AutismKB 2.0

Annotation Detail for SLC7A1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SLC7A1 ( ATRC1,CAT-1,ERR,HCAT1,REC1L )
Gene Full Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
Band: 13q12.3
Quick LinksEntrez ID:6541; OMIM: 104615; Uniprot ID:CTR1_HUMAN; ENSEMBL ID: ENSG00000139514; HGNC ID: 11057
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Transmembrane transport of small molecules
Amino acid and oligopeptide SLC transporters
Metabolism of amino acids and derivatives
No data
No data
Pathway IDPathway Name
500341Amino acid transport across the plasma membrane
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2091Hypertension
Desease Name
endothelial dysfunction hypertension
CARDIOVASCULAR
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of SLC7A1 mRNAincreases expression 19933214
C000188 alachlor alachlor results in increased expression of SLC7A1 mRNAincreases expression 12419858
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC7A1 mRNAaffects expression 16483693
D000728 Androgens Androgens results in decreased expression of SLC7A1 mRNAdecreases expression 11401523
C006632 arsenic trioxide arsenic trioxide results in increased expression of SLC7A1 mRNAincreases expression 20458559
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of SLC7A1 mRNAaffects cotreatment|increases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SLC7A1 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC7A1 mRNAdecreases expression 19150397
C095105 bexarotene bexarotene results in decreased expression of SLC7A1 mRNAdecreases expression 17178900
C006780 bisphenol A bisphenol A results in decreased expression of SLC7A1 mRNAdecreases expression 20678512
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SLC7A1 mRNAaffects expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of SLC7A1 proteinincreases expression 17544377
D002713 Chlorine [Ozone co-treated with Chlorine] results in decreased expression of SLC7A1 mRNAaffects cotreatment|decreases expression 18636392
D016572 Cyclosporine Cyclosporine results in increased expression of SLC7A1 mRNAincreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of SLC7A1 mRNAaffects cotreatment|increases expression 18164116
D002117 Calcitriol Calcitriol results in decreased expression of SLC7A1 mRNAdecreases expression 16002434
D007213 Indomethacin Indomethacin results in increased expression of SLC7A1 mRNAincreases expression 16184411
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of SLC7A1 mRNAincreases expression 17616710
D010126 Ozone [Ozone co-treated with Chlorine] results in decreased expression of SLC7A1 mRNAaffects cotreatment|decreases expression 18636392
D010126 Ozone Ozone results in increased expression of SLC7A1 mRNAincreases expression 16716893
D010269 Paraquat Paraquat affects the expression of SLC7A1 mRNAaffects expression 16854511
D010656 Phenylephrine Phenylephrine results in increased expression of SLC7A1 mRNAincreases expression 18158353
C006253 pirinixic acid pirinixic acid results in increased expression of SLC7A1 mRNAincreases expression 12832660
D013467 Sulindac Sulindac results in increased expression of SLC7A1 mRNAincreases expression 11906190
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SLC7A1 mRNAincreases expression 19933214
C052342 topiramate topiramate results in decreased expression of SLC7A1 mRNAdecreases expression 16979414
D014212 Tretinoin Tretinoin results in decreased expression of SLC7A1 mRNAdecreases expression 16054129
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 5.3014745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6615322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.3718287403
MESH:D058186 Acute Kidney Injury Sulindac 4.147897758
MESH:D055371 Acute Lung Injury Chlorine 8.5520601635
MESH:D055371 Acute Lung Injury pirinixic acid 8.5518653653
MESH:D000230 Adenocarcinoma arsenic trioxide 9.8411798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.8420127859 20464547
MESH:D000230 Adenocarcinoma Indomethacin 9.8416537180
MESH:D000230 Adenocarcinoma Sulindac 9.8411910360
MESH:D000236 Adenoma Benzo(a)pyrene 19.886695378
MESH:D000236 Adenoma beta-Naphthoflavone 19.8819389873
MESH:D000236 Adenoma Diethylnitrosamine 19.886695378 10737359
MESH:D000236 Adenoma Indomethacin 19.8811497255
MESH:D000236 Adenoma Sulindac 19.8810223192
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 16.1619061943 19052882 17162532 16434500 18056438 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.1616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.1616835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.4315623613 11535846 17611924 11874996 19003578 16460482 12394442
MESH:D000382 Agricultural Workers' Diseases alachlor 8.4414769641 11874814
MESH:D000382 Agricultural Workers' Diseases Paraquat 8.4411874814
MESH:D000437 Alcoholism topiramate 4.8818552399 19331489 17925516
