AutismKB 2.0

Annotation Detail for SLC8A1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SLC8A1 ( DKFZp779F0871,FLJ37694,FLJ43417,MGC119581,NCX1 )
Gene Full Name: solute carrier family 8 (sodium/calcium exchanger), member 1
Band: 2p22.1
Quick LinksEntrez ID:6546; OMIM: 182305; Uniprot ID:NAC1_HUMAN; ENSEMBL ID: ENSG00000183023; HGNC ID: 11068
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04020Calcium signaling pathway
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
hsa04974Protein digestion and absorption
hsa04260Cardiac muscle contraction
Pathway IDPathway Name
Transmembrane transport of small molecules
Hemostasis
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1878Ischemia
2091Hypertension
Desease Name
CARDIOVASCULAR
hypertension
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C101670 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased transport of Calcium]decreases reaction|increases transport 15375168
C101670 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased uptake of Calcium]decreases reaction|increases uptake 14660663
C101670 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased susceptibility to Chlorodiphenyl (54% Chlorine)]decreases reaction|increases response to substance 16009740
C101670 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased transport of Calcium]decreases reaction|increases transport 18822394
C101670 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate results in decreased activity of SLC8A1 proteindecreases activity 17541957
D000493 Allopurinol Allopurinol affects the expression of SLC8A1 mRNAaffects expression 17071724
D000493 Allopurinol Allopurinol affects the expression of SLC8A1 proteinaffects expression 17071724
D000638 Amiodarone Amiodarone results in decreased activity of SLC8A1 proteindecreases activity 15288574
D000638 Amiodarone Amiodarone results in increased expression of SLC8A1 proteinincreases expression 7573397
D001464 Barium SLC8A1 protein affects the transport of Bariumaffects transport 17560225
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SLC8A1 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC8A1 mRNAdecreases expression 20382639
D015764 Bepridil Bepridil inhibits the reaction [SLC8A1 protein results in increased susceptibility to Chlorodiphenyl (54% Chlorine)]decreases reaction|increases response to substance 16009740
C070515 bisindolylmaleimide I bisindolylmaleimide I inhibits the reaction [Phenylephrine results in decreased expression of SLC8A1 mRNA]decreases expression|decreases reaction 17257893
C006780 bisphenol A bisphenol A affects the expression of SLC8A1 mRNAaffects expression 20170705
D002118 Calcium 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased transport of Calcium]decreases reaction|increases transport 15375168
D002118 Calcium 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased uptake of Calcium]decreases reaction|increases uptake 14660663
D002118 Calcium SEA 0400 inhibits the reaction [SLC8A1 protein results in increased uptake of Calcium]decreases reaction|increases uptake 14660663
D002118 Calcium SLC8A1 protein results in increased transport of Calciumincreases transport 15375168
D002118 Calcium SLC8A1 protein results in increased uptake of Calciumincreases uptake 14660663
D002118 Calcium Calcium inhibits the reaction [SLC8A1 protein results in increased uptake of Nickel]decreases reaction|increases uptake 10329968
D002118 Calcium PPP3R1 gene mutant form inhibits the reaction [SLC8A1 protein affects the transport of Calcium]affects transport|decreases reaction 19700627
D002118 Calcium 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased transport of Calcium]decreases reaction|increases transport 18822394
D002118 Calcium SLC8A1 protein results in increased transport of Calciumincreases transport 18822394
D020111 Chlorodiphenyl (54% Chlorine) 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased susceptibility to Chlorodiphenyl (54% Chlorine)]decreases reaction|increases response to substance 16009740
D020111 Chlorodiphenyl (54% Chlorine) Bepridil inhibits the reaction [SLC8A1 protein results in increased susceptibility to Chlorodiphenyl (54% Chlorine)]decreases reaction|increases response to substance 16009740
