AutismKB 2.0

Annotation Detail for SLC6A8


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Basic Information Top
Gene Symbol:SLC6A8 ( CRT,CRTR,CT1,MGC87396 )
Gene Full Name: solute carrier family 6 (neurotransmitter transporter, creatine), member 8
Band: Xq28
Quick LinksEntrez ID:6535; OMIM: 300036; Uniprot ID:SC6A8_HUMAN; ENSEMBL ID: ENSG00000130821; HGNC ID: 11055
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Metabolism of amino acids and derivatives
No data
Pathway IDPathway Name
P00044Nicotinic acetylcholine receptor signaling pathway
P00043Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Pathway IDPathway Name
500785Creatine metabolism
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2221Behavior disease
No data
No data
Desease Name
Creatine deficiency syndrome, X-linked
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SLC6A8 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SLC6A8 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of SLC6A8 mRNAaffects expression 17562736
D000641 Ammonia Ammonia affects the expression of SLC6A8 proteinaffects expression 20227315
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC6A8 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of SLC6A8 mRNAincreases expression 20458559
D001262 Atenolol Atenolol results in decreased expression of SLC6A8 mRNAdecreases expression 19915711
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SLC6A8 mRNAincreases expression 19150397
C002791 bismuth tripotassium dicitrate bismuth tripotassium dicitrate results in increased expression of SLC6A8 mRNAincreases expression 15912405
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SLC6A8 mRNAaffects expression 17484886
D004390 Chlorpyrifos Chlorpyrifos results in decreased expression of SLC6A8 mRNAdecreases expression 17452286
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of SLC6A8 mRNAincreases expression 18812211
D003401 Creatine SLC6A8 protein results in increased transport of Creatineincreases transport 18428409
D016572 Cyclosporine Cyclosporine results in decreased expression of SLC6A8 mRNAdecreases expression 20106945
C014347 decitabine decitabine results in increased expression of SLC6A8 mRNAincreases expression 17908484
D003976 Diazinon Diazinon results in increased expression of SLC6A8 mRNAincreases expression 18812211
D004026 Dieldrin Dieldrin results in increased expression of SLC6A8 mRNAincreases expression 18812211
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of SLC6A8 mRNAdecreases expression 17557909
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of SLC6A8 geneincreases mutagenesis 16495775
C030691 gluconic acid gluconic acid results in increased expression of SLC6A8 mRNAincreases expression 16556975
D012402 Rotenone Rotenone results in increased expression of SLC6A8 mRNAincreases expression 19013527
D012643 Selenium Selenium results in increased expression of SLC6A8 mRNAincreases expression 19244175
D014050 Toluene Toluene affects the expression of SLC6A8 mRNAaffects expression 18653662
D014212 Tretinoin Tretinoin results in decreased expression of SLC6A8 mRNAdecreases expression 16604517
D014810 Vitamin E Vitamin E results in increased expression of SLC6A8 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.3918287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7717505938
MESH:D000230 Adenocarcinoma arsenic trioxide 4.1419825857 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.1414692618
MESH:D000236 Adenoma Ethylnitrosourea 3.626695378
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 8.6011874814 16611668 17119214
MESH:D000382 Agricultural Workers' Diseases Diazinon 8.6016487989
MESH:D000505 Alopecia Tretinoin 3.4815955085
MESH:D000799 Angioedema Acetaminophen 3.6710982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.8615885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.8616412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2316292516
MESH:D001249 Asthma Tretinoin 2.2916456186
MESH:D001321 Autistic Disorder marker/mechanism 18461508
MESH:D001321 Autistic Disorder Acetaminophen 2.8018445737
MESH:D001321 Autistic Disorder Creatine 2.8016818868
MESH:D001471 Barrett Esophagus Tretinoin 4.2416935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.6516206674
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.6516197459 16206674
MESH:D001927 Brain Diseases Ethylnitrosourea 4.7314991843
MESH:D001929 Brain Edema Ammonia 6.1020217200 11481608 19393034
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.1415144691 18412241 16651633 16357521 16436596
MESH:D001943 Breast Neoplasms decitabine 2.1019208741 18320071
MESH:D001943 Breast Neoplasms Dieldrin 2.1015770527 11859874
