Annotation Detail for SLC8A3
Basic Information Top
| Gene Symbol: | SLC8A3 ( NCX3 ) |
|---|---|
| Gene Full Name: | solute carrier family 8 (sodium/calcium exchanger), member 3 |
| Band: | 14q24.2 |
| Quick Links | Entrez ID:6547; OMIM: 607991; Uniprot ID:NAC3_HUMAN; ENSEMBL ID: ENSG00000100678; HGNC ID: 11070 |
| Relate to Another Database: | SFARIGene; denovo-db |
Related Diseases/Disorders| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| C101670 | 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate | 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Kainic Acid results in increased cleavage of SLC8A3 protein] | decreases reaction|increases cleavage | 17585341 |
| D000638 | Amiodarone | Amiodarone results in decreased activity of SLC8A3 protein | decreases activity | 15288574 |
| D002118 | Calcium | SLC8A3 protein results in increased transport of Calcium | increases transport | 17585341 |
| D002118 | Calcium | SLC8A3 protein results in increased uptake of Calcium | increases uptake | 14660663 |
| D004041 | Dietary Fats | Dietary Fats results in decreased expression of SLC8A3 mRNA | decreases expression | 18042831 |
| D004041 | Dietary Fats | Dietary Fats results in increased expression of SLC8A3 mRNA | increases expression | 18042831 |
| D007608 | Kainic Acid | 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Kainic Acid results in increased cleavage of SLC8A3 protein] | decreases reaction|increases cleavage | 17585341 |
| D007608 | Kainic Acid | Kainic Acid results in increased cleavage of SLC8A3 protein | increases cleavage | 17585341 |
| C041786 | palm oil | palm oil results in decreased expression of SLC8A3 mRNA | decreases expression | 18042831 |
| C041786 | palm oil | palm oil results in increased expression of SLC8A3 mRNA | increases expression | 18042831 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D001145 | Arrhythmias, Cardiac | Amiodarone | 4.11 | 20041841 18218290 18057881 | |
| MESH:D001161 | Arteriosclerosis | Dietary Fats | 4.31 | 15238619 | |
| MESH:D001281 | Atrial Fibrillation | Amiodarone | 4.13 | 19698954 18651412 | |
| MESH:D001778 | Blood Coagulation Disorders | Amiodarone | 4.22 | 19483382 | |
| MESH:D001943 | Breast Neoplasms | Dietary Fats | 2.25 | 20435547 | |
| MESH:D002311 | Cardiomyopathy, Dilated | Amiodarone | 2.98 | 19225199 15710769 | |
| MESH:D002341 | Carotid Artery Thrombosis | Amiodarone | 5.55 | 18974383 | |
| MESH:D056486 | Drug-Induced Liver Injury | Amiodarone | 2.46 | 18218290 15265979 | |
| MESH:D050171 | Dyslipidemias | Dietary Fats | 3.67 | 18367378 | |
| MESH:D005234 | Fatty Liver | Amiodarone | 9.08 | 14986274 | |
| MESH:D005234 | Fatty Liver | Dietary Fats | 9.08 | 19551842 18296743 19004024 17967931 | |
| MESH:D005355 | Fibrosis | Dietary Fats | 3.94 | 18296743 | |
| MESH:D006529 | Hepatomegaly | Amiodarone | 4.16 | 15265979 | |
| MESH:D006937 | Hypercholesterolemia | Amiodarone | 10.27 | 9751232 8137927 | |
| MESH:D006937 | Hypercholesterolemia | Dietary Fats | 10.27 | 21332399 | |
| MESH:D006949 | Hyperlipidemias | Dietary Fats | 3.97 | 21332399 | |
| MESH:D007037 | Hypothyroidism | Amiodarone | 4.93 | 17991464 18020914 | |
| MESH:D007249 | Inflammation | Dietary Fats | 2.57 | 20412841 | |
| MESH:D007333 | Insulin Resistance | Dietary Fats | 3.30 | 18457598 11836018 | |
| MESH:D007683 | Kidney Tubular Necrosis, Acute | Calcium | 5.57 | 16316344 | |
| MESH:D008064 | Lipidoses | Amiodarone | 3.73 | 17567588 15342952 | |
| MESH:D008103 | Liver Cirrhosis | Dietary Fats | 3.03 | 18296743 | |
| MESH:D008133 | Long QT Syndrome | Amiodarone | 3.82 | 17391786 15350150 11989578 | |
| MESH:D008171 | Lung Diseases | Amiodarone | 3.57 | 12587719 | |
| MESH:D017563 | Lung Diseases, Interstitial | Amiodarone | 5.00 | 18516814 | |
| MESH:D009181 | Mycoses | Amiodarone | 5.42 | 12754197 17974566 | |
| MESH:D009765 | Obesity | Dietary Fats | 2.34 | 17217161 16723640 20132043 18674790 20518802 11836018 21332399 18457598 19632207 | |
| MESH:D010024 | Osteoporosis | Calcium | 3.96 | 17882678 | |
| MESH:D011658 | Pulmonary Fibrosis | Amiodarone | 2.95 | 11597910 12490602 12832656 | |
| MESH:D012640 | Seizures | Kainic Acid | 4.57 | 19414003 10686065 19186208 16336964 15686955 1641125 18657176 17827730 14637104 | |
| OMIM:609620 | SHORT QT SYNDROME 1 | Amiodarone | 5.55 | 18724381 | |
| MESH:D012893 | Sleep Disorders | Kainic Acid | 6.16 | 19414003 | |
| MESH:D013276 | Stomach Ulcer | Amiodarone | 3.64 | 18087811 | |
| MESH:D013610 | Tachycardia | Amiodarone | 4.67 | 11238279 | |
| MESH:D017180 | Tachycardia, Ventricular | Amiodarone | 4.57 | 19225199 | |
| MESH:D013959 | Thyroid Diseases | Amiodarone | 5.28 | 19731979 | |
| MESH:D013971 | Thyrotoxicosis | Amiodarone | 5.28 | 18020914 19584973 | |
| MESH:D016171 | Torsades de Pointes | Amiodarone | 4.65 | 11989578 17467628 | |
| MESH:D015430 | Weight Gain | Dietary Fats | 4.02 | 16723640 |
| Pathway ID | Pathway Name |
|---|---|
| KEGG:04020 | Calcium signaling pathway |
| REACT:604 | Hemostasis |
| KEGG:04974 | Protein digestion and absorption |
| REACT:15518 | Transmembrane transport of small molecules |