122
MESH:D008113 Liver Neoplasms Dieldrin 6.688742319 9539021
MESH:D008113 Liver Neoplasms pirinixic acid 6.6815890375 16377806 20007298
MESH:D008133 Long QT Syndrome Serotonin Uptake Inhibitors 6.1320210726
MESH:D008175 Lung Neoplasms Arsenic 2.8019168569 17306315 17976673
MESH:D008175 Lung Neoplasms Ethylnitrosourea 2.806695378 17703301 16019985 16271038
MESH:D008223 Lymphoma Ethylnitrosourea 3.6615790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 4.6615375218
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.8016891317 17203775 11807958 11408345
MESH:D008325 Mammary Neoplasms, Experimental estradiol 3-benzoate 8.8015375486
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 8.8010838139 10767621 18041768
MESH:D020149 Manganese Poisoning Estradiol 4.0819453300
MESH:D008579 Meningioma Ethylnitrosourea 5.5817943659
MESH:D001523 Mental Disorders Citalopram 30.6316856516
MESH:D001523 Mental Disorders Clozapine 30.6316856516
MESH:D001523 Mental Disorders Haloperidol 30.6316856516
MESH:D001523 Mental Disorders Nortriptyline 30.6316856516
MESH:D001523 Mental Disorders Paroxetine 30.6316856516
MESH:D001523 Mental Disorders Sertraline 30.6316856516
MESH:D001523 Mental Disorders venlafaxine 30.6316856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.0919142101
MESH:D008881 Migraine Disorders Tyramine 7.9810792367
MESH:D008881 Migraine Disorders venlafaxine 7.9818803445
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.1515863610
MESH:D009041 Motion Sickness Dextroamphetamine 5.121613127
MESH:D009101 Multiple Myeloma Raloxifene 3.1616497877
MESH:D009135 Muscular Diseases pirinixic acid 3.1216239165
MESH:D009203 Myocardial Infarction pirinixic acid 1.9719151258
MESH:D017202 Myocardial Ischemia Arsenic 3.6715371236
MESH:D015428 Myocardial Reperfusion Injury Estradiol 12.5916810080
MESH:D015428 Myocardial Reperfusion Injury Norepinephrine 12.5915642760
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 12.5916411023
MESH:D009232 Myxoma Raloxifene 5.1516343187
MESH:D009369 Neoplasms Dieldrin 4.638820588
MESH:D009369 Neoplasms pirinixic acid 4.6317405874
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.0216707424
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3417289903
MESH:D009421 Nervous System Malformations Estradiol 3.2816427766 11399458
MESH:D009436 Neural Tube Defects Arsenic 3.2016620997
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.0217160924 16003739 16651423
MESH:D020078 Neurogenic Inflammation Arsenic 4.0117056641
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 3.9015081274
MESH:D009765 Obesity Clozapine 4.3319142110 18515891
MESH:D009765 Obesity pirinixic acid 4.3320558911
MESH:D009771 Obsessive-Compulsive Disorder marker/mechanism 18197083
MESH:D009771 Obsessive-Compulsive Disorder Paroxetine 10.7217503984
MESH:D009771 Obsessive-Compulsive Disorder venlafaxine 10.7217503984
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.5817160924
MESH:D010024 Osteoporosis Alendronate 6.9717882678
MESH:D010024 Osteoporosis Raloxifene 6.9715775268 19059307 17882678
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.8717893378 17823083 15758505 15579764
MESH:D010051 Ovarian Neoplasms Arsenic 4.5017306315
MESH:D010051 Ovarian Neoplasms Estradiol 4.5019401270
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3211578682
MESH:D010300 Parkinson Disease Dieldrin 3.3716112328 16809432 11181820 17291500 11445065
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.8116093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.6015371236 6392382 16905509
MESH:D011041 Poisoning Diazinon 3.9917603234
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5320887781
MESH:D011471 Prostatic Neoplasms Arsenic 2.7916140617
MESH:D011471 Prostatic Neoplasms Estradiol 2.7916740699
MESH:D011471 Prostatic Neoplasms Raloxifene 2.7915731164 16220300 16536755
MESH:D011507 Proteinuria Arsenic 3.6421343184
MESH:D011537 Pruritus Ethinyl Estradiol 2.9215861022 16919318
MESH:D011595 Psychomotor Agitation Haloperidol 4.5711575062
MESH:D011618 Psychotic Disorders Clozapine 8.2115331141
MESH:D011618 Psychotic Disorders Haloperidol 8.2111575062
MESH:D011693 Purpura Raloxifene 5.1515770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.1919058328
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.2511874814 17119214 16611668
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.4917119214 16611668
MESH:D012206 Rhabdomyolysis Lamivudine 5.149296927
MESH:D012559 Schizophrenia marker/mechanism 18583979