D020111 Chlorodiphenyl (54% Chlorine) SLC8A1 protein results in increased susceptibility to Chlorodiphenyl (54% Chlorine)increases response to substance 16009740
D002117 Calcitriol Calcitriol results in increased expression of SLC8A1 mRNAincreases expression 16857747
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of SLC8A1 mRNAaffects expression 20170705
D007545 Isoproterenol EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 mRNA]affects cotreatment|affects reaction|increases expression 15621046
D007545 Isoproterenol EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]affects cotreatment|affects reaction|increases expression 15621046
D007545 Isoproterenol Propranolol inhibits the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]affects cotreatment|decreases reaction|increases expression 15621046
D007545 Isoproterenol Isoproterenol results in increased expression of SLC8A1 mRNAincreases expression 11179087
D009532 Nickel Calcium inhibits the reaction [SLC8A1 protein results in increased uptake of Nickel]decreases reaction|increases uptake 10329968
D009532 Nickel SLC8A1 protein results in increased uptake of Nickelincreases uptake 10329968
D009532 Nickel Sodium promotes the reaction [SLC8A1 protein results in increased uptake of Nickel]increases reaction|increases uptake 10329968
D009638 Norepinephrine Norepinephrine results in increased expression of SLC8A1 mRNAincreases expression 11179087
D009638 Norepinephrine Norepinephrine results in increased expression of SLC8A1 proteinincreases expression 11179087
C111654 NPS R-467 NPS R-467 results in decreased expression of SLC8A1 mRNAdecreases expression 16164647
D010100 Oxygen Oxygen deficiency results in increased expression of SLC8A1 mRNAincreases expression 17394575
D010100 Oxygen Oxygen deficiency results in increased expression of SLC8A1 proteinincreases expression 17394575
D010269 Paraquat IGF1 gene mutant form inhibits the reaction [Paraquat results in decreased expression of SLC8A1 protein]decreases expression|decreases reaction 17979500
D010269 Paraquat Paraquat results in decreased expression of SLC8A1 proteindecreases expression 17979500
D010656 Phenylephrine EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 mRNA]affects cotreatment|affects reaction|increases expression 15621046
D010656 Phenylephrine EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]affects cotreatment|affects reaction|increases expression 15621046
D010656 Phenylephrine Propranolol inhibits the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]affects cotreatment|decreases reaction|increases expression 15621046
D010656 Phenylephrine bisindolylmaleimide I inhibits the reaction [Phenylephrine results in decreased expression of SLC8A1 mRNA]decreases expression|decreases reaction 17257893
D010656 Phenylephrine Phenylephrine results in decreased expression of SLC8A1 mRNAdecreases expression 17257893
D010656 Phenylephrine Prazosin inhibits the reaction [Phenylephrine results in decreased expression of SLC8A1 mRNA]decreases expression|decreases reaction 17257893
D010656 Phenylephrine Phenylephrine results in decreased expression of SLC8A1 proteindecreases expression 19244478
D010656 Phenylephrine Phenylephrine results in increased expression of SLC8A1 mRNAincreases expression 11179087
D011224 Prazosin Prazosin inhibits the reaction [Phenylephrine results in decreased expression of SLC8A1 mRNA]decreases expression|decreases reaction 17257893
D011433 Propranolol Propranolol inhibits the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein]affects cotreatment|decreases reaction|increases expression 15621046
C430918 SEA 0400 SEA 0400 inhibits the reaction [SLC8A1 protein results in increased uptake of Calcium]decreases reaction|increases uptake 14660663
C430918 SEA 0400 SEA 0400 binds to and results in decreased activity of SLC8A1 proteinaffects binding|decreases activity 17917422
D012964 Sodium Sodium promotes the reaction [SLC8A1 protein results in increased uptake of Nickel]increases reaction|increases uptake 10329968
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate inhibits the reaction [Thapsigargin results in increased expression of SLC8A1 mRNA]decreases reaction|increases expression 19244478
D019284 Thapsigargin Tetradecanoylphorbol Acetate inhibits the reaction [Thapsigargin results in increased expression of SLC8A1 mRNA]decreases reaction|increases expression 19244478