MESH:D000505 Alopecia Tretinoin 3.4615955085
MESH:D016301 Alveolar Bone Loss Indomethacin 5.1817225004
MESH:D000544 Alzheimer Disease Androgens 6.6217182789 17917157
MESH:D000544 Alzheimer Disease Indomethacin 6.6217627676 15579461
MESH:D000544 Alzheimer Disease Ozone 6.6215513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7811748828
MESH:D001014 Aortic Aneurysm Indomethacin 4.6610231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 11.0819183758
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 11.0810388637
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.9517460149
MESH:D018771 Arthralgia Indomethacin 4.982160914
MESH:D001169 Arthritis, Experimental Tretinoin 2.9616412693
MESH:D001172 Arthritis, Rheumatoid Indomethacin 7.2011248219
MESH:D001172 Arthritis, Rheumatoid Ozone 7.2015570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 7.2016292516
MESH:D001249 Asthma Ozone 4.7617854713 16373670
MESH:D001249 Asthma Tretinoin 4.7616456186
MESH:D001471 Barrett Esophagus Tretinoin 4.2216935849
MESH:D001477 Bartter Syndrome Indomethacin 4.7910684365
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 20.5216206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 20.5219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 20.5212125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 20.5216206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6415746008
MESH:D001862 Bone Resorption bisphenol A 3.6911985600
MESH:D001913 Bowen's Disease Sulindac 5.1611207687
MESH:D001919 Bradycardia Phenylephrine 4.3515306635
MESH:D001929 Brain Edema Indomethacin 4.8311481608
MESH:D002545 Brain Ischemia Indomethacin 4.2312524144
MESH:D001943 Breast Neoplasms Androgens 6.8217018787
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 6.8220146248 17474063
MESH:D001943 Breast Neoplasms bexarotene 6.8216818667 16344269
MESH:D001943 Breast Neoplasms bisphenol A 6.8217123778
MESH:D001943 Breast Neoplasms Calcitriol 6.8211237771
MESH:D001943 Breast Neoplasms Diethylnitrosamine 6.8217474063
MESH:D001943 Breast Neoplasms Indomethacin 6.8217401462
MESH:D001943 Breast Neoplasms Sulindac 6.8216642371
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.8220435547
MESH:D001943 Breast Neoplasms Tretinoin 6.8216166294 16873071 16443354
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5315516495 16777450 18417511 18315731 17626835 14754758 19059883
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.4016813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1511589617
MESH:D002056 Burns Indomethacin 4.5210459503
MESH:D002100 Cachexia Indomethacin 11.7615141370 16537180 11239499 15625704
MESH:D002100 Cachexia Ozone 11.7616183385
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5916227642 16124888 15700767 16097048 15721981 18705752 15673190 3786805 16192424 10355542 16050911 16011737
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6516835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9716168501
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 8.5416217749 15553829 14691202 15073043 11135700
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.5418788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.5419418558 3084413 20935162 17055752 20432363 20524982 16830150 18393292 18978308 17761372 16698587 20007298 17428255 20084675 17162532 19394651 16681979 19208518 20512989 18785209 18056438 3581430 20514400 16502159 20101231 19919837 19107877 19539802 18691550 19171122 16540662 16328049 20727157 21159647 18665156 19701751 19383236 16288022 18494052 18506893 18971187 16779866 10737359 16807293 18788625 17173139 16878318 19822196 16935385 20214788 17978847 16569478 19519916 19052882 18210153 11831363 10672840 17138121 19335982
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 8.5416391822
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 8.541917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.8017123778
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.5311053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.1614736730 11352223 18791128
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.1616247446
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6819014326
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.2917341418
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9512490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.3520419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 10.3511237771
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 10.3515482327 12636206
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.3516096774 16051514
MESH:D006332 Cardiomegaly Phenylephrine 6.5315728586 11754973 11179087 17124262 17287366 16170337
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.5318670907 18850075 16120746
MESH:D002386 Cataract Tretinoin 2.9817460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.3920889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.3912371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.3921159647 17174075 7505956 2727394
