AutismKB 2.0

Annotation Detail for SLC7A2


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Basic Information Top
Gene Symbol:SLC7A2 ( ATRC2,CAT2,HCAT2 )
Gene Full Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
Band: 8p22
Quick LinksEntrez ID:6542; OMIM: 601872; Uniprot ID:CTR2_HUMAN; ENSEMBL ID: ENSG00000003989; HGNC ID: 11060
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Transmembrane transport of small molecules
Amino acid and oligopeptide SLC transporters
Metabolism of amino acids and derivatives
No data
No data
Pathway IDPathway Name
500341Amino acid transport across the plasma membrane
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of SLC7A2 mRNAdecreases expression 19933214
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of SLC7A2 mRNAdecreases expression 20406850
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of SLC7A2 mRNAincreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC7A2 mRNAaffects expression 16483693
C015001 arsenite arsenite results in decreased expression of SLC7A2 mRNAdecreases expression 18929588
C015001 arsenite TRP53 protein affects the reaction [arsenite results in decreased expression of SLC7A2 mRNA]affects reaction|decreases expression 18929588
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SLC7A2 mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in increased expression of SLC7A2 mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of SLC7A2 mRNAdecreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SLC7A2 mRNAaffects cotreatment|affects expression 17602206
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of SLC7A2 mRNAaffects cotreatment|increases expression 17404688
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC7A2 mRNAaffects cotreatment|increases expression 17942748
D005419 Flavonoids Flavonoids results in decreased expression of SLC7A2 mRNAdecreases expression 18035473
D001556 Lindane Lindane results in increased expression of SLC7A2 mRNAincreases expression 17785943
C041786 palm oil palm oil results in decreased expression of SLC7A2 mRNAdecreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of SLC7A2 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of SLC7A2 mRNAdecreases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of SLC7A2 mRNAincreases expression 19270015
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SLC7A2 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of SLC7A2 mRNAincreases expression 18445702
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of SLC7A2 mRNAaffects cotreatment|increases expression 17404688
C009250 sevoflurane sevoflurane affects the expression of SLC7A2 mRNAaffects expression 15967596
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC7A2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SLC7A2 mRNAdecreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.096195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.0914514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.5018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8917505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.0518653653
MESH:D000230 Adenocarcinoma Estradiol 4.1611473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.1614692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.543712494
MESH:D000236 Adenoma Diethylnitrosamine 6.5410737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 24.3719061943 17620307 16434500 19052882 17162532 18056438
MESH:D018248 Adenoma, Liver Cell Phenobarbital 24.3717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 24.3716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 24.3716835633
MESH:D000382 Agricultural Workers' Diseases Lindane 4.3112661182
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8911748828
MESH:D001161 Arteriosclerosis Dietary Fats 9.7015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.7011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6215885639
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.9611289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.5619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.5612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7215746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.2817868700
MESH:D001930 Brain Injuries Progesterone 4.1915665606 15845082 15380490
MESH:D001943 Breast Neoplasms Dietary Fats 2.9320435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.9317474063
MESH:D001943 Breast Neoplasms Estradiol 2.9317261762 17289903 14630087 12948864 17018787 19861407 16675129 18497071
MESH:D001943 Breast Neoplasms Lindane 2.9314688026
MESH:D001943 Breast Neoplasms Progesterone 2.9317614352 16175315 15562024
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9320435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4016111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7416835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.7616705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.763581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.7619335982 16569478 18393292 16935385 3084413 16830150 20524982 18665156 20727157 19418558 19052882 16698587 18210153 18056438 20007298 20432363 16502159 19383236 19519916 10737359 18506893 17055752 20084675 18978308 3581430 16779866 19701751 18691550 20935162 18971187 19394651 20214788 20514400 19208518 19919837 16540662 16878318 20101231 16328049 21159647 17173139 16681979 16807293 18494052 16288022 10672840 18785209 19107877 17761372 19822196 17138121 11831363 17428255 20512989 19171122 17162532 17978847 18788625 19539802
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.7616924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 8.766705139 1701930 20007298 20935162 17173139
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.647296757
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3318850075 16120746 18670907
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 20.606135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 20.607505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 20.6012371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 20.607505956 21159647 17174075 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 20.6018566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.194080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.1319052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.1316835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 18.8019486331 9022650