D019284 Thapsigargin Thapsigargin results in increased expression of SLC8A1 mRNAincreases expression 19244478
D019284 Thapsigargin Thapsigargin results in increased expression of SLC8A1 proteinincreases expression 19244478
D014415 Tunicamycin Tunicamycin results in increased expression of SLC8A1 mRNAincreases expression 17127020
D014501 Uranium Uranium results in decreased expression of SLC8A1 mRNAdecreases expression 17118558
D014635 Valproic Acid Valproic Acid results in increased expression of SLC8A1 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.238875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.6919490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6817505938
MESH:D055371 Acute Lung Injury Nickel 8.9616166738
MESH:D055371 Acute Lung Injury Oxygen 8.9616759491
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 3.9520127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 3.9514692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.506695378
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.5111874814
MESH:D000550 Amblyopia Valproic Acid 4.9717688650
MESH:D000860 Anoxia Oxygen 4.7920872349
MESH:D001008 Anxiety Disorders Valproic Acid 3.3717497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8219183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 8.3918218290 20041841 18057881
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 8.3917460149
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5015885639
MESH:D050197 Atherosclerosis Oxygen 3.6516391483
MESH:D001281 Atrial Fibrillation Amiodarone 3.7119698954 18651412
MESH:D001321 Autistic Disorder Norepinephrine 2.538570775
MESH:D001321 Autistic Disorder Propranolol 2.5318766980
MESH:D001321 Autistic Disorder Valproic Acid 2.5318396377 18775368 17157402 20603192 19232924 15238991 18316065 18558336 17688650 18177632 19460635 17507914 18940202 18985861 16609825
MESH:D001714 Bipolar Disorder Valproic Acid 2.9417594078 20046352
MESH:D001778 Blood Coagulation Disorders Amiodarone 3.6719483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.248888407
MESH:D001862 Bone Resorption bisphenol A 3.6311985600
MESH:D001919 Bradycardia Isoproterenol 16.366740701
MESH:D001919 Bradycardia Phenylephrine 16.3615306635
MESH:D001919 Bradycardia Propranolol 16.366740701
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.2917474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 2.2917123778
MESH:D001943 Breast Neoplasms Calcitriol 2.2911237771
MESH:D001943 Breast Neoplasms Nickel 2.2915986119
MESH:D001943 Breast Neoplasms Oxygen 2.2917263869
MESH:D002278 Carcinoma in Situ bisphenol A 4.7217123778
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.1720419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 7.1711237771
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 7.1718922899
MESH:D006332 Cardiomegaly Isoproterenol 11.027544033 11179087
MESH:D006332 Cardiomegaly Norepinephrine 11.0211179087
MESH:D006332 Cardiomegaly Phenylephrine 11.0217124262 15728586 11179087 11754973 17287366 16170337
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8019225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.8218974383
MESH:D002375 Catalepsy Norepinephrine 5.278216760
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.5520889678
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6120734317
MESH:D002779 Cholestasis Ethinyl Estradiol 2.6817681005 17110522 16105132 15861022 16919318 17333356 11677210
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.8817688650 16575769 8888407
MESH:D017449 Dermatitis, Allergic Contact Nickel 3.7017244072 19470301 17100760
MESH:D003877 Dermatitis, Contact Nickel 4.392952479
MESH:D004283 Dog Diseases Allopurinol 5.9910449224
MESH:D056486 Drug-Induced Liver Injury Amiodarone 8.4718218290 15265979
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 8.4717851650
MESH:D056486 Drug-Induced Liver Injury Prazosin 8.4718071297
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 8.4719641884 1733752
MESH:D004417 Dyspnea Oxygen 4.5720016425
MESH:D004421 Dystonia Valproic Acid 3.811851702
MESH:D004487 Edema bisindolylmaleimide I 6.938273558
MESH:D004487 Edema Tetradecanoylphorbol Acetate 6.937812673 15177302 8113982 9599246 11698051 16716910 8273558