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.4016129372
MESH:D002659 Child Development Disorders, Pervasive topiramate 4.0315650499
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.7919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.7916835633
MESH:D002764 Cholecystitis Indomethacin 4.9811181007
MESH:D002779 Cholestasis Cyclosporine 7.2919486331
MESH:D002779 Cholestasis pirinixic acid 7.2919176532
MESH:D002822 Choriocarcinoma Tretinoin 4.9716461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.5012621046 8697196 15668235 15340226 16354765
MESH:D002972 Cleft Palate Tretinoin 5.509407595
MESH:D003092 Colitis Tretinoin 3.5217035595
MESH:D003110 Colonic Neoplasms Indomethacin 4.0915637740 11260862 15625704 15936596 15963497 15786552
MESH:D003110 Colonic Neoplasms Sulindac 4.0912902858 12458338
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.5020501625
MESH:D015179 Colorectal Neoplasms Indomethacin 3.5018059344 12606626 17054584 11197048
MESH:D015179 Colorectal Neoplasms Sulindac 3.5010666051 11197048 18059344 11076880
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9014669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0012609071
MESH:D018352 Coronavirus Infections Indomethacin 5.5217302372
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.6410525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6420055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.6416925845 9664655 10589399 9224671 17551590 8800419 9125849 14991402 9142499 9211117
MESH:D016638 Critical Illness Androgens 5.8716670151
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9215213294
MESH:D017449 Dermatitis, Allergic Contact alachlor 4.018428444
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3418249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.9820387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.9817107852
MESH:D003924 Diabetes Mellitus, Type 2 topiramate 6.9816979414
MESH:D003930 Diabetic Retinopathy Sulindac 4.9917621415 12861449
MESH:D003967 Diarrhea Indomethacin 3.617237001 7907874
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 5.857120509 11566570 16227642 6884620 4309450 2869522 19336974 10092053 15968718 10915739 16177239 3732212 19085960 21278145 17522070 6623471 3786805 15998439 9327722 7179309 7440962 15027814
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 5.8519107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.8520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6211462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.9612774134 18446180 16133044 17190690 18043480 16326151
MESH:D004381 Duodenal Ulcer Indomethacin 3.9511595431 10671773 17202747 17045617 17351913 17151854 11991626 17329845 16699067 11595415 11535926
MESH:D004417 Dyspnea Chlorine 4.4320016425
MESH:D004487 Edema Indomethacin 10.4519703484 7907874 10653021 7990266 8985016 16100529 8273558
MESH:D004487 Edema pirinixic acid 10.4512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.4511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.3016714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.3018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 3.7515138306
MESH:D016889 Endometrial Neoplasms Tretinoin 2.9816569247
MESH:D004715 Endometriosis Indomethacin 14.4315652904
MESH:D004715 Endometriosis Sulindac 14.4315652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 14.439294722 10568697
MESH:D019446 Endotoxemia Indomethacin 4.3118509659
MESH:D004751 Enteritis Indomethacin 4.5510567023 17763956 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.7917980183
MESH:D004802 Eosinophilia Indomethacin 3.8711298111
MESH:D004827 Epilepsy topiramate 4.2319148780
MESH:D004833 Epilepsy, Temporal Lobe topiramate 6.0816499746
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9216302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 16.8220426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 16.8212903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 16.8216530937
MESH:D004938 Esophageal Neoplasms Indomethacin 16.8211005569
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 16.8215623463 15264214 16510608 15878914 15547721 15150132 16704527 16805852 15547733
MESH:D004938 Esophageal Neoplasms Sulindac 16.8212235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.3711564622
MESH:D005124 Eye Abnormalities Tretinoin 8.379664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 22.8015073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 22.8015959796 16045604 16239168 61145 17595544 12795759 19224547 12631006
MESH:D005234 Fatty Liver Cyclosporine 22.8019224547
MESH:D005234 Fatty Liver Diethylnitrosamine 22.8021071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 22.8019236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2711858732
MESH:D005334 Fever Indomethacin 3.9511852909 17627676 10431976