MESH:D001943 Breast Neoplasms Tretinoin 2.1016166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.4216813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1711589617
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 9.373786805 16011737 10355542 16097048 16227642 16192424 15673190 16050911 15721981 16124888 15700767 18705752
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 9.3716050911
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9916168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 11.0216705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.0216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.023084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 11.0215553829 14691202 15073043 11135700 16217749
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 11.0218788625
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 11.021917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.7019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9712490120
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.6019215824
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.6016096774 16051514
MESH:D006332 Cardiomegaly Atenolol 4.6615969258
MESH:D002386 Cataract Acetaminophen 6.8910977129
MESH:D002386 Cataract Tretinoin 6.8917460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 15.086135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 15.0820889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.0812371664
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 15.0816003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.8117160924
MESH:D002547 Cerebral Palsy Toluene 5.689294310
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.4216129372
MESH:D002779 Cholestasis Cyclosporine 7.3619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.3615861022 16105132 17333356 17681005 17110522 11677210 16919318
MESH:D002822 Choriocarcinoma Tretinoin 4.9916461808
MESH:D002972 Cleft Palate Tretinoin 2.609407595
MESH:D003092 Colitis Selenium 8.9317936198
MESH:D003092 Colitis Tretinoin 8.9317035595
MESH:D003110 Colonic Neoplasms decitabine 2.3117616700
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.5420501625
MESH:D015179 Colorectal Neoplasms decitabine 2.5418981723
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 5.3210525206
MESH:D019465 Craniofacial Abnormalities Toluene 5.329294310
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.329211117 17551590 9224671 9664655 16925845 14991402 9125849 9142499 10589399 8800419
MESH:D019465 Craniofacial Abnormalities Vitamin E 5.3219769572
MESH:C535598 Creatine deficiency, X-linked marker/mechanism 12210795 11326334
MESH:C535598 Creatine deficiency, X-linked Creatine 7.2612210795
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.3318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.3318551238
MESH:D003643 Death Toluene 5.496431079
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9315213294
MESH:D017449 Dermatitis, Allergic Contact Ammonia 4.5916823706
MESH:D002658 Developmental Disabilities marker/mechanism 11326334
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 11.4621346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 11.4621346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.4616393943 16177239 11421492 19739265 2444490 18071297 10774834 11739529 19164858 14986274 12594235 16081117 19420014 10663392 16485898 14550746 17522070 19416960 17562736 19085960 15968718 11743745 19370779 12153990 15619225 11834606 19923254 10915739 12392966 11529661 16227642 11287661 17906064 16109766 11461765 14725611 12540782 16781746 12958197 12705907 18713872
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.4615027814 21278145 2869522 17522070 10092053 16227642 7179309 15998439 6884620 19336974 11566570 3732212 3786805 10915739 7440962 9327722 16177239 4309450 7120509 6623471 19085960 15968718
MESH:D056486 Drug-Induced Liver Injury Selenium 11.4615131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9319426721
MESH:D004417 Dyspnea Diazinon 4.6316487989
MESH:C538011 Eales disease Vitamin E 4.539068938
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.8118357618
MESH:D004489 Edema, Cardiac Tretinoin 4.2918230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.0212538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.9419294695
MESH:D016889 Endometrial Neoplasms Tretinoin 3.0016569247
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.3120426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.3112903497
MESH:D005124 Eye Abnormalities Tretinoin 3.4516938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 17.4715073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 17.4712795759 61145 15959796 16045604 17595544 16239168 12631006 19224547