MESH:D002779 Cholestasis Cyclosporine 18.8019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 18.8017110522 17681005 11677210 16919318 15861022 16105132 17333356
MESH:D002779 Cholestasis pirinixic acid 18.8019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0812621046 8697196 15340226 16354765 15668235
MESH:D003110 Colonic Neoplasms arsenite 2.5815037631
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0014669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 15322242 20055451
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.9518551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7418759878 8156756 11906362 8970840 12868966 11298694 2524372 14531868
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3918249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.433621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.1720387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1717107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.3519279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.4317187935
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.8021346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 8.8018289764 1440618 11289319 8291058 9653073 16192314 6482804 9022650 18692083 9328219 18648102 6679447 7440962
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.8019107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.8020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7111462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4018367378
MESH:D004421 Dystonia Phenobarbital 3.941851702
MESH:D004487 Edema pirinixic acid 6.3312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.3312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8518230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.8212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.8217692515
MESH:D016889 Endometrial Neoplasms Estradiol 2.9418566989 11473722 19148513
MESH:D004715 Endometriosis Progesterone 8.7316134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.7310568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.043659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.823922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8620417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.486401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.197750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.963659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0616302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.093581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9611564622
MESH:D005234 Fatty Liver arsenite 29.9418296743
MESH:D005234 Fatty Liver Cyclosporine 29.9419224547
MESH:D005234 Fatty Liver Dietary Fats 29.9418296743 19551842 19004024 17967931
MESH:D005234 Fatty Liver Diethylnitrosamine 29.9420387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 29.9415345470
MESH:D005234 Fatty Liver pirinixic acid 29.9419236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3911858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.966705139
MESH:D005355 Fibrosis arsenite 20.6518296743
MESH:D005355 Fibrosis Cyclosporine 20.6512168785 12639820
MESH:D005355 Fibrosis Dietary Fats 20.6518296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 20.6520067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.168708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.977505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3010048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2711000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.456705139
MESH:D006529 Hepatomegaly Phenobarbital 14.0216109766
MESH:D006529 Hepatomegaly pirinixic acid 14.0219772884 19176532 18467677 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.0216120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.9815709030
MESH:D019584 Hot Flashes Estradiol 3.7017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9916959395 15340226 18606429 16354765 8697196
MESH:D006937 Hypercholesterolemia Dietary Fats 3.5321332399
MESH:D006943 Hyperglycemia pirinixic acid 3.1220558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.5521332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8815034207
MESH:D006973 Hypertension Cyclosporine 4.8610903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8618670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7516569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.3415869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4417937319
MESH:D007249 Inflammation Dietary Fats 15.5020412841
MESH:D007249 Inflammation Diethylnitrosamine 15.5018785209
MESH:D007249 Inflammation Flavonoids 15.5017296493
MESH:D007249 Inflammation Progesterone 15.5015869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 15.5012200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 12.0411836018 18457598
MESH:D007333 Insulin Resistance Estradiol 12.0416393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 12.0416306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.969022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2716580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3915604871
MESH:D007674 Kidney Diseases Cyclosporine 5.818314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 5.8115618244
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 17.2816705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 17.286582329
MESH:D007680 Kidney Neoplasms Cyclosporine 17.2812371664
MESH:D007680 Kidney Neoplasms Estradiol 17.2815610895
MESH:D007859 Learning Disorders sevoflurane 4.7119212262
MESH:D008103 Liver Cirrhosis arsenite 15.4918296743
MESH:D008103 Liver Cirrhosis Dietary Fats 15.4918296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 15.4918522880 20032147 18407596 18665156 19638242
MESH:D008103 Liver Cirrhosis Phenobarbital 15.4921047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.159327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.3314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.3315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.3312878042
MESH:D008107 Liver Diseases Diethylnitrosamine 6.5817034775
MESH:D008107 Liver Diseases Lindane 6.581715830
MESH:D008107 Liver Diseases Phenobarbital 6.5819363144
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 17.677678174
MESH:D008113 Liver Neoplasms Clofibric Acid 17.6717602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 17.672422723 12112319 18977376 21047994 21167192 19638242 21071580 19426721 2862719 10737359 18978307 21278145 18648771 19499222 19255062 19427195 20434301 19294768 19642983 18644402 20583210 20405173 19090486 16942905 19850985 19833225 15175105 20137499 20118626 12771043 19551842 20492335 19073162 9163691 15885732 19690152 20501860 18754104 19254457 20452335 19996281 19812893 20101389 19256749
MESH:D008113 Liver Neoplasms Phenobarbital 17.678742319 15975961 19812893 19073162 21047994 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 17.6715890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.6716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 18.202876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 18.20598648 6587162 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 18.2017854601 17942915 18282651 19009564 19519916 16267830 16842330 19126423 9362446 3124819 18308698 19539802 17174075 18253720 19004024 18079962 2563599 18164116 21159647 18775883 18544905 18093689
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 18.201399818 18308698 6150874 17172636 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 18.2012151625
MESH:D008175 Lung Neoplasms arsenite 3.4116809336
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.4121163286 6695378 20512841 20970405
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4119555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.9111807958 11408345 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 5.9117203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.4319453300
MESH:D008569 Memory Disorders sevoflurane 4.6819212262
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7316801185
MESH:D009135 Muscular Diseases pirinixic acid 3.4416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.0816810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.0816411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.4117484760
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.8018551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.613581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.619029167 3581430
MESH:D009369 Neoplasms Lindane 5.1512807735 16818664
MESH:D009369 Neoplasms pirinixic acid 5.1517405874
MESH:D009389 Neovascularization, Pathologic arsenite 9.9515738583
MESH:D009389 Neovascularization, Pathologic Estradiol 9.9517289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2318481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 9.2516427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.2514600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.876679447
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.2820387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0620387270
MESH:D009765 Obesity Dietary Fats 4.3820132043 17217161 20518802 21332399 16723640 18674790 18457598 19632207 11836018
MESH:D009765 Obesity pirinixic acid 4.3820558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.6816049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.686482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.963988306
MESH:D010018 Osteomalacia Phenobarbital 4.3017016548
MESH:D010051 Ovarian Neoplasms Estradiol 4.8019401270
MESH:D010051 Ovarian Neoplasms Progesterone 4.8017393432 16525653
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.1816540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.1816965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6211578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.427296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1912520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.416228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4918163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.9412371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.942563599
MESH:D011230 Precancerous Conditions Phenobarbital 14.942563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1311399792 11896295 11222880 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8220887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.5716740699
MESH:D011471 Prostatic Neoplasms Lindane 3.5712661182 14688026
MESH:D011537 Pruritus Ethinyl Estradiol 3.2515861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.4412752131
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.3519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7718990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.323692021
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8318045962
MESH:D012640 Seizures 2,6-dinitrotoluene 9.6918551238
MESH:D012640 Seizures Lindane 9.697539098 15475178 12842176
MESH:D012640 Seizures Phenobarbital 9.6911442880 16876388 4039156 3137016
MESH:D003294 Seizures, Febrile Phenobarbital 4.766407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.8916709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.2215862959 16503802
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8512697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 11.651399818 3712494 6587162 6582329 7505956
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 11.657505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 11.651399818
MESH:D013978 Tibial Fractures Estradiol 4.6319048282
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 4.9216049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 4.928074119
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.2610091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2314692618
MESH:D014605 Uveitis Cyclosporine 3.931336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1915886252
MESH:D015430 Weight Gain Dietary Fats 3.6816723640
MESH:D014985 Xerophthalmia Cyclosporine 4.3917120751
Pathway ID Pathway Name
REACT:19419 Amino acid and oligopeptide SLC transporters
REACT:13 Metabolism of amino acids and derivatives
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35920
    • No data
    No data
    Releated drug ID Related drug Name
    PA448055l-alanine
    PA448478l-arginine
    PA450197l-leucine
    PA450280l-lysine
    PA451330l-serine
    PA451822l-tyrosine
    PA451843l-valine
    PA451590taurine
    PA10323l-tryptophan
    PA449789glycine
    PA449173l-cysteine
    PA451125l-proline
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00123 - L-Lysine Dietary supplement;Micronutrient;Essential Amino Acids
    DB00129 - L-Ornithine Dietary supplement;Micronutrient;Non-Essential Amino Acids
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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