MESH:D018221 Fibromatosis, Abdominal Sulindac 5.2914745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 4.9419069698
MESH:D005354 Fibrosarcoma Indomethacin 4.7010962813
MESH:D005355 Fibrosis Carbon Tetrachloride 25.7218705752
MESH:D005355 Fibrosis Cyclosporine 25.7212168785 12639820
MESH:D005355 Fibrosis Indomethacin 25.7217994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 25.7220067830
MESH:D005355 Fibrosis Tretinoin 25.7217994277
MESH:D005499 Folliculitis Indomethacin 4.9811298111
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0816904648
MESH:D005739 Gas Poisoning Chlorine 4.8220016425
MESH:D005756 Gastritis Indomethacin 4.5515046732
MESH:D005764 Gastroesophageal Reflux Sulindac 4.8311910360
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.038708960
MESH:D005909 Glioblastoma Indomethacin 6.9112870263
MESH:D005909 Glioblastoma Tretinoin 6.9117312396
MESH:D005910 Glioma Indomethacin 3.1516487511 18371953
MESH:D005911 Gliosis Paraquat 4.9711124998
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.1311849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4010696789
MESH:D006073 Gout Indomethacin 5.1611248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 7.5015482327
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.5016096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9716084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.5120471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.5111294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 10.519664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.4220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2315720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1611000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.4015633222
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4119900420 19110552
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.5015135802
MESH:D006529 Hepatomegaly pirinixic acid 7.6316221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.6316120746 12621046 15340226
MESH:D006628 Hirsutism Androgens 5.8916914592 17019078
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.858697196 16354765 15340226 18606429 16959395
MESH:D006930 Hyperalgesia Indomethacin 7.5212727271
MESH:D006930 Hyperalgesia Tretinoin 7.5216870215
MESH:D034321 Hyperamylasemia Indomethacin 5.5217883296
MESH:D017588 Hyperandrogenism Androgens 5.5417019078
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3416899240
MESH:D006940 Hyperemia Indomethacin 4.8112524144
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3816778211
MESH:D006943 Hyperglycemia pirinixic acid 3.0220558911
MESH:D006949 Hyperlipidemias Indomethacin 3.9817546600
MESH:D006973 Hypertension Cyclosporine 8.1810903974
MESH:D006973 Hypertension Phenylephrine 8.1812717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.1818670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9015338365
MESH:D006984 Hypertrophy Phenylephrine 4.3812791704 18502941
MESH:D007077 Ileal Diseases Indomethacin 4.8318306037 10574470
MESH:D007079 Ileitis Indomethacin 5.1610651667 16133968 10647630
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.1816133044
MESH:D007248 Infertility, Male alachlor 6.9312948887 17049205 16466525
MESH:D007248 Infertility, Male Paraquat 6.934850670
MESH:D007249 Inflammation Diethylnitrosamine 11.2018785209
MESH:D007249 Inflammation Indomethacin 11.203291741 12568917 7812673
MESH:D007249 Inflammation Sulindac 11.203291741
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.2012878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 6.9016393666
MESH:D007333 Insulin Resistance pirinixic acid 6.9016306350
MESH:D007410 Intestinal Diseases Indomethacin 9.2617994277 11855677 11713966 11686837 18236018 15610444 17329856 10210152 15831440
MESH:D007410 Intestinal Diseases Tretinoin 9.2617994277
MESH:D007414 Intestinal Neoplasms Sulindac 4.4712628509 12351151 10223192 12584176 10213222 12663524
MESH:D007417 Intestinal Polyps Sulindac 4.8111245490 12394442
MESH:D019586 Intracranial Hypertension Indomethacin 5.1815241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.3616580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.3617551590 15992940
MESH:D007579 Jejunal Diseases Indomethacin 4.8318306037 10574470 16133968
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2515604871
MESH:D007674 Kidney Diseases Cyclosporine 5.838314463 10903974 18776723
MESH:D007674 Kidney Diseases Indomethacin 5.8317190690
MESH:D007680 Kidney Neoplasms Cyclosporine 2.5812371664
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.7510320625 12228301 11703811
MESH:D007938 Leukemia alachlor 10.0814769641
MESH:D007938 Leukemia arsenic trioxide 10.0815070760
MESH:D007938 Leukemia Tretinoin 10.0817143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.6217077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1116972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 8.0914633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 8.0910785260 16572323 15631656