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 8.2615138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.2612538720
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.9017275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.653922381 16628512
MESH:D004827 Epilepsy Norepinephrine 6.73821787
MESH:D004827 Epilepsy Valproic Acid 6.7320417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.377562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.047750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.803659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.1120426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.1116530937
MESH:D005234 Fatty Liver Amiodarone 11.8014986274
MESH:D005234 Fatty Liver Ethinyl Estradiol 11.8015345470
MESH:D005234 Fatty Liver Valproic Acid 11.8014986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 4.6216575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.888888407 18558336
MESH:D005739 Gas Poisoning Oxygen 4.9520016425
MESH:D005911 Gliosis Paraquat 4.9011124998
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.5220471113
MESH:D006333 Heart Failure Isoproterenol 7.6118097624
MESH:D006333 Heart Failure Propranolol 7.6120082655
MESH:D006529 Hepatomegaly Amiodarone 8.4915265979
MESH:D006529 Hepatomegaly Propranolol 8.4916371745
MESH:D015658 HIV Infections Nickel 3.6817263646
MESH:D006849 Hydrocephalus Valproic Acid 4.6017688650
MESH:D006930 Hyperalgesia Prazosin 4.6612727271
MESH:D006937 Hypercholesterolemia Amiodarone 3.649751232 8137927
MESH:D006962 Hyperparathyroidism, Secondary NPS R-467 6.8215086907
MESH:D006973 Hypertension Phenylephrine 2.9712717712 8949925
MESH:D006984 Hypertrophy Isoproterenol 10.2212791704
MESH:D006984 Hypertrophy Phenylephrine 10.2212791704 18502941
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5516569931 16945680
MESH:D007022 Hypotension Isoproterenol 14.266740701
MESH:D007022 Hypotension Norepinephrine 14.266740701
MESH:D007022 Hypotension Propranolol 14.266740701
MESH:D007037 Hypothyroidism Amiodarone 4.2617991464 18020914
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.1617937319
MESH:D007248 Infertility, Male Paraquat 6.164850670
MESH:D007249 Inflammation bisindolylmaleimide I 7.998273558
MESH:D007249 Inflammation Nickel 7.9916166738
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 7.9915177302 8273558 7562506 7812673 11698051
MESH:D007333 Insulin Resistance bisphenol A 3.1216393666
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.7816316344
MESH:D016773 Leishmaniasis, Cutaneous Allopurinol 5.0512207774 9314461
MESH:D007898 Leishmaniasis, Visceral Allopurinol 4.9211332679 10449224 7498017
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1116294345 17596541
MESH:D008064 Lipidoses Amiodarone 3.3217567588 15342952
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 1.9520195826 21137059
MESH:D008133 Long QT Syndrome Amiodarone 3.3817391786 11989578 15350150
MESH:D008171 Lung Diseases Amiodarone 3.2012587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 10.3718516814
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 10.3717228818
MESH:D055370 Lung Injury Oxygen 4.2518339021
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.5520135361 20064080 18569708 20869020 6695378 18520028 18816296 17053015 20464547
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 2.5511807781
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 3.198985016
MESH:D008531 Megacolon marker/mechanism 17560225 15185227
MESH:D008881 Migraine Disorders Valproic Acid 3.0118803445 18765137
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9916381670
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.798888407
MESH:D009181 Mycoses Amiodarone 4.6312754197 17974566
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.0117596541
MESH:D009203 Myocardial Infarction Isoproterenol 3.7419595682 16584858 16697266 15740881 17052832 16538859 19172585
MESH:D015428 Myocardial Reperfusion Injury marker/mechanism 15215644
MESH:D015428 Myocardial Reperfusion Injury Norepinephrine 9.4015642760
MESH:D015428 Myocardial Reperfusion Injury SEA 0400 9.4015215644
MESH:D009369 Neoplasms Benzo(a)pyrene 2.0511141357
MESH:D009397 Nephrocalcinosis NPS R-467 6.8215086907
MESH:D009410 Nerve Degeneration Paraquat 3.5216893418
MESH:D009421 Nervous System Malformations bisphenol A 3.7216427766 11399458