MESH:D012559 Schizophrenia Clozapine 3.8718806925 20521320 20452607 20580759 11763009 16141801 20521326 17123785 17726453 17667964 18855531 11151749 20107430 19369910 20168265
MESH:D012559 Schizophrenia Haloperidol 3.871830565 18513383 20107430 19369910
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.696418539
MESH:D012871 Skin Diseases Arsenic 2.6416702368 18709164 16759981 17548696 16353154 17453740 19834688 15952646 6392382 17938729 17050553
MESH:D012878 Skin Neoplasms Arsenic 2.8217976673 17050553 17029826 16251483 15504454 19538983
MESH:D013088 Spermatocele Ethinyl Estradiol 3.5416709447
MESH:D020521 Stroke Raloxifene 3.5116837676
MESH:D013610 Tachycardia Norepinephrine 5.063261545
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.3320210726
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8215669648
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 4.7715790496
MESH:D013978 Tibial Fractures Estradiol 12.3719048282
MESH:D013978 Tibial Fractures Raloxifene 12.3719048282
MESH:D001749 Urinary Bladder Neoplasms Arsenic 4.8517306315 18640142 17976673 15987713 11144890 19429237 19322015
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 4.8517572228
MESH:D014570 Urologic Diseases Diazinon 4.8716487989
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.9314692618
MESH:D014652 Vascular Diseases Arsenic 4.3417056641
MESH:D054556 Venous Thromboembolism Raloxifene 4.8116837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1914671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 5.1516343187
MESH:D015430 Weight Gain Clozapine 4.1416402076 20107430 16141801 17502770 20564506 20521320
MESH:D015431 Weight Loss Clozapine 4.6817933447
Pathway ID Pathway Name
KEGG:05016 Huntington's disease
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA312
    • Releated gene ID Related gene Name
    PA312SLC6A4
    Releated disease ID Related disease Name
    PA447321Depressive Disorder, Major
    PA447207Depressive Disorder
    PA443853Dementia
    PA447211Obsessive-Compulsive Disorder
    PA447199Bipolar Disorder
    PA447198Autistic Disorder
    PA443309Alcoholism
    PA447210Neurotic Disorders
    PA447195Anorexia Nervosa
    PA445769Sudden Infant Death
    PA447209Mood Disorders
    PA444494Huntington Disease
    PA447216Schizophrenia
    PA447294Depression, Postpartum
    PA447278Depression
    PA447218Sexual Dysfunctions, Psychological
    Releated drug ID Related drug Name
    PA10066duloxetine
    PA164752812milnacipran
    PA451744trazodone
    PA165860812berberine
    PA165860788evodiamine
    PA449061clozapine
    PA452229antidepressants
    PA450626nicotine
    PA449394donepezil
    PA448385amitriptyline
    PA449015citalopram
    PA449048clomipramine
    PA449409doxepin
    PA10074escitalopram
    PA449673fluoxetine
    PA450522mirtazapine
    PA10389non-selective monoamine reuptake inhibitors
    PA144614922Opipramol
    PA450801paroxetine
    PA144614921reboxetine
    PA451333sertraline
    PA451741tranylcypromine
    PA451791trimipramine
    PA451866venlafaxine
    PA449233desipramine
    PA452604xenobiotics
    PA452347glucocorticoids
    PA449690fluvoxamine
    PA164713257Selective serotonin reuptake inhibitors
    PA450243lithium
    PA450657nortriptyline
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00176 antagonist Fluvoxamine Anti-anxiety Agents;Selective Serotonin Reuptake Inhibitors (SSRIs);Antidepressive Agents;Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB00191 antagonist Fen-phen Adrenergic Agents;Central Nervous System Stimulants;Sympathomimetics;Central Nervous System Agents;Appetite Depressants;Anorexigenic Agents;Stimulants
    DB00193 antagonist Tramadol Narcotics;Analgesics;Analgesics, Opioid
    DB00215 antagonist Citalopram Antidepressants;Selective Serotonin Reuptake Inhibitors (SSRIs);Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB00285 antagonist Venlafaxine Antidepressants;Analgesics;Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB00289 - Atomoxetine Antidepressants;Adrenergic Uptake Inhibitors;Central Nervous System Agents
    DB00321 antagonist Triavil Tab Adrenergic Uptake Inhibitors;Analgesics, Non-Narcotic;Antidepressive Agents, Tricyclic
    DB00344 antagonist Protriptyline Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors;Antidepressive Agents
    DB00422 antagonist Methylphenidate Adrenergic Agents;Dopamine Uptake Inhibitors;Adrenergic Uptake Inhibitors;Central Nervous System Stimulants;Sympathomimetics