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.9019077051
MESH:D007951 Leukemia, Myeloid Tretinoin 8.9016482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 5.9719850784 20471514 16968895 16467208 17050201
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 5.9718360721
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 5.9717596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.2216823087 19035177 12679006 15622746 17649720 15336539 19075265 17217047 19225113 12712474 17869043 16330433 16891316 16112521 15213294 17107899 16966277 11161223 17712046 19642359 16331271 15748426 9834237 12018890 11468182
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.2219035177 17107899 17649720 17712046 16823087 16935935 19642359 16766008 12679006 17217047 19075265 17301526 17506722 15748426 17294898 17368321 16788101 17339181 19029980 16331271 19225113 16140955 16891316 9834237 17361223
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1716882451
MESH:D007964 Leukocytosis Indomethacin 5.1816537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.5217980183
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.179224671
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.5211479899
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.2611408273 16239168 16221502 17334410 17174718 16943688 11903743 17157831 21278145
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.2618522880 19638242 20032147 18665156 18407596
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.1112468960
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.4716011737 12958196 16015684 18251166 16033810 12546737 14512876 17714472 15370692 15123356 12666154 10355542 18317297 18205269 17823541 18429990 18263696 15650968 15673190 18156304 16136751 18418968 16248980 16027843 17698563 15996030 17944888 14724832 14716496 18395914 14716833 18412020 18277467 18187930 12389079 17525996 18472094 16192424 16097048 12741479 15925388 20821823 14620537 12898905 17900296 18339082 18210741 12632512 18006644 17721639 18166357 12667390 17976157 15876570 17922224 17631135 18420326 11481614 15818738 17766677 16638106 12586293 17761835 13678700 15931870 15362042 17869086 15893842 14748882 18279442 15959796 17640975 18054572 12445421 12649538 18376398 17805973 17557913 15057751 18395095 17481882 18705752 18472332 12632514 16116963 15338365 17708605 15730626 12609069 17565644 18481824 15052691 12445418
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 6.4718194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.4715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.4712878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.4716248980 18397230
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.3616964402 17285989 15830285 16246199 15720792
MESH:D008107 Liver Diseases Diethylnitrosamine 6.3617034775
MESH:D008107 Liver Diseases Sulindac 6.3614986274 16867024
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.5216899240 14706259
MESH:D008113 Liver Neoplasms arsenic trioxide 20.7914682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 20.7920195826 21137059
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 20.7919389873 21295105
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 20.7919294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 20.7920583210 19638242 19642983 20405173 19294768 19812893 19850985 19254457 19996281 19427195 20118626 19426721 2862719 19499222 19255062 12112319 19833225 21278145 19090486 20137499 20501860 21047994 15885732 18977376 18978307 10737359 21071580 20492335 21167192 18648771 20434301 12771043 19256749 20452335 2422723 18754104 9163691 19073162 19551842 16942905 19690152 20101389 18644402 15175105
MESH:D008113 Liver Neoplasms pirinixic acid 20.7915890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.7916984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 17.3920377131
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 17.3918164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 17.3912014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 17.3917174075 18544905 16267830 17942915 19004024 3124819 16842330 18253720 19519916 18079962 2563599 18164116 18308698 18775883 21159647 19126423 9362446 19009564 18093689 19539802 18282651 17854601
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.3912151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2115213294
MESH:D008171 Lung Diseases Ozone 3.258266340 19066396
MESH:D055370 Lung Injury Ozone 3.6620417186
MESH:D008175 Lung Neoplasms arsenic trioxide 12.5819825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 12.5820064080 18816296 18520028 20464547 6695378 18569708 17053015 20869020 20135361
MESH:D008175 Lung Neoplasms bexarotene 12.5817849452
MESH:D008175 Lung Neoplasms Diethylnitrosamine 12.5820512841 20970405 6695378 21163286