MESH:D005234 Fatty Liver Cyclosporine 17.4719224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 17.4715345470
MESH:D005355 Fibrosis Carbon Tetrachloride 13.8018705752
MESH:D005355 Fibrosis Cyclosporine 13.8012639820 12168785
MESH:D005355 Fibrosis Tretinoin 13.8017994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.1016904648
MESH:D005756 Gastritis Acetaminophen 3.5016983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.058708960
MESH:D005909 Glioblastoma Ethylnitrosourea 7.0516436596
MESH:D005909 Glioblastoma Tretinoin 7.0517312396
MESH:D005910 Glioma Ethylnitrosourea 3.4318412241 16651633 16357521
MESH:D006258 Head and Neck Neoplasms decitabine 7.4519215824
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.4516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9916084493
MESH:D006330 Heart Defects, Congenital Tretinoin 6.489664655 14991402
MESH:D006330 Heart Defects, Congenital Vitamin E 6.4816080930
MESH:D006333 Heart Failure Atenolol 7.4420082655
MESH:D006333 Heart Failure Selenium 7.4417162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2515720958
MESH:D006501 Hepatic Encephalopathy Ammonia 5.6612420312 20549931 16338762
MESH:D006505 Hepatitis Carbon Tetrachloride 9.0619110552 19900420
MESH:D006505 Hepatitis Diazinon 9.0616487989
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6416490937 16863852
MESH:D019584 Hot Flashes Vitamin E 3.8014716179
MESH:D006930 Hyperalgesia Acetaminophen 7.1716870215
MESH:D006930 Hyperalgesia Tretinoin 7.1716870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3616899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4016778211
MESH:D006973 Hypertension Atenolol 5.6114597852 14700505 12022239 12717102 15614026 11910301 15188945 15969258 19249413 15237695 15453913 11593098
MESH:D006973 Hypertension Cyclosporine 5.6110903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9215338365
MESH:D017379 Hypertrophy, Left Ventricular Atenolol 5.5515237695
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6416569931 16945680
MESH:D007247 Infertility, Female Dieldrin 9.7510630421
MESH:D007247 Infertility, Female Ethinyl Estradiol 9.7512013081
MESH:D007248 Infertility, Male decitabine 10.6817581917
MESH:D007248 Infertility, Male Diazinon 10.6816466525 12948887
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.6817937319
MESH:D007251 Influenza, Human Selenium 10.3816624496
MESH:D007251 Influenza, Human Vitamin E 10.3816624496
MESH:D007410 Intestinal Diseases Tretinoin 3.6017994277
MESH:D007569 Jaw Abnormalities Tretinoin 3.7415992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2715604871
MESH:D007674 Kidney Diseases Acetaminophen 9.4415629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 9.4418776723 10903974 8314463
MESH:D007674 Kidney Diseases Vitamin E 9.4412488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.7316518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 16.6316705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 16.6316705839
MESH:D007680 Kidney Neoplasms Cyclosporine 16.6312371664
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 16.6317379185
MESH:D007938 Leukemia arsenic trioxide 10.0115070760
MESH:D007938 Leukemia decitabine 10.0118980019 19235587
MESH:D007938 Leukemia Tretinoin 10.0117143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.6417077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1316972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3014633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 15.1019077051
MESH:D007951 Leukemia, Myeloid decitabine 15.1017236224 19117987 18454857
MESH:D007951 Leukemia, Myeloid Tretinoin 15.1019285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 5.9617050201 16467208 20471514 19850784 16968895
MESH:D015470 Leukemia, Myeloid, Acute decitabine 5.9619387464 18206229 19010910 18704418 17679729 18460780
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 5.9617596541 19850784 16294345
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.2918055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.2619225113 15622746 16823087 17107899 12679006 17217047 16891316 16331271 16966277 16330433 9834237 12712474 16112521 15748426 19642359 17869043 11468182 15336539 19035177 17712046 19075265 12018890 15213294 17649720 11161223
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.2616331271 17506722 16766008 19075265 17107899 19029980 16140955 17361223 17339181 9834237 17217047 17294898 19642359 16823087 17368321 16788101 15748426 16891316 17712046 12679006 17649720 16935935 19035177 17301526 19225113