MESH:D009436 Neural Tube Defects Valproic Acid 2.9616359493 8888407
MESH:D010024 Osteoporosis Calcium 3.6217882678
MESH:D010049 Ovarian Diseases bisphenol A 4.7211985600
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 3.0415976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4411578682
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.048330346 18404319 18922899 12065085
MESH:D010300 Parkinson Disease Paraquat 2.7216140633 12911755 15824117 11124998 15451049 11181820 16510128 11445065
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.1716190885
MESH:D011014 Pneumonia Paraquat 4.1912504350
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 8.8710548101
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 8.8720603192
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.5215572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 3.9720887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6817292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.6816740699
MESH:D011471 Prostatic Neoplasms Calcitriol 2.6816289102 12479363 18247401 16644109 15754350
MESH:D011537 Pruritus Ethinyl Estradiol 3.0515861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.2712752131 11422049
MESH:D011629 Puberty, Precocious bisphenol A 4.5210548101
MESH:D011654 Pulmonary Edema Isoproterenol 4.9810903255
MESH:D011658 Pulmonary Fibrosis Amiodarone 5.5012832656 12490602 11597910
MESH:D011658 Pulmonary Fibrosis Paraquat 5.5016324872 17997886
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 8.6418339021 17627322
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 8.6411700416
MESH:D012135 Respiratory Sounds Paraquat 3.8011874814
MESH:D012162 Retinal Degeneration Paraquat 3.6716458197
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.9319155313
MESH:D012559 Schizophrenia Valproic Acid 2.0319110320 15737665
MESH:D012640 Seizures Valproic Acid 2.5715475178 1511512 3137016 16876388 17978042 14763951 11738929 11044598
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.8218724381
MESH:D012852 Sinusitis Phenylephrine 4.447327846
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.5110029692 19755658
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 5.5111807781 8330346 12065085 8985016 18404319
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6816709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.5819490988
MESH:D013226 Status Epilepticus Valproic Acid 4.2712833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5520155912 2093021
MESH:D013276 Stomach Ulcer Amiodarone 3.0918087811
MESH:D019966 Substance-Related Disorders bisphenol A 3.7216045194 16684133
MESH:D013398 Sudden Infant Death Oxygen 5.2812563064
MESH:D013610 Tachycardia Amiodarone 10.2711238279
MESH:D013610 Tachycardia Norepinephrine 10.273261545
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.9419225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9315669648
MESH:D013959 Thyroid Diseases Amiodarone 4.4919731979
MESH:D013971 Thyrotoxicosis Amiodarone 4.6018020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 3.9317467628 11989578
MESH:D014178 Translocation, Genetic Valproic Acid 4.9717262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.263119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.0817053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.388888407
MESH:D014591 Uterine Diseases bisphenol A 4.7414652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0514692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3014671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Isoproterenol 4.8618097624
MESH:D020257 Ventricular Remodeling Isoproterenol 5.4218097624
Pathway ID Pathway Name
KEGG:05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
KEGG:04020 Calcium signaling pathway
KEGG:04260 Cardiac muscle contraction
KEGG:05414 Dilated cardiomyopathy
KEGG:04961 Endocrine and other factor-regulated calcium reabsorption
REACT:604 Hemostasis
KEGG:05410 Hypertrophic cardiomyopathy (HCM)
KEGG:04978 Mineral absorption
KEGG:04974 Protein digestion and absorption
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00132 - Alpha-Linolenic Acid Dietary supplement;Micronutrient
DB00159 antagonist Icosapent Dietary supplement;Micronutrient
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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