MESH:D008175 Lung Neoplasms Indomethacin 12.5816537180 11497255 11053908
MESH:D008175 Lung Neoplasms Ozone 12.588597069 7614698
MESH:D008175 Lung Neoplasms Sulindac 12.5815713900 19359593
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 12.5819555203 11884234
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.9611161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 3.2915591091 19196722 19196723
MESH:D008527 Medulloblastoma Tretinoin 2.7117453147
MESH:D008545 Melanoma Sulindac 3.5216642371
MESH:D008545 Melanoma Tretinoin 3.5216752155
MESH:D008591 Meningomyelocele Tretinoin 4.2416940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5916801185
MESH:D008679 Metaplasia Ozone 4.9110496685
MESH:D008881 Migraine Disorders Indomethacin 7.7811903285
MESH:D008881 Migraine Disorders topiramate 7.7818803445 18765137 18759728 16942474
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.1816381670
MESH:D009062 Mouth Neoplasms Indomethacin 8.1812636206
MESH:D009101 Multiple Myeloma alachlor 7.2714769641
MESH:D009101 Multiple Myeloma arsenic trioxide 7.2711468182 19417148 14977855 19549372 15949261
MESH:D009135 Muscular Diseases pirinixic acid 3.3216239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4818349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.0316105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.0317596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8712213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8016411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7816624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.713581430 9029167
MESH:D009362 Neoplasm Metastasis Indomethacin 5.7116537180 11239499 11053908
MESH:D009369 Neoplasms Benzo(a)pyrene 7.6411141357
MESH:D009369 Neoplasms pirinixic acid 7.6417405874
MESH:D009369 Neoplasms Tretinoin 7.6416946489 16594593
MESH:D009374 Neoplasms, Experimental Indomethacin 3.9510663608 15625704
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.5919196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1219348381 18481113
MESH:D009410 Nerve Degeneration Paraquat 3.5716893418
MESH:D009421 Nervous System Malformations bisphenol A 15.3111399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.3114600291
MESH:D009421 Nervous System Malformations Tretinoin 15.319125849
MESH:D009436 Neural Tube Defects arsenic trioxide 6.8910525206
MESH:D009436 Neural Tube Defects Tretinoin 6.899142499
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 13.3620387270
MESH:D019636 Neurodegenerative Diseases Indomethacin 13.3612349958
MESH:D019636 Neurodegenerative Diseases Sulindac 13.3616850258 17266991
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9220387270
MESH:D009669 Nose Neoplasms alachlor 4.6316698726 11127290 16178123 14563481 15580706
MESH:D009765 Obesity pirinixic acid 1.7720558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.986374098
MESH:D010003 Osteoarthritis Indomethacin 3.557009135
MESH:D010049 Ovarian Diseases bisphenol A 4.8011985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.6716624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms Tretinoin 4.6716936753
MESH:D010146 Pain Indomethacin 10.573291741 17627676 17440234 13679232
MESH:D010146 Pain Sulindac 10.573291741
MESH:D010146 Pain Tretinoin 10.5716870215
MESH:D010149 Pain, Postoperative Indomethacin 4.4918702446 12538197
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 11.8015580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.8016540662
MESH:D010190 Pancreatic Neoplasms Sulindac 11.8016820089 11504793
MESH:D010190 Pancreatic Neoplasms Tretinoin 11.8015976015
MESH:D010195 Pancreatitis Indomethacin 3.7415028970 17883296
MESH:D010235 Paraganglioma arsenic trioxide 3.9819927285
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.5216537180
MESH:D010300 Parkinson Disease Paraquat 2.7416510128 15451049 15824117 11445065 16140633 11124998 12911755 11181820
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.2416190885
MESH:D020734 Parkinsonian Disorders Indomethacin 3.9512349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.5211903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0612520081
MESH:D010437 Peptic Ulcer Indomethacin 4.9611148446
MESH:D010518 Periodontitis Indomethacin 4.7217225004
MESH:D010538 Peritonitis Ozone 3.9416369182
MESH:D011014 Pneumonia Ozone 10.4218929643 18007984 18381685
MESH:D011014 Pneumonia Paraquat 10.4212504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3718163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.4112371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.412563599
MESH:D047928 Premature Birth Indomethacin 4.9417000239
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 8.8710548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.8711118676 11399792 11222880 11896295
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.5915572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.0320887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 11401523