    DB00458 antagonist Imipramine Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00472 antagonist Fluoxetine Selective Serotonin Reuptake Inhibitors (SSRIs);Antidepressants, Second-Generation;Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB00476 antagonist Duloxetine Dopamine Uptake Inhibitors;Adrenergic Uptake Inhibitors;Antidepressive Agents;Serotonin Uptake Inhibitors
    DB00514 antagonist Tussin Cough Medicine Dm Antitussive Expectorant Decongestant Analgesics, Opioid;Antitussive Agents;Excitatory Amino Acid Antagonists
    DB00540 antagonist Nortriptyline Antidepressants;Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00543 antagonist Amoxapine Adrenergic Uptake Inhibitors;Dopamine Antagonists;Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation;Neurotransmitter Uptake Inhibitors
    DB00574 antagonist Fen-phen Anorexigenic Agents;Stimulants;Serotonin Agonists;Serotonin reuptake inhibitor
    DB00579 antagonist Mazindol Dopamine Uptake Inhibitors;Adrenergic Uptake Inhibitors;Central Nervous System Stimulants
    DB00656 antagonist Trazodone Anti-anxiety Agents;Antidepressants, Second-Generation;Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB00661 other/unknown Tarka Vasodilator Agents;Antiarrhythmic Agents;Calcium Channel Blockers;Anti-Arrhythmia Agents
    DB00715 antagonist Paroxetine Antidepressants;Selective Serotonin Reuptake Inhibitors (SSRIs);Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB00726 antagonist Trimipramine Antidepressants;Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB00805 antagonist Minaprine Central Nervous System Agents;Antiparkinson Agents;Antidepressive Agents
    DB00852 antagonist Tussin Cough Medicine DM Antitussive Expectorant Decongestant Vasoconstrictor Agents;Adrenergic Agents;Sympathomimetics;Central Nervous System Agents;Bronchodilator Agents;Nasal Decongestants
    DB00907 blocker Cocaine Vasoconstrictor Agents;Dopamine Uptake Inhibitors;Anesthetics;Local Anesthetics;Anesthetics, Local
    DB01104 antagonist Sertraline Antidepressants;Selective Serotonin Reuptake Inhibitors (SSRIs);Antidepressive Agents;Serotonin Uptake Inhibitors
    DB01105 antagonist Sibutramine Antidepressants;Appetite Depressants;Anorexigenic Agents;Stimulants;Antidepressive Agents
    DB01114 antagonist Triaminicol Dm Syrup Antipruritics;Anti-Allergic Agents;Histamine H1 Antagonists;Antihistamines
    DB01142 antagonist Doxepin Antidepressants;Anti-anxiety Agents;Antipruritics;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors;Histamine Antagonists
    DB01149 antagonist Nefazodone Antidepressants;Analgesics;Antidepressive Agents, Second-Generation;Serotonin Agents
    DB01151 antagonist Desipramine Antidepressants;Adrenergic Uptake Inhibitors;Enzyme Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    DB01175 antagonist Escitalopram Serotonin Uptake Inhibitors;Antidepressive Agents, Second-Generation
    DB01191 antagonist Dexfenfluramine Appetite Depressants;Serotonin Agonists;Serotonin reuptake inhibitor;Antiobesity Agents
    DB01242 antagonist Clomipramine Antidepressive Agents, Tricyclic;Serotonin Uptake Inhibitors
    DB01363 negative modulator Tartephedreel
    DB01442 negative modulator MMDA Psychotropic Drugs
    DB01454 negative modulator 3,4-Methylenedioxymethamphetamine Adrenergic Uptake Inhibitors;Hallucinogens;Serotonin Agents
    DB01472 antagonist 4-Methoxyamphetamine Hallucinogens
    DB01577 negative modulator Methamphetamine Adrenergic Agents;Dopamine Agents;Dopamine Uptake Inhibitors;Adrenergic Uptake Inhibitors;Central Nervous System Stimulants;Sympathomimetics
    DB04832 - Zimelidine Selective Serotonin Reuptake Inhibitors (SSRIs);Antidepressive Agents;Serotonin Uptake Inhibitors
    DB04836 - Amineptine Antidepressive Agents, Tricyclic;Psychotropic Drugs
    DB04896 antagonist Milnacipran Adrenergic Uptake Inhibitors;Antidepressive Agents;Serotonin Uptake Inhibitors
    DB06148 blocker Mianserin Serotonin Antagonists;Histamine H1 Antagonists;Adrenergic alpha-Antagonists;Antidepressive Agents, Second-Generation
    DB06700 antagonist Desvenlafaxine Antidepressants;Antidepressive Agents;Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs)
    DB06701 antagonist Dexmethylphenidate
    No data
    Drugbank ID Action Drug Name Description
    DB01079 inhibitor Tegaserod Gastrointestinal Agents;Serotonin Agonists
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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