AutismKB 2.0

Annotation Detail for SLC6A11


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Basic Information Top
Gene Symbol:SLC6A11 ( GAT-3,GAT3,GAT4 )
Gene Full Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 11
Band: 3p25.3
Quick LinksEntrez ID:6538; OMIM: 607952; Uniprot ID:S6A11_HUMAN; ENSEMBL ID: ENSG00000132164; HGNC ID: 11044
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Amine compound SLC transporters
Synaptic Transmission
Transmembrane transport of small molecules
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC6A11 mRNAaffects expression 16483693
D003975 Diazepam Diazepam results in increased expression of SLC6A11 mRNAincreases expression 15802192
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of SLC6A11 mRNAdecreases expression 20360939
C098607 JP8 aviation fuel JP8 aviation fuel affects the expression of SLC6A11 mRNAaffects expression 12539871
D010126 Ozone Ozone results in decreased expression of SLC6A11 mRNAdecreases expression 16330353
C033457 phenobarbital quinidine phenobarbital quinidine results in increased expression of SLC6A11 mRNAincreases expression 15802192
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SLC6A11 mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2415322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D000236 Adenoma Diethylnitrosamine 2.9910737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.4116434500 19061943 17620307 19052882 17162532 18056438
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.4116835633
MESH:D000544 Alzheimer Disease Ozone 2.4815513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D001008 Anxiety Disorders Diazepam 5.4216284244 18313124
MESH:D001172 Arthritis, Rheumatoid Ozone 2.6115570426
MESH:D001249 Asthma Ozone 2.7017854713 16373670
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9417474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.9016777450 19059883 15516495 17626835 18315731 18417511 14754758
MESH:D002100 Cachexia Ozone 5.1416183385
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 1.8719107877 19335982 16502159 17173139 17761372 19701751 19919837 20084675 19208518 20935162 16935385 20524982 16878318 20007298 18494052 16698587 18788625 16681979 20512989 17978847 10672840 18971187 20727157 18691550 19383236 16288022 20101231 18506893 20214788 21159647 17055752 19539802 16569478 18210153 18978308 18665156 17162532 16830150 20514400 17138121 18393292 3084413 16328049 10737359 18785209 19418558 20432363 11831363 19171122 16540662 19822196 16807293 17428255 16779866 19519916 18056438 19052882 3581430 19394651
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.047505956 2727394 17174075 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 10.1719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 10.1716835633
MESH:D002972 Cleft Palate Diazepam 6.723629520
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.7215668235 16354765 8697196 12621046 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D017453 Dermatitis, Irritant JP8 aviation fuel 7.5717574719
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.4120387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4117107852
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 3.9519107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004421 Dystonia Diazepam 5.971851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3518230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.299294722 10568697
MESH:D004828 Epilepsies, Partial Diazepam 5.983922381
MESH:D004827 Epilepsy Diazepam 4.68821787
MESH:D004832 Epilepsy, Absence Diazepam 5.466426943 6401628
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.5616302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Diethylnitrosamine 3.4621071580 20387270
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4611294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2516120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.498697196 18606429 16959395 15340226 16354765
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918850075 18670907
MESH:D007249 Inflammation Diethylnitrosamine 5.3318785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3312200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9620032147 18407596 19638242 18665156 18522880
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1517034775
MESH:D008113 Liver Neoplasms Diethylnitrosamine 4.7020101389 18978307 19294768 2422723 21167192 19090486 15175105 21278145 19254457 20118626 20434301 16942905 18648771 12771043 20452335 19073162 19850985 9163691 15885732 19833225 18977376 19499222 19812893 19426721 19427195 18754104 21071580 19690152 19256749 19255062 19996281 19638242 19642983 20137499 21047994 20501860 2862719 19551842 10737359 20492335 20405173 20583210 12112319 18644402
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7016984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.3018253720 18544905 19004024 18079962 18093689 19539802 19519916 19009564 18775883 17854601 18164116 18308698 3124819 16842330 17174075 21159647 9362446 16267830 19126423 2563599 18282651 17942915
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.3012151625
MESH:D008171 Lung Diseases Ozone 3.5519066396 8266340
MESH:D055370 Lung Injury Ozone 4.2120417186
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.5620970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Ozone 3.568597069 7614698
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5611884234 19555203
MESH:D008545 Melanoma marker/mechanism 21499247
MESH:D008679 Metaplasia Ozone 5.5510496685
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.663581430 9029167
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.5620387270
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5016540662
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D010538 Peritonitis Ozone 4.4916369182
MESH:D011014 Pneumonia Ozone 4.7918381685 18929643 18007984
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.802563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911896295 11222880 11399792 11118676
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012640 Seizures Diazepam 4.5310087439 15946322 9754883
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1516192470
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013375 Substance Withdrawal Syndrome Diazepam 5.719754883
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.197505956
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
Pathway ID Pathway Name
REACT:20679 Amine compound SLC transporters
REACT:13685 Synaptic Transmission
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35907
    • No data
    Releated disease ID Related disease Name
    PA447268tardive dyskinesia
    Releated drug ID Related drug Name
    PA452229antidepressants
    PA451956zinc
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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