MESH:D011471 Prostatic Neoplasms Androgens 1.9017909013 16998812 15389811
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.9019131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.9017292933
MESH:D011471 Prostatic Neoplasms bisphenol A 1.9016740699
MESH:D011471 Prostatic Neoplasms Calcitriol 1.9015754350 16289102 18247401 12479363 16644109
MESH:D011507 Proteinuria Indomethacin 8.7411849393
MESH:D011507 Proteinuria Tretinoin 8.7416636307
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D011625 Pterygium Tretinoin 4.6016723453
MESH:D011629 Puberty, Precocious bisphenol A 4.5910548101
MESH:D011658 Pulmonary Fibrosis Paraquat 2.8417997886 16324872
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D012120 Respiration Disorders Chlorine 5.0218579056
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.7311700416
MESH:D012135 Respiratory Sounds alachlor 9.4311874814
MESH:D012135 Respiratory Sounds Paraquat 9.4311874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6518990726
MESH:D012162 Retinal Degeneration Paraquat 3.7316458197
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9216116481 16283617
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.7816646077
MESH:D012640 Seizures topiramate 4.0016499746
MESH:D012852 Sinusitis Phenylephrine 4.517327846
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.8719755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.8716192470
MESH:D012878 Skin Neoplasms Tretinoin 8.8716467112
MESH:D013272 Stomach Diseases Indomethacin 4.2317160473 10192188 10215738 15472012 15038085 16280098 10486359 17638125 16113693 17207306 16184426 18209964 18545984
MESH:D013274 Stomach Neoplasms arsenic trioxide 8.0517007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 8.052093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 8.0518456281
MESH:D013274 Stomach Neoplasms Indomethacin 8.0515609394
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 8.0517575124 12958204
MESH:D013274 Stomach Neoplasms Tretinoin 8.0517261132
MESH:D013276 Stomach Ulcer Indomethacin 3.4211729361 17657623 12077510 18193104 15138204 18181030 18543354 10878458 11595415 17654042 14567935 18209962 11523592 16252198 15104355 10423059 17627676 18726076 17135157 12787963 12498302 16169175 11906479 11145282 1323529 12500499 18431645 16934674 18299717 17895592 17977527 11595431 16631530 17918041 16150113 16755016 18087811 12467913 16397915 18237397 10750652 15255614
MESH:D019966 Substance-Related Disorders bisphenol A 3.7916045194 16684133
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7112697716
MESH:D013964 Thyroid Neoplasms alachlor 20.968812207
MESH:D013964 Thyroid Neoplasms arsenic trioxide 20.9619014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 20.967505956
MESH:D013964 Thyroid Neoplasms Indomethacin 20.9614736730 18791128 11352223
MESH:D013964 Thyroid Neoplasms Tretinoin 20.9617045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.6216051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7715213294
MESH:D014376 Tuberculosis Tretinoin 3.1116040207
MESH:D014456 Ulcer Indomethacin 4.7010574470 17380554
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 4.7911780464 12845720 20435036 12973940
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.7917053015
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.5116129372
MESH:D014591 Uterine Diseases bisphenol A 4.8214652134
MESH:D014594 Uterine Neoplasms Sulindac 4.4218645019
MESH:D014604 Uveal Neoplasms Tretinoin 4.4216752155
MESH:D014605 Uveitis Cyclosporine 3.791336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4012125929
MESH:D014820 Vitiligo Tretinoin 3.8716761959
MESH:D014839 Vomiting Indomethacin 4.5511897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0615886252
MESH:D009396 Wilms Tumor Tretinoin 3.8116287080
MESH:D014985 Xerophthalmia Cyclosporine 4.2517120751
Pathway ID Pathway Name
REACT:19419 Amino acid and oligopeptide SLC transporters
REACT:13 Metabolism of amino acids and derivatives
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35917
    • No data
    No data
    Releated drug ID Related drug Name
    PA448055l-alanine
    PA450197l-leucine
    PA450280l-lysine
    PA451330l-serine
    PA451822l-tyrosine
    PA451843l-valine
    PA451590taurine
    PA164744376adenosine monophosphate
    PA164747225l-citrulline
    PA450635nitric oxide
    PA448478l-arginine
    PA10323l-tryptophan
    PA449789glycine
    PA449173l-cysteine
    PA451125l-proline
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00123 - L-Lysine Dietary supplement;Micronutrient;Essential Amino Acids
    DB00125 - L-Arginine Dietary supplement;Micronutrient;Conditionally Essential Amino Acids
    DB00129 - L-Ornithine Dietary supplement;Micronutrient;Non-Essential Amino Acids
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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