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1916882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.199224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.7111408273 17174718 16239168 11903743 16943688 17157831 21278145 17334410 16221502
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.4215925388 15123356 16116963 18187930 17869086 16097048 18412020 17557913 12649538 10355542 18472094 12898905 15650968 16192424 17823541 17721639 18006644 12546737 17698563 16027843 16015684 14716833 18277467 18263696 16638106 14724832 14620537 17944888 17922224 15818738 14748882 15959796 18472332 18429990 14716496 18156304 18317297 17714472 15370692 17976157 14512876 17640975 17565644 15057751 18210741 18705752 12445418 17525996 15931870 15996030 18395914 18418968 15893842 12632512 16136751 12632514 18054572 15730626 15052691 12586293 15338365 15876570 17805973 12741479 17481882 18376398 16248980 15673190 12389079 18420326 12666154 18481824 17761835 17766677 18395095 12609069 16033810 12667390 17631135 15362042 13678700 18205269 18166357 17708605 11481614 12958196 16011737 20821823 17900296 18339082 18251166 18279442 12445421
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.4216248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.4216169303
MESH:D008107 Liver Diseases Acetaminophen 6.3419784758 16611625 19014921 11587558 19460945 12587719 16610002 12969438
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.3415720792 16246199 16964402 15830285 17285989
MESH:D008107 Liver Diseases Chlorpyrifos 6.3415991261
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9915123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.9117185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.9114706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.237678174
MESH:D008113 Liver Neoplasms arsenic trioxide 10.2314682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 10.2319294768
MESH:D008113 Liver Neoplasms Dieldrin 10.239539021 8742319
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.256135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 9.2520377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.2515583823 12014681
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2215213294
MESH:D008171 Lung Diseases Vitamin E 3.0616863852
MESH:D008175 Lung Neoplasms arsenic trioxide 3.4819825857 11798837
MESH:D008175 Lung Neoplasms Ethylnitrosourea 3.4816019985 16271038 6695378 17703301
MESH:D008175 Lung Neoplasms Vitamin E 3.4811062179
MESH:D008223 Lymphoma decitabine 7.5019470736
MESH:D008223 Lymphoma Ethylnitrosourea 7.5015790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 4.8815375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 6.0118041768 10838139 10767621
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.0115318939
MESH:D008382 Marfan Syndrome Atenolol 6.0819430350
MESH:D008527 Medulloblastoma Tretinoin 2.7217453147
MESH:D008545 Melanoma decitabine 3.3216505122 17785578
MESH:D008545 Melanoma Tretinoin 3.3216752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4019513568
MESH:D008579 Meningioma Ethylnitrosourea 5.8117943659
MESH:D008591 Meningomyelocele Tretinoin 4.2516940565
MESH:D008607 Mental Retardation Toluene 3.599294310
MESH:D008654 Mesothelioma Selenium 2.7215107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6216801185
MESH:D019957 Motor Skills Disorders Toluene 5.079294310
MESH:D009101 Multiple Myeloma arsenic trioxide 6.9715949261 11468182 14977855 19549372 19417148
MESH:D009101 Multiple Myeloma decitabine 6.9718172295
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.5018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 11.7816882451 16105982
MESH:D009190 Myelodysplastic Syndromes decitabine 11.7819010910 19157545 18608210 16882708
MESH:D009190 Myelodysplastic Syndromes Tretinoin 11.7817596541
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.7718551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.7718551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7916624393
MESH:D009369 Neoplasms decitabine 7.9819116145 17925555 19470736
MESH:D009369 Neoplasms Dieldrin 7.988820588
MESH:D009369 Neoplasms Tretinoin 7.9816594593 16946489
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.2316707424
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1419348381 18481113
MESH:D009410 Nerve Degeneration Rotenone 3.7518619942 15790535 17356569
MESH:D009421 Nervous System Malformations Tretinoin 3.619125849
MESH:D009436 Neural Tube Defects arsenic trioxide 6.9310525206
MESH:D009436 Neural Tube Defects Tretinoin 6.939142499
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.2417160924 16003739 16651423
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7318514411
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.0515081274
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.3816049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.3816049721
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.8117160924
MESH:D010051 Ovarian Neoplasms arsenic trioxide 7.6116624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms decitabine 7.6119259094 19331143
MESH:D010051 Ovarian Neoplasms Tretinoin 7.6116936753
MESH:D010146 Pain Acetaminophen 6.1316870215
MESH:D010146 Pain Tretinoin 6.1316870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.3015580305
MESH:D010190 Pancreatic Neoplasms decitabine 8.3019294695
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.3015976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5311578682
MESH:D010235 Paraganglioma arsenic trioxide 4.0019927285
MESH:D010300 Parkinson Disease Dieldrin 5.6311181820 16809432 17291500 16112328 11445065
MESH:D010300 Parkinson Disease Rotenone 5.6316140633 19232380 16412576 11535288 19114014 11445065 18191903 18619942 15451049
MESH:D020734 Parkinsonian Disorders Rotenone 3.9315927086 15795934 15574749 18197244
MESH:D010954 Plasmacytoma Selenium 4.7215087411
MESH:D011041 Poisoning Diazinon 4.1917603234
MESH:D011230 Precancerous Conditions Cyclosporine 3.0812371664
MESH:D055728 Primary Myelofibrosis decitabine 4.5617616702
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.3619131511
MESH:D011471 Prostatic Neoplasms Vitamin E 3.3615084515
MESH:D011507 Proteinuria Tretinoin 3.4416636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.1415861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.1716882103
MESH:D011625 Pterygium Tretinoin 4.6216723453
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.4716611668 11874814 17119214
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.7216611668 17119214
MESH:D012208 Rhabdomyosarcoma decitabine 10.4119155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.4116116481 16283617
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.7916646077
MESH:D012640 Seizures 2,4-dinitrotoluene 9.2818551238
MESH:D012640 Seizures 2,6-dinitrotoluene 9.2818551238
MESH:D012640 Seizures Toluene 9.286431079 9294310
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.926418539
MESH:D012871 Skin Diseases Vitamin E 2.4018709164
MESH:D012878 Skin Neoplasms Tretinoin 2.5316467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7716709447
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.3217007042
MESH:D013274 Stomach Neoplasms decitabine 3.3219037991
MESH:D013274 Stomach Neoplasms Tretinoin 3.3217261132
MESH:D020521 Stroke Vitamin E 3.3816517955
MESH:D013733 Testicular Diseases Toluene 4.7810048760 10514026
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0115669648
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 4.9915790496
MESH:D018382 Thyroid Hormone Resistance Syndrome Atenolol 6.229349583
MESH:D013964 Thyroid Neoplasms arsenic trioxide 11.2719014326
MESH:D013964 Thyroid Neoplasms decitabine 11.2717967635
MESH:D013964 Thyroid Neoplasms Tretinoin 11.2716026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.6416051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7915213294
MESH:D014376 Tuberculosis Tretinoin 3.1216040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 11.3816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.3816049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 11.3812973940 11780464 12845720 20435036
MESH:D001749 Urinary Bladder Neoplasms decitabine 11.3817616700 19087683
MESH:D014570 Urologic Diseases Diazinon 5.1016487989
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.4110091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.4110091137
MESH:D014581 Urticaria Acetaminophen 2.8210982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.5316129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1314692618
MESH:D014604 Uveal Neoplasms decitabine 12.2517785578
MESH:D014604 Uveal Neoplasms Tretinoin 12.2516752155
MESH:D014605 Uveitis Cyclosporine 3.811336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3815869587 14671159
MESH:D014820 Vitiligo Tretinoin 3.8916761959
MESH:D009396 Wilms Tumor Tretinoin 3.8216287080
MESH:D014985 Xerophthalmia Cyclosporine 4.2717120751
Pathway ID Pathway Name
REACT:13 Metabolism of amino acids and derivatives
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35915
    • No data
    No data
    Releated drug ID Related drug Name
    PA449014cisplatin
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00148 - Creatine Dietary supplement;Micronutrient
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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