AutismKB 2.0

Annotation Detail for SLC7A4


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Basic Information Top
Gene Symbol:SLC7A4 ( CAT-4,CAT4,HCAT3,MGC129976,MGC129977,VH )
Gene Full Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 4
Band: 22q11.21
Quick LinksEntrez ID:6545; OMIM: 603752; Uniprot ID:CTR4_HUMAN; ENSEMBL ID: ENSG00000099960; HGNC ID: 11062
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of SLC7A4 mRNAincreases expression 19933214
D015735 Mifepristone Mifepristone results in decreased expression of SLC7A4 mRNAdecreases expression 17584828
D020849 Raloxifene Raloxifene affects the expression of SLC7A4 mRNAaffects expression 16079270
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SLC7A4 mRNAincreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.4714514962 11752688 15322242
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.0116835633
MESH:D000419 Albuminuria Raloxifene 5.1017451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.6015800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.3411748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0015746008
MESH:D001930 Brain Injuries Raloxifene 5.0416580743
MESH:D001943 Breast Neoplasms Raloxifene 2.0917242785 17595753 15758505 15572757 17893378 17440819 16912660 16837676 15775269 17049068 17261762 17952589
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0920435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.4717572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5618670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Raloxifene 3.7115775269
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5316835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2415340226 15668235 8697196 16354765 12621046
MESH:D003072 Cognition Disorders Raloxifene 5.1815800139
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2710048152 20055451 15322242
MESH:D003865 Depressive Disorder, Major Raloxifene 4.5317474826
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7417107852
MESH:D003928 Diabetic Nephropathies Raloxifene 4.3017308373 17451421 15920148
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0511462148
MESH:D004487 Edema Raloxifene 8.2915860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 8.2911000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.6218230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 4.5015845917
MESH:D004715 Endometriosis Mifepristone 10.4916134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 10.499294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3111564622
MESH:D005234 Fatty Liver Raloxifene 4.0417473493
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.0211858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.5120067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.3210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5111294989 10048152
MESH:D006331 Heart Diseases Raloxifene 3.8011110106
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.4515340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.7715340226 16959395 18606429 16354765 8697196
MESH:D006973 Hypertension Raloxifene 5.6317577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.6318850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0312200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7616580747
MESH:D007889 Leiomyoma Raloxifene 4.9616973256
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8316984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3312151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 6.2815863610
MESH:D009101 Multiple Myeloma Raloxifene 3.7116497877
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3412213967
MESH:D009232 Myxoma Raloxifene 6.2816343187
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.7214600291
MESH:D010024 Osteoporosis Raloxifene 3.6119059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.6915758505 15579764 17893378 17823083
MESH:D010051 Ovarian Neoplasms Mifepristone 3.2216525653
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.9712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0718163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.8211222880 11118676 11399792 11896295
MESH:D011471 Prostatic Neoplasms Raloxifene 3.5415731164 16220300 16536755
MESH:D011693 Purpura Raloxifene 6.2815770314
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.3518990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.2016192470
MESH:D020521 Stroke Raloxifene 4.1516837676
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.6212697716
MESH:D013978 Tibial Fractures Raloxifene 5.9319048282
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 2.9317572228
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.3212125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.9316837676
MESH:D014846 Vulvar Neoplasms Raloxifene 6.2816343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.9715886252
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00123 - L-Lysine Dietary supplement;Micronutrient;Essential Amino Acids
DB00125 - L-Arginine Dietary supplement;Micronutrient;Conditionally Essential Amino Acids
DB00129 - L-Ornithine Dietary supplement;Micronutrient;Non-Essential Amino Acids
No data
No data
No